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NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling

Cellular & Molecular Immunology 2021年第4期18卷 1045-1057页

作者： Xabier Unamuno javier gomez-ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti Rafael Moncada Camilo Silva javier Salvador Gema Fruhbeck Victoria Catalan Metabolic Research Laboratory Clfnica Universidad de NavarraPamplonaSpain CIBER Fisiopatologfa de la Obesidad y Nutricion(CIBEROBN) Instituto de Salud Carlos ⅢPamplonaSpain Obesity and Adipobiology Group Instituto de Investigaci6n Sanitaria de Navarra(IdiSNA)PamplonaSpain Department of Surgery Clinica Universidad de NavarraPamplonaSpain Department of Anesthesia Clinica Universidad de NavarraPamplonaSpain Department of Endocrinology&Nutrition Clfnica Universidad de NavarraPamplonaSpain

The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated *** aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)*** obtained from 98 subjects were used in a case-control *** expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were *** impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was *** demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in *** also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and *** showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral *** revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture ***,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation.

关键词： NLRP3 Inflammasone Inflammation Obesity Type 2 diabetes Nonalcoholic fatty liver disease

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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Neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto javier Ramos Laboratorio de Neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRNAs or lncRNA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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Beyond neurodegeneration:engineering amyloids for biocatalysis

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Neural Regeneration Research 2025年第10期20卷 2915-2916页

作者： Andrea Bartolomé-Nafría javier García-Pardo Salvador Ventura Institut de Biotecnologia i de Biomedicina(IBB)and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Universitari Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet *** formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).

关键词： structure amyloid

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Endovascular treatment for early hepatic artery occlusion after liver transplantation: Angioplasty or stent

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 614-615页

作者： Mikel Gastaca javier gomez Ignacio Terreros Hepatobiliary Surgery and Liver Transplantation Unit Biocruces Bizkaia Health Research InstituteHospital Universitario CrucesBilbaoSpain University of the Basque Country BilbaoSpain Servicio de Cirugía General y Aparato Digestivo Hospital Universitario San CecilioGranadaSpain Interventional Radiology Unit Hospital Universitario CrucesBilbaoSpain

To the Editor:We read with great interest the recent article by Zhu et al.[1].In the study,the authors analyzed the outcomes of 26 patients diagnosed with hepatic artery occlusion(HAO)and treated with an endovascular approach(EVT)within the first 30 days after ortho-topic liver transplantation(LT).The median interval from LT to EVT was 7 days,most patients were treated with angioplasty and only two(7.7%)needed stent *** authors should be congrat-ulated as they achieved a 100%of success rate with an 80.8%of 1-year survival rate.

关键词： liver artery after

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The Locust (Tropidacris spp) within the Ejido “El Cuayo”

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Advances in Entomology 2025年第1期13卷 200-224页

作者： Compeán-Guzmán Francisco javier Carlos Ricardo Menéndez Gámiz Institute of Social Sciences and Faculty of Forestry Sciences Jurez University of the State of Durango Durango Mexico Agricultural Development Planning UNAM FES Aragn Nezahualcyotl Mexico

Tropidacris spp. represent the largest known group among acridoids. Their presence ranges from southeastern Mexico and has so far been confirmed only in tropical habitats. This publication seeks to highlight the current and potential challenges associated with their presence. For decades, the use of chemical insecticides has been the primary method for controlling locust populations, though these substances pose significant risks to human health and the environment. Recent research efforts are directed toward developing control methods that are less detrimental to both ecological and human health, such as biopesticides derived from pathogenic fungi, plant extracts, and strategically prescribed burns. Satellite surveillance enables the monitoring of the origination and progression of outbreaks to inform control strategy selection.

关键词： Ejido “El Cuayo” Locust Infestation Tropidacris Collaris

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Predictors of colorectal cancer testing using the California Health Inventory Survey

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World Journal of Gastroenterology 2013年第8期19卷 1247-1255页

作者： Alexandra Modiri Kian Makipour javier gomez Frank Friedenberg Section of Gastroenterology Department of MedicineTemple University HospitalPhiladelphiaPA 19140United States

AIM:To identify key variables associated with colon cancer testing using the 2009 California Health Inventory Survey(CHIS).METHODS:The CHIS has been conducted biennially since 2001 using a two-stage,geographically stratified random-digit-dial sample design to produce a representative sample of the entire *** this study we used survey data from 2001-2009 *** restricted our analysis to White,Black,and Hispanic/Latinos aged 50-80 *** data was used to calculate the proportion of participants who underwent some form of colon cancer testing(colonoscopy,flexible sigmoidoscopy or fecal occult blood testing) within the previous 5 years stratified by race/*** inferential analysis,boot-strapping with replacement was performed on the weighted sample to attain variance estimates at the 95%*** mean differences among categories we used t-tests and for comparisons of categorical data we used Pearson's χ *** logistic regression was used to identify independent variables associated with undergoing some form of *** analysis was performed to determine rates of testing over the study period stratified by ***:The CHIS database for 2009 had 30 857 unique respondents corresponding to a weighted sample size of 10.6 million ***,63.0%(63.0-63.1) underwent a colon cancer test within the previous 5 years;with 70.5%(70.5%-70.6%) of this subset having undergone *** is 44.5%(44.4%-44.5%) of all individuals 50-80 underwent *** multivariable regression,those tested were more likely to be male(OR = 1.06;95%CI:1.06-1.06),Black(OR = 1.30;95%CI:1.30-1.31),have a family member with colon cancer(OR = 1.71;95%CI:1.70-1.72),and have health insurance(OR = 2.71;95%CI:2.70-2.72).Progressive levels above the poverty line were also associated with receiving a test(100%-199%:1.21;1.20-1.21),(200%-299%:1.41;1.40-1.42),(> 300:1.69;1.68-1.70).The strongest variable was physician recommendation(OR = 3.90;95%CI:3.88

关键词： California Health Inventory Survey Colon cancer testing Colonoscopy Hispanic

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Hepatitis C virus genotype 3: Meta-analysis on sustained virologic response rates with currently available treatment options

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World Journal of Gastroenterology 2016年第22期22卷 5285-5292页

作者： javier Ampuero K Rajender Reddy Manuel Romero-gomez Inter-Centre Unit of Digestive Diseases and CIBERehd Virgen Macarena Virgen del Rocio University Hospitals University of Sevilla 41018 Sevilla Spain Instituto de Biomedicina de Sevilla 41018 Sevilla Spain Division of Gastroenterology and Hepatology Department of Medicine University of Pennsylvania Philadelphia PA 19107 United States

AIM: To address the therapeutic efficacy of various treatment regimens in genotype 3 selecting randomized clinical trials and prospective National Cohort ***:(1) PEG-INF-based therapy including sofosbuvir(SOF) + RBV for 12 wk vs SOF + RBV 24 wk;(2) SOF + RBV therapy 12 wk/16 wk vs 24 wk; and(3) the role of RBV in SOF + daclatasvir(DCV) and SOF + ledipasvir(LDV) combinations. This metaanalysis provides robust information with the intention of addressing treatment strategy for hepatitis C virus genotype ***: A combination treatment including SOF + RBV + PEG-IFN for 12 wk notes better SVR than with only SOF + RBV for 12 wk, although its association with more frequent adverse effects may be a limiting factor. Longer duration therapy with SOF + RBV(24 wk) has achieved higher SVR rates than shorter durations(12 or 16 wk). SOF + LDV are not an ideal treatment for genotype 3. CONCLUSION: Lastly, SOF + DCV combination is probably the best oral therapy option and the addition of RBV does not appear to be needed to increase SVR rates substantially.

关键词： Hepatitis C Genotype 3 Sofosbuvir Daclatasvir Ledipasvir

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Transformation of leather waste into microwave-activated and N-doped carbon for Li-S batteries

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新型炭材料(中英文) 2025年

作者： Carolina Pano-Azucena Roberto Rosas-Rangel Miguel Olvera-Sosa David Salvador González-González Rene Rangel-Mendez Luis Felipe Chazaro-Ruiz Miguel Avalos-Borja javier Antonio Arcibar-Orozco CIATEC.Center for Applied Innovation in Competitive Technologies Tecnologico de Monterrey School of Engineering and Sciences Instituto Potosino de Investigación Científica y Tecnológica Universidad Autónoma de Coahuila Facultad de SistemasCiudad Universitaria

The use of carbon from waste biomass has the potential to buffer the drawbacks of Li-S batteries and improve their overall performance. Chrome-Tanned-LeatherShavings(CTLS) are undesirable wastes, highly available for transformation into porous carbon. Microwave activation is an efficient state-of-the-art procedure to obtain unique porous structures and nitrogen incorporation can improve the performance of porous carbons. This study proposes the transformation of CTLS into a microwave activated porous carbon, and then was modified to introduce nitrogen. A microporous activated carbon with a specific surface area of 556 m2g-1 with honeycomb-like structure was obtained. Both urea thermal decomposition and ethanolamine impregnation improves the nitrogen and amine presence of surface groups. However,the results indicated that only urea treatment was effective in improving the initial capacity of the cell(1363 mAhg-1), which is probably linked with the sorption of long-chain polysulfides. This investigation confirms that it is possible to obtain carbon materials from CTLS, for use as sulfur-host cathodes in Li-S batteries, and improve their performance with urea thermal decomposition. Furthermore, a Radial basis function neural network was fitted to provide statistical support to the experimental results. The trained model corroborated the importance of nitrogen content of the carbons in the discharge capacity of the cells.

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes

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Cellular & Molecular Immunology 2021年第10期18卷 2457-2459页

作者： Gema Frühbeck Victoria Catalán Víctor Valentí Rafael Moncada javier Gómez-ambrosi Sara Becerril Camilo Silva Piero Portincasa javier Escalada Amaia Rodríguez Metabolic Research Laboratory Clínica Universidad de NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos IIIMadridSpain Obesity and Adipobiology Group Instituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Department of Endocrinology and Nutrition Clínica Universidad de NavarraPamplonaSpain Department of Surgery Clínica Universidad de NavarraPamplonaSpain Department of Anesthesia Clínica Universidad de NavarraPamplonaSpain Department of Biomedical Sciences and Human Oncology Clinica Medica“A.Murri”University of Bari Medical SchoolPoliclinico HospitalBariItaly.

A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death[1,2].Excessive adipose tissue(AT)might contribute to more extensive viral spread with increased shedding,immune activation,and cytokine amplification[3].Several factors secreted by contracting muscle,termed myokines,mediate the beneficial effects of exercise in a wide range of diseases,including obesity[4].Thus,we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family,FNDC4 and FNDC5,in mechanisms underlying the increased susceptibility to COVID-19 complications in obesity.

关键词： FNDC5 obesity FND

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