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欧洲儿科胃肠病学、肝病学和营养协会儿童及青少年炎症性肠病诊断的改良波尔图标准(2014年版)

中华儿科杂志 2016年第10期54卷 728-732页

作者： Arie Levine Sibylle Koletzko Dan Turner Johanna C.Escher Salvatore Cucchiara Lissy de Ridder Kaija-Leena Kolho Gabor Veres Richard K.Russell Anders Paerregaard Stephan Buderus Mary-Louise C.Greer Jorge A.Dias Gigi Veereman-Wauters Paolo Lionetti Malgorzata Sladek javier martin de carpi Annamaria Staiano Frank M.Ruemmele David C.Wilson 罗优优陈洁 Pediatric Gastroenterology and Nutrition Unit Wolfson Medical CenterSackler School of MedicineTel-Aviv University the Dr von Hauner Children's Hospital Ludwig Maximilians University the Pediatric Gastroenterology Unit Shaare Zedek Medical CenterThe Hebrew University of Jerusalem the Pediatric Gastroenterology Department of PediatricsErasmus MC-Sophia Children's Hospital 5. the Pediatric Gastroenterology and Liver UnitSapienza University of Rome 6. the Children's HospitalUniversity of Helsinki 7. the Semmelweis University 8. the Department of Paediatric Gastroenterology and NutritionYorkhill Children's Hospital 9. the Department of PaediatricsHvidovre University Hospital 10. the St.Marien-HospitalDepartment of Pediatrics 11. the Department of Diagnostic ImagingThe Hospital for Sick Childrenthe Department of Medical ImagingUniversity of Toronto 12. the Hospital S.Joao 13. the-Pediatric Gastroenterology and Nutrition 14. the Departement NeurofarbaUniversity of FlorenceMeyer Children Hospital 15. the Department of PediatricsGastroenterology and NutritionJagiellonian University Medical College 16. the Department of Pediatric GastroenterologyHepatology and NutritionHospital Sant Joan de De'u 17. the Department of Translational Medical SciencesSection of PediatricsUniversit

炎症性肠病(IBD)包括克罗恩病(CD)、溃疡性结肠炎(UC)和未分型IBD(IBDU)。IBD的确切诊断需综合病史、体检、实验室检查、内镜以及影像学的检查,并严格排除肠道感染、过敏性疾病或原发性免疫缺陷病(PID)。近年对儿童期起病的IBD(PIBD)的... 详细信息

炎症性肠病(IBD)包括克罗恩病(CD)、溃疡性结肠炎(UC)和未分型IBD(IBDU)。IBD的确切诊断需综合病史、体检、实验室检查、内镜以及影像学的检查,并严格排除肠道感染、过敏性疾病或原发性免疫缺陷病(PID)。近年对儿童期起病的IBD(PIBD)的研究高度提示3种PIBD的亚型均存在不典型的表型。本标准对2005年波尔图标准进行改良,利用循证方法,整合最新证据,包括诊断方法、以巴黎分型为基础的PIBD亚型的定义以及诊断误区,为新一代的PIBD提供优质的个体化管理以及可靠的诊断、评估和预后。

关键词：体检实验室检查内镜

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Arabidopsis photoperiodic regulator CONSTANS feeds back to control the circadian clock

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Molecular Plant 2024年第9期17卷 1338-1340页

作者： Abril San martin Marcelo javier Yanovsky Instituto de Investigaciones Bioquimicas de Buenos Aires(Fundacion Instituto Leloir-CONICET) Av.Patricias Argentinas 435Buenos Aires C1405BWEAraentina

Human beings live in a world defined by daily cycles of light and darkness caused by the Earth’s rotation around its ***,like most living organisms,have evolved internal circadian clocks that time biological processes in anticipation of these daily environmental changes(Young and Kay,2001).The plant clock relies on core genes encoding transcription factors(TFs),which regulate each other’s expression through intricate networks of interlocking transcriptional-translational feedback loops(Nohales and Kay,2016).These loops ultimately control the expression of thousands of genes,allowing plants to adapt to daily fluctuations in light,temperature,and humidity(Covington et al.,2008).In addition to daily rhythms,the Earth experiences yearly seasonal cycles marked by longer,warmer days in spring and summer,followed by shorter,cooler days in autumn and *** changes in day length and temperature intensify with distance from the ***,the ability of plants to adjust their growth and development in anticipation of seasonal changes determines their latitudinal distribution(McMillan,1960).

关键词： circadian seasonal Arabidopsis

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Elutriation, attrition and segregation in a conical spouted bed with a fountain confiner

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Particuology 2020年第4期18卷 35-44页

作者： Aitor Pablos Roberto Aguado Jorge Vicente Mikel Tellabide javier Bilbao martin Olazar department of Chemical Engineering University of the Basque Country UPV/EHUP.O.Box 644E48080 BilbaoSpain Novattia desarrollos Ltd.Scientific and Technologic Park of BizkaiaAstondo BideaBuilding 612E48160 DerioSpain

This study examined elutriation,attrition,and segregation in a conical spouted bed with a fountain confiner and incorporating an open sided draft *** silica sand with a wide particle size distribution was employed as a model material,operating in both the batch and continuous *** use of a fountain confiner is crucial when operating with fine particles,because otherwise the bed rapidly exhibits significant *** extent of attrition was quantified using a tracing technique based on differently-coloured sand fractions as well as monitoring size distributions by *** breakage was found to be the primary attrition mechanism,and the fountain confiner was determined to limit the elutriation of fine particles resulting from ***,only a small fraction of the finest particles were entrained from the *** incorporation of a confiner increased operational stability while reducing segregation,especially in the upper half of the bed where the majority of segregation typically ***,the bed was perfectly mixed apart from very minimal segregation close to the wall and at the bottom of the *** results provide a basis for the design and operation of larger scale equipment for the continuous drying of materials.

关键词： Spouted bed Fine sand Elutriation Attrition Segregation Fountain confinement device

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Effects of dielectric stoichiometry on the photoluminescence properties of encapsulated WSe2 monolayers

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Nano Research 2018年第3期11卷 1399-1414页

作者： javier Martfn-Sanchez Antonio Mariscal Marta de Luca Aitana Tarazaga martin-Luengo Georg Gramse Alma Halilovic Rosalia Serna Alberta Bonanni Ilaria Zardo Rinaldo Trotta Armando Rastelli Institute of Semiconductor and Solid State Physics Johannes Kepler University Linz Altenbergerstrasse 69 A-4040 Linz Austria Laser Processing Group Instituto de Optica CSIC C/Serrano 121 28006 Madrid Spain department of Physics University of Basel Klingelbergstrasse 82 4056 Basel Switzerland Institute for Biophysics Johannes Kepler University Linz Gruberstrasse 40 A-4020 Linz Austria

Two-dimensional transition metal dichalcogenide semiconductors have emerged as promising candidates for optoelectronic devices with unprecedented properties and ultra-compact footprints. However, the high sensitivity of atomically thin materials to the surrounding dielectric media imposes severe limitations on their practical applicability. Hence, to enable the effective integration of these materials in devices, the development of reliable encapsulation procedures that preserve their physical properties is required. Here, the excitonic photoluminescence （at room temperature and 10 K） is assessed on mechanically exfoliated WSe2 monolayer flakes encapsulated with SiOx and AlxOy layers by means of chemical and physical deposition techniques. Conformal coating on untreated and non- functionalized flakes is successfully achieved by all the techniques examined, with the exception of atomic layer deposition, for which a cluster-like oxide coating is formed. No significant compositional or strain state changes in the flakes are detected upon encapsulation, independently of the technique adopted. Remarkably, our results show that the optical emission of the flakes is strongly influenced by the stoichiometry quality of the encapsulating oxide. When the encapsulation is carried out with slightly sub-stoichiometric oxides, two remarkable phenomena are observed. First, dominant trion （charged exciton） photoluminescence is detected at room temperature, revealing a clear electrical doping of the monolayers. Second, a strong decrease in the optical emission of the monolayers is observed, and attributed to non-radiative recombination processes and/or carrier transfer from the flake to the oxide. Power- and temperature-dependent photoluminescence measurements further confirm that stoichiometric oxides obtained by physical deposition lead to a successful encapsulation, opening a promising route for the development of integrated two-dimensional devices.

关键词： two dimensional (2D)materials dielectric encapsulation transition metaldichalcogenides semiconductors photoluminescence WSe2

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Analysis of MIF,FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population

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Journal of Genetics and Genomics 2010年第4期37卷 257-264页

作者： Khalid Sadki Hoda Lamsyah Blanca Rueda ELmahfoud Akil Abderrahim Sadak javier martin Rajae El Aouad Human Genomic Unit Laboratory of ImmunologyNational Institute of Hygiene department of Biology Faculty of SciencesUniversity Mohammed V-Rabat Agdal 10000 department of Immunology Instituto de Parasitología y Biomedicina López-NeyraCSIC National Reference Laboratory of Tuberculosis National Institute of Hygiene Immunology and Virology department National Institute of Hygiene

In order to investigate the influence of functional polymorphisms of macrophage migration inhibitory factor （M/F）, Fcg receptors CD16A （FCGR3A） and CD32A （FCGR2A） genes on susceptibility to pulmonary tuberculosis （PTB） in the Moroccan population, we analyzed 123 patients with PTB and 154 healthy controls. The genotyping for M/F-173 （G/C）（rs755622）, FCGR2A- 131H/R （rs 1801274） and FCGR3A-158V/F （rs396991） was carried out using TaqMan SNP Genotyping Assay method. We found a statistically significant in- crease of the MIF-173CC homozygote genotype and M/F-173＂C allele frequencies in PTB patients compared with healthy controls （17.07% versus 5.84%, P = 0.003; and 35.37% versus 26.30%, P = 0.02; respectively）. In contrast, no association was observed between FCGR2A-131H/R and FCGR3A-158V/F polymorphisms and tuberculosis disease. Our finding suggests that M/F-173℃ variant may play an important role in the development of active tuberculosis.

关键词： FCGR MIF polymorphism susceptibility pulmonary tuberculosis Moroccan

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Infrared phononic nanoantennas:Localized surface phonon polaritons in SiC disks

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Chinese Science Bulletin 2010年第24期55卷 2625-2628页

作者： AMEEN Mohamed GARCIA-ETXARRI Aitzol SCHNELL martin HILLENBRAND Rainer AIZPURUA javier department of Materials Physics University of the Basque Country UPV/EHU Centro Mixto de Física de Materiales CSIC-UPV/EHU and Donostia International Physics Centre Nanooptics Group CIC Nanogune Consolider Ikerbasque

The electromagnetic interaction of light with polar materials shows a sharp and well defined electromagnetic response in the infrared(IR)region that consists mainly of excitation of optical *** to surface plasmons in the visible region,surface phonons can couple efficiently to infrared light in micron-sized antennas made of polar *** applied the boundary element method to calculating the infrared electromagnetic response of single SiC disks acting as effective infrared antennas as a function of different parameters such as disk size and *** also analyzed the effect of locating a probing metallic tip near the SiC disk to scatter light in the proximity of the SiC disk,thereby obtaining new spectral peaks connected with localized modes between the tip and the SiC *** then further investigated their application in IR scanning probe microscopy.A near-field map of the phononic resonances enhances the understanding of the nature of the IR extinction peaks.

关键词：表面声子碳化硅光磁盘红外线极化激元扫描探针显微技术电磁相互作用电磁响应

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HEART RATE VARIABILITY DURING HIGH-INTENSITY EXERCISE

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Journal of Systems Science & Complexity 2013年第1期26卷 104-116页

作者： SARMIENTO Samuel GARCIA-MANSO Juan Manuel martin-GONZALEZ Juan Manuel VA-AMONde Diana CALdeRóN javier DA SILVA-GRIGOLETTO Marzo Edir department of Physical Education University of Las Palmas de Gran Canaria Spain. Physics department University of Las Palmas de Gran Canaria Spain. department of Morphological Sciences School of Medicine University of Cdrdoba Spain. Physical Activity Sciences Faculty Polytechnic University of Madrid Spain. Andalusian Centre of Sports Medicine Cdrdoba Spain.

The aim of this paper is to describe and analyse the behaviour of heart rate variability(HRV)during constant-load,high-intensity exercise using a time frequency analysis(Wavelet Transform).Eleven elite cyclists took part in the study(age:18.6±3.0 years;VO_(2max):4.88±0.61 litres·min^(-1)).Initially,all subjects performed an incremental cycloergometer test to determine load power in a constant load-test(379.55±36.02 W;89.0%).HRV declined dramatically from the start of testing(pdensity within the LF band mirrored that of total energy,recording a significant decrease from the outset LF peaks fell rapidly thereafter,remaining stable until the end of the ***-VHF fell sharply in the first 20 to 30 *** relative weighting(%) of HF-VHF was inverted with the onset of fatigue,[1.6%at the start,7.1(pderate initial increase,followed by a slight fall,thereafter increasing to the end of the *** LF/HF-VHF ratio increased at the start,later falling progressively until the end of the first phase and remaining around minimal values until the end of the test.

关键词： Cycling heart rate variability wavelet.

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Potential strategies offered by animals to implement in buildings' energy performance: Theory and practice

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Frontiers of Architectural Research 2019年第1期8卷 17-31页

作者： Cesar martin-Gomez Amaia Zuazua-Ros javier Bermejo-Busto Enrique Baquero Rafael Miranda Cristina Sanz department of Building Construction Building Services and Structures Universidad de Navarra Pamplona 31009 Spain School of Sciences Department of Environmental Biology Universidad de Navarra Pamplona 31080 Spain

The strategies for thermal regulation and envir on mental control found in nature are countless. In this article, a parallelism between animals and building energy systems is defined in order to identJfy and emphasize the immediate opportunities that biomimicry offers for future research. The motivation was the need to find alternative solutions to tackle problems mainly in the efficiency of heating, ventilation and cooling systems. Due to the wide range of possibilities offered by animals, this study is largely limited to the strategies that cold-blooded animals have developed through evolutionary adaptation to the environment. The method used for the an a lysis is based on a soluti on-based approach. Firstly, differe nt animal thermoregulation strategies are defined (biological domain). Then the strategy is an a lyzed and classified into three categories. This classification is esse ntial in order to formulate the parallelism with building systems (transfer phase). The final step is to identify the potential implementation (technological domain).This approach has been seen to be useful in creating new research opportunities based on biomimicry. In addition, suitable solutions arising from multidisciplinary team research are presented as promising answers to the challenges that building energy systems face no wadays.

关键词： Biomimicry Building services Energy systems Passive design Multidisciplinary

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Kinetic behaviour of commercial catalysts for methane reforming in ethanol steam reforming process

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Journal of Energy Chemistry 2014年第5期23卷 639-644页

作者： Jorge Vicente javier Erea martin Olazar Pedro L.Benito javier Bilbao Ana G.Gayubo departamento de Ingeniería Química Universidad del País Vasco UPV/EHU Apartado 644 48080 Bilbao Spain departamento de Ingeniería Minera y Metalúrgica y Ciencia de los Materiales Universidad del País Vasco UPV/EHUNieves Cano 12 01006 Vitoria-Gasteiz Spain

Ethanol steam reforming has been studied in a fluidized bed （in order to ensure bed isothermicity） on commercial catalysts for methane reforming. The results allow analyzing the effect of temperature （in 300-700℃ range）, and both metal and support nature on the reaction indices （ethanol conversion, yields and selectivities to H2 and byproducts （CO2, CO, CH4 and C2H4O））. Special attention has been paid to catalysts＇ stability by comparing the evolution of the reaction indices with time on stream at 500°C （minimum CO formation） and 700℃ （minimum deactivation by coke deposition）. Although they provide a slightly lower H2 yield, the results evidence a good behaviour of Ni based catalysts, indicating that they are an interesting alternative of more expensive Rh based ones.

关键词： ethanol steam reforming hydrogen commercial catalyst selectivity deactivation

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Auricular embryonal rhabdomyosarcoma

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World Journal of Pediatrics 2022年第5期18卷 358-360页

作者： javier Arredondo Montero Monica Bronte Anaut Sara Hernandez-martin Juan Carlos Lopez-Gutierrez Pediatric Surgery department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology department Complejo Hospitalario de NavarraPamplonaSpain Pediatric Surgery department Hospital Universitario La PazMadridSpain

A 13-month-old girl presented with a red-violaceous tumor of 13 mm in diameter on the inner side of the root of the right helix,with increased temperature and cystic consistency(Fig.1).No pulse was palpable in the *** ultrasonography was performed,showing a 1.6 cm rounded lesion with well-defined margins,hypoechogenic and homogeneous,compatible with *** treatment with oral propranolol was started without improve-ment.

关键词： sarcoma ultrasonography showing

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