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Insights into the role of major bioactive dietary nutrients in lamb meat quality:a review

Journal of Animal Science and Biotechnology 2022年第4期13卷 951-966页

作者： javierálvarez-rodríguez Olaia Urrutia Sandra Lobón Guillermo Ripoll Juan Ramón Bertolín Margalida Joy Departament de Ciència Animal Universitat de Lleida25198 LleidaSpain Departamento de Agronomía Biotecnología y AlimentaciónIS-FOOD InstituteEscuela Técnica Superior de Ingeniería Agronómica y BiocienciasUniversidad Pública de NavarraPamplonaSpain Centro de Investigación y Tecnología Agroalimentaria de Aragón(CITA) Avda.Montañana 93050059 ZaragozaSpain Instituto Agroalimentario de Aragón–IA2(CITA-Universidad de Zaragoza) Avda.Miguel Servet17750013 ZaragozaSpain.

Feed supplementation withα-linolenic acid(ALA)and linoleic acid(LA)increases their content in muscle,ALA increases n-3 polyunsaturated fatty acids and decrease n-6/n-3 ratio in muscle,and LA increases rumenic ***,high LA supplementation may have negative effects on lambs’lipid oxidative stability of *** the sources of ALA and LA are fed as fresh forage,the negative effects are counterbalanced by the presence of other bioactive compounds,as vitamin E(mainlyα-tocopherol)and polyphenols,which delay the lipid oxidation in *** is a wide consensus on the capability of vitamin E delaying lipid oxidation on lamb meat,and its feed content should be adjusted to the length of supplementation.A high dietary inclusion of proanthocyanidins,phenolic compounds and terpenes reduce the lipid oxidation in muscle and may improve the shelf life of meat,probably as a result of a combined effect with dietary vitamin ***,the recommended dietary inclusion levels depend on the polyphenol type and concentration and antioxidant capacity of the feedstuffs,which cannot be compared easily because no routine analytical grading methods are yet *** phenolic compounds content in dietary ingredients/supplements for lambs are reported,no specific association with animal physiology responses may be established.

关键词： Fatty acid Forage Oilseed Polyphenol Vitamin E

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The Hypothesis of Hyperia from the Perspective of Neuronal Plasticity

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Open Journal of Medical Psychology 2016年第1期5卷 17-26页

作者： javier Álvarez-rodríguez Servicio de Psiquiatría Complejo Asistencial Universitario de León León Spain

We analyze certain mental automatisms appearing in the consciousness with phenomenological features of simple partial seizures (SPSs). We propose to include all these phenomena into a cognitive function to which we term hyperia. In this paper, we analyze the similarities between the nature of this cognitive function and the mechanisms used by our brain to elicit neuronal plasticity.

关键词： Bipolar Disorder Glutamate Partial Seizures RDoC Repetition Reflex Epilepsies Schizophrenia

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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Neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto javier Ramos Laboratorio de Neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRNAs or lncRNA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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Beyond neurodegeneration:engineering amyloids for biocatalysis

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Neural Regeneration Research 2025年第10期20卷 2915-2916页

作者： Andrea Bartolomé-Nafría javier García-Pardo Salvador Ventura Institut de Biotecnologia i de Biomedicina(IBB)and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Universitari Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet *** formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).

关键词： structure amyloid

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Building geometry data from online maps for accurate thermal simulations of districts

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Building Simulation 2023年第9期16卷 1659-1674页

作者： Laura Romero rodríguez JoséSánchez Ramos ServandoÁlvarez Domínguez Grupo Termotecnia.Departamento de Máquinas y Motores Térmicos University of CádizPuerto RealCádizSpain Grupo Termotecnia.Departamento de Ingenieria Energética University of SevilleSevilleSpain

Current approaches for simulating the energy performance of buildings on a large scale are limited by numerous assumptions and simplifications,which can lead to inaccurate *** new tools and procedures are emerging to improve accuracy,there remains a need for more user-friendly *** study proposes a new tool based on online maps to create the geometry of districts in a simple *** tool also enables an automatic evaluation of all buildings through dynamic hourly simulations,using a building simulation software and allowing to consider different weather *** illustrate the procedure,a district at risk of energy poverty in Seville(Spain)is modeled,where hourly temperature data for a whole year are available to demonstrate the need for building *** tool is used to evaluate the energy demands of the district under several retrofitting alternatives,and free-floating simulations are also performed to evaluate the improvement of thermal comfort without air-conditioning *** aim is not to discuss the actual values for this particular case,but rather to identify the correct direction for large-scale studies,so as to make them more easily ***,it may be concluded that the results provided by comprehensive tools,such as the one proposed in this study,enable easy yet accurate evaluations of buildings on a large scale with significant time savings,as well as the identification of locations where retrofitting interventions would have the greatest impact.

关键词： buildings districts energy demand efficiency GIS urban scale

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Assessment of Technical and Economic Impacts of EV User Behavior on EV Aggregator Smart Charging

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 356-366页

作者： Jean-Michel Clairand javier rodriguez-Garcia Carlosalvarez-Bel the Facultad de Ingenieria y Ciencias Agropecuarias Universidad de las Americas-Ecuador170122 QuitoEcuador the Institute for Energy Engineering Universitat Politecnica de Valencia46022 ValenciaSpain

The increase in global electricity consumption has made energy efficiency a priority for ***,there has been a focus on the efficient integration of a massive penetration of electric vehicles(EVs)into energy *** study presents an assessment of various strategies for EV *** this analysis,the smart charging methodology proposed in a previous study is *** smart charging technique employs charging power rate modulation and considers user *** adopt several strategies,this study simulates the effect of these actions in a case study of a distribution system from the city of Quito,*** actions are simulated,and the EV aggregator costs and technical conditions are evaluated.

关键词： Electric vehicle(EV) smart grid aggregator smart charging charging power modulation charging strategies

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Development and postnatal neurogenesis in the retina: a comparison between altricial and precocial bird species

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Neural Regeneration Research 2021年第1期16卷 16-20页

作者： Guadalupe Álvarez-Hernán José Antonio de Mera-rodríguez Yolanda Gañán Jorge Solana-Fajardo Gervasio Martín-Partido Joaquín rodríguez-León javier Francisco-Morcillo Área de Biología Celular Departamento de AnatomíaBiología Celular y ZoologíaFacultad de CienciasUniversidad de ExtremaduraBadajozSpain Área de Anatomía Humana Departamento de AnatomíaBiología Celular y ZoologíaFacultad de MedicinaUniversidad de ExtremaduraBadajozSpain Servicio de Oftalmología Complejo Hospitalario Universitario de BadajozBadajozSpain

The visual system is affected by neurodegenerative diseases caused by the degeneration of specific retinal neurons,the leading cause of irreversible blindness in *** vertebrate phylogeny,the retina has two kinds of specialized niches of constitutive neurogenesis:the retinal progenitors located in the circumferential marginal zone and Müller *** proliferative activity in the retinal progenitors located in the circumferential marginal zone in precocial birds such as the chicken,the commonest bird model used in developmental and regenerative studies,is very *** region adds only a few retinal cells to the peripheral edge of the retina during several months after hatching,but does not seem to be involved in retinal regeneration.Müller cells in the chicken retina are not proliferative under physiological conditions,but after acute damage some of them undergo a reprogramming event,dedifferentiating into retinal stem cells and generating new retinal ***,regenerative response after injury occurs with low efficiency in the precocial avian *** contrast,it has recently been shown that neurogenesis is intense in the retina of altricial birds at *** particular,abundant proliferative activity is detected both in the circumferential marginal zone and in the outer half of the inner nuclear ***,stem cell niches are very active in the retina of altricial *** more extensive research is needed to assess the potential of proliferating cells in the adult retina of altricial birds,it emerges as an attractive model for studying different aspects of neurogenesis and neural regeneration in vertebrates.

关键词： altricial birds circumferential marginal zone Müller glia postnatal neurogenesis precocial regeneration retinogenesis

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New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

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Neural Regeneration Research 2020年第9期15卷 1580-1589页

作者： Carlos González-Fernández Pau González Francisco javier rodríguez Laboratory of Molecular Neurology Hospital Nacional de Parapléjicos (HNP)

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2–5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. As a consequence, a great effort is being done by the scientific community in order to achieve a better understanding of the different molecular and cellular processes that influence the progression and/or outcome of this neuropathological condition and, therefore, unravel new potential targets for therapeutic intervention. Interestingly, a growing number of experimental evidences have recently shown that, besides its well-known physiological roles in the developing and adult central nervous system, the Wnt family of proteins is involved in different neuropathologica conditions, including amyotrophic lateral sclerosis. These proteins are able to modulate, at least, three different signaling pathways, usually known as canonical(β-catenin dependent) and non-canonical(β-catenin independent) signaling pathways. In the present review, we aim to provide a general overview of the current knowledge that supports the relationship between the Wnt family of proteins and its associated signaling pathways and amyotrophic lateral sclerosis pathology, as well as their possible mechanisms of action. Altogether, the currently available knowledge suggests that Wnt signaling modulation might be a promising therapeutic approach to ameliorate the histopathological and functional deficits associated to amyotrophic lateral sclerosis, and thus improve the progression and outcome of this neuropathology.

关键词： ALS astrocytes Frizzled human microglia motor neuron neurodegeneration neuroinflammation spinal cord Wnt

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Fungal contamination of stored automobile-fuels in a tropical environment

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Journal of Environmental Sciences 2010年第10期22卷 1595-1601页

作者： Carlos E.rodríguez-rodríguez Evelyn rodríguez Rigoberto Blanco Ivannia Cordero Daniel Segura Research Center in Tropical Diseases and Laboratory of Research in Anaerobic Bacteriology Faculty of MicrobiologyUniversity of Costa Rica Department of Chemical Engineering School of EngineeringAutonomous University of Barcelona Research Center in Electrochemistry and Chemical Energy University of Costa Rica

Because of the lack of reports, the base levels of microbial contamination on stored fuels are unknown in tropical regions and it is unclear whether these levels have some influence on fuel quality parameters. Therefore, fungal quality in automobile fuels stored across Costa Rican territory was evaluated during two years according to the standard ASTM D6974-04. For a total of 96 samples, counts and identification of molds and yeasts were performed on regular gas, premium gas and diesel taken from the bottom and superior part of the container tanks. The highest contamination was found on the bottom of the tanks, where an aqueous phase was usually identified, showing populations over the ones present in the hydrocarbon itself （up to 108 CFU/L）. Diesel was the most contaminated fuel （up to 107 CFO/L）; however, an alteration on the physicochemical parameters was not observed in any kind of fuel. Seventy-five mold strains were isolated, Penicillium sp. being the most common genus （45.8% of the samples）, and ten yeast strains, from the genera Candida sp. and Rhodotorula sp. Four of the yeasts were able to grow on diesel as the sole carbon source, at concentrations ranging from 0.5% to 25%. Increasing the frequency of tank cleaning, adding antimicrobial agents and monitoring microbial populations are recommended strategies to improve microbial quality of stored fuels.

关键词： fuel microbial contamination biodegradation molds yeasts

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