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Evolutionary Safe Padé Approximation Scheme for Dynamical Study of Nonlinear Cervical Human Papilloma Virus Infection Model

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2275-2296页

作者： javaid ali Armando Ciancio Kashif ali Khan Nauman Raza Haci Mehmet Baskonus Muhammad Luqman Zafar-Ullah Khan Department of Mathematics Govt.Graduate College TownshipLahore54770Pakistan Universitàdegli Studi di Messina Dipartimento di Scienze BiomedicheOdontoiatriche e delle Immagini Morfologiche e FunzionaliMessina98122Italy Department of Mathematics University of Engineering and TechnologyLahore54890Pakistan Department of Mathematics University of the PunjabLahore54590Pakistan Mathematics Research Center Near East University TRNCMersin 10Nicosia99138Turkey Department of Mathematics and Science Education Faculty of EducationHarran UniversitySanliurfa63190Turkey Department of Dermatology Rashid Latif Medical CollegeLahore54600Pakistan

This study proposes a structure-preserving evolutionary framework to find a semi-analytical approximate solution for a nonlinear cervical cancer epidemic(CCE)*** underlying CCE model lacks a closed-form exact *** solutions obtained through traditional finite difference schemes do not ensure the preservation of the model’s necessary properties,such as positivity,boundedness,and ***,the development of structure-preserving semi-analytical approaches is always *** research introduces an intelligently supervised computational paradigm to solve the underlying CCE model’s physical properties by formulating an equivalent unconstrained optimization ***-free safe Padérational functions approximate the mathematical shape of state variables,while the model’s physical requirements are treated as problem *** primary model of the governing differential equations is imposed to minimize the error between approximate *** evolutionary algorithm,the Genetic Algorithm with Multi-Parent Crossover(GA-MPC),executes the optimization *** resulting method is the Evolutionary Safe PadéApproximation(ESPA)*** proof of unconditional convergence of the ESPA scheme on the CCE model is supported by numerical *** performance of the ESPA scheme on the CCE model is thoroughly investigated by considering various orders of non-singular Padéapproximants.

关键词： Nonlinear cervical cancer epidemic non-singular Padéapproximants approximate solutions computational biology

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Fractional Analysis of Dynamical Novel COVID-19 by Semi-Analytical Technique

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Computer Modeling in Engineering & Sciences 2021年第11期129卷 705-727页

作者： S.Iqbal D.Baleanu javaid ali H.M.Younas M.B.Riaz School of Systems and Technology University of Management and TechnologyLahore54770Pakistan Department of Mathematics Cankaya UniversityAnkara06530Turkey Institute of Space Sciences MagureleBucharest077125Romania Department of Mathematics Govt.College TownshipPunjab Higher Education DepartmentLahore54770Pakistan Department of Mathematics Islamia University of BahawalpurBahawalpur63100Pakistan Department of Mathematics University of Management and TechnologyLahore54770Pakistan Institute for Groundwater Studies University of the Free StateBloemfontein9300South Africa

This study employs a semi-analytical approach,called Optimal Homotopy Asymptotic Method(OHAM),to analyze a coronavirus(COVID-19)transmission model of fractional *** proposed method employs Caputo’s fractional derivatives and Reimann-Liouville fractional integral sense to solve the underlying *** the best of our knowledge,this work presents the first application of an optimal homotopy asymptotic scheme for better estimation of the future dynamics of the COVID-19 *** proposed fractional-order scheme for the parameterized model is based on the available number of infected cases from January 21 to January 28,2020,in Wuhan City of *** the considered real-time data,the basic reproduction number is R0≈2.48293 that is quite *** proposed fractional-order scheme for solving the COVID-19 fractional-order model possesses some salient features like producing closed-form semi-analytical solutions,fast convergence and non-dependence on the discretization of the *** graphical presentations have demonstrated the dynamical behaviors of subpopulations involved in the underlying fractional COVID-19 *** successful application of the scheme presented in this work reveals new horizons of its application to several other fractional-order epidemiological models.

关键词： Novel COVID-19 semi-analytical scheme fractional analysis

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Toxoplasma gondii Elongation Factor 1-Alpha(TgEF-1α) Is a Novel Vaccine Candidate Antigen against Toxoplasmosis

Toxoplasma gondii Elongation Factor 1-Alpha(TgEF-1α) Is a N...

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第五届全国人畜共患病学术研讨会

作者： Shuai Wang ZhenChao Zhang Yujian Wang javaid ali Gadahi LiXin Xu Ruofeng Yan XiaoKai Song Xiangrui Li 南京农业大学动物医学院

Toxoplasma gondii(***)is an obligate intracellular parasite which can infect almost all warm-blood animals,leading to *** and discovery of an effective vaccine candidate or new drug target is crucial for the control of this *** this study,the recombinant *** elongation factor 1-alpha(rTgEF-1α)was successfully expressed in

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Analysis of humoral immune response and cytokines in chickens vaccinated with Eimeria brunetti apical membrane antigen-1(EbAMA1) DNA vaccine

Analysis of humoral immune response and cytokines in chicken...

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中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： Tran Duc Hoan Doan Thi Thao javaid ali Gadahia Xiaokai Song Lixin Xu Ruofeng Yan 李祥瑞南京农业大学动物医学院

This study aimed to determine the changes of cytokines,specific serum IgG and several parameters in chickens vaccinated with DNA vaccine encoding Eimeria brunetti apical membrane antigen-1(EbAMA1) ***-week-old chickens were divided into five groups(four groups for experiment)*** groups of chickens were immunized with DNA vaccine while control group of chickens were injected with pVAX1 plasmid alone or TE buffer *** immunizations were boosted 2weeks *** EbAMA1 specific IgG antibody responses were measured at weeks 1-6 post-second immunizations and several parameters were also *** result showed that the antibody titers in chickens vaccinated with DNA vaccines were significantly different from those of the control groups 1 week after the second immunization and reached the maximum values 3 weeks post-second ***-γconcentration was increased the highest level against EbAMAl of all chickens vaccinated with vaccines up to 56-fold,follow by the specific IgG antibody levels were increased 10-17-fold compared with those of TE solution and plasmid(pVAXl) control chickens 1-6 weeks post-second *** case of the levels of IL-10 and IL-17 was increased in experimental chickens with *** though it was statistically significant,TGF-p and IL-4 levels were higher in vaccinated than unvaccinated *** results suggested that DNA vaccines encoding *** apical membrane antigen-1(EbAMAl) could increase serum specific IgG antibody and cytokines concentration and could give protection against *** infection.

关键词： Eimeria brunetti Apical membrane antigen protein-1 gene Chicken DNA vaccine

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Haemonchus contortus excretory and secretory proteins(HcESPs) suppress functions of goat PBMCs in vitro

Haemonchus contortus excretory and secretory proteins(HcESPs...

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中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： javaid ali Gadahi Yongqian Bu Muhammad Ehsan Zhenchao Zhang Shuai Wang Ruofeng Yan Xiaokai Song Lixin Xu Xiangrui Li College of Veterinary Medicine Nanjing Agricultural University

Excretory and secretory products(ESPs) of nematode contain various proteins which are capable of inducing the instigation or depression of the host immune response and are involved in the pathogenesis of the worms. In the present study, Haemonchus contortus excretory and secretory products(Hc ESPs) were collected from the adult worms. Binding of Hc ESPs to goat peripheral blood mononuclear cells(PBMCs) was confirmed by immune-fluorescence assay. Effects of the Hc ESPs on cytokine production, cell proliferation, cell migration and nitric oxide(NO) production of PBMCs were checked by co-incubation of Hc ESPs with goat PBMCs. The results indicated that the production of IL-4 and IFN-γ were significantly decreased by Hc ESPs in dose dependent manner. On the contrary, the production of IL-10 and IL-17 were increased. Cell migration was significantly enhanced by Hc ESPs, whereas, Hc ESPs treatment significantly suppressed the cell proliferation and NO production. These results indicated that the Hc ESPs played important suppressive regulatory roles on PBMCs and provided highlights to the understanding of the host-parasite interactions.

关键词： Haemonchus contortus ESP goat PBMC immunomodulation

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Nanoparticles(PLGA and Chitosan)-Entrapped ADP-Ribosylation Factor 1 of Haemonchus contortus Enhances the Immune Responses in ICR Mice

Nanoparticles(PLGA and Chitosan)-Entrapped ADP-Ribosylation ...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Muhammad Waqqas Hasan Muhammad Haseeb Muhammad Ehsan javaid ali Gadahi Muhammad ali-Ul-Husnain Naqvi Qiang Qiang Wang Xinchao Liu Shakeel Ahmed Lakho Ruofeng Yan Lixin Xu Xiaokai Song 李祥瑞 College of Veterinary Medicine Nanjing Agricultural University

ADP-ribosylation factor 1(HcARF1) is one of the Haemonchus contortus(***)excretory/secretory proteins involved in modulating the immune response of goat peripheral blood mononuclear cells(PBMC).Here,we evaluated the immunogenic potential of recombinant HcARF1(rHcARF1) against *** infection in Institute of Cancer Research(ICR) ***,rHcARF1 was entrapped in poly(D,L-lactide-co-glycolide)(PLGA) and chitosan(CS)nanoparticles(NP) and injected into mice as a ***-six ICR mice were assigned randomly into seven groups,with eight animals in each group,and they were vaccinated *** the end of the experiment(14 th day),the blood and the spleen were collected from euthanized mice to detect lymphocyte proliferation,cytokine analysis,and the production of antigen-specific *** electron microscope was used to determine the size,morphology,and zeta potential of *** cytometry was performed,which presented the increase percentages of CD4+T cells(CD3 e+CD4+),CD8+T cells(CD3 e+CD8+) and dendritic cells(CD11 c+CD83+,CD11 c+CD86+) in mice vaccinated with rHcARF1+PLGA *** analysis show raised humoral(Immunoglobulin(Ig)G1,IgG2 a,IgM) and cell-mediated immune response(Interleukin(IL)-4,IL-12,and IL-17,and Interferon(IFN)-γ)induced by rHcARFl+PLGA *** groups that were treated with the antigen-loaded NP yield higher lymphocyte proliferation than the control *** on these results,we could propose that the rHcARF1 encapsulated in NP could stimulate a strong immune response in mice rather than administering alone against the infection of ***.

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The immunogenic maturation of goat monocyte-derived dendritic cells and upregulation of toll-like receptors by five antigens of Haemonchus contortus in-vitro

The immunogenic maturation of goat monocyte-derived dendriti...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Muhammad Waqqas Hasan Muhammad Haseeb Muhammad Ehsan javaid ali Gadahi Qiangqiang Wang Muhammad ali Memon Muhammad Tahir Aleem Shakeel Ahmed Lakho Ruo Feng Yan Li Xin Xu Xiao Kai Song 李祥瑞 College of Veterinary Medicine Nanjing Agricultural University

Previously,it was found that several proteins of Haemonchus contortus were involved in the stimulation of the host immune ***,the information about the selection of superlative antigens with immunogenic efficacies on host DCs is *** the current study,the stimulatory effects of five recombinant proteins(elongation factor-1α,arginine kinase,ES-15,ES-24,and ADP-ribosylation factor 1) of *** on the maturation of goat monocyte-derived dendritic cells(md-DCs) were *** proteins were purified separately in *** expression and incubated with isolated goat peripheral blood mononuclear cells(PBMC).Immunofluorescence assay(IFA) results confirmed the binding of these molecules to the md-DC’s surface as compared to control *** the flow cytometry analysis,recombinant proteins induced md-DC stimulation via the up-regulation of the expression of the costimulatory molecule(CD80) and MHC-Ⅱ.Quantitative RT-PCR data showed a significant increase in the expression of specific genes of the WNT and toll-like receptor(TLR) signaling *** result of ELISA indicated the higher levels of cytokine(IL-10,IL-12,IFN-y,and TNF-α) secretion in the md-DC compared to the negative(pET-32 a His-Tag) and blank(PBS)control *** data gives valuable support in the selection of potential antigens for future studies on the immunomodulation of the host against the infection of ***.

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Protective immunity against acute toxoplasmosis in BALB/c mice induced by a DNA vaccine encoding Toxoplasma gondii 10kDa excretory-secretory antigen(TgESA10)

Protective immunity against acute toxoplasmosis in BALB/c mi...

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第五届全国人畜共患病学术研讨会

作者： Shuai Wang YuJian Wang XinChao Liu ZhengChao Zhang XiaoNi Sun javaid ali Gadahi TingQi Liu Ibrahim A.Hassan LiXin Xu RuoFeng Yan XiaoKai Song Xiangrui Li 南京农业大学动物医学院

Toxoplasma gondii 10kDa excretory-secretory antigen(TgESAlO)is involved in the early stages of host *** aim of this study was to evaluate the immune protective efficacy of a DNA vaccine encoding TgESAlO gene against acute *** infection in *** gene sequence encoding TgESAlO was inserted into the eukaryotic expression vector pVAX1,and the efficacy of

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Ultrastructural Changes of Scolex on Cysticercus pisiformis during Relative Rest and Motion States

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Agricultural Science & Technology 2014年第1期15卷 111-115页

作者：潘耀谦张柳平王帅李瑞珍刘志科孙玉倩 javaid ali Gadahi 刘兴友河南科技学院动物科学学院河南新乡453003 江苏大学医学院江苏镇江212013 南京农业大学动物医学学院江苏南京210095 信德农业大学/兽医寄生虫学系

[Objective] This study aimed to research the ultra-morphological changes of scolex of Cysticercus pisiformis during the relative rest and motion states. [Method] The ultrastructure changes of scolex located in cyst and evaginated from cyst after cultivation were comparatively observed by scanning electron microscope. [Result] When the scolex was in the relative rest state, observed from the top, the rostel um with the tegument muscular column that connected to tooth-hook looked like the umbrel a and covered on the front end of the scolex. Viewed from the side of the scolex, the tooth-hook on the rostel um looked like the antler branch and had only one row. Four suckers looked like cavities, and were located in the back of the rostel um and distributed around the scolex in the equidistance. When the scolex was in the motion states, the tegument muscular column on the rostel um contracted, the antler-like tooth-hook extended to periphery, and the sucker also made the ring-like and longitudinal-like contraction. [Conclusion] Ultrastructure of the scolex of C. pisiformis changed apparently during relative rest and motion states. Those changes help scolex to invade the host tissue.

关键词： Cysticercus pisiformis Scolex Rostellum Sucker Ultrastructure

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Heat Transfer Enhancement of an Automobile Engine Radiator using ZnO Water Base Nanofluids

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Journal of Thermal Science 2020年第4期29卷 1010-1024页

作者： Muhammad QASIM Muhammad SAJID KAMRAN Muhammad AMMAR Muhammad ali JAMAL Muhammad YASAR javaid Department of Mechanical Engineering University of Engineering and TechnologyLahore 54890Pakistan Department of Chemical Engineering Technology Government College UniversityFaisalabad 38000Pakistan Department of Mechanical Engineering Technology Government College UniversityFaisalabad 38000Pakistan

In this research paper, the forced convective heat transfer enhancement of a Suzuki Mehran(VXR) 2016 radiator(heat exchanger) along with pressure drop and friction factor by utilizing Zinc oxide(Zn O) water based nanofluids has been experimentally studied. Three types of nanofluids with different volumetric concentrations of Zn O nanoparticles(0–0.3%) were employed in order to understand its effect on heat transfer enhancement. The experimental setup was completely designed as closely as possible to the car cooling system. The experimentation has been done under laminar flow conditions(186≤Re≤1127) at different fluid volume flow rates(2–12 L/min) and constant fluid inlet temperature(70°C) to the automobile radiator. A maximum enhancement in heat transfer rate, overall heat transfer coefficient and Nusselt number was obtained up to 41%, 50% and 31% by using nanofluid with 0.2% volumetric concentration of nanoparticles respectively. On the other hand, the mean enhancement in pressure drop and friction factor was obtained up to 47% and 46% by using nanofluid with the same volumetric concentration of nanoparticles i.e. 0.2% respectively. The experimental results also revealed that the heat transfer rate, overall heat transfer coefficient and Nusselt number of nanofluids increases by increasing the volume flow rates and volumetric concentration of nanoparticles. However, these thermal performance parameters of nanofluids started to decline when the volumetric concentration of nanoparticles was increased from 0.2% to 0.3%. Furthermore, pressure drop and friction factor of nanofluids increase by increasing the volumetric concentration of nanoparticles, while pressure drop increases and friction factor decreases by increasing the volume flow rate of nanofluids respectively. At the end, the thermal efficiency of automobile radiator with high cooling rates was obtained by using nanofluid with 0.2% volumetric concentration of nanoparticles.

关键词： ZnO nanoparticles heat transfer enhancement thermal efficiency automobile radiator

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