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Aerobic interval training preconditioning protocols inhibit isoproterenol-induced pathological cardiac remodeling in rats:Implications on oxidative balance,autophagy,and apoptosis

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Sports Medicine and Health Science 2024年第4期6卷 344-357页

作者： Hakimeh Shahsavarnajand Bonab javad tolouei azar Hamid Soraya Akbar Nouri Habashi Department of Exercise Physiology and Corrective Exercises Faculty of Sport SciencesUrmia UniversityUrmiaIran Department of Pharmacology and Toxicology School of PharmacyUrmia University of Medical SciencesUrmiaIran

This study aimed to investigate the potential cardioprotective effects of moderate and high-intensity aerobic interval training(MIIT and HIIT)*** focus was on histological changes,pro-oxidant-antioxidant balance,autophagy initiation,and apoptosis in myocardial tissue incited by isoproterenol-induced pathological cardiac remodeling(ISO-induced PCR).Male Wistar rats were randomly divided into control(n=6),ISO(n=8),MIIT(n=4),HIIT(n=4),MIIT+ISO(n=8),and HIIT+ISO(n=8)*** MIIT and HIIT protocols were administered for 10 weeks,followed by the induction of cardiac remodeling using subcutaneous injection of ISO(100 mg/kg for two consecutive days).Alterations in heart rate(HR),mean arterial pressure(MAP),rate pressure product(RPP),myocardial oxygen consumption(MVO_(2)),cardiac hypertrophy,histopathological changes,prooxidant-antioxidant balance,autophagy biomarkers(Beclin-1,Atg7,p62,LC3Ⅰ/Ⅱ),and apoptotic cell distribution were *** findings revealed that the MIIT+ISO and HIIT+ISO groups demonstrated diminished myocardial damage,hemorrhage,immune cell infiltration,edema,necrosis,and apoptosis compared to ISO induced *** and HIIT preconditioning mitigated HR,enhanced MAP,and preserved MVO_(2)and *** pro-oxidant-antioxidant balance was sustained in both MIIT+ISO and HIIT+ISO groups,with MIIT primarily inhibiting pro-apoptotic autophagy progression through maintaining pro-oxidant-antioxidant balance,and HIIT promoting pro-survival *** results demonstrated the beneficial effects of both MIIT and HIIT as AITs preconditioning in ameliorating ISO-induced PCR by improving exercise capacity,hemodynamic parameters,and histopathological *** of these protective effects can be attributed to the modulation of cardiac apoptosis,autophagy,and oxidative stress.

关键词： Pathological cardiac remodeling Aerobic interval training preconditioning Oxidative stress Autophagy Apoptosis

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Advances and opportunities in wind energy harvesting using plasma actuators:a review

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Clean Energy 2024年第1期8卷 197-225页

作者： javad Omidi Department of Chemical Engineering Columbia UniversityNew YorkNYUSA

The dielectric barrier discharge plasma actuator has been recognized as a leading technology for controlling fluid flow and has found remarkable applications in wind energy harvesting over the past *** turbine aerodynamics are critical in this concept and performance is mainly determined by flow controllers,although significant technical progress is still *** paper examines all the critical studies to investigate the potential application of plasma actuators for airflow control over wind *** approach has been divided into three categories:wind turbine airfoils,horizontal-axis wind turbines and vertical-axis wind turbines aerodynamic performance and generated ***,the potential functions of plasma actuators in current and future wind turbine generators are *** actuators offer promising solutions to increasing power output,minimizing torque fluctuations and enabling self-starting capabilities,particularly in vertical-axis wind *** adjusting blade pitch angles in conjunction with plasma actuators,significant improvements in airflow optimization and power extraction have been *** the advancements,challenges persist,such as determining optimal actuator placement and overcoming structural limitations,especially concerning 3D effects and high Reynolds *** plasma actuators enhance aerodynamic efficiency,their complexity needs to be balanced against marginal gains in power production,especially in high-megawatt turbines,for which controlling flow at low wind speeds is *** research must focus on the sustainable integration of plasma actuators,pitch angle adjustments and active control mechanisms to fully exploit the potential of wind energy for a sustainable future.

关键词： plasma actuator wind turbine aerodynamic performance generated power

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Increasing the Maximum Capacity Path in a Network and Its Application for Improving the Connection Between Two Routers

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Tsinghua Science and Technology 2024年第3期29卷 753-765页

作者： Adrian M.Deaconu javad Tayyebi Department of Mathematics and Computer Science Transilvania University of BrasovBrasov 500036Romania Department of Industrial Engineering Birjand University of TechnologyBirjand 000097Iran

Abstract:This paper addresses the problem of improving the optimal value of the Maximum Capacity Path(MCP)through expansion in a flexible network,and minimizing the involved *** only condition applied to the cost functions is to be non-decreasing *** is a non-restrictive condition,reflecting the reality in practice,and is considered for the first time in the ***,the total cost of expansion is a combination of max-type cost(e.g.,for supervision)and sum-type cost(*** building infrastructures,price of materials,price of labor,etc.).For this purpose,two types of strategies are combined:(l)increasing the capacity of the existing arcs,and(l)adding potential new *** different problems are introduced and *** the problems have immediate applications in Internet routing *** first one is to extend the network,so that the capacity of an McP in the modified network becomes equal to a prescribed value,therefore the cost of modifications is minimized.A strongly polynomial-time algorithm is deduced to solve this *** second problem is a network expansion under a budget constraint,so that the capacity of an McP is maximized.A weakly polynomial-time algorithm is presented to deal with *** the special case when all the costs are linear,a Meggido's parametric search technique is used to develop an algorithm for solving the problem in strongly polynomial *** new approach has a time complexity of O(n^(4)),which is better than the time complexity of O(n4 log(n)of the previously known method from literature.

关键词： Maximum Capacity Path(MCP) network expansion Internet routing polynomial-time algorithms

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Changes in climatic conditions drive variations in arbuscular mycorrhizal fungi diversity and composition in semi-arid oak forests

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Journal of Forestry Research 2024年第5期35卷 106-119页

作者： Nahid Jafarian javad Mirzaei Reza Omidipour Yahya Kooch Department of Forest Science Faculty of AgricultureIlam UniversityIlam 69315-516Iran Department of Range and Watershed Management Faculty of AgricultureIlam UniversityIlam 69315-516Iran Faculty of Natural Resources and Marine Sciences Tarbiat Modares UniversityNoor 46417-76489MazandaranIran

Arbuscular mycorrhizal fungi(AMF)play a vital role in plant productivity and ecosystem ***,their responses to abiotic factors(i.e.,climate,physiography,and soil properties)are unknown,especially across climatic gradients and slope aspects in arid and semi-arid *** this study,using 60 composite soil samples,direct and indirect effects of climate factors and slope aspects on AMF diversity,composition and spore density were *** findings indicate that climate has a more direct influ-ence on soil properties(P<0.001)in comparison to slope aspect(P=0.449).In contrast,climate significantly affected AMF diversity and composition,with the highest diversity in dryer *** pH had the highest correlation with different facets of AMF *** equation modeling(SEM)indicated that only a small part of the variation in AMF diversity and spore density could be explained by climate characteristics,slope aspect and soil *** on SEM results,climate was the most important determinant of AMF diversity and spore density;slope aspect had a less critical *** outputs suggest that variations in AMF diversity are derived by the direct effects of climate and the indirect effect of soil chemical *** addition,with increasing dryness,sporulation and AMF diversity increased.

关键词： AMF diversity and composition Physiographic factors Semi-arid ecosystems Zagros forest

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Performance analysis of a tuned point absorber using SPH calm water and wave tank simulations

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Journal of Ocean Engineering and Science 2024年第5期9卷 409-436页

作者： Kaveh Soleimani Mohammad javad Ketabdari Department of Maritime Engineering Amirkabir University of TechnologyTehranIran

In this paper,two smoothed particle hydrodynamics(SPH)models,namely SPH-W and SPH-C were used to evaluate the motion response of a point absorber wave energy converter(WEC).In the SPH-W model,a long wave flume was constructed and a long simulation was performed to obtain the motion response of the *** the SPH-C model,the SPH method is only used to find the hydrodynamic coefficients of the device by analysing a few seconds of free-decaying motion of WEC in calm water in a much smaller numerical ***,these coefficients were inserted in the equation of motion of a heaving WEC that was solved using a 4th order Runge-Kutta(ODE45)solver in ***,the energy conservation property of the WCSPH model was examined through a standing wave benchmark ***,the wavepoint absorber interaction was *** the simulation time for SPH-C model is much smaller than that of SPH-W,it gave almost similar results for the motion response of *** two models were used to evaluate the effects of the control force and the draft of a cone-cylinder point absorber on its hydrodynamic *** results showed that compared to the effect of the supplementary inertia,changes in the draft of the WEC have a small influence on its hydrodynamic *** buoy draft has an inverse relationship with both added mass and damping ***,increasing the supplementary mass increases the added mass and decreases the hydrodynamic damping coefficients.

关键词： Point absorber Power take-off Control forces SPH wave tank test SPH calm water test DualSPHysics

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Modelling rapid non-destructive test using light weight deflectometer on granular soils across different degrees of saturation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2732-2748页

作者： javad Ghorbani Arooran Sounthararajah Troyee Tanu Dutta Jayantha Kodikara ARC Smart Pavements Hub Dept.of Civil EngineeringMonash UniversityVIC3800Australia

This study introduces an advanced finite element model for the light weight deflectometer(LWD),which integrates contact mechanics with fully coupled *** simulating LWD tests on granular soils at various saturation levels,the model accurately reflects the dependence of the LWD modulus on dry density,water content,and effective *** model addresses and overcomes the limitations of previous finite element models for this specific ***,this research presents the first experimentally validated fully coupled contact impact ***,the research provides a comparative assessment of elastoplastic and nonlinear elastic models and contrasts an enriched node-tosegment method(developed in this study)with the more precise mortar technique for contact *** comparisons reveal unique advantages and challenges for each ***,the study underscores the importance of careful application of the LWD modulus,emphasising the need for sophisticated tools to interpret soil behaviour accurately.

关键词： Granular soils Plasticity Finite element analysis Contact mechanics Modulus Degree of saturation

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Suspended particulate matter promotes epithelial-to-mesenchymal transition in alveolar epithelial cells via TGF-β1-mediated ROS/IL-8/SMAD3 axis

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Journal of Environmental Sciences 2024年第7期141卷 139-150页

作者： Shahrzad Molavinia Dian Dayer Mohammad javad Khodayar Gholamreza Goudarzi Maryam Salehcheh Cellular and Molecular Research Center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Toxicology School of PharmacyAhvaz Jundishapur University of Medical SciencesAhvazIran Student Research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Toxicology Research Center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran Air Pollution and Respiratory Diseases Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Iranian Scientific Association of Clean Air TehranIran

Epidemiological evidence presents that dust storms are related to respiratory diseases,such as pulmonary fibrosis(PF).However,the precise underlying mechanisms of SPM-elicited adverse effects still need to be ***-mesenchymal transition(EMT)process is a characteristic of *** discussed whether suspended particulate matter(SPM)is involved in EMT induction via transforming growth factor-β1(TGF-β1).In this study,a detailed elemental analysis(55 elements),particle size,and morphology were *** investigate the toxicity of SPM,an MTT test was performed to detect cell ***,A549cells were exposed to selected concentrations of SPM(20 and 40μg/mL)for single and repeated *** DCFH-DA assay showed that exposure to SPM could produce reactive oxygen species(ROS).The ELISA assay demonstrated increased levels of interleukin-8(IL-8)and TGF-β1 in the *** blot was used to detect the expression of proteins associated with EMT and the SMAD3-dependent *** of western blot demonstrated that E-cadherin was reduced,whereas p-SMAD3,vimentin,andα-smooth muscle actin were *** findings indicated that SPM triggered EMT by induction of oxidative stress,inflammation,and the TGF-β1/SMAD3 pathway activation.

关键词： Particulate matter TGF-β1 Oxidative stress Epithelial-mesenchymal transition Pulmonary fibrosis Cells

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Effects of heat stress and long photoperiod on the prostate of rats

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Asian pacific Journal of Reproduction 2024年第4期13卷 187-196页

作者： Hamid Reza Ghaffari javad Poursamimi Department of Basic Sciences School of MedicineZabol University of Medical SciencesZabolIran Department of Immunology Faculty of MedicineZabol University of Medical SciencesZabolIran

Objective:To examine light and heat effects on the morphological,histological,and micrometric structure of the prostate of ***:Thirty adult male rats were divided into three *** control group was kept under 20℃-22℃ and an artificial 12 h/12 h day/night cycle;the temperature group was under normal light and at(42±1)℃ heat for 4 to 5 h daily,and the light group was exposed to 8 h/16 h day/night cycle with 20℃-22℃.Rats were weighed five times(at the beginning of the study and every seven days).Five milliliters(mL)of their peripheral blood were *** tissue staining was performed using the hematoxylin-eosin(H&E)stain and periodic acid-Schiff(PAS).In the following,tissue and cellular reactions to the PAS were ***:Folds were located entirely on the surface of the anterior lobe and periphery of the other *** secretory units in the anterior lobe were more than the lateral lobe.A strong reaction of the secretory cells to the PAS was *** serum levels of the light group also significantly increased compared to the control group(P<0.05).The most histometric changes of the lobes were established in the lateral *** stress resulted in a significant decrease in testosterone levels and transformed prostate *** epithelium and parenchyma to scaffold ratio in the temperature group ***:Maximum and minimum changes in the ventral lobe happened under the ascent of temperature and light,*** ventral lobe in the study of prostatic hyperplasia should be more considered.

关键词： Prostate Heat stress Photoperiod Histology Testosterone Rat

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Temperature-jump tensile tests to induce optimized TRIP/TWIP effect in a metastable austenitic stainless steel

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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2025-2036页

作者： Mohammad javad Sohrabi Hamed Mirzadeh Saeed Sadeghpour Abdol Reza Geranmayeh Reza Mahmudi School of Metallurgy and Materials Engineering College of EngineeringUniversity of Tehran14395-515TehranIran Centre for Advanced Steels Research Materials and Mechanical EngineeringUniversity of Oulu90014 OuluFinland

In the present work,plastic deformation mechanisms were initially tailored by adjusting the deformation temperature in the range of 0 to 200℃ in AISI 304L austenitic stainless steel,aiming to optimize the strength-ductility *** was shown that the combined twinning-induced plasticity(TWIP)/transformation-induced plasticity(TRIP)effects and a wider strain range for the TRIP effect up to higher strains by adjusting the deformation temperature are good strategies to improve the strength-ductility synergy of this metastable stainless *** this regard,by consideration of the observed temperature-dependency of plastic deformation,the controlled sequence of TWIP and TRIP effects for archiving superior strength-ductility trade-off was intended by the pre-designed temperature jump tensile ***,the optimum tensile toughness of 846 MJ/m^(3) and total elongation to 133% were obtained by this strategy via exploiting the advantages of the TWIP effect at 100℃ and the TRIP effect at 25℃ at the later stages of the ***,a deformation-temperature-transformation(DTT)diagram was developed for this metastable ***,based on work-hardening analysis,it was found that the main phenomenon constraining further improvement in the ductility and strengthening was the yielding of the deformation-induced α′-martensite.

关键词： metastable stainless steels transformation-induced plasticity twinning-induced plasticity stacking fault energy mechanical properties

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Interplay between temperature-dependent strengthening mechanisms and mechanical stability in high-performance austenitic stainless steels

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2182-2188页

作者： Mohammad javad Sohrabi Hamed Mirzadeh Saeed Sadeghpour Milad Zolfipour Aghdam Abdol Reza Geranmayeh Reza Mahmudi School of Metallurgy and Materials Engineering College of EngineeringUniversity of Tehran14395-515 TehranIran Centre for Advanced Steels Research Materials and Mechanical EngineeringUniversity of Oulu90014 OuluFinland Department of Mechanical Engineering College of EngineeringUniversity of Tehran14395-515 TehranIran

The effects of deformation temperature on the transformation-induced plasticity(TRIP)-aided 304L,twinning-induced plasti-city(TWIP)-assisted 316L,and highly alloyed stable 904L austenitic stainless steels were compared for the first time to tune the mechan-ical properties,strengthening mechanisms,and strength-ductility *** this purpose,the scanning electron microscopy(SEM),electron backscattered diffraction(EBSD),X-ray diffraction(XRD),tensile testing,work-hardening analysis,and thermodynamics calcu-lations were *** induced plasticity effects led to a high temperature-dependency of work-hardening behavior in the 304L and 316L stainless *** the deformation temperature increased,the metastable 304L stainless steel showed the sequence of TRIP,TWIP,and weakening of the induced plasticity mechanism;while the disappearance of the TWIP effect in the 316L stainless steel was also ***,the solid-solution strengthening in the 904L superaustenitic stainless steel maintained the tensile properties over a wide temper-ature range,surpassing the performance of 304L and 316L stainless *** this regard,the dependency of the total elongation on the de-formation temperature was less pronounced for the 904L alloy due to the absence of additional plasticity *** results re-vealed the importance of solid-solution strengthening and the associated high friction stress for superior mechanical behavior over a wide temperature range.

关键词： austenitic stainless steels mechanical behavior stacking fault energy metastability mechanical twinning

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