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Basic subgroup and Reid's theorem

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Science China Mathematics 2011年第10期54卷 2249-2251页

作者： NGU min Hui wong Kok Bin wong Peng Choon Institute of Mathematical Sciences University of Malaya

We give conditions under which a torsion-free abelian group is the sum of two basic subgroups.

关键词：自由Abel群定理子群扭转

Quercetin-3-O-β-D-glucuronide Inhibits Mitochondria Pathway-mediated Platelet Apoptosis via the Phosphatidylinositol-3-kinase/AKT Pathway in Immunological Bone Marrow Failure

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World Journal of Traditional Chinese Medicine 2022年第1期8卷 115-122页

作者： Le-min Xia Ai-Ping Zhang Qin Zheng Jie Ding Zhe Jin Hai Yu Wan-Hui wong He-Ping Yu Department of Hematology Jing'an District Centre Hospital of Shanghai(Jing'an BranchHuashan HospitalFudan University)ShanghaiChina Department of Hematology Shanghai Bao'shan Hospital of Integrated Traditional Chinese and Western Medicine(Bao'shan Branch of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine)ShanghaiChina Department of Hematology Laboratory Singapore General HospitalSingapore

Objective: Quercetin-3-O-β-D-glucuronide(QG) can alleviate immunological bone marrow failure(BMF) by increasing platelet counts. However, the principal mechanism is less known. This study aimed at deciphering the possible underlying mechanism of QG that is indicated in thrombocytopenic purpura. Methods: In vitro and in vivo experiments were carried out for investigating the mechanism behind QG-facilitated inhibition of mitochondrial pathway-mediated excessive apoptosis of platelets through the phosphatidylinositol-3-kinase(PI3K)/AKT pathway. Results: Our results revealed that QG, the main effective ingredient of Herba Sarcandrae, increases the number of platelets and decreases the expression of Bax, Bad, Bid, and caspase-9 in immunological BMF, indicating the inhibition of mitochondrial pathway-mediated apoptosis. Moreover, we found that the protein and m RNA expressions, as well as the phosphorylated levels of PI3K and AKT, were increased significantly by QG, suggesting the activation of the PI3K/AKT pathway. Furthermore, the inhibition of the PI3K/AKT pathway by LY294002 antagonizes the effects of QG on platelet counts and mitochondrial pathway-mediated apoptosis. Conclusion: We demonstrate that QG inhibits the mitochondria pathway-mediated platelet apoptosis via the PI3K/AKT pathway in immunological BMF. This study thus sheds light on exploring the possible regulatory mechanism of traditional Chinese medicine in the treatment of thrombocytopenia induced by BMF.

关键词： Apoptosis mitochondrial pathway phosphatidylinositol-3-kinase/AKT platelets Quercetin-3-O-β-D-glucuronide

Correction: Genomic diversity and ecological distribution of marine Pseudoalteromonas phages

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Marine Life Science & Technology 2023年第2期5卷 286-288页

作者： Kaiyang Zheng Yue Dong Yantao Liang Yundan Liu Xinran Zhang Wenjing Zhang Ziyue Wang Hongbing Shao Yeong Yik Sung Wen Jye Mok Li Lian wong Andrew Mcminn min Wang College of Marine Life Sciences Institute of Evolution and Marine Biodiversityand Frontiers Science Center for Deep Ocean Multispheres and Earth SystemOcean University of ChinaQingdao 266100China UMT-OUC Joint Center for Marine Studies Qingdao 266003China Institute of Marine Biotechnology Universiti Malaysia Terengganu(UMT)21030 Kuala NerusMalaysia Institute for Marine and Antarctic Studies University of TasmaniaHobartAustralia Haide College Ocean University of ChinaQingdao 266100China The Afliated Hospital of Qingdao University Qingdao 266000China

In this article the graphics relating to Figs.2 and 3 captions had been interchanged;the fgure(s)should have appeared as shown *** original article has been *** Access This article is licensed under a Creative Commons... 详细信息

关键词： Open Creative Access License

Relatively rapid evolution rates of SARS-CoV-2 spike gene at the primary stage of massive vaccination

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维普期刊数据库

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Biosafety and Health 2022年第4期4卷 228-233页

作者： Jing Yang min Han Liang Wang Likui Wang Tianrui Xu Linhuan Wu Juncai Ma Gary wong Wenjun Liu George F.Gao Yuhai Bi CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Anatomy and Cell Biology McGill UniversityMontreal H3A0G4Canada Microbial Resource and Big Data Center Chinese National Microbiology Data Center(NMDC)Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai 200031China

A series of stringent non-pharmacological and pharmacological interventions were implemented to contain the pandemic but the pandemic ***,vaccination breakthrough infection and reinfection in convalescent coronavirus disease 2019(COVID-19)cases have been ***,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants emerged with mutations in spike(S)gene,the target of most current ***,the mutations exhibit a trend of immune escape from the *** the scientific question that if the vaccination drives genetic or antigenic drifts of SARS-CoV-2 remains *** performed correlation analyses to uncover the impacts of wide vaccination on epidemiological characteristics of *** addition,we investigated the evolutionary dynamics and genetic diversity of SARS-CoV-2 under immune pressure by utilizing the Bayesian phylodynamic inferences and the lineage entropy calculation *** found that vaccination coverage was negatively related to the infections,severe cases,and deaths of COVID-19 *** the increasing vaccination coverage,the lineage diversity of SARS-CoV-2 dampened,but the rapid mutation rates of the S gene were identified,and the vaccination could be one of the explanations for driving mutations in S ***,new epidemics resurged in several countries with high vaccination coverage,questioning their current pandemic control ***,integrated vaccination and non-pharmacological interventions are critical to control the ***,novel vaccine preparation should enhance its capabilities to curb both disease severity and infection possibility.

关键词： SARS-CoV-2 Vaccine Genetic evolution Genetic drift Antigenic drift Lineage divergence Epidemiological characteristics

Investigation and Comparison of Two Models in Galvanic Coupling Intra-body Communications

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China Communications 2010年第4期7卷 35-40页

作者： PUN Siohang GAO Yueming wong Kuokkit MAK Pengun VAI Mangi DU min Department of Electrical and Electronics Engineering Faculty of Science and Technology Universi（y of Macao Macao China Key Laboratory of Medical Instrumentation ＆ Pharmaceutical Technology Fujian Province China Institute of Precision Instrument Fuzhou University Fuzhou China

Intra-body communication (IBC) is a new,emerging,short-range and human body based communication *** is a technique to network various devices on human body,by utilizing the conducting properties of human tissues,suitable for currently fast developing Body area network (BAN)/Body sensor network (BSN).IBC is believed to have advantages in power consumption,electromagnetic radiation,interference from external electromagnetic noise,security,and restriction in spectrum *** this article,the authors develop two models,which are analytical and empirical approaches,for comparing the performance and accuracy of IBC on a human *** in vivo experiment of five volunteers,both models basically match with the experimental result with equivalent circuit model superior than electromagnetic model in term of maximum error.

关键词：通讯方法网络电磁辐射干扰

Study on Interaction of L-Tryptophan with p-Suffonatocalix[4]arene by Spectrofluorometry

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Chinese Chemical Letters 2006年第12期17卷 1592-1594页

作者： Wen Ye LI Ying Li WEI Wen Ting AN Shao min SHUANG Man Shing wong School of Chemistry and Chelmcal Engmeenng Shanxi University Taiyuan 030006 Department of Chemistry Hong Kong Baptist University Hong Kong

The interactions between L-tryptophan（L-Trp） and water-soluble p-sulfonatocalix[4]- arene （SCX4） were investigated by spectrofluorometry. The effect of pH was discussed. The interaction process was estimated from the thermodynamic viewpoint. The SCX4 was found to be able to adjust its conformation to fit the size of L-Trp, and the benzene of L-Trp penetrated into the hydrophobic cavity of SCX4. Meanwhile, the binding mechanism was further elucidated by IHNMR and molecular mechanics calculations.

关键词： L-Tryptophan p-sulfonatocalixarene fluorescence.

Clinical and molecular characteristics of East Asian patients with von Hippel–Lindau syndrome

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Chinese Journal of Cancer 2016年第9期35卷 441-446页

作者： Meihua wong Ying-Hsia Chu Hwei Ling Tan Hideharu Bessho Joanne Ngeow Tiffany Tang min-Han Tan Division of Medical Oncology National Cancer Centre SingaporeSinga-pore 169610Singapore. Institute of Bioengineering and Nanotechnology Singapore 138669Singapore. Department of Urology Kitasato University School of MedicineSagamiharaKanagawa 252-0374Japan.

Background: Von Hippel–Lindau(VHL) syndrome is a dominantly inherited multisystem cancer syndrome caused by a heterozygous mutation in the VHL tumor suppressor gene. Previous studies suggested that similar populations of Caucasian and Japanese patients have similar genotype or phenotype characteristics. In this comprehensive study of East Asian patients, we investigated the genetic and clinical characteristics of patients with VHL ***: To create a registry of clinical characteristics and mutations reported in East Asian patients with VHL syndrome, we conducted a comprehensive review of English language and non?English language articles identi?fied through a literature search. Publications in Japanese or Chinese language were read by native speakers of the language, who then performed the data ***: Of 237 East Asian patients with VHL syndrome, 154 unique kindreds were identified for analysis. Analyzed by kindred, missense mutations were the most common(40.9%, 63/154), followed by large/complete deletions(32.5%, 50/154) and nonsense mutations(11.7%, 18/154). Compared with a previously reported study of both East Asian and non?East Asian patients, we found several key differences. First, missense and frameshift mutations in the VHL gene occurred less commonly in our population of East Asian patients(40.9% vs. 52.0%; P = 0.012 and 8.4% vs. 13.0%; P < 0.001, respectively). Second, large/complete deletions were more common in our population of East Asian patients(32.5% vs. 10.5%; P < 0.001). Third, phenotypically, we observed that, in our population of East Asian patients with VHL syndrome, the incidence of retinal capillary hemangioblastoma was lower, whereas the incidence of renal cell carcinoma was ***: Evidence suggests that the genotypic and phenotypic characteristics of East Asian patients with VHL syndrome differ from other populations. This should be considered when making screening recommendations for VHL syndrome in Asi

关键词：临床特征综合征分子特征东亚患者基因突变肿瘤抑制基因表型特征

Comparative Genomics Reveals Evolutionary Drivers of Sessile Life and Left-right Shell Asymmetry in Bivalves

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1078-1091页

作者： Yang Zhang Fan Mao Shu Xiao Haiyan Yu Zhiming Xiang Fei Xu Jun Li Lili Wang Yuanyan Xiong Mengqiu Chen Yongbo Bao Yuewen Deng Quan Huo Lvping Zhang Wenguang Liu Xuming Li Haitao Ma Yuehuan Zhang Xiyu Mu min Liu Hongkun Zheng Nai-Kei wong Ziniu Yu CAS Key Laboratory of Tropical Marine Bio-resources and Ecology and Guangdong Provincial Key Laboratory of Applied Marine Biology Innovation Academy of South China Sea Ecology and Environmental EngineeringSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Biomarker Technologies Co. LtdBeijing 101301China CAS Key Laboratory of Experimental Marine Biology Center for Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdao 266071China State Key Laboratory of Biocontrol College of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Zhejiang Key Laboratory of Aquatic Germplasm Resources College of Biological and Environmental SciencesZhejiang Wanli UniversityNingbo 315100China College of Fisheries Guangdong Ocean UniversityZhanjiang 524088China Hebei Key Laboratory of Applied Chemistry College of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066044China Department of Pharmacology Shantou University Medical CollegeShantou 515041China

Bivalves are species-rich mollusks with prominent protective roles in coastal *** these ancient lineages,colony-founding larvae anchor themselves either by byssus production or by cemented *** latter mode of sessile life is strongly molded by left-right shell asymmetry during larval development of Ostreoida oysters such as Crassostrea ***,we sequenced the genome of *** in high resolution and compared it to reference bivalve genomes to unveil genomic determinants driving cemented attachment and shell ***,loss of the homeobox gene Antennapedia(Antp)and broad expansion of lineagespecific extracellular gene families are implicated in a shift from byssal to cemented attachment in *** transcriptomic analysis shows a conspicuous divergence between leftright asymmetrical *** and symmetrical Pinctada fucata in their expression ***,a couple of orthologous transcription factor genes and lineage-specific shell-related gene families including that encoding tyrosinases are elevated,and may cooperatively govern asymmetrical shell formation in Ostreoida oysters.

关键词： Comparative genomics Ostreoida oyster Attachment Shell asymmetry Bivalve

Comparison of virus-capsid mimicking biologic-shell based versus polymeric-shell nanoparticles for enhanced oral insulin delivery

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Asian Journal of Pharmaceutical Sciences 2023年第5期18卷 125-135页

作者： Zhixiang Cui Shuman Cui Lu Qin Yalin An Xin Zhang Jian Guan Tin Wui wong Shirui Mao School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China Particle Design Research Group Faculty of PharmacyUniversiti Teknologi MARA SelangorPuncak Alam 42300Malaysia Non-Destructive Biomedical and Pharmaceutical Research Centre Smart Manufacturing Research InstituteUniversiti Teknologi MARA SelangorPuncak Alam 42300Malaysia

Virus-capsid mimicking mucus-permeable nanoparticles are promising oral insulin carriers which surmount intestinal mucus ***,the impact of different viruscapsid mimicking structure remains *** this study,utilizing biotin grafted chitosan as the main skeleton,virus-mimicking nanoparticles endowed with biologicshell(streptavidin coverage)and polymeric-shell(hyaluronic acid/alginate coating)were designed with insulin as a model drug by self-assembly *** was demonstrated that biologic-shell mimicking nanoparticles exhibited a higher intestinal trans-mucus(>80%,10 min)and transmucosal penetration efficiency(1.6–2.2-fold improvement)than polymeric-shell *** mechanism studies revealed caveolae-mediated endocytosis was responsible for the absorption of biologic-shell mimicking nanoparticles whereas polymeric-shell mimicking nanoparticles were characterized by clathrin-mediated pathway with anticipated lysosomal insulin ***,in vivo hypoglycemic study indicated that the improved effect of regulating blood sugar levels was virus-capsid structure dependent out of which biologic-shell mimicking nanoparticles presented the best performance(5.1%).Although the findings of this study are encouraging,much more work is required to meet the standards of clinical *** together,we highlight the external structural dependence of virus-capsid mimicking nanoparticles on the mucopenetrating and uptake mechanism of enterocytes that in turn affecting their in vivo absorption,which should be pondered when engineering virus-mimicking nanoparticles for oral insulin delivery.

关键词： Oral insulin Streptavidin Virus-mimicking Nanoparticles Muco-penetrating Mucus