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Screening and early detection of pancreatic cancer in high risk population

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World Journal of Gastroenterology 2014年第9期20卷 2358-2364页

作者： ming-Chu Chang jau-min wong Yu-Ting Chang Department of Internal Medicine National Taiwan University Hospital College of Medicine National Taiwan University

Pancreatic cancer is a serious growing health issue in developed *** patients diagnosed with pancreatic cancer,the five year survival rate is below 5%.One major important reason leads to the poor survival rate is lack of early detection of pancreatic *** 80% of the patients are diagnosed in advanced disease *** for pancreatic cancer is a desirable option for high risk individuals to allow early detection and treatment of curable pancreatic neoplasms at a pre-invasive *** article highlights the need,endpoint,population,method,diagnostic yield,and the problems of current screening programs.

关键词： Pancreatic cancer screening High risk population P

Unraveling adaptive changes in electric vehicle charging behavior toward the postpandemic era by federated meta-learning

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The Innovation 2024年第2期5卷 21-23页

作者： Linlin You Rui Zhu Mei-Po Kwan min Chen Fan Zhang Bisheng Yang Man Sing wong Zheng Qin School of Intelligent Systems Engineering Sun Yat-Sen UniversityShenzhen 518107China Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A*STAR)1 Fusionopolis WaySingapore 138632Republic of Singapore Institute of Space and Earth Information Science Chinese University of Hong KongHong KongChina Key Laboratory of Virtual Geographic Environment(ministry of Education) Nanjing Normal UniversityNanjing 210023China Institute of Remote Sensing and Geographical Information System School of Earth and Space SciencesPeking UniversityBeijing 100871China State Key Laboratory of Information Engineering in Surveying Mappingand Remote SensingWuhan UniversityWuhan 430079China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong KongChina

Dear Editor,Electric vehicle(EV)sales have significantly grown over the years to fulfill growing demands for economic travel and greenhouse gas mitigation.1 However,the surge in the number of EVs has led to charging anxiety as users struggle to find an available charging station before running out of electricity,resulting in longer reserve and waiting times.2 Moreover,severe mobility restrictions caused by infectious diseases,such as coronavirus disease 2019(COVID-19),have greatly affected people’s travel behavior3,4 and hindered their willingness to use EVs,given that charging in public spaces consumes time and increases the risk of contracting the virus.5 This implies that in the postpandemic era,in which individuals coexist with the virus,the interplay between the two important trends,namely vehicle electrification and mobility restrictions,can extensively affect people’s daily commuting by using EVs.

关键词： travel behavior charging

Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis

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World Journal of Gastroenterology 2015年第32期21卷 9534-9543页

作者： Yu-Ting Chang ming-Chu Chang Chien-Chih Tung Shu-Chen Wei jau-min wong Department of Internal Medicine National Taiwan University Hospital College of Medicine National Taiwan University Department of Integrated Diagnostics and Therapeutics National Taiwan University Hospital

AIM: To investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis. METHODS: Primary pancreatic acinar cells were treated with low and high concentrations of different saturated and unsaturated fatty acids, and changes in the cytosolic Ca2+ signal and the expression of protein kinase C(PKC) were measured after treatment. RESULTS: Unsaturated fatty acids at high concentrations, including oleic acid, linoleic acid, palmitoleic acid, docosahexaenoic acid, and arachidonic acid, induced a persistent rise in cytosolic Ca2+ concentrations in acinar cells. Unsaturated fatty acids at low concentrations and saturated fatty acids, including palmitic acid, stearic acid, and triglycerides, at low and high concentrations were unable to induce a rise in Ca2+ concentrations in acinar cells. Unsaturated fatty acids at high concentrations but not saturated fatty acids induced intra-acinar cell trypsin activation and cell damage and increased PKC ***: At sufficiently high concentrations, unsaturated fatty acids were able to induce acinar cells injury and promote the development of pancreatitis. Unsaturated fatty acids may play a distinctive role in the pathogenesis of pancreatitis through the activation of PKC family members.

关键词： Unsaturated fatty acid Saturated fatty acid Hypert

Hepatitis B and C viruses are not risks for pancreatic adenocarcinoma

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World Journal of Gastroenterology 2014年第17期20卷 5060-5065页

作者： ming-Chu Chang Chien-Hung Chen Ja-Der Liang Yu-Wen Tien Chiun Hsu jau-min wong Yu-Ting Chang Department of Internal Medicine National Taiwan University HospitalCollege of MedicineNational Taiwan University Department of Surgery National Taiwan University HospitalCollege of MedicineNational Taiwan University Graduate Institute of Oncology College of MedicineNational Taiwan University

AIM:To investigate whether hepatitis B virus(HBV)and hepatitis C virus(HCV)increase risk of pancreatic ductal adenocarcinoma(PDAC).METHODS:We recruited 585 patients with cytological and/or pathologically confirmed PDAC in National Taiwan University Hospital from September 2000 to September 2013,and 1716 age-,sex-,and race-matched controls who received a screening program in a community located in Northern *** samples were tested for the presence of HCV antibodies(anti-HCV),HBV surface antigen(HBsAg),antibodies against HBsAg(anti-HBs),and hepatitis B core antigen(anti-HBc)in all cases and *** odds ratio(OR)of PDAC was estimated by logistic regression analysis with adjustment diabetes mellitus(DM)and ***:HBsAg was positive in 73 cases(12.5%)and 213 controls(12.4%).Anti-HCV was positive in22 cases(3.8%)and 45 controls(2.6%).Anti-HBs was positive in 338 cases(57.8%)and 1047 controls(61.0%).The estimated ORs of PDAC in multivariate analysis were as follows:DM,2.08(95%CI:1.56-2.76,P<0.001),smoking,1.36(95%CI:1.02-1.80,P=0.035),HBsAg+/anti-HBc+/anti-HBs-,0.89(95%CI:0.89-1.68,P=0.219),HBsAg-/anti-HBc+/anti-HBs+,1.03(95%CI:0.84-1.25,P=0.802).CONCLUSION:HBV and HCV infection are not associated with risk of PDCA after adjustment for age,sex,DM and smoking,which were independent risk factors of PDAC.

关键词： Hepatitis B virus Hepatitis C virus Pancreatic duc

Temperate Stutzerimonas Phage Encoding Toxin-Antitoxin System Genes Represents a Novel Genus

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Journal of Ocean University of China 2024年第4期23卷 1087-1101页

作者： ZHANG Hong GUO Ruizhe GAO Chen ZHENG Kaiyang XIONG Yao DONG Yue LIU Yundan WANG Ziyue CHEN Ying WANG Hongmin SHAO Hongbing SUNG Yeong Yik MOK Wen Jye wong Li Lian MCminN Andrew WANG min LIANG Yantao College of Marine Life Sciences Institute of Evolution and Marine BiodiversityMOE Laboratory of Evolution and Marine BiodiversityFrontiers Science Center for Deep Ocean Multispheres and Earth SystemCenter for Ocean Carbon NeutralityOcean University of ChinaQingdao 266003China UMT-OUC Joint Center for Marine Studies Qingdao 266003China Institute of Marine Biotechnology Universiti Malaysia Terengganu21030 Kuala TerengganuMalaysia Institute for Marine and Antarctic Studies University of TasmaniaHobartTAS 7001Australia Haide College Ocean University of ChinaQingdao 266100China The Affiliated Hospital of Qingdao University Qingdao 266001China

Stutzerimonas have been extensively studied due to their remarkable metabolic and physiological ***,research on its phages is currently *** this study,we isolated a novel double-stranded DNA(dsDNA)phage,vB_SstM-PG1,from the marine environment that infects Stutzerimonas stutzeri *** dsDNA genome is 37204 bp long with a G/C content of 64.14%and encodes 54 open reading *** phage possesses a tail packaging structure that is different from known Stutzerimonas stutzeri phages and exhibits structural protein characteristics similar to those of temperate *** addition,two genes of toxin-antitoxin system,including YdaS_antitoxin and HEPN_SAV_6107,were found in the vB_SstM-PG1 genome and play important roles in regulating host growth and *** phylogenetic tree and comparative genomic analysis,it has been determined that vB_SstM-PG1 is not closely related to any phages previously identified in the GenBank ***,it has a connection with enigmatic,uncultured ***,the vB_SstM-PG1 virus exhibits an average nucleotide identity of over 70%with six uncultivated viruses identified in the IMG/VR v4 *** significant finding has resulted in the identification of a novel viral genus known as Metabovirus.

关键词： Stutzerimonas vB_SstM-PG1 Metabovirus temperate phage genomic and phylogenetic analysis

Chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against “ESKAPE” pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： min Wang Huangsheng Pu Yangfan Xu Chenxuan Wu Yuanxin Gu Qingyun Cai Guoxing Yin Peng Yin Chunhui Zhang Wing-Leung wong Muyang Wan Yugang Bai Xinxin Feng State Key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical Engineering Hunan University College of Biology Hunan University College of Advanced Interdisciplinary Studies & Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense Technology Nanhu Laser Laboratory National University of Defense Technology Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (ministry of Education) College of Chemistry and Chemical Engineering Hunan Normal University State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs The Third Hospital of Changsha (The Affiliated Changsha Hospital of Hunan University)

The global antibiotic resistance crisis necessitates urgent solutions. One innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters. A major drawback of these membrane-active boosters is their limited biocompatibility, as they struggle to differentiate between prokaryotic and eukaryotic membranes. This study reports the chemical biology investigation of a dual-action oligoamidine(OA1) booster with a glutathione-triggered decomposition mechanism. OA1, when combined with other antimicrobial molecules, exhibits a triple-targeting mechanism including cell membrane disruption, DNA targeting, and intracellular enzyme inhibition. This multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant “ESKAPE” pathogens, but also suppresses the development of bacterial resistance. Furthermore, OA1 maintains its activity in bacterial cells by creating an oxidative environment, while it quickly decomposes in mammalian cells due to high glutathione levels. These mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

Fecal calprotectin correlated with endoscopic remission for Asian inflammatory bowel disease patients

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World Journal of Gastroenterology 2015年第48期21卷 13566-13573页

作者： Wei-Chen Lin jau-min wong Chien-Chih Tung Ching-Pin Lin Jen-Wei Chou Horng-Yuan Wang ming-Jium Shieh Chin-Hao Chang Heng-Hsiu Liu Shu-Chen Wei Division of Gastroenterology Department of internal MedicineMackay Memorial Hospital Departments of Internal Medicine National Taiwan University Hospital Integrated Diagnostics and Therapeutics National Taiwan University Hospital Division of Gastroenterology Department of internal MedicineChung Shan Medical University Hospital Division of Gastroenterology Department of internal MedicineChina Medical University Hospital Medical Research National Taiwan University Hospital Institute of Epidemiology and Preventive Medicine College of Public HealthNational Taiwan University

AIM: To evaluate the correlation between fecal calprotectin(f C), C-reactive protein(CRP), and endoscopic disease score in Asian inflammatory bowel disease(IBD) ***: Stool samples were collected and assessed for calprotectin levels by Quantum Blue Calprotectin High Range Rapid test. Crohn's disease endoscopic index of severity(CDEIS) and ulcerative colitis endoscopic index of severity(UCEIS) were used for endoscopic lesion scoring. RESULTS: A total of 88 IBD patients [36 patients with Crohn's disease(CD) and 52 with ulcerative colitis(UC)] were enrolled. For CD patients, f C correlated with CDEIS(r = 0.465, P = 0.005) and CRP(r = 0.528, P = 0.001). f C levels in UC patients correlated with UCEIS(r = 0.696, P < 0.0001) and CRP(r = 0.529, P = 0.0005). Calprotectin could predict endoscopic remission(CDEIS < 6) with 50% sensitivity and 100% specificity(AUC: 0.74) in CD patients when using 918 μg/g as the cutoff. When using 191 μg/g as the cut-off in UC patients, calprotectin could be used for predicting endoscopic remission(UCEIS < 3) with 88% sensitivity and 75% specificity(AUC: 0.87). CONCLUSION: f C correlated with both CDEIS and UCEIS. f C could be used as a predictor of endoscopic remission for Asian IBD patients.

关键词： Inflammatory bowel disease Endoscopicscore Fecal calprotectin Crohn's disease Ulcerativecolitis

Diet and physical activity influence the composition of gut microbiota,benefit on Alzheimer's disease

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Food Science and Human Wellness 2024年第2期13卷 541-555页

作者： Jinyue Zhou min Tang Wanyi Li Rui Fang Chunlan Tang Qinwen Wang 无 School of Public Health Health Science CenterNingbo UniversityNingbo 315211China Department of Neurology Ningbo Rehabilitation HospitalNingbo 3151000China Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315100China Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Ningbo 315100China

Alzheimer's disease is a neurodegenerative disease with complex *** microbiota influences the gutbrain axis,which may affect pathways related to the pathogenesis of Alzheimer's ***,diet and physical activity are likely to affect the pathology of Alzheimer's disease as well as the gut *** demonstrates that it may be possible to prevent or halt the progression of Alzheimer's disease by regulating the gut microbiota using diet and physical activity ***,the present study reviews the association between these two interventions and gut microbiota in the human *** also summarizes how these two interventions benefit Alzheimer's ***,the primary limitations of these two interventions are discussed and promising strategies are proposed,which may be beneficial to further study and develop the intervening measure for the progression of Alzheimer's disease.

关键词： Alzheimer’s disease Gut microbiota Brain-gut axis Diet Physical activity

Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： Chao Sun George Boon-Bee Goh Wan-Cheng Chow Wah-Kheong Chan Grace Lai-Hung wong Wai-Kay Seto Yi-Hsiang Huang Han-Chieh Lin I-Cheng Lee Hye Won Lee Seung Up Kim Vincent Wai-Sun wong Jian-Gao Fan Center for Fatty Liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of Clinical Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Faculty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFLD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(CKD)were defined by an estimated glomerular filtration rate(eGFR)with value ofmin/1.73 m^(2) andmin/1.73 m^(2),respectively,as estimated by the CKD-Epidemiology Collaboration(CKD-EPI)***:Among 529 included NAFLD patients,the prevalence rates of impaired renal function and CKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for CKD(P<0.05).Furthermore,increased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(P<0.05).Compared with patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/L or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(P<0.05).Conclusions:Agile 3+and Agile 4 are reliable for identifying NAFLD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome