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Soft tissue swelling incidence using demineralized bone matrix in the outpatient setting

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World Journal of Orthopedics 2017年第10期8卷 770-776页

作者： Kingsley R Chin Fabio JR Pencle jason A Seale Juan m Valdivia Charles E. Schmidt College of medicine at Florida Atlantic University Less Ex-posure Surgery Specialists Institute Herbert Wertheim College of medicine at Florida International University Less Exposure Surgery Society

AIm To assess use of demineralized bone matrix(DBm) use in anterior cervical discectomy and fusion(ACDF) in outpatient *** One hundred and forty-five patients with prospectively collected data undergoing single and two level ACDF with DBm packed within and anterior to polyetheretherketone(PEEK) cages. Two groups created, Group 1(75) outpatients and control Group 2(70) hospital patients. Prevertebral soft tissue swelling(PVSTS) was measured anterior to C2 and C6 on plain lateral cervical radiographs preoperatively and one week postoperatively and fusion assessed at two years. RESULTS There was no intergroup significance between preoperative and postoperative visual analogue scales(VAS)and neck disability index(NDI) scores between Group 1 and 2. mean preoperative PVSTS in Group 1 was 4.7 ± 0.2 mm at C2 level and 11.1 ± 0.5 at C6 level compared to Group 2 mean PVSTS of 4.5 ± 0.5 mm and 12.8 ± 0.5, P = 0.172 and 0.127 respectively. There was no radiographic or clinical evidence of adverse reaction noted. In Group 1 mean postoperative PVSTS was 5.5 ± 0.4 mm at C2 and 14.9 ± 0.6 mm at C6 compared Group 2 mean PVSTS was 4.9 ± 0.3 mm at C2 and 14.8 ± 0.5 mm at C6, P = 0.212 and 0.946 respectively. No significant increase in prevertebral soft tissue space at C2 and C6 level *** ACDF with adjunct DBm packed PEEK cages showed a statistical significant intragroup improvement in VAS neck pain scores and NDI scores(P = 0.001). There were no reported serious patient complications; post-operative radiographs demonstrated no significant difference in prevertebral space. We conclude that ACDF with DBmpacked PEEK cages can be safely done in an ASC with satisfactory outcomes.

关键词： Ambulatory surgery center Anterior cervical discectomy and fusion Demineralized bone matrix Less Exposure Surgery Packed polyetheretherketone cages

Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome

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World Journal of Gastroenterology 2014年第2期20卷 363-375页

作者： Jan Dabritz jason musci Dirk Foell Gastrointestinal Research in Inflammation and Pathology Murdoch Children’s Research InstituteThe Royal Children’s Hospital MelbourneParkville 3052VICAustralia Department of Paediatrics Melbourne Medical SchoolUniversity of MelbourneParkville 3052VICAustralia Department of Paediatric Rheumatology and Immunology University Children’s Hospital Munster48149 MunsterGermany

Irritable bowel syndrome(IBS)is a common functional gastrointestinal(GI)disorder characterized by unspecific *** clinical practice it is crucial to distinguish between non-inflammatory functional problems and inflammatory,malignant or infectious diseases of the GI *** between these involves the use of clinical,radiological,endoscopic,histological and serological techniques,which are invasive,expensive,time-consuming and/or hindered by inaccuracies arising from subjective components.A range of faecal markers now appears to have the potential to greatly assist in the differentiation of inflammatory bowel disease(IBD)and *** markers of neutrophil influx into the mucosa are reliable indicators of intestinal inflammation and their role has been mainly studied in discriminating IBD from non-IBD conditions(including IBS)rather than organic from non-organic *** proteins of the S100 family(S100A12,calprotectin)are amongst the most promising faecal biomarkers of *** leukocyte degranulation markers(lactoferrin,polymorphonuclear elastase and myeloperoxidase)have also been suggested as diagnostic tools for the differentiation of IBD and *** recently,additional proteins,including granins,defensins and matrix-metalloproteases,have been discussed as differential diagnostic markers in IBD and *** this review,some of the most promising faecal markers,which have the potential to differentiate IBD and IBS and to advance diagnostic practices,will be discussed.

关键词： S100A12 Calprotectin Lactoferrin m2-pyruvate kinase Polymorphonuclear elastase Defensins Granins Irritable bowel syndrome

Transcranial photobiomodulation with near-infrared light:a promising therapeutic modality for Alzheimer's disease

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Neural Regeneration Research 2023年第9期18卷 1944-1945页

作者： Hanli Liu Damir Nizamutdinov jason H.Huang Bioengineering Department the University of Texas at ArlingtonArlingtonTXUSA Neurosurgery Neuroscience InstituteBaylor Scott and White HealthTempleTXUSA Neurosurgery College of MedicineTexas A&M UniversityTempleTXUSA

Transcranial photobiomodulation(tPBm) is a noninvasive neuromodulation technique that delivers near-infrared(NIR) light with low irradiance(i.e.,power density in mW/cm2) in the wavelength range of 800-1070 *** recently published books or collected literature(Hamblin,2019;GonzalezLima,2021) and papers(Nizamutdinov et al. 2022)offer comprehensive reviews of the mechanism of action and potential clinical translations of tPBm for the treatment of a variety of diseases,including neurodegenerative diseases(Alzheimer’s disease(AD),and Parkinson’s disease),traumatic brain injury.

关键词： Alzheimer diseases

memory-enhanced noiseless cross-phase modulation

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Light(Science & Applications) 2012年第1期1卷 6-10页

作者： mahdi Hosseini Stojan Rebic Ben m Sparkes jason Twamley Ben C Buchler Ping K Lam Centre for Quantum Computation and Communication Technology Department of Quantum ScienceThe Australian National UniversityCanberraAustralia Centre for Engineered Quantum Systems Department of Physics&AstronomyMacquarie UniversityNorth Ryde NSW 2109Australia

Large nonlinearity at the single-photon level can pave the way for the implementation of universal quantum ***,realizing large and noiseless nonlinearity at such low light levels has been a great challenge for scientists in the past ***,we propose a scheme that enables substantial nonlinear interaction between two light fields that are both stored in an atomic *** and quantum simulations demonstrate the feasibility of achieving large cross-phase modulation(XPm)down to the single-photon *** proposed scheme can be used to implement parity gates from which CNOT gates can be ***,we present a proof of principle experimental demonstration of XPm between two optical pulses:one stored and one freely propagating through the memory medium.

关键词： CNOT gate cross-phase modulation electromagnetically induced transparency parity gate quantum memory

The class A macrophage scavenger receptor type I (SR-AI) recognizes complement iC3b and mediates NF-κB activation

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Protein & Cell 2010年第2期1卷 174-187页

作者： jason W.K.Goh Yen Seah Tan Alister W.Dodds Kenneth B.m.Reid Jinhua Lu Department of microbiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore mRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUnited Kingdom Immunology Programme National University of SingaporeSingapore 117597Singapore

The macrophage scavenger receptor SR-AI binds to host tissue debris to perform clearance and it binds to bacteria for *** addition,SR-AI modulates macrophage activation through cell ***,investigation of SR-AI signaling on macrophages is complicated due to its promiscuous ligand specificity that overlaps with other macrophage ***,we expressed SR-AI on HEK 293T cells to investigate its ligand binding and *** 293T cells,SR-AI could respond to *** DH5α,leading to NF-κB activation and IL-8 ***,this requires *** DH5αto be sensitized by fresh serum that is treated with heat-inactivation or complement C3 ***-C3 antibody inhibits the binding of SR-AI to serum-sensitized DH5αand blocks DH5αstimulation of SR-AI *** analysis showed that SR-AI can directly bind to purified iC3b but not C3 or *** mutagenesis,The SRCR domain of SR-AI was found to be essential in SR-AI binding to serum-sensitized DH5α.These results revealed a novel property of SR-AI as a complement receptor for iC3b-opsonized bacteria that can elicit cell signaling.

关键词： SR-AI complement iC3b signalling 293T cells macrophage

Elevated NKCC1 transporter expression facilitates early post-traumatic brain injury seizures

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Neural Regeneration Research 2017年第3期12卷 401-402页

作者： Buqing Liang jason H.Huang Department of Neurosurgery Neuroscience InstituteBaylor Scott&White HealthCentral DivisionTempleTXUSA Department of Surgery Texas A&M University Health ScienceCenterCollege of MedicineTempleTXUSA

As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic p... 详细信息

关键词： TBI Elevated NKCC1 transporter expression facilitates early post-traumatic brain injury seizures Cl TGF

Heat and drought impact on carbon exchange in an age-sequence of temperate pine forests

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Ecological Processes 2022年第1期11卷 108-125页

作者： m.Altaf Arain Bing Xu jason J.Brodeur myroslava Khomik matthias Peichl Eric Beamesderfer Natalia Restrepo‑Couple Robin Thorne School of Earth Environment and Society and McMaster Centre for Climate ChangeMcMaster University1280 Main Street WestHamiltonON L8S 4K1Canada Department of Biological Sciences University of CalgaryAlbertaCanada Department of Geography and Environmental management University of WaterlooWaterlooONCanada Department of Forest Ecology and management Swedish University of Agricultural SciencesUmeåSweden School of Informatics Computingand Cyber SystemsNorthern Arizona UniversityFlagstaffAZUSA Department of Ecology and Evolutionary Biology University of ArizonaTucsonAZUSA Department of Geography Wilfrid Laurier UniversityWaterlooONCanada

Background:most North American temperate forests are plantation or regrowth forests,which are actively *** forests are in different stages of their growth cycles and their ability to sequester atmospheric carbon is affected by extreme weather *** this study,the impact of heat and drought events on carbon sequestration in an age‑sequence(80,45,and 17 years as of 2019)of eastern white pine(Pinus strobus L.)forests in southern Ontario,Canada was examined using eddy covariance flux measurements from 2003 to ***:Over the 17‑year study period,the mean annual values of net ecosystem productivity(NEP)were 180±96,538±177 and 64±165 g C m^(–2)yr^(–1)in the 80‑,45‑and 17‑year‑old stands,respectively,with the highest annual carbon sequestration rate observed in the 45‑year‑old *** found that air temperature(Ta)was the dominant control on NEP in all three different‑aged stands and drought,which was a limiting factor for both gross ecosystem productivity(GEP)and ecosystems respiration(RE),had a smaller impact on ***,the simultaneous occurrence of heat and drought events during the early growing seasons or over the consecutive years had a significant negative impact on annual NEP in all three *** observed a similar trend of NEP decline in all three stands over three consecutive years that experienced extreme weather events,with 2016 being a hot and dry,2017 being a dry,and 2018 being a hot *** youngest stand became a net source of carbon for all three of these years and the oldest stand became a small source of carbon for the first time in 2018 since observations started in ***,in 2019,all three stands reverted to annual net carbon ***:Our study results indicate that the timing,frequency and concurrent or consecutive occurrence of extreme weather events may have significant implications for carbon sequestration in temperate conifer forests in Eastern North *** study is one of few globally available t

关键词： Carbon fluxes Net ecosystem productivity Ecosystem respiration Extreme weather events Drought Temperate forest White pine Eddy covariance

Association between admission haematocrit and mortality among men with acute ischaemic stroke

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Stroke & Vascular Neurology 2018年第3期3卷 160-168页

作者： jason J Sico Laura J myers Brenda J Fenton John Concato Linda S Williams Dawn m Bravata Neurology Service VA Connecticut Healthcare SystemWest HavenConnecticutUSA Department of Neurology Center for NeuroEpidemiological and Clinical Neurological ResearchYale University School of MedicineNew HavenConnecticutUSA Department of Internal medicine Yale University School of MedicineNew HavenConnecticutUSA Clinical Epidemiology Research Center(CERC) VA Connecticut Healthcare SystemWest HavenConnecticutUSA Pain Research InformaticsMultimorbidities and Education(PRIME)Center of InnovationVA Connecticut Healthcare SystemWest HavenConnecticutUSA Communication and the HSR&D Stroke Quality Enhancement Research Initiative(QUERI) Richard L Roudebush VA Medical CenterIndianapolisIndianaUSA VA Health Services Research and Development(HSR&D) Center for Healthcare InformaticsRichard L Roudebush VA Medical CenterIndianapolisIndianaUSA Division of Chronic Disease Epidemiology Yale School of Public HealthWest HavenConnecticutUSA medical Service VA Connecticut Healthcare SystemWest HavenConnecticutUSA Regenstrief Institute IndianapolisIndianaUSA Department of Neurology Indiana University School of MedicineIndianapolisIndianaUSA Department of Internal medicine Indiana University School of MedicineIndianapolisIndianaUSA

Objective Anaemia is associated with higher mortality among patients with non-stroke cardiovascular conditions;less is known regarding the relationship between anaemia and mortality among patients with acute ischaemic *** medical records were abstracted for n=3965 veterans from 131 Veterans Health Administration facilities who were admitted with ischaemic stroke in fiscal year *** values within 24 hours of admission were classified as≤27%,28%-32%,33%-37%,38%-42%,43%-47% or≥48%.multivariate logistic regression was used to examine the relationship between anaemia and in-hospital,30-day,6-month and 1-year mortality,adjusting for age,medical comorbidities,modified Acute Physiology and Chronic Health Evaluation-III and stroke *** factors were calculated to standardise comparisons between haematocrit tier and other *** Among n=3750 patients included in the analysis,the haematocrit values were≤27%in 2.1%(n=78),28%-32% in 6.2%(n=234),33%-37%in 17.9%(n=670),38%-42% in 36.4%(n=1366),43%-47% in 28.2%(n=1059)and≥48% in 9.1%(n=343).Patients with haematocrit≤27%,compared with patients in the 38%-42% range,were more likely to have died across all follow-up intervals,with statistically significant adjusted ORs(aORs)ranging from 2.5 to *** with polycythaemia(ie,haematocrit≥48%)were at increased risk of in-hospital mortality(aOR=2.9;95%CI 1.4 to 6.0),compared with patients with mid-range admission *** differences between patients receiving and not receiving blood transfusion limited our ability to perform a propensity *** factors in the 1-year mortality model were 0.46(severe anaemia),0.06(cancer)and 0.018(heart disease).Conclusions Anaemia is independently associated with an increased risk of death throughout the first year post stroke;high haematocrit is associated with early poststroke *** anaemia is associated with 1-year mortality to a greater degree than cancer or heart dise

关键词： mortality admitted transfusion

Nanoscale control of Ag nanostructures for plasmonic fluorescence enhancement of near-infrared dyes

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Nano Research 2013年第7期6卷 496-510页

作者： Fang Xie Jing S. Pang Anthony Centeno mary P. Ryan D. jason Riley Neil m. Alford Department of materials and London Centre for Nanotechnology Imperial College London London SW72AZ UK malaysia Japan International Institute of Technology University Technology Malaysia International Campus Jalan Semarak 54100 Kuala Lumpur Malaysia

Potential utilization of proteins for early detection and diagnosis of various diseases has drawn considerable interest in the development of protein-based detection techniques. metal induced fluorescence enhancement offers the possibility of increasing the sensitivity of protein detection in clinical applications. We report the use of tunable plasmonic silver nanostructures for the fluorescence enhancement of a near-infrared （NIR） dye （Alexa Fluor 790）. Extensive fluorescence enhan- cement of -2 orders of magnitude is obtained by the nanoscale control of the Ag nanostructure dimensions and interparticle distance. These Ag nanostructures also enhanced fluorescence from a dye with very high quantum yield （7.8 fold for Alexa Fluor 488, quantum efficiency （Qy） = 0.92）. A combination of greatly enhanced excitation and an increased radiative decay rate, leading to an associated enhancement of the quantum efficiency leads to the large enhancement. These results show the potential of Ag nanostructures as metal induced fluorescence enhancement （mIFE） substrates for dyes in the NIR ＂biological window＂ as well as the visible region. Ag nanostructured arrays fabricated by colloidal lithography thus show great potential for NIR dye-based biosensing applications.

关键词： Ag triangular-like nanostructures fluorescence enhancement NIR dyes scattering absorption