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Degradation and resynthesis of c.l.rophyll during increased oxidative stress and prolonged darkness differ between annual and perennial flax(linum l.)

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Oil crop Science 2024年第2期9卷 121-130页

作者： Kenyon J. Nisbett Abida Alokozai Su Hyun Elizabeth Ko G. Adam Mott jason c.l. browna Department of Biologic.l.Sciences University of Toronto ScarboroughTorontoONCanada Department of c.l.&Systems Biology University of TorontoTorontoONCanada centre for the Analysis of Genome Evolution&Function University of TorontoTorontoONCanada

Among plants,there is considerable variation in lifespan:annuals live less than one year,whereas perennials live for several years,with the longest-living perennial having survived 43,600 *** proposed by the Disposable Soma Theory,this lifespan variation among plants likely reflects differential investment of limited energy and nutrient resources,with perennials investing more energy and nutrients into biomolec.l.r maintenance compared to annuals in order to ensure persistence over multiple *** differential investment may be partic.l.rly important during periods of exogenous stress,which are known to acc.l.rate biomolec.l.r *** present study evaluated this hypothesis using annual and perennial flax(linum l.)subjected to two exogenous stressors—increased oxidative stress(i.e.,foliar H2O2spraying)and complete prolonged *** c.l.rophyll has been shown to exhibit degradation in response to changes in environmental conditions,we utilized changes in c.l.rophyll levels during and after periods of exogenous stress to evaluate our *** predicted that i)perennials would exhibit a slower rate of c.l.rophyll degradation during exposure to exogenous stressors compared to annuals,and ii)perennials would exhibit a faster rate of c.l.rophyll resynthesis following such exposure compared to *** levels before,during,and after exposure to both exogenous stressors were measured in two separate trails,once using image c.l.ur analysis and once using *** c.l.rophyll degradation rates in response to oxidative stress did not differ between annuals and perennials,contrary to our predictions,c.l.rophyll resynthesis rates following such exposure were significantly higher in perennials,as *** plants were subjected to complete prolonged darkness,c.l.rophyll degradation rates were significantly lower in perennials than annuals,as predicted;however,when plants were subsequently reintroduced to natural photoperiod,ch

关键词： Ageing life history Maximum lifespan Oxidative stress Somatic maintenance

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canonic.l.and noncanonic.l.Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng connie chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey Hong lily Song William Wagstaff Rex c.Haydon Hue H.luu Sherwin H.Ho jason Strelzow Russell R.Reid Tong-chuan He lewis l.Shi chicago Medic.l.School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molec.l.r Onc.l.gy laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of clinic.l.laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedic.l.Engineering Vanderbilt UniversityNashvilleTN 37235USA laboratory of craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating c.l. proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and lRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonic.l.pathway or through a series of other proteins in the nonca-nonic.l.*** of the individual components of both canonic.l.and noncanonic.l.Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many c.l.ular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryologic.l.defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonic.l.noncanonic.l.Wnt/PcP,and the noncanonic.l.Wnt/ca2+*** description involved each of its components and their involvement in other c.l.ular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin canonic.l.Wnt Noncanonic.l.Wnt Signal transduction Signaling crosstalk

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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vasc.l.r Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： jason Philip Appleton lisa J Woodhouse craig S Anderson Sandeep Ankolekar lesley c.l. Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter christopher I Price Marc Randall Thompson G Robinson christine Roffe Else c Sandset Jeffrey l Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Fac.l.y of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute china at Peking University Health Science center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Fac.l.y of Health and Medic.l.Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK centre for clinic.l.Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of cardiovasc.l.r Sciences and NIHR leicester Biomedic.l.Research centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and comprehensive Stroke center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinic.l.outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin sc.l.(mRS)at day *** outcomes included death;a global analysis(Wei-lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression sc.l.;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow coma Sc.l. 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%cI 0.85 to 1.54),death or global analysis(MWD 0.00,95%cI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinic.l.outcomes in a population with more clinic.l.and radiologic.l.frailty than seen in previous in-hospital *** IS AlREADY KNOWN ON THIS TOPIc⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman jason lynch christopher E.Stevens christopher Munley chentao li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis coen Kevin li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electric.l.and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of chemic.l.and Biomolec.l.r Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanic.l.Engineering Columbia UniversityNew YorkNY10027USA Department of Electric.l.and computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optic.l.*** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optic.l.cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optic.l.dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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Brain-derived neurotrophic factor and inflammation in depression:Pathogenic partners in crime?

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World Journal of Psychiatry 2022年第1期12卷 77-97页

作者： Grace A Porter jason c O’connor Department of Pharmac.l.gy UT Health San AntonioSan AntonioTX 78229United States Department of Pharmac.l.gy University of Texas Health San AntonioSan AntonioTX 78229United States Audie l.Murphy VA Hospital South Texas Veterans Health SystemSan AntonioTX 78229United States

Major depressive disorder is a debilitating disorder affecting millions of people each ***-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable *** clinic.l.and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of ***,less is known about potential interaction between BDNF and inflammation,partic.l.rly within the central nervous *** evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant *** levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the *** this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biologic.l.pathogenesis of depression and for identifying novel therapeutic *** we review these two prominent risk factors for depression with a partic.l.r focus on pathogenic implications of their interaction.

关键词： Brain-derived neurotrophic factor Microglia Neuroinflammation Growth factors Depression

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Exercise catheterization for Hemodynamic Evaluation of Adults with coarctation of the Aorta

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congenital Heart Disease 2022年第6期17卷 605-615页

作者： Irene Martin de Miguel c.charles Jain Alexander c.Egbe jason H.Anderson Heidi M.connolly William R.Miranda Department of cardiovasc.l.r Medicine Mayo ClinicRochesterMinnesotaUSA Department of Pediatric and Adolescent Medicine Division of Pediatric CardiologyMayo ClinicRochesterMinnesotaUSA

Background: coarctation of the aorta (coA) is associated with a generalized arteriopathy and long-term complicationsdespite repair. Data on invasive exercise hemodynamics in this population are lacking. Accordingly, wereviewed adults with coA undergoing exercise catheterization to assess 1. hemodynamic profile;2. feasibilityfor assessment of coA severity. Methods: Twenty patients undergoing exercise cardiac catheterization (12 armadduction and 8 supine cycle ergometry) at a quaternary care center between 2004 and 2021 were identified. Restingand exercise hemodynamic data were abstracted from the procedure logs. Results: Mean age was 43.6 ±12.0 years. Eleven patients (55%) had resting pulmonary arterial wedge pressure (PAWP) >15 mmHg;amongthose undergoing arterial catheterization, left ventric.l.r end-diastolic pressure was >15 mmHg in 63%. Elevenpatients (55%) had pulmonary hypertension: 7 (35%) combined and 4 (20%) isolated post-capillary. At peak exercise,ΔPAWP/Δcardiac output (cO) ≥2 and Δmean pulmonary artery pressure/ΔcO ≥3 mmHg/l/min were foundin 7 (78%) and 6 (67%) patients, respectively;the composite of exercise PAWP ≥25 mmHg or ΔPAWP/ΔcO>2 was seen in 12 (86%). coA peak-to-peak gradients at baseline (n = 14) and during exercise (n = 9) were 12(3–16) and 16 mmHg (9–28), respectively. Only 2 patients had an increase in coA gradient to >20 mmHg withexercise. conclusions: Diastolic dysfunction and pulmonary hypertension were highly prevalent, with exerciseunmasking abnormal diastolic and pulmonary vasc.l.r reserve in some individuals. Most patients failed to showsignificant increases in coA peak-to-peak gradients with exercise. Further studies are warranted to establish thebest diagnostic method for coA severity assessment.

关键词： coarctation of the aorta exercise heart catheterization diastolic dysfunction hypertension

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Internal hemorrhoid harboring adenocarcinoma:A case report

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World Journal of Gastrointestinal Onc.l.gy 2021年第1期13卷 87-91页

作者： Michael l caparelli jason c Batey Anisha Tailor Timothy Braverman cory Barrat of Surgery The Jewish HospitalCincinnatiOH 45236United States Department of Pathology The Jewish HospitalCincinnatiOH 45236United States

BAcKGROUND The incidence of carcinoma found within an internal hemorrhoid specimen is exceptionally ***,the presence of primary anal canal adenocarcinoma within internal hemorrhoids is even more *** describe a case in which anal canal adenocarcinoma was found within an internal hemorrhoidectomy specimen and perform a review of the current *** SUMMARY The patient was a 79-year-old male who presented with rectal bleeding and was found to have large thrombosed internal hemorrhoids during screening *** patient subsequently underwent a three-c.l.mn *** analysis revealed one of three specimens containing a 1.5 cm moderate-to-poorly differentiated adenocarcinoma of anal origin with superficial submucosal *** three-month follow up,he was taken to the operating theatre for biopsy and re-excision of his non-healing wound,which showed no *** wound has since healed and he was cancer free at ten-month follow *** When faced with primary anal canal adenocarcinoma an interdisciplinary approach to treatment should be *** pathologic.l.analysis of hemorrhoidectomy specimens may be beneficial due to the severity of anal canal carcinomas if left undiagnosed and untreated in a timely manner.

关键词： Hemorrhoidectomy Adenocarcinoma c.l.rectal Anal canal Onc.l.gy Hematochezia case report

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Testing for selection on c.l.r and pattern in a mimetic radiation

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current Zoology 2012年第4期58卷 668-676页

作者： Justin YEAGER jason l. BROWN Victor MORAlES Molly cUMMINGS Kyle SUMMERS Department of Biology East Carolina University Greenville NC 27858 Department of Ec.l.gy and Evolutionary Biology Tulane University New Orleans LA 70118 Department of Biology Duke University Durham NC 27708 Universidad de Ricardo Palma Lima Peru Department of Integrative Biology University of Texas Austin Texas 78712

In this paper, we analyze variation in spectral reflectance and c.l.r pattern among populations to demonstrate dramatic divergence between four distinct morphs of the mimic poison frogRanitomeya imitator. We also analyze genetic divergence in d-loop mtDNA sequences between populations. We then use coalescent-based simulations to demonstrate that the high levels of observed phenotypic divergence are not consistent with levels of genetic divergence expected under neutral drift among populations, implying an important role for selection in driving divergence between these populations.

关键词：彩色图案辐射测试模仿颜色遗传分化光谱反射率成膜助剂种群

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DeepSun:machine-learning-as-a-service for solar flare prediction

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Research in Astronomy and Astrophysics 2021年第7期21卷 51-61页

作者： Yasser Abduallah jason T.l.Wang Yang Nie chang liu Haimin Wang Institute for Space Weather Sciences New Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102-1982USA Department of computer Science New Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102-1982USA Big Bear Solar Observatory New Jersey Institute of Technology40386 North Shore LaneBig Bear CityCA 92314-9672USA center for Solar-Terrestrial Research New Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102-1982USA

Solar flare prediction plays an important role in understanding and forecasting space *** main goal of the Helioseismic and Magnetic Imager(HMI), one of the instruments on NASA's Solar Dynamics Observatory, is to study the origin of solar variability and characterize the Sun's magnetic *** provides continuous full-disk observations of the solar vector magnetic field with high cadence data that lead to reliable predictive capability;yet, solar flare prediction effort utilizing these data is still limited. In this paper, we present a machine-learning-as-a-service(Mlaa S) framework, c.l.ed Deep Sun,for predicting solar flares on the web based on HMI's data products. Specific.l.y, we construct training data by utilizing the physic.l.parameters provided by the Space-weather HMI Active Region Patch(SHARP)and categorize solar flares into four classes, namely B, c, M and X, according to the X-ray flare catalogs available at the National centers for Environmental Information(NcEI). Thus, the solar flare prediction problem at hand is essentially a multi-class(i.e., four-class) classification problem. The Deep Sun system employs several machine learning algorithms to tac.l. this multi-class prediction problem and provides an application programming interface(API) for remote programming users. To our knowledge, Deep Sun is the first Mlaa S tool capable of predicting solar flares through the internet.

关键词： Sun:flares Sun:activity methods:data analysis

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Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions

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Journal of Pharmaceutic.l.Analysis 2018年第6期8卷 407-412页

作者： Jayesh A.Dhanani Suzanne l.Parker Jeffrey lipman Steven c.Wallis Jeremy cohen John Fraser Adrian Barnett Michelle chew jason A.Roberts Burns Trauma and Critical Care Research Centre The University of Queensland UQ Centre for Clinical Research Department of Intensive care Medicine Royal Brisbane & Women's Hospital Fac.l.y of Health Queensland University of Technology critic.l.care Research Group The University of Queensland Institute of Health and Biomedic.l.Innovation & School of Public Health and Social Work Queensland University of Technology Department of Anaesthesiology and Intensive care and Department of Medical and Health Sciences Link?ping University School of Pharmacy The University of Queensland Department of Pharmacy Royal Brisbane & Women's Hospital

Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to c.l.brating the microdialysis system for in vivo studies. The effect of a combination of antibiotics on recovery into microdialysate requires investigation. In vitro microdialysis recovery studies were conducted on a combination of vancomycin and tobramycin, in a simulated in vivo model. comparison was made between recoveries for three different concentrations and three different perfusate flow rates. The overall relative recovery for vancomycin was lower than that of tobramycin. For tobramycin, a concentration of 20μg/ml and flow rate of 1.0μl/min had the best recovery. A concentration of 5.0μg/ml and flow rate of 1.0μl/min yielded maximal recovery for vancomycin. large molec.l.r size and higher protein binding resulted in lower relative recoveries for vancomycin. Perfusate flow rates and drug concentrations affected the relative recovery when a combination of vancomycin and tobramycin was tested. low perfusate flow rates were associated with higher recovery rates. For combination antibiotic measurement which includes agents that are highly protein bound, in vitro studies performed prior to in vivo studies may ensure the reliable measurement of unbound concentrations.

关键词： Microdialysis combination antibiotic therapy Relative recovery rate Pharmacokinetics Anti-infectives Protein binding

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