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Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo

Light(Science & Applications) 2020年第1期9卷 1298-1308页

作者： Zhongya Qin Sicong He Chao Yang jasmine sum-yee yung Congping Chen Christopher Kai-Shun Leung Kai Liu Jianan Y.Qu Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of Life Science The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and TechnologyClear Water BayKowloonHongKongChina Center of Systems Biology and Human Health The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

In vivo fundus imaging offers non-invasive access to neuron structures and biochemical processes in the ***,optical aberrations of the eye degrade the imaging resolution and prevent visualization of subcellular retinal *** developed an adaptive optics two-photon excitation fluorescence microscopy(AO-TPEFM)system to correct ocular aberrations based on a nonlinear fluorescent guide star and achieved subcellular resolution for in vivo fluorescence imaging of the mouse *** accurate wavefront sensing and rapid aberration correction,AOTPEFM permits structural and functional imaging of the mouse retina with submicron ***,simultaneous functional calcium imaging of neuronal somas and dendrites was ***,the timelapse morphological alteration and dynamics of microglia were characterized in a mouse model of retinal *** addition,precise laser axotomy was achieved,and degeneration of retinal nerve fibres was *** highresolution AO-TPEFM is a promising tool for non-invasive retinal imaging and can facilitate the understanding of a variety of eye diseases as well as neurodegenerative disorders in the central nervous system.

关键词： optics functional photon

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Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele Castellani Vineet Gauhar Khi yung Fong Mario Sofer Moisés Rodríguez Socarrás Azimdjon N Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho yee Tiong Dean Elterman Abhay Mahajan Mark Taratkin Sorokin Nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev Nariman Gadzhiev Mohammed Taif Bendigeri Jeremy Yuen-Chun Teoh Marco Dellabella Fernando Gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and Reproductive Health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho UrologyCentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(Group 1)versus 2-lobe/3-lobe techniques(Group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(MUI).There were 1711 patients in Group 1 and 3357 patients in Group *** in Group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).Median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in Group 1 vs 70[54–90]ml in Group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in Group *** 1 month,overall incontinence rate was 6.3%in Group 1 versus 5.3%in Group 2(P=0.12),and urge incontinence was significantly higher in Group 1(55.1%vs 37.3%in Group 2,P<0.001).After 3 months,the overall rate ofincontinence was 1.7%in Group 1 versus 2.3%in Group 2(P=0.06),and SUI was significantly higher in Group 2(55.6%vs 24.1%in Group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/MUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

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Artificial Intelligence Based MPPT Techniques for Solar Power System: A review

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Journal of Modern Power Systems and Clean Energy 2020年第6期8卷 1043-1059页

作者： Kah yung Yap Charles R.Sarimuthu Joanne Mun-yee Lim the Department of Electrical and Computer Systems Engineering(ECSE) School of EngineeringMonash UniversitySubang JayaMalaysia

In the last decade,artificial intelligence(AI)techniques have been extensively used for maximum power point tracking(MPPT)in the solar power *** is because conventional MPPT techniques are incapable of tracking the global maximum power point(GMPP)under partial shading condition(PSC).The output curve of the power versus voltage for a solar panel has only one GMPP and multiple local maximum power points(MPPs).The integration of AI in MPPT is crucial to guarantee the tracking of GMPP while increasing the overall efficiency and performance of *** selection of AI-based MPPT techniques is complicated because each technique has its own merits and *** general,all of the AI-based MPPT techniques exhibit fast convergence speed,less steady-state oscillation and high efficiency,compared with the conventional MPPT ***,the AI-based MPPT techniques are computationally intensive and costly to ***,the hybrid MPPT is favorable in terms of the balance between performance and complexity,and it combines the advantages of conventional and AI-based MPPT *** this paper,a detailed comparison of classification and performance between 6 major AI-based MPPT techniques have been made based on the review and MATLAB/Simulink simulation *** merits,open issues and technical implementations of AI-based MPPT techniques are *** intend to provide new insights into the choice of optimal AI-based MPPT techniques.

关键词： Maximum power point tracking(MPPT) artificial intelligence(AI) fuzzy logic control(FLC) artificial neural network(ANN) genetic algorithm(GA) swarm intelligence(SI) machine learning(ML)

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Structural analysis of the promoter of tomato 1-aminocyclopropane-1-carboxylate synthase 6 gene(Le-ACS6)

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Chinese Science Bulletin 2007年第9期52卷 1217-1222页

作者： LIN JingYu FAN Rong WAN XiaoRong CHARNG yee-yung WANG NingNing Department of Plant Biology and Ecology Nankai University Tianjin 300071 China Institute of BioAgricutural Sciences Academia Sinica Nankang Taipei 11529 China

Ethylene plays an important role in the regulation of many growth and developmental processes of higher plants. In tomato,Le-ACS6,a member of the ACC synthase multigene family involved in system 1 ethylene biosynthesis during fruit ripening,is subject to negative feedback regulation by ethylene. To identify the cis-elements that are responsible for the negative feedback control,we established an in vitro transient assay system employing particle bombardment on mature-green tomato fruit pericarp to examine the expression of a luciferase(LUC) reporter gene driven by a 5′-serially deleted Le-ACS6 promoter. The results localized putative cis-elements required for negative ethylene-response between -347 and -266 upstream from the translational start site ATG. Several lines of stable transformation of the Le-ACS6 promoter and GUS reporter fusion gene containing internal deletion from -347 to -266 were generated. The expression pattern of the GUS reporter showed that removal of the nucleotides from -347 to -266 completely eliminated the response of the Le-ACS6 promoter to exogenous ethylene.

关键词：番茄乙烯 1-氨基环丙烷-1-羧酸盐合酶6基因 Le-ACS6 启动子结构分析

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LOGISTICS SCHEDULING: ANALYSIS OF TWO-STAGE PROBLEMS

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Systems Science and Systems Engineering 2003年第4期12卷 385-407页

作者： yung-Chia CHANG Chung-yee LEE Davicom America Corporation 1135 Kern Avenue Sunnyvale CA 94085 U.S.A.Department of Industrial Engineering and Engineering Management Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong

This paper studies the coordination effects between stages for scheduling problems where decision-making is a two-stage process. Two stages are considered as one system. The system can be a supply chain that links two stages, one stage representing a manufacturer; and the other, a distributor It also can represent a single manufacturer, while each stage represents a different department responsible for a part of operations. A problem that jointly considers both stages in order to achieve ideal overall system performance is defined as a system problem. In practice, at times, it might not be feasible for the two stages to make coordinated decisions due to (i) the lack of channels that allow decision makers at the two stages to cooperate, and/or (ii) the optimal solution to the system problem is too difficult (or costly) to achieve.Two practical approaches are applied to solve a variant of two-stage logistic scheduling problems. The Forward Approach is defined as a solution procedure by which the first stage of the system problem is solved first, followed by the second stage. Similarly, the Backward Approach is defined as a solution procedure by which the second stage of the system problem is solved prior to solving the first stage. In each approach, two stages are solved sequentially and the solution generated is treated as a heuristic solution with respect to the corresponding system problem. When decision makers at two stages make decisions locally without considering consequences to the entire system, ineffectiveness may result - even when each stage optimally solves its own problem. The trade-off between the time complexity and the solution quality is the main concern. This paper provides the worst-case performance analysis for each approach.

关键词： Logistics scheduling worst case analysis dynamic programming

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Tardive sensory syndrome related to lurasidone:A case report

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World Journal of Psychiatry 2023年第3期13卷 126-130页

作者： Mei-Chun Lin yung-yee Chang Yu Lee Liang-Jen Wang Department of Psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine KaohsiungKaohsiung 83301Taiwanchina Department of Neurology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine KaohsiungKaohsiung 83301Taiwanchina Department of Child and Adolescent Psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301Taiwanchina

BACKGROUND Tardive sensory syndrome(TSS)is a subtype of tardive syndrome(TS),and its etiology is still *** is an atypical antipsychotic that has high affinity for dopamine D2-and serotonergic 5HT2A-and *** sumMARY A 52-year-old woman,previously diagnosed with schizophrenia,and with no history of movement disorders and no sensory paresthesia,had taken lurasidone,initiate dose 40 mg daily then up titration to 120 mg daily,since March 2021,and developed mandibular sensory(pain)paresthesia after 3 mo of *** switching from lurasidone to quetiapine,she reported obvious improvement in her mandibular *** It is noteworthy that TSS is a rare subtype of TS,and lurasidone,an atypical antipsychotic,usually has a lower risk of causing *** light of the temporal relationship,it is therefore concluded that use of lurasidone might have caused TSS in this *** reported this rare case as a reminder that clinicians should adopt a cautious approach when prescribing atypical antipsychotics,so as to prevent TS.

关键词： Antipsychotic Tardive syndrome Tardive sensory syndrome Lurasidone Case report

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Synthesis of a highly recoverable 3D MnO2/rGO hybrid aerogel for efficient adsorptive separation of pharmaceutical residue

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Journal of Environmental Sciences 2022年第8期34卷 194-203页

作者： Billie Yan Zhang Hiew Wan Ting Tee Nicholas yung Li Loh Kar Chiew Lai Svenja Hanson Suyin Gan Suchithra Thangalazhy-Gopakumar Lai yee Lee Department of Chemical and Environmental Engineering University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of Chemical and Environmental Engineering University of Nottingham Ningbo ChinaNingbo 315100China

Water contamination by non-steroidal anti-inflammatory drugs,such as acetaminophen,is an emerging ecological *** this study,a newthree-dimensionalmanganese dioxideengrafted reduced graphene oxide(3D MnO_(2)/rGO)hybrid aerogel was developed for acetaminophen *** synthesis involved firstly the self-assembly of GO aerogel,followed by thermal reduction and in-situ MnO_(2) growth by *** aerogel demonstrated interlinked planes with smooth surfaces deposited with MnO_(2) nanospheres and pores of 138.4–235.3μm *** influences of adsorbent dosage,initial pH,acetaminophen concentration,temperature and contact time were *** was determined that the adsorption of acetaminophen occurred on uniform sorption sites in the aerogel,as suggested by the best fit of data to the Langmuir isotherm,yielding a maximum adsorption capacity of 252.87 mg/*** highest adsorption performance of the 3D MnO_(2)/rGO aerogel was attained at a dosage of 0.6 g/L,initial pH of 6.2 and temperature of 40℃.The process kinetics were in-line with the pseudo-first-order and pseudo-second-order kinetics at 10 and 20–500 mg/L concentrations,*** assay showed the spontaneity and endothermicity features of the 3D MnO_(2)/rGO-acetaminophen *** acetaminophen adsorption mechanisms were mainly hydrogen bonding and pore ***,the as-synthesised aerogel was effectively regenerated using acetone and re-utilised in four adsorption-desorption ***,the results highly recommend the implementation of the 3D MnO_(2)/rGO hybrid aerogel for purification of wastewater polluted by acetaminophen residue.

关键词： Acetaminophen Adsorption Adsorption mechanism 3D reduced graphene oxide Manganese oxide nanoparticles Regeneration

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真假针刺对原发性失眠症的作用比较研究

真假针刺对原发性失眠症的作用比较研究

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作者： jasmine yee Hing Leung 广州中医药大学

学位级别：硕士

目的：本研究观察针刺在治疗原发性失眠中是否具有真正的临床效应或它只是安慰剂的另一种形式,做出单纯针刺和非穿透性的假针刺比较。通过观察患者治疗前后的症状评估是否得改善的情况下, 为针灸疗效提供进一步的证明和确认。方法：使... 详细信息

目的：本研究观察针刺在治疗原发性失眠中是否具有真正的临床效应或它只是安慰剂的另一种形式,做出单纯针刺和非穿透性的假针刺比较。通过观察患者治疗前后的症状评估是否得改善的情况下, 为针灸疗效提供进一步的证明和确认。方法：使用随机对照的实验方法, 将符合纳入表准的60例失眠患者按照1：1的比例随机分为常规体针针刺的治疗组与非穿刺假针刺的对照组。要求参与者在治疗的一个月前没有接受任何的针灸治疗, 选择的参与者都是进一年内很少接触或从未接受过针灸的参与者。两组失眠患者每周治疗的次数为2-3次, 每次间隔的时间为至少2天完成10次治疗为1个疗程。常规针刺治疗组主要选的穴位是内关、神门、百会、照海、申脉和三阴交;非穿刺假针刺对照组会在非经络穴位上进行运作。治疗结果是在治疗前后由匹兹堡睡眠质量评分量表衡量而做比较。结果：60位参与者当中,没有参与者脱落退出研究。共有60为患者完成治疗而被列入统计分析1.治疗前：有基线数据上两组间无统计学差异(P＞0.05),也在匹兹堡睡眠质量评分量表(PSQI)分数的差异,使得两组患者具有可比性。2.将常规针刺组和非穿刺假刺组治疗前后的匹兹堡睡眠质量评分量表的总分和其中的六项项目,睡眠时间、入睡时间、睡眠质量、睡眠效率、睡眠障碍、日常功能障碍积分进行组内比较, 经过t检验分析, P＜0.05, 差异有统计学意义。在治疗组的治疗前各成分和总分均比治疗后成分高, 研究显示常规针刺的治疗组对失眠在匹兹堡睡眠质量评分量表中的成分都有较好的改善作用。在对照组里,治疗前各成分,除了睡眠效率和睡眠障碍的部分,和总分均比治疗后成分高, 研究显示非穿刺假针的治疗组对失眠在匹兹堡睡眠质量评分量表中的成分也有部分的改善作用。对照组的匹兹堡睡眠质量评分量表治疗后的总分比对照组高, 而在各成分的积分经组间比较治疗组的疗效也优于对照组。3.观察的60例患者中,常规体刺针灸治疗组的临床总有效率为90%：9例治愈,13例显著改善,5例显效,和3例无效总30例患者;非穿刺假针灸的有效率为73.33%：6例治愈,7显著改善,9显效,和8例无效总30例患者.结论：在本临床研究结果发现, 常规针刺组和假针刺对照组对失眠的疗效都取得一定的效果, 都能一定的程度上改善失眠患者的匹兹堡睡眠质量评分量表的总分。治疗组在在治疗后的各成分积分上都比对照组优胜。虽然对照组大部分在治疗后的各成分评分都有好转, 却在睡眠效率和睡眠障碍上不没有改善。针灸是一个非药物治疗失眠的方法, 不但没有依赖性或耐药性的副作用, 也不会对人体造成严重的不良反应, 而且也是一个可以长期使用的一种治疗放法。

关键词：失眠针灸体针假针刺非穿刺匹兹堡睡眠质量评分

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Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1

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Asian Journal of Andrology 2017年第3期19卷 286-290页

作者： Lincoln GL Tan yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong Department of Urology National University Hospital National University Health System Singapore Department of Urology Tan Tock Seng Hospital Singapore Saw Swee Hock School of Public Health National University of Singapore Singapore Department of Laboratory Medicine National University Hospital Singapore Department of Urology Alexandra Hospital Jurong Health Singapore Department of Laboratory Medicine Tan Teck Seng Hospital Singapore Department of Pathology National University Hospital Singapore.

Despite its widespread use for prostate cancer screening, low specificity makes PSA a suboptimal biomarker, especially in the diagnostic ＂gray zone＂ of 4-10 ng ml-1, False-positives lead to unnecessary biopsies with attendant morbidities. This is the first prospective validation study of %p2PSA and the Prostate Health Index （PHI） in Asian men presenting with a total PSA between 4.0 and 10 ng m1-1. We studied 157 Asian men between 50 and 75 years old, with normal per rectal prostate examinations, undergoing their first prostate biopsy, using a standardized biopsy protocol, for PSA levels of 4-10 ng ml-1, Thirty （19.1%） were found to have prostate cancer on biopsy. Statistically significant differences between patients with and without prostate cancer were found for total PSA, p2PSA, %p2PSA, and PHh The areas under the curve of the receiver operating characteristic curve for total PSA, %fPSA, %p2PSA, and PHI were 0.479, 0.420, 0.695, and 0.794, respectively. PHI predicts prostatic biopsies results best. At a sensitivity of 90%, the specificity （95% CI） of PHI was 58.3%, more than triple the specificity of total PSA at 17.3%, potentially avoiding 77 （49%） unnecessary biopsies. Similar to studies in mainly Caucasian populations, we have prospectively shown that %p2PSA and PHI greatly outperform total and free to total PSA ratio, in the detection of prostate cancer at first biopsy. Higher PHi levels also correspond to increasing the risk of detecting GS ≥7 cancers. We have validated the use of PHI to aid decision-making regarding prostate biopsies in Asian men with serum PSA between 4 and 10 ng *** its widespread use for prostate cancer screening, low specificity makes PSA a suboptimal biomarker, especially in the diagnostic ＂gray zone＂ of 4-10 ng m1-1, False-positives lead to unnecessary biopsies with attendant morbidities. This is the first prospective validation study of %p2PSA and the Prostate Health Index （PHI） in Asian men presenting with a total PSA betwe

关键词： biological markers prostate specific antigen prostatic neoplasms

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Imaging of the anterior cruciate ligament

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World Journal of Orthopedics 2011年第8期2卷 75-84页

作者： Wing Hung Alex Ng James Francis Griffith Esther Hiu yee Hung Bhawan Paunipagar Billy Kan Yip Law Patrick Shu Hang yung Department of Imaging and Interventional Radiology Prince of Wales HospitalChinese University of Hong KongHong KongChina Department of Orthopedics and Traumatology Prince of Wales HospitalChinese University of Hong KongHong KongChina

The anterior cruciate ligament(ACL)is an important structure in maintaining the normal biomechanics of the knee and is the most commonly injured knee ***,the oblique course of the ACL within the intercondylar fossa limits the visualization and assessment of the pathology of the *** pictorial essay provides a comprehensive and illustrative review of the anatomy and biomechanics as well as updated information on different modalities of radiological investigation of ACL,particularly magnetic resonance imaging.

关键词： Magnetic resonance Knee Anterior cruciate ligament Tear

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