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Prevalence of-and risk factors for work disability in Dutch patients with inflammatory bowel disease

World Journal of Gastroenterology 2017年第46期23卷 8182-8192页

作者： Lieke M Spekhorst Bas Oldenburg Ad A van Bodegraven Dirk J de Jong Floris Imhann Andrea E van der Meulen-de Jong Marieke J Pierik janneke c van der woude Gerard Dijkstra Geert D'Haens Mark Lowenberg Rinse K Weersma Eleonora AM Festen 无 Department of Gastroenterology and Hepatology University of Groningen and University Medical Centre Groningen Department of Genetics University of Groningen and University Medical Centre Groningen Department of Gastroenterology and Hepatology University Medical Center Utrecht Department of Gastroenterology and Hepatology VU University Medical Center Department of Gastroenterology and Hepatology University Medical Center St. Radboud Department of Gastroenterology and Hepatology Leiden University Medical Center Department of Gastroenterology and Hepatology University Medical Center Maastricht Department of Gastroenterology and Hepatology Erasmus Medical Center Department of Gastroenterology and Hepatology Amsterdam Medical Center Parelsnoer Institute and the Dutch Initiative on crohn and colitis

AIM To determine the prevalence of work disability in inflammatory bowel disease(IBD), and to assess risk factors associated with work disability.METHODS For this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population. Multivariate analyses were performed for work disability(sick leave, partial and full disability) and long-term full work disability(> 80% work disability for > 2 years).RESULTS Prevalence of work disability was higher in crohn's disease(cD)(29%) and ulcerative colitis(Uc)(19%) patients compared to the general Dutch population(7%). In all IBD patients, female sex, a lower education level, and extra-intestinal manifestations, were associated with work disability. In cD patients, an age > 40 years at diagnosis, disease duration > 15 years,smoking, surgical interventions, and anti-TNFα use were associated with work disability. In Uc patients, an age > 55 years, and immunomodulator use were associated with work disability. In cD patients, a lower education level(OR = 1.62, 95%cI: 1.02-2.58), and in Uc patients, disease complications(OR = 3.39, 95%cI: 1.09-10.58) were associated with long-term full work disability.cONcLUSION The prevalence of work disability in IBD patients is higher than in the general Dutch population. Early assessment of risk factors for work disability is necessary, as work disability is substantial among IBD patients.

关键词： Inflammatory bowel disease crohn’s disease Ulcerative colitis Work disability Health care costs

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Prehabilitation prior to intestinal resection in crohn’s disease patients:An opinion review

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World Journal of Gastroenterology 2022年第22期28卷 2403-2416页

作者： Michiel T J Bak Marit F E Ruiterkamp Oddeke van Ruler Marjo J E campmans-Kuijpers Bart c Bongers Nico L U van Meeteren c janneke van der woude Laurents P S Stassen Annemarie c de Vries Department of Gastroenterology and Hepatology Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery IJsselland HospitalCapelle aan den IJssel 2906 ZCNetherlands Department of Surgery Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Gastroenterology and Hepatology University Medical Center Groningen and University of GroningenGroningen 9713 GZNetherlands Department of Nutrition and Movement Sciences School of Nutrition and Translational Research in MetabolismMaastricht UniversityMaastricht 6200 MDNetherlands Department of Epidemiology Care and Public Health Research InstituteMaastricht UniversityMaastricht 6200 MDNetherlands Department of Anaesthesiology Erasmus MC University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery Maastricht University Medical CenterMaastricht 6229 HXNetherlands

Patients with crohn’s disease(cD)are at a considerable risk for intestinal surgery.Approximately 25%of patients with cD will undergo an intestinal resection within 10 years of diagnosis.Postoperative complications after cD surgery have been reported in 20%-47%of the patients.Both general and cD-related risk factors are associated with postoperative complications,and comprise non-modifiable(e.g.,age)and potentially modifiable risk factors(e.g.,malnutrition).Prehabilitation focuses on the preoperative period with strategies designed to optimize modifiable risk factors concerning the physical and mental condition of the individual patient.The aim of prehabilitation is to enhance postoperative recovery and return to or even improve preoperative functional capacity.Preoperative improvement of nutritional status,physical fitness,cessation of smoking,psychological support,and critical revision of preoperative use of cD medication are important strategies.Studies of the effect on postoperative outcome in cD patients are scarce,and guidelines lack recommendations on tailored management.In this opinion review,we review the current evidence on the impact of screening and management of nutritional status,physical fitness,cD medication and laboratory values on the postoperative course following an intestinal resection in cD patients.In addition,we aim to provide guidance for individualized multimodal prehabilitation in clinical practice concerning these modifiable factors.

关键词： crohn’s disease Prehabilitation strategies Nutrition Physical fitness Medication Laboratory values

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Sex-dimorphic adverse drug reactions to immune suppressive agents in inflammatory bowel disease

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World Journal of Gastroenterology 2012年第47期18卷 6967-6973页

作者： Zuzana Zelinkova Evelien Bultman Lauran Vogelaar cheima Bouziane Ernst J Kuipers c janneke van der woude Department of Gastroenterology and Hepatology Erasmus MC University Medical CenterNL-3000 CA RotterdamThe Netherlands

AIM:To analyze sex differences in adverse drug reactions(ADR) to the immune suppressive medication in inflammatory bowel disease(IBD) patients.METHODS:All IBD patients attending the IBD outpatient clinic of a referral hospital were identified through the electronic diagnosis registration system.The electronic medical records of IBD patients were reviewed and the files of those patients who have used immune suppressive therapy for IBD,i.e.,thiopurines,methotrexate,cyclosporine,tacrolimus and anti-tumor necrosis factor agents(anti-TNF);infliximab(IFX),adalimumab(ADA) and/or certolizumab,were further analyzed.The reported ADR to immune suppressive drugs were noted.The general definition of ADR used in clinical practice comprised the occurrence of the ADR in the temporal relationship with its disappearance upon discontinuation of the medication.Patients for whom the required information on drug use and ADR was not available in the electronic medical record and patients with only one registered contact and no further followup at the outpatient clinic were excluded.The difference in the incidence and type of ADR between male and female IBD patients were analyzed statistically by χ 2 test.RESULTS:In total,1009 IBD patients were identified in the electronic diagnosis registration system.Out of these 1009 patients,843 patients were eligible for further analysis.There were 386 males(46%),mean age 42 years(range:16-87 years) with a mean duration of the disease of 14 years(range:0-54 years);578 patients with crohn's disease,244 with ulcerative colitis and 21 with unclassified colitis.Seventy percent(586 pts) of patients used any kind of immune suppressive agents at a certain point of the disease course,the majority of the patients(546 pts,65%) used thiopurines,176 pts(21%) methotrexate,46 pts(5%) cyclosporine and one patient tacrolimus.One third(240 pts,28%) of patients were treated with anti-TNF,the majority of patients(227 pts,27%) used IFX,99(12%) used ADA and five patients certolizumab.There were no differences between m

关键词：药物不良反应免疫抑制肠道疾病性别差异鸡传染性法氏囊病肿瘤坏死因子溃疡性结肠炎环孢霉素A

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cD4^(+)T cells produce IFN-I to license cDc1s for induction of cytotoxic T-cell activity in human tumors

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cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël c.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos charlotte L.Zuur Noel F.c.c.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

cD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDc1s)to induce cD8^(+)cytotoxic T lymphocyte(cTL)anticancer responses,as proven in mouse models.We recently identified cDc1s with a transcriptomic imprint of cD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting immunotherapy.Here,we delineate the mechanism of cDc1 licensing by cD4^(+)T cells in humans.Activated cD4^(+)T cells produce IFNβvia the STING pathway,which promotes MHc-I antigen(cross-)presentation by cDc1s and thereby improves their ability to induce cTL anticancer responses.In cooperation with cD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDc1s required for cTL response induction.IFN-I-producing cD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to cTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDcs and tumor-reactive cD8^(+)T cells.In agreement with this scenario,the presence of IFN-I-producing cD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： cD4^(+)T-cell help cDc1 licensing IFN-I signaling cD40 costimulation (cross-)presentation cTL priming Tumor control

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Artificial intelligence for characterization of diminutive colorectal polyps:A feasibility study comparing two computer-aided diagnosis systems

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Artificial Intelligence in Gastrointestinal Endoscopy 2024年第1期5卷 11-22页

作者： Quirine Eunice Wennie van der Zander Ramon M Schreuder Ayla Thijssen carolus H J Kusters Nikoo Dehghani Thom Scheeve Bjorn Winkens Mirjam c M van der Ende-van Loon Peter H N de With Fons van der Sommen Ad A M Masclee Erik J Schoon Department of Gastroenterology and Hepatology Maastricht University Medical CenterMaastricht 6202 AZNetherlands GROW School for Oncology and ReproductionMaastricht UniversityMaastricht 6200 MDNetherlands Division of Gastroenterology and Hepatology Catharina Hospital EindhovenEindhoven 5602 ZANetherlands Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBNetherlands Department of Methodology and Statistics Maastricht UniversityPostbus 6166200 MD MaastrichtNetherlands School for Public Health and Primary care Maastricht UniversityMaastricht 6200 MDNetherlands

BAcKGROUND Artificial intelligence(AI)has potential in the optical diagnosis of colorectal polyps.AIM To evaluate the feasibility of the real-time use of the computer-aided diagnosis system(cADx)AI for coloRectal Polyps(AI4cRP)for the optical diagnosis of diminutive colorectal polyps and to compare the performance with cAD EYE^(TM)(Fujifilm,Tokyo,Japan).cADx influence on the optical diagnosis of an expert endoscopist was also investigated.METHODS AI4cRP was developed in-house and cAD EYE was proprietary software provided by Fujifilm.Both cADxsystems exploit convolutional neural networks.colorectal polyps were characterized as benign or premalignant and histopathology was used as gold standard.AI4cRP provided an objective assessment of its characterization by presenting a calibrated confidence characterization value(range 0.0-1.0).A predefined cut-off value of 0.6 was set with valuescating benign and values≥0.6 indicating premalignant colorectal polyps.Low confidence characterizations were defined as values 40%around the cut-off value of 0.6(0.76).Self-critical AI4cRP’s diagnostic performances excluded low confidence characterizations.RESULTS AI4cRP use was feasible and performed on 30 patients with 51 colorectal polyps.Self-critical AI4cRP,excluding 14 low confidence characterizations[27.5%(14/51)],had a diagnostic accuracy of 89.2%,sensitivity of 89.7%,and specificity of 87.5%,which was higher compared to AI4cRP.cAD EYE had a 83.7%diagnostic accuracy,74.2%sensitivity,and 100.0%specificity.Diagnostic performances of the endoscopist alone(before AI)increased nonsignificantly after reviewing the cADx characterizations of both AI4cRP and cAD EYE(AI-assisted endoscopist).Diagnostic performances of the AI-assisted endoscopist were higher compared to both cADx-systems,except for specificity for which cAD EYE performed best.cONcLUSION Real-time use of AI4cRP was feasible.Objective confidence values provided by a cADx is novel and self-critical AI4cRP showed higher diagnostic performances compared to A

关键词： Artificial intelligence colorectal polyp characterization computer aided diagnosis Diminutive colorectal polyps Optical diagnosis Self-critical artificial intelligence

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Littoral landforms of Lake Hulun and Lake Buir(china and Mongolia):Wind-driven hydro-sedimentary dynamics and resulting clastics distribution

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Journal of Palaeogeography 2024年第2期13卷 309-326页

作者： Li Wang Mathieu Schuster Shi-Wei Xin Florin Zainescu Xin-Yu Xue Joep Storms Jan-Hendrik May Alexis Nutz Helena van der Vegt Guilherme Bozetti Zai-Xing Jiang School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Universite de Strasbourg CNRSENGEESInstitut Terre et Environnement de StrasbourgUMR 70635 Rue DescartesStrasbourgFrance Tamsag Mongolia(XIX)Ltd. PetroChinaDaqing 163000China cEREGE Aix-Marseille UniversitéCNESIRDCollege de FranceINRAAix en ProvenceFrance School of Marine Science Sun Yat-sen UniversityZhuhai 519083China Delft University of Technology Department of Geoscience and EngineeringDelfthe Netherlands School of Geography Earth and Atmospheric SciencesUniversity of Melbourne253 Elgin St.CarltonVIC 3053Australia Deltares Delfthe Netherlands ScMF Faculty of GeographyUniversity of Bucharest1 N.Balcescu Blv.BucharestRomania

Two rectangular-shaped lakes,Lake Hulun and Lake Buir,located at the boundary between china and Mongolia,only c.75 km apart and therefore experiencing similar wind fields,have been studied based on satellite images and field surveys in order to compare their geomorphological and sedimentological characteristics.The wind-driven hydrodynamics,which have a significant effect on the development of littoral landforms and on sediment distribution,have been discussed for the two similar lakes that experienced a prevailing wind perpendicular to their long axis.A conceptual model related to wind-driven water bodies and sediment distribution is proposed.Wave-influenced to wave-dominated deltas,beaches,spits,and eolian dune deposits develop around these two lakes,with a strikingly similar distribution pattern.These features locally inform the longshore drift and help reconstruct the water circulation induced by wind forcing.Under the NW prevailing wind regime,the spits developed on the SW coast with a NW—SE extension,which was influenced by the NW—SE longshore currents.The same influence was observed in the delta extension in the NE area.The differences lie in the presence of fan deltas in the NW region of Lake Hulun,but not in Lake Buir.Additionally,the width of the beach and eolian deposits on the downwind coast of Lake Hulun is three times greater than that of Lake Buir which were caused by the differences in sediment supply and wind fetch between the two lakes.Lake Hulun and Lake Buir provide two reliable examples to understand the relationship among the wind field,provenance,hydrodynamics,landforms,and asymmetrical distribution of clastics in elongated lakes.They also represent relevant modern analogs,which may also be of guiding significance to wind-driven sand body prediction in lacustrine basins.

关键词： Wind-driven lakes Fetch Sedimentary facies Hydrodynamics Geomorphology Spits Shoreline Lake Hulun Lake Buir

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Urban rail transit disruption management: Research progress and future directions

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Frontiers of Engineering Management 2024年第1期11卷 79-91页

作者： Lebing WANG Jian Gang JIN Lijun SUN der-Horng LEE School of Naval Architecture Ocean&Civil Engineeringand State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of civil Engineering McGill UniversityMontrealQuebec H3A 0C3Canada ZJU-UIUc Institute Zhejiang UniversityHaining 314400China

Urban rail transit (URT) disruptions present considerable challenges due to several factors: i) a high probability of occurrence, arising from facility failures, disasters, and vandalism;ii) substantial negative effects, notably the delay of numerous passengers;iii) an escalating frequency, attributable to the gradual aging of facilities;and iv) severe penalties, including substantial fines for abnormal operation. This article systematically reviews URT disruption management literature from the past decade, categorizing it into pre-disruption and post-disruption measures. The pre-disruption research focuses on reducing the effects of disruptions through network analysis, passenger behavior analysis, resource allocation for protection and backup, and enhancing system resilience. conversely, post-disruption research concentrates on restoring normal operations through train rescheduling and bus bridging services. The review reveals that while post-disruption strategies are thoroughly explored, pre-disruption research is predominantly analytical, with a scarcity of practical pre-emptive solutions. Moreover, future research should focus more on increasing the interchangeability of transport modes, reinforcing redundancy relationships between URT lines, and innovating post-disruption strategies.

关键词： urban rail transit disruption management resilient network train rescheduling bus bridging services

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欧洲研究区跨区域协同创新治理举措及启示

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科技管理研究 2024年第4期44卷 159-166页

作者：刘慧金·范德波特石家庄学院经济管理学院河北石家庄050035 布鲁塞尔自由大学法律与犯罪学学院布鲁塞尔1050

协同创新共同体建设遇到的最大困难是跨区域协同治理问题,可以说治理机制是否有效直接决定跨区域协同创新效果。建设欧洲研究区是欧盟促进其成员国间跨区域协同创新的重要举措,目标是整合成员国创新资源和力量以提升欧盟整体创新竞争力... 详细信息

协同创新共同体建设遇到的最大困难是跨区域协同治理问题,可以说治理机制是否有效直接决定跨区域协同创新效果。建设欧洲研究区是欧盟促进其成员国间跨区域协同创新的重要举措,目标是整合成员国创新资源和力量以提升欧盟整体创新竞争力。欧盟成员国创新能力不平衡,为实现各国有效跨区域协同治理,欧盟搭建了欧盟及其成员国和地区多层治理下的共同治理框架,通过设立欧洲研究区咨询建议机构、注重决策的民主化形成政策咨询建议机制,通过编制《欧洲研究区发展报告》《欧洲研究区发展路线图》和纳入“欧洲学期”构建监督机制,并开发基金工具、项目工具和各种对话机制等治理工具,在成员国间建立创新伙伴关系,推进各国创新资源、项目和政策的协同,提升欧盟治理能力、改善欧盟创新系统失灵问题。欧洲研究区加强创新能力发展不平衡地区间协同创新治理方面的经验对中国跨区域协同创新共同体建设,在加强不同层级主体共同治理、形成有效咨询建议机制、设计多种互补治理工具等方面带来有益启示。

关键词：欧洲研究区创新治理创新系统咨询建议机制监督机制治理工具协同创新创新共同体

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Modeling the effects of salt concentration on aqueous and organic electrolytes

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npj computational Materials 2023年第1期9卷 546-552页

作者： Stephanie c.c.van der Lubbe Pieremanuele canepa Department of Materials Science and Engineering National University of Singapore9 Engineering Drive 1117575 SingaporeSingapore Department of chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4117585 SingaporeSingapore Department of Electrical and computer Engineering and Texas center for Superconductivity University of HoustonHoustonTX 77204USA

Understanding the thermodynamic properties of electrolyte solutions is of vital importance for a myriad of physiological and technological applications.The mean activity coefficientγ±is associated with the deviation of an electrolyte solution from its ideal behavior and may be obtained by combining the Debye-Hückel(DH)and Born(B)equations.However,the DH and B equations depend on the concentration and temperature-dependent static permittivity of the solutionεr(c,T)and the size of the solvated ions ri,whose experimental data is often not available.Here,we use a combination of molecular dynamics and density functional theory to predictεr(c,T)and ri,which enables us to apply the DH and B equations to any technologically relevant aqueous and nonaqueous electrolyte at any concentration and temperature of interest.

关键词： equations electrolyte apply

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Adsorption of yttrium(Y^(3+)) and concentration of rare earth elements from phosphogypsum using chitin and chitin aerogel

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Journal of Rare Earths 2024年第4期42卷 775-782页

作者： Glaydson S.dos Reis Diana Pinto Sabrina F.Lütke Eder c.Lima Luis F.O.Silva Irineu A.S.De Brum Guilherme L.Dotto Department of Forest Biomaterials and Technology Biomass Technology centre Swedish University of Agricultural SciencesUmeaE13Swedn Universidad De La costa Calle 58#55-66080002BarranquillaAtlanticoColombia Research Group on Adsorptive and catalytic Process Engineering(ENGEPAc) Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute of chemistry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

chitin powder and chitin-aerogel were prepared from shrimp wastes and used to uptake Y^(3+)from aqueous solutions and concentrate this rare earth element from phosphogypsum(PG).chitin aerogel displays a specific surface area of 945 m^(2)/g,while chitin powder is 3.6 m^(2)/g,which largely influences its adsorption ability.Regarding the adsorption in synthetic solutions,the effect of pH on Y^(3+)removal is strong for chitin powder adsorbent.In contrast,no big pH influence was detected for chitin aerogel.Electrostatic interactions and chelation can highlight the proposed mechanism of Y^(3+)on chitin adsorbents for the powder and aerogel.Furthermore,in addition to these interactions,pore filling/pore diffusion is the main mechanism of Y^(3+)removal in the chitin aerogel.chitin aerogel is efficient in concentrating 8 times the Y^(3+)from PG,a very complex matrix.The complex chitin aerogel-Y^(3+)can be a secondary source of rare earth elements for other applications.

关键词： Rare earths Sustainable material chitin powder chitin porous aerogel Yttrium adsorption and recovery

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