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the role of the general practitioner in men's health

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Asian Journal of Andrology 2020年第3期22卷 229-232页

作者： janine David Porthcawl Medical Centre Porthcawl S Wales CF36 5DJ UK

the general practitioner(GP)is pivotally placed as an access point to provide holistic healthcare for *** are the gateway to men's *** is the GP who has the power to impact on the present health and ameliorate the future health of *** active health promotion and targeted advice and investigation,the healthcare shy man has the potential to look forward to a healthier,more fulfilled,and active life.

关键词： gateway promotion placed

Drug targets and resistance mechanisms in multiple myeloma

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Cancer Drug Resistance 2018年第2期1卷 87-117页

作者： janine Nass thomas Efferth Department of Pharmaceutical Biology Institute of Biochemistry and PharmacyJohannes Gutenberg UniversityMainz 55128Germany

Multiple myeloma(MM),a malignancy of plasma cells,is the second most prevalent blood cancer(10%).A PubMed search has been conducted for English research papers and reviews published until January *** drugs are used in treatment of *** include the antineoplastic alkylating agents cyclophosphamide,busulfan and melphalan,immunomodulators such as lenalidomide and thalidomide,corticosteroids including dexamethasone,microtubule-targeting agents,such as paclitaxel and vinca alkaloids,as well as the proteasome inhibitors bortezomib and *** the considerable number of treatment options,MM is still difficult to treat,which is mirrored by the poor 10-year survival rate of 3%.Resistance to chemotherapy is often the cause for therapy *** resistances can be due to the overexpression of efflux pumps,genetic and epigenetic aberrations and the microenvironment of *** the gain of knowledge regarding genetic and molecular changes,many molecular targeted therapies including cell signaling targeted therapies are being developed against relapsed/refractory ***,epigenetic aberrations such as DNA methylation and histone modifications steered MM management in new *** these novel targeted therapies,inhibitors of histone deacetylase,Aurora kinase,inhibitors of the PI3K/AKt/mtOR pathway and cyclin dependent kinases are promising.

关键词： Cancer drug resistance drug targets chemotherapy genetics immunotherapy

Changes in demand and supply of ecosystem services under scenarios of future land use in Vorarlberg, Austria

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Journal of Mountain Science 2019年第12期16卷 2793-2809页

作者： SAUtER Isabel KIENASt Felix BOLLIGER janine WINtER Benjamin PAZuR Robert Swiss Federal Research Institute WSL Zurcherstrasse 1118903 BirmensdorfSwitzerland ALPS-Centre for Climate Change Adaptation Grabenweg 686020 InnsbruckAustria Institute of Geography University of InnsbruckInnrain 526020 InnsbruckAustria Institute of Geography Slovak Academy of SciencesStefanikova 4981473 BratislavaSlovakia

Ecosystem services(ES)are highly impacted by human-induced land-use *** urbanization and agricultural land abandonment in Western Europe necessitate assessments of future land-change impacts on ES to ensure sustainable service *** present study aims at evaluating future demand and supply of three key services(flood protection,nearby recreation and biodiversity)in the mountainous region of Vorarlberg,*** mapped the ES for the referenced time step 2016 and two scenarios for 2050,assuming the continuation of current land-change trends and pressure on landscape *** for the referenced landscape in 2016 show the highest ES supply for intermediate levels,while ES supply was low in the lowlands and valley bottoms and in high-elevation *** found a high positive correlation of ES with the distribution of forested *** contrast,service demand was highest in lowelevation areas and decreased with increasing *** indicates that densely settled and intensively used agricultural areas currently suffer from ES *** projected future development of land use showed an increase in both supply and demand of the selected *** overall service supply increased more than the respective demand due to some reforestation of open *** forests were found to be important synergistic areas for overall service provision,we expect decreasing demand on related ***,demand was found to exceed the supply of ES,especially in the densely populated Rhine valley-requiring further policy *** ES-related information may contribute to regional policy making and ensure the long-term provision of ESs for future generations.

关键词： Land-use change Future land-use scenarios Regional assessment Ecosystem services Synergies Conflicts

the CRISPR/Cas revolution continues: From efficient gene editing for crop breeding to plant synthetic biology

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Journal of Integrative Plant Biology 2018年第12期60卷 1127-1153页

作者： Jochen Kumlehn janine Pietralla Goetz Hensel Michael Pacher Holger Puchta Plant Reproductive Biology Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Botanical Institute Molecular Biology and Biochemistry Karlsruhe Institute of Technology

Since the discovery that nucleases of the bacterial CRISPR(clustered regularly interspaced palindromic repeat)-associated(Cas) system can be used as easily programmable tools for genome engineering,their application massively transformed different areas of plant biology. In this review, we assess the current state of their use for crop breeding to incorporate attractive new agronomical traits into specific cultivars of various crop plants. this can be achieved by the use of Cas9/12 nucleases for double-strand break induction,resulting in mutations by non-homologous recombinatr e-tion. Strategies for performing such experiments à from Rthe design of guide RNA to the use of different transformation technologies à are evaluated. Furtherweive-more, we sum up recent developments regarding the use of nuclease-deficient Cas9/12 proteins, as DNAbinding moieties for targeting different kinds of enzyme activities to specific sites within the genome. Progress in base deamination, transcriptional induction and transcriptional repression, as well as in imaging in plants, is also discussed. As different Cas9/12 enzymes are at hand, the simultaneous application of various enzyme activities, to multiple genomic sites, is now in reach to redirect plant metabolism in a multifunctional manner and pave the way for a new level of plant synthetic biology.

关键词： From efficient gene editing for crop breeding to plant synthetic biology the CRISPR/Cas revolution continues

Electroencephalogram response in premature infants to different odors: a feasibility study

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World Journal of Pediatrics 2022年第12期18卷 845-848页

作者： janine Gellrich Sandy Schlage Veronika Messer Valentin A.Schriever Abteilung Neuropädiatrie Medizinische Fakultät Carl Gustav Carus Technische UniversitätDresdenGermany Klinik und Poliklinik für Kinder-und Jugendmedizin Medizinische Fakultät Carl Gustav CarusTechnische Universität DresdenFetscherstrasse 7401307DresdenGermany Center for Chronically Sick Children(Sozialpädiatrisches Zentrum SPZ)Charité-Universitätsmedizin BerlinBerlinGermany Department of Pediatric Neurology Charité-Universitätsmedizin BerlinBerlinGermany

the importance of olfaction for newborns,especially for mother-associated odors is well *** receptor neurons were found in preterm infants as early as 24–27 weeks of gestation[1].therefore,it can be assumed that the olfactory sense is functioning in preterm infants[2],but only very little is known about olfactory processing at this *** studies dealing with the processing of olfactory stimuli have been conducted on mature ***,in 2001 a research group demonstrated,using near-infrared spectroscopy,that a change in blood oxygenation of premature infants could be detected in the orbitofrontal cortex after olfactory stimulation with disinfectant and detergent[3].Electroencephalogram(EEG)techniques have broadly been used to measure central odor processing in adults and children[4,5,6].

关键词： mother stimulation cortex

A history of Yugoslavia

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A history of Yugoslavia

Risk factors for endophthalmitis after cataract surgery in diabetic patients: a case control study

作者： Marie-janine Calic

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 417-423页

作者： Sukhum Silpa-archa Apichaya Papirachnart Panisa Singhanetr janine M Preble Department of Ophthalmology Faculty of Medicine Rajavithi Hospital Rangsit University Wayne State University School of Medicine

AIM: to identify risk factors associated with post-cataract surgery endophthalmitis(PCE) in type 2 diabetic ***: A hospital-based retrospective case-control study was conducted on 194 type 2 diabetic patients undergoing cataract surgery in Rajavithi Hospital from January 2007 to December 2015. Fifteen patients with PCE were included as the case group and 179 patients without PCE were included as the control group. Potential factors associated with PCE among both groups including demographics, pre-operative characteristics, surgical settings and complications, were statistically analyzed using Chi-square testing and a logistic regression ***: Within the case group, 53% were females and the median age was 68 y. Univariate analysis of pre-operative characteristics, surgical settings and complications revealed that recent pre-operative fasting plasma glucose, insulin therapy, presence of diabetic retinopathy, and severe non-proliferative or proliferative diabetic retinopathy were significantly associated with PCE. In a multivariate analysis adjusting for blood glucose level, insulin treatment was the only significant factor associated with an increased risk of PCE(OR 3.9, 95%CI 1.0-15.0, P=0.04) compared to patients without insulin treatment. the most common causative organisms were gram-positive bacteria(89%). Staphylococcus species represented the most common group(67%). Median best corrected visual acuity at 1-month and 3-month follow-up was equal at 0.7 logMAR(20/100).CONCLUSION: the authors identify insulin treatment as the only risk factor associated with endophthalmitis after cataract surgery in type 2 diabetic patients. Further studies with serum levels of pre-operative glycated hemoglobin(HbA_(1c)) and post-operative fasting plasma glucose level are essential to truly demonstrate the role of peri-operative glycemic markers as a risk factor for PCE.

关键词： endophthalmitis cataract surgery diabetic patients insulin fasting plasma glucose

High-throughput computational discovery of In_(2)Mn_(2)O_(7) as a high Curie temperature ferromagnetic semiconductor for spintronics

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npj Computational Materials 2019年第1期5卷 529-535页

作者： Wei Chen janine George Joel B.Varley Gian-Marco Rignanese Geoffroy Hautier Institute of Condensed Matter and Nanoscicence(IMCN) Universitécatholique de Louvain1348 Louvain-la-NeuveBelgium Lawrence Livermore National Laboratory LivermoreCA 94550USA

Materials combining strong ferromagnetism and good semiconducting properties are highly desirable for spintronic applications(e.g.,in spin-filtering devices).In this work,we conduct a search for concentrated ferromagnetic semiconductors through highthroughput computational *** screening reveals the limited availability of semiconductors combining ferromagnetism and a low effective *** identify the manganese pyrochlore oxide In_(2)Mn_(2)O_(7) as especially promising for spin transport as it combines low electron effective mass(0.29m0),a large exchange splitting of the conduction band(1.1 eV),stability in air,and a Curie temperature(about 130 K)among the highest of concentrated ferromagnetic *** rationalise the high performance of In_(2)Mn_(2)O_(7) by the unique combination of a pyrochlore lattice favouring ferromagnetism with an adequate alignment of O–2p,Mn–3d,and In–5s forming a dispersive conduction band while enhancing the Curie temperature.

关键词： temperature ferromagnetic semiconductors

A systematic review of objective burn scar measurements

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Burns & trauma 2016年第2期4卷 90-122页

作者： Kwang Chear Lee janine Dretzke Liam Grover Ann Logan Naiem Moiemen the Healing Foundation Burn Research Centre University Hospital Birmingham Foundation TrustBirmingham B152THUK School of Clinical and Experimental Medicine College of Medical and Dental SciencesUniversity of BirminghamBirmingham B152TTUK Public Health Epidemiology and BiostatisticsInstitute of Applied Health ResearchCollege of Medical and Dental SciencesUniversity of BirminghamBirmingham B152TTUK School of Chemical Engineering University of BirminghamBirmingham B152TTUK School of Clinical and Experimental Medicine College of Medical and Dental SciencesUniversity of BirminghamBirmingham B152TTUK the Healing Foundation Burn Research Centre University Hospital Birmingham Foundation TrustBirmingham B152THUK

Background:Problematic scarring remains a challenging aspect to address in the treatment of burns and can significantly affect the quality of life of the burn *** present,there are few treatments available in the clinic to control adverse scarring,but experimental pharmacological anti-scarring strategies are now beginning to *** comparative success must be based on objective measurements of scarring,yet currently the clinical assessment of scars is not carried out systematically and is mostly based on subjective review of ***,several techniques and devices are being introduced that allow objective analysis of the burn *** aim of this article is to evaluate various objective measurement tools currently available and recommend a useful panel that is suitable for use in clinical trials of anti-scarring ***:A systematic literature search was done using the Web of Science,PubMed and Cochrane *** identified devices were then classified and grouped according to the parameters they *** tools were then compared and assessed in terms of inter-and intra-rater reproducibility,ease of use and ***:After duplicates were removed,5062 articles were obtained in the *** further screening,157 articles which utilised objective burn scar measurement systems or tools were *** scar measurement devices can be broadly classified into those measuring colour,metric variables,texture,biomechanical properties and pathophysiological ***:Objective scar measurement tools allow the accurate and reproducible evaluation of scars,which is important for both clinical and scientific ***,studies to evaluate their relative performance and merits of these tools are scarce,and there remain factors,such as itch and pain,which cannot be measured *** reviewing the available evidence,a panel of devices for objective scar measurement is recommended consisting of the 3D cameras(Eyk

关键词： Scar measurement Burn Objective measurement 3D camera Laser imaging High-frequency ultrasound image Colorimeter Cutometer