Transient elastography improves detection of liver cirrhosis compared to routine screening tests
瞬时弹性成像提高了检测肝硬化相比常规筛查测试作者机构：Klinik für GastroenterologieHepatologie und InfektiologieUniversitatsklinikum Düsseldorf40225 DüsseldorfGermany Klinik für GastroenterologieHepatologie und DiabetologiePetrus-Krankenhaus Wuppertal42283 WuppertalGermany Pathologie München-NordErnst-Platz-StraBe 280992 MünchenGermany
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2015年第21卷第3期
页 面：953-960页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Transient elastography Fibroscan Liver cirrhosis Liver disease Chronic hepatitis
摘 要：AIM:To investigate the diagnostic significance oftransient elastography(TE) in a daily routine clinical setting in comparison to clinical signs,laboratory parameters and ***:TE,ultrasound,laboratory parameters and cutaneous liver signs were assessed in 291 consecutive patients with chronic liver disease of various aetiologies who underwent liver biopsy in daily ***:Sensitivity of TE for the detection of liver cirrhosis was 90.4%,compared to 80.1% for ultrasound,58.0% for platelet count and 45.1% for cutaneous liver signs(P 0.0001 for comparisons with histology).AUROC for TE was 0.760(95%CI:0.694-0.825).Combination of TE with ultrasound increased sensitivity to 96.1% and AUROC to 0.825(95%CI:0.768-0.882).TE correlated with laboratory parameters of cirrhosis progression like albumin(r =-0.43),prothrombin time(r =-0.44),and bilirubin(r = 0.34; P 0.001 for each).Particularly,in patients with Child Pugh score A or normal platelet count TE improved sensitivity for the detection of liver cirrhosis compared to ultrasound by 14.1%(P 0.04) and 16.3%(P 0.02),***:Transient elastography is superior to routine diagnostic tests allowing detection of liver cirrhosis in additional 10%-16% of patients with chronic liver disease that would have been missed by clinical examinations.
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