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Palliative long-term abdominal drains vs large volume paracenteses for the management of refractory ascites in end-stage liver disease

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World Journal of Hepatology 2024年第3期16卷 428-438页

作者： Senamjit Kaur Rodrigo V Motta Bryony Chapman Victoria Wharton jane d collier Francesca Saffioti Oxford Liver Unit Department of Gastroenterology and HepatologyOxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom Oxford Liver Unit and Translational Gastroenterology Unit Nuffield Department of MedicineUniversity of OxfordOxford OX39DUUnited Kingdom

BACKGROUNd Long-term abdominal drains(LTAd)are a cost-effective palliative measure to manage malignant ascites in the community,but their use in patients with end-stage chronic liver disease and refractory ascites is not routine *** safety and cost-effectiveness of LTAd are currently being studied in this setting,with preliminary positive *** hypothesised that palliative LTAd are as effective and safe as repeat palliative large volume paracentesis(LVP)in patients with cirrhosis and refractory ascites and may offer advantages in patients’quality of *** To compare the effectiveness and safety of palliative LTAd and LVP in refractory ascites secondary to end-stage chronic liver *** A retrospective,observational cohort study comparing the effectiveness and safety outcomes of palliative LTAd and regular palliative LVP as a treatment for refractory ascites in consecutive patients with end-stage chronic liver disease followed-up at our United Kingdom tertiary centre between 2018 and 2022 was ***’s exact tests and the Mann-Whitney U test were used to compare qualitative and quantitative variables,***-Meier survival estimates were generated to stratify time-related outcomes according to the type of *** Thirty patients had a total of 35 indwelling abdominal drains and nineteen patients underwent regular *** baseline characteristics were similar between the *** antibiotics were more frequently prescribed in patients with LTAd(P=0.012),while the incidence of peritonitis did not differ between the two groups(P=0.46).The incidence of acute kidney injury(P=0.014)and ascites/drain-related hospital admissions(P=0.004)were significantly higher in the LVP *** overall survival was similar in the two groups(log-rank P=0.26),but the endpoint-free survival was significantly shorter in the LVP group(P=0.003,Pdrain-related admission,acute kidney injury and drain

关键词： decompensated liver cirrhosis Indwelling abdominal catheter Rocket drain Palliative care Safety Quality of life

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deep Energies for Estimating Three-dimensional Facial Pose and Expression

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Communications on Applied Mathematics and Computation 2024年第2期6卷 837-861页

作者： jane Wu Michael Bao Xinwei Yao Ronald Fedkiw department of Computer Science Stanford University353 Jane Stanford WayStanfordCA 94305USA Epic Games 620 Crossroads BlvdCaryNC 27518USA

While much progress has been made in capturing high-quality facial performances using motion capture markers and shape-from-shading,high-end systems typically also rely on rotoscope curves hand-drawn on the *** curves are subjective and difficult to draw consistently;moreover,ad-hoc procedural methods are required for generating matching rotoscope curves on synthetic renders embedded in the optimization used to determine three-dimensional(3d)facial pose and *** propose an alternative approach whereby these curves and other keypoints are detected automatically on both the image and the synthetic renders using trained neural networks,eliminating artist subjectivity,and the ad-hoc procedures meant to mimic *** generally,we propose using machine learning networks to implicitly define deep energies which when minimized using classical optimization techniques lead to 3d facial pose and expression estimation.

关键词： Numerical optimization Neural networks Motion capture Face tracking

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Estimating the subsolar magnetopause position from soft X-ray images using a low-pass image filter

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Earth and Planetary Physics 2024年第1期8卷 173-183页

作者： Hyangpyo Kim Hyunju K.Connor Jaewoong Jung Brian M.Walsh david Sibeck Kip d.Kuntz Frederick S.Porter Catriana K.Paw U Rousseau A.Nutter Ramiz Qudsi Rumi Nakamura Michael collier Space Research Institute Austrian Academy of Sciences8042 GrazAustria Geophysical Institute University of Alaska FairbanksFairbanksAlaska 99775USA National Aeronautics and Space Administration(NASA)Goddard Space Flight Center GreenbeltMaryland 20771USA Astronomy department University of Maryland College ParkCollege ParkMaryland 20742USA Center for Space Physics Boston UniversityBostonMassachusetts 02215USA department of Physics and Astronomy Johns Hopkins UniversityBaltimoreMaryland 21218USA Howard University WashingtonDC 20059USA

The Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)missions will image the Earth’s dayside magneto pause and cusps in soft X-rays after their respective launches in the near future,to specify glo bal magnetic reconnection modes for varying solar wind *** suppo rt the success of these scientific missions,it is critical to develop techniques that extract the magnetopause locations from the observed soft X-ray *** this research,we introduce a new geometric equation that calculates the subsolar magnetopause position(RS)from a satellite position,the look direction of the instrument,and the angle at which the X-ray emission is *** assumptions are used in this method:(1)The look direction where soft X-ray emissions are maximized lies tangent to the magnetopause,and(2)the magnetopause surface near the subsolar point is almost spherical and thus RSis nea rly equal to the radius of the magneto pause *** create synthetic soft X-ray images by using the Open Geospace General Circulation Model(OpenGGCM)global magnetohydrodynamic model,the galactic background,the instrument point spread function,and Poisson *** then apply the fast Fourier transform and Gaussian low-pass filte rs to the synthetic images to re move noise and obtain accurate look angles for the soft X-ray pea *** the filte red images,we calculate RS and its accuracy for different LEXI locations,look directions,and solar wind densities by using the OpenGGCM subsolar magnetopause location as ground *** method estimates RS with an accuracy ofd density exceeds>10 *** accuracy improves for greater solar wind densities and during southward interplanetary magnetic *** method ca ptures the magnetopause motion during southwa rd interplaneta ry magnetic field ***,the technique will enable quantitative analysis of the magnetopause motion and help reveal the daysi

关键词： soft X-ray magnetopause reconnection low-pass filter LEXI SMILE

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Health behavior outcomes in stroke survivors prescribed wearables for atrial fibrillation detection stratified by age

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Journal of Geriatric Cardiology 2024年第3期21卷 323-330页

作者： Joanne Mathew Jordy Mehawej Ziyue Wang Taylor Orwig Eric ding Andreas Filippaios Syed Naeem Edith Mensah Otabil Alex Hamel Kamran Noorishirazi IrinaRadu jane Saczynski david d.McManus Khanh-Van Tran division of Cardiovascular Medicine Department of MedicineUniversity of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA department of Internal Medicine Central Michigan UniversityMount PleasantUSA department of Pharmacy and Health Systems Sciences School of PharmacyNortheastern UniversityBostonUSA department of Population and Quantitative Health Sciences University of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA

BACKGROUNd Smartwatches have become readily accessible tools for detecting atrial fibrillation(AF).There remains limited data on how they affect psychosocial outcomes and engagement in older *** examine the health behavior outcomes of stroke survivors prescribed smartwatches for AF detection stratified by *** We analyzed data from the Pulsewatch study,a randomized controlled trial that enrolled patients(≥50 years)with a history of stroke or transient ischemic attack and CHA2dS2-VASc≥*** participants were equipped with a cardiac patch monitor and a smartwatch-app dyad,while control participants wore the cardiac patch monitor for up to 44 *** evaluated health behavior parameters using standardized tools,including the Consumer Health Activation Index,the Generalized Anxiety disorder questionnaire,the 12-Item Short Form Health Survey,and wear time of participants categorized into three age groups:Group 1(ages 50-60),Group 2(ages 61-69),and Group 3(ages 70-87).We performed statistical analysis using a mixedeffects repeated measures linear regression model to examine differences amongst age *** Comparative analysis between Groups 1,2 and 3 revealed no significant differences in anxiety,patient activation,perception of physical health and wear *** use of smartwatch technology was associated with a decrease in perception of mental health for Group 2 compared to Group 1(β=-3.29,P=0.046).CONCLUSION Stroke survivors demonstrated a willingness to use smartwatches for AF ***,among these study participants,the majority did not experience negative health behavior outcomes or decreased engagement as age increased.

关键词： prescribed stratified wear

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A 63-Year-Old Male with d-Transposition of the Great Arteries Who Had an Early Form of the Arterial Switch Operation

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Congenital Heart disease 2024年第1期19卷 65-68页

作者： Michael A.Rebolledo jane S.Yao Jason N.Johnson Umar S.Boston Benjamin R.Waller III division of Pediatric Cardiology Department of PediatricsThe University of Tennessee Health Science CenterThe Heart InstituteLe Bonheur Children’s HospitalMemphisUSA College of Medicine The University of Tennessee Health ScienceMemphisUSA division of Pediatric Cardiothoracic Surgery Department of SurgeryThe University of Tennessee Health Science CenterHeart InstituteLe Bonheur Children’s HospitalMemphisUSA

We describe a 63-year-old male who appears to have undergone an early form of the arterial switch operation for d-transposition of the great arteries performed in the *** review the clinical and imaging data that support our *** had a diagnostic cardiac catheterization which demonstrated severe pulmonary hypertension responsive to epoprostenol and *** case may represent one example of the experimental surgical work done prior to *** Jatene’s description of theﬁrst successful arterial switch performed in 1975.

关键词： Adult congenital heart disease arterial switch operation great vessel anomaly imaging(all modalities)

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Repeat endoscopic retrograde cholangiopancreaticography after failed initial precut sphincterotomy for biliary cannulation

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World Journal of Gastroenterology 2014年第36期20卷 13153-13158页

作者： Michael Pavlides Ashley Barnabas Nilesh Fernandopulle Adam A Bailey jane collier jane Phillips-Hughes Anthony Ellis Roger Chapman Barbara Braden Translational Gastroenterology Unit Oxford University Hospitals Oxford OX3 9DU United Kingdom department of Radiology Oxford Uni-versity Hospitals Oxford OX3 9DU United Kingdom

AIM: To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography (ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation.

关键词： Mortality Post-endoscopic retrograde cholangio-pancreaticography pancreatitis Precut sphincterotomy Endoscopic retrograde cholangio-pancreaticography Choledocholithiasis

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Contemporary management of locally advanced rectal cancer:Resolving issues, controversies and shifting paradigms

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Chinese Journal of Cancer Research 2018年第1期30卷 131-146页

作者： Aeris jane d.Nacion Youn Young Park Nam Kyu Kim department of Surgery Eastern Visayas Regional Medical Center division of Colorectal Surgery Department of Surgery Yonsei University College of Medicine

Advancements in rectal cancer treatment have resulted in improvement only in locoregional control and have failed to address distant relapse, which is the predominant mode of treatment failure in rectal cancer. As the efficacy of conventional chemoradiotherapy（CRT） followed by total mesorectal excision（TME） reaches a plateau, the need for alternative strategies in locally advanced rectal cancer（LARC） has grown in relevance. Several novel strategies have been conceptualized to address this issue, including： 1） neoadjuvant induction and consolidation chemotherapy before CRT; 2） neoadjuvant chemotherapy alone to avoid the sequelae of radiation; and 3） nonoperative management for patients who achieved pathological or clinical complete response after CRT. This article explores the issues, recent advances and paradigm shifts in the management of LARC and emphasizes the need for a personalized treatment plan for each patient based on tumor stage, location, gene expression and quality of life.

关键词： Locally advanced rectal cancer neoadjuvant treatment chemoradiotherapy

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China's funding system and research innovation

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National Science Review 2014年第1期1卷 161-163页

作者： jane Qiu writes for NSR from Beijing.

In the past decade,China’s total expenditure on research and development(R&d)has been increasing by about20%per *** the total output of scientific research from China has not failed to impress:a 2011 study by Britain’s Royal Society found that,in 2004–08,the country produced 10%of the world’s published scientific articles,putting it second after the United States.

关键词： Wang

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Sedimentary diatom and pigment-inferred recent anthropogenic accelerated eutrophication of a Mediterranean lake(Lake dojran,Republic of North Macedonia/Greece)

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Journal of Oceanology and Limnology 2020年第6期38卷 1787-1798页

作者： ZHANG Xiaosen XU Xinyu jane MREEd Institute of Loess Plateau Shanxi UniversityTaiyuan 030006China department of Geography Geology and EnvironmentUniversity of HullHull HU67RXUK

Lake eutrophication is recognised as a serious global challenge,and many regional legislative programmes are being made to attempt to relieve nutrient pollution and restore deteriorated lake ecological ***,it is of primary importance to understand the degradation processes and reference *** palaeolimnological approach allows us to use ecological evidences preserved in lake sediments to track the changes of lake trophic status under human ***,a proxy for ecological and limnological change,and pigments,a proxy for algal production and composition,were analysed on a short sediment sequence from Lake dojran(Republic of North Macedonia and Greece),and their preservation qualities were evaluated before environmental *** diatom preservation is inferred mainly from the consistent co-occurrence of robust,highly-silicified taxa and small taxa throughout the *** evaluation of the comparison between wet sediment samples in dark and cold storage and their corresponding dry sediment samples lyophilized immediately after the recovery reveals that sediment restoration conditions are critical for the accuracy of *** show that the increased chlorophyll and xanthophyll pigment concentrations,particularly the siliceous-algae pigment fucoxanthin and diatoxanthin,together with the distinct increase in diatom concentration,indicate accelerated lake eutrophication and a major ecological shift linked to intensified water abstraction practice and agricultural expansion in the late 18th to early 19th *** of diatom assemblage composition is muted probably by the dominance of widely-tolerant small fragilaroid species in diatom composition and the better competitive ability of cyanobacteria and chlorophytes than diatoms for low light under eutrophic and turbid *** study improves our understanding of recent human-induced environmental change and current ecological restoration target in this lake.

关键词： diatom,pigment Lake dojran Mediterranean lake eutrophication palaeolimnology

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Mechanical Simulation of a diatom Frustule Structure

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Journal of Bionic Engineering 2015年第1期12卷 98-108页

作者： Jie Lu Cheng Sun Q. jane Wang department of Mechanical Engineering Northwestern University Evanston IL 60208

diatoms possess intricately complicated nanopatterned silica outer shells, the so called frustules. due to their excellent three-dimensional （3d） nanostructures, diatom frustules have attracted attentions from many fields to look for potential appli- cations, such as structural material design, light harvesting, photonics, molecular separation and bio-sensing. However, the mechanical property of frustule, especially the role of each single portion that structures a frustule, need to be clearly examined in order to provide a scientific support to frustule utilization. The reported work uses the Finite-Element （FE）-based simulation to investigate the relative mechanical properties of the frustule of the diatom Coscinodiscus sp. as compared with reference non-frustule structures. A three-dimensional model for the three featured layers of this frustule and a simplified model for its girdle band are built with the assistance of ABAQUS. A basic-cell concept is suggested; and the comparative results of several simulation groups are reported. The numerical results indicate that the seven-unit-cell model is able to catch the essential me- chanics of the Coscinodiscus sp. frustule under pressure and that the layered and porous structure of this frustule can effectively resist pressure.

关键词： diatom frustule FE simulation structure analysis bio-material

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