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New yellow Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor for warm-white light-emitting diodes through single-emitting-center conversion

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Light(Science & Applications) 2013年第1期2卷 226-233页

作者： Xufan Li John D Budai Feng Liu jane y howe Jiahua Zhang Xiao-Jun Wang Zhanjun Gu Chengjun Sun Richard S Meltzer Zhengwei Pan College of Engineering University of GeorgiaAthensGA 30602USA Department of Physics and Astronomy University of GeorgiaAthensGA 30602USA Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831USA State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Department of Physics Georgia Southern UniversityStatesboroGA 30460USA Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China X-ray Science Division Argonne National LaboratoryArgonneIL 60439USA

Phosphor-converted white light-emitting diodes for indoor illumination need to be warm-white(i.e.,correlated color temperature,4000 K)with good color rendition(i.e.,color rendering index.80).however,no single-phosphor,single-emitting-center-converted white light-emitting diodes can simultaneously satisfy the color temperature and rendition requirements due to the lack of sufficient red spectral component in the phosphors’emission ***,we report a new yellow Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor that has a new orthorhombic lattice structure and exhibits a broad yellow photoluminescence band with sufficient red spectral ***-white emissions with correlated color temperature,4000 K and color rendering index.80 were readily achieved when combining the Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor with a blue light-emitting diode(440–470 nm).This study demonstrates that warm-white light-emitting diodes with high color rendition(i.e.,color rendering index.80)can be achieved based on single-phosphor,single-emitting-center conversion.

关键词： luminescence single-phosphor-conversion warm-white light-emitting diode yellow phosphor

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Neuronal guidance genes in health and diseases

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Protein & Cell 2023年第4期14卷 238-261页

作者： Junichi yuasa-Kawada Mariko Kinoshita-Kawada yoshio Tsuboi jane y.Wu Department of Neurology Fukuoka University7.451 NanakumaJohnan.kuFukuoka 814-0180Japan Department of Neurology Center for Genetic MedicineLurie Cancer CenterNorthwestern University Feinberg School of MedicineWard Building Box 6117303E.Chicago AvenueChicagoIlinois 60611.USA

Neurons migrate from their birthplaces to the destinations,and extending axons navigate to their synaptic targets by sensing various extracellular cues in spatiotemporally controlled *** evolutionally conserved guidance cues and their receptors regulate multiple aspects of neural development to establish the highly complex nervous system by mediating both short-and long-range cell-cell *** guidance genes(encoding cues,receptors,or downstream signal transducers)are critical not only for development of the nervous system but also for synaptic maintenance,remodeling,and function in the adult *** emerging theme is the combinatorial and complementary functions of relatively limited classes of neuronal guidance genes in multiple processes,including neuronal migration,axonal guidance,synaptogenesis,and circuit ***,neuronal guidance genes also regulate cell migration and cell-cell communications outside the nervous *** are just beginning to understand how cells integrate multiple guidance and adhesion signaling inputs to determine overall cellular/subcellular behavior and how aberrant guidance signaling in various cell types contributes to diverse human diseases,ranging from developmental,neuropsychiatric,and neurodegenerative disorders to cancer *** review classic studies and recent advances in understanding signaling mechanisms of the guidance genes as well as their roles in human ***,we discuss the remaining chalienges and therapeutic potentials of modulating neuronal guidance pathways in neural repair.

关键词： axon guidance neuronal migration synaptogenesis neural circuit formation neural mapping cell-cell communications angiogenesis organogenesis cancermetastasis

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Tongue as a first-line immune organ?

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Protein & Cell 2021年第3期12卷 162-164页

作者： jane y.Wu Department of Neurology Center for Genetic MedicineLurie Cancer CenterNorthwestern University Feinberg School of MedicineChicagoUSA

The tongue is an organ strategically situated at the beginning of the gastrointestinal(Gl)system,yet it has been remarkably *** only there is no separate subspecialty dedicated to the tongue,it is even excluded from 27 human organs/tissues thoroughly archived in the NCBI gene expression *** none of my physician colleagues in Western medicine have paid attention to it,except a few who study tongue *** tongue is typically described as a muscular organ important for taste,mastication,speech and *** than its development,anatomy/gross structural analyses and taste function(for recent reviews,see Roper and Chaudhari,2017),the human tongue is poorly studied in Western medicine,in particular,in terms of its roles in systemic *** traditional Chinese medicine(TCM),however,the tongue holds a special *** the“tongue coating”,"tongue body”and morphological features is one of the most critical skills that TCM doctors have relied on for disease diagnoses for thousands of years before the advent of Western Medicine.

关键词： anatomy sensation organs

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Autism, an area that needs public attention and investment

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Science China(Life Sciences) 2015年第10期58卷 931-932页

作者： jane y.WU Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School of Medicine State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences

I would like to dedicate this special issue to children and adults who are affected by autism or related developmental disorders,as well as to their families and friends.I am indebted to the clinicians and care providers who have made tremendous effort in supporting these *** have inspired me to invest a significant amount of my energy to adventure into this area.I greatly appreciate all the contributing authors around the world whose hard work made

关键词：自闭投资公众成年人

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Intestinal parasitic infections in Aetas and domesticated swine in Pampanga,Philippines

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Asian Pacific Journal of Tropical Medicine 2022年第11期15卷 522-524页

作者： Jessica Joyce R De Guia Mary jane C Flores Derick Erl P Sumalapao Eligio Santiago V Maghirang Vicente y Belizario Jr. Department of Biology College of ScienceDe La Salle UniversityManilaPhilippines Biological Control Research Unit(BCRU) Center for Natural Sciences and Environmental Research(CENSER)College of ScienceManila Ehime University-De La Salle University International Collaborative Research Laboratory De La Salle UniversityLaguna CampusLaguna ProvincePhilippines Department of Epidemiology and Biostatistics College of Public HealthUniversity of the PhilippinesManilaPhilippines Department of Internal Medicine-Section of General Medicine Department of Medical Education and Research the Makati Medical Center Department of Emergency Medicine Asian Hospital and Medical CenterMetro ManilaPhilippines Department of Parasitology College of Public HealthUniversity of the PhilippinesManilaPhilippines

Indigenous peoples account for about 6%of the world’s population and are highly vulnerable to parasitic infections[1,2].Aetas,one of the indigenous people groups in the Philippines,rely on backyard swine production as their primary means of livelihood[3].Literature indicated that zoonoses arise from close physical contact and the cohabitation of humans with domesticated animals[4].Ascaris spp.

关键词： swine domestica habitat

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Complications associated with energy-based devices during thyroidectomy from 2010–2020

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第1期9卷 35-44页

作者： Esther Lee jane y.Tong Luke J.Pasick Daniel A.Benito Arjun Joshi Punam G.Thakkar Joseph F.Goodman Division of Otolaryngology-Head and Neck Surgery George Washington University School of Medicine&amp Health SciencesWashingtonDCUSA Western University of Health Sciences PomonaCAUSA Department of Otolaryngology-Head and Neck Surgery Drexel University College of MedicinePhiladelphiaPAUSA Department of Otolaryngology-Head and Neck Surgery University of Miami Miller School of MedicineMiamiFLUSA

Objective:Harmonic Focus(Ethicon,Johnson and Johnson,Cincinnati,OH,USA),LigaSure Small Jaw(Medtronic,Covidien Products,Minneapolis,MN,USA),and Thunderbeat Open Fine Jaw(Olympus,Japan)are electrosurgical instruments used widely in head and neck *** study aims to compare device malfunctions,adverse events to patients,operative injuries,and interventions related to Harmonic,LigaSure,and Thunderbeat use during ***:The US Food and Drug Administration's Manufacture and User Facility Device Experience(MAUDE)database was queried for adverse events associated with Harmonic,LigaSure,and Thunderbeat from January 2005 to August *** were extracted from reports pertaining to ***:Of the 620 adverse events extracted,394(63.5%)involved Harmonic,134(21.6%)LigaSure,and 92(14.8%)*** reported device malfunctions most frequently associated with Harmonic was damage to the blade(110(27.9%)),LigaSure was inappropriate function(47(43.1%)),Thunderbeat was damage to the tissue or Teflon pad(27(30.7%)),*** injury and incomplete hemostasis were the most commonly reported adverse *** operative injury reported most frequently when using Harmonic and LigaSure was burn *** operator injuries were reported with Thunderbeat ***:The most frequently reported device malfunctions were damage to the blade,inappropriate function,and damage to the tissue or Teflon *** most frequently reported adverse events to patients was a burn injury and incomplete *** aimed at improving physician education may help reduce adverse events attributed to improper use.

关键词： Adverse events Harmonic LigaSure Manufacture and User Facility Device Experience Patient safety Quality Thunderbeat Thyroidectomy

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RNA-binding proteins in neurological diseases

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Science China(Life Sciences) 2014年第4期57卷 432-444页

作者： ZHOU HuaLin MANGELSDORF Marie LIU JiangHong ZHU Li WU jane y Institute of Biophysics Chinese Academy of Sciences Queensland Brain Institute The University of QueenslandBrisbane Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School of Medicine

Emerging studies support that RNA-binding proteins(RBPs)play critical roles in human biology and *** are essential players in RNA processing and metabolism,including pre-mRNA splicing,polyadenylation,transport,surveillance,mRNA localization,mRNA stability control,translational control and editing of various types of *** expression of and mutations in RBP genes affect various steps of RNA processing,altering target gene *** have been associated with various diseases,including neurological ***,we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2,HuR/HuB/HuC/HuD,TDP-43,Fus,Rbfox1/Rbfox2,QKI and FMRP,discussing their function and roles in human diseases.

关键词： RNA结合蛋白神经系统疾病 RNA加工稳定性控制 mRNA 人类生物学 RNA剪接发病机制

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Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity,recapitulating key features of FUS proteinopathy

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Protein & Cell 2011年第2期2卷 141-149页

作者： Kazuo Fushimi Charles Long Neha Jayaram Xiaoping Chen Liming Li jane y.Wu Department of Neurology Center for Genetic MedicineLurie Comprehensive Cancer CenterNorthwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA Department of Molecular Pharmacology and Biological Chemistry Northwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA

Mutations in the fused in sarcoma/translocated in liposarcoma(FUS/TLS)gene have been associated with amyotrophic lateral sclerosis(ALS).FUS-positive neuropathology is reported in a range of neurodegenerative diseases,including ALS and fronto-temporal lobar degeneration with ubiquitin-positive pathology(FTLDU).To examine protein aggregation and cytotoxicity,we expressed human FUS protein in *** of either wild type or ALS-associated R524S or P525L mutant FUS in yeast cells led to formation of aggregates and cytotoxicity,with the two ALS mutants showing increased ***,yeast cells expressing human FUS protein recapitulate key features of FUSpositive neurodegenerative ***,a significant fraction of FUS expressing yeast cells stained by propidium iodide were without detectable protein aggregates,suggesting that membrane impairment and cellular damage caused by FUS expression may occur before protein aggregates become microscopically detectable and that aggregate formation might protect cells from FUS-mediated *** N-terminus of FUS,containing the QGSy and G rich regions,is sufficient for the formation of aggregates but not *** C-terminal domain,which contains a cluster of mutations,did not show aggregation or *** to TDP-43 when expressed in yeast,FUS protein has the intrinsic property of forming aggregates in the absence of other human *** the other hand,the aggregates formed by FUS are thioflavin T-positive and resistant to 0.5%sarkosyl,unlike TDP-43 when expressed in yeast ***,TDP-43 and FUS display distinct domain requirements in aggregate formation and cytotoxicity.

关键词： FUS/TLS protein aggregation cytotoxicity

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AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth

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Protein & Cell 2013年第2期4卷 155-161页

作者： Kun Zhu Xiaoping Chen Jianghong Liu Haihong ye Li Zhu jane y.Wu State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Department of Neurology Center for Genetic MedicineLurie Cancer CenterNorthwestern University Feinberg School of MedicineChicagoIL 60611USA

Down syndrome cell adhesion molecule(DSCAM)acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural ***,the signaling mechanisms of netrin-DSCAM remain *** we report that AMP-activated protein kinase(AMPK)interacts with DSCAM through itsγsubunit,but does not interact with DCC(deleted in co-lorectal cancer),another major receptor for ***-treatment of cultured cortical neurons leads to increased phosphorylation of *** AMPK mu-tant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite ***,these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite *** study uncovers a previously unknown component,AMPK,in netrin-DSCAM signaling pathway.

关键词： AMP-activated protein kinase(AMPK) neurite outgrowth Down syndrome cell adhesion molecule(DSCAM) netrin

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Candidate Mycobacterium tuberculosis genes targeted by human microRNAs

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Protein & Cell 2010年第5期1卷 419-421页

作者： WeiRui Guo Jiong-Tang Li Xiao Pan Liping Wei jane y.Wu Institute of Biophysics Chinese Academy of Sciences15 Datun RoadBeijing 100101China Center for Bioinformatics National Laboratory of Protein Engineering and Plant Genetic EngineeringCollege of Life SciencesPeking UniversityBeijing 100871China Department of Neurology Center for Genetic MedicineLurie Comprehensive Cancer CenterNorthwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA Graduate University of Chinese Academy of Sciences 19A Yuquan RoadBeijing 100039China

Tuberculosis(TB)remains a major health issue,causing approximately three million deaths every year(Pelicic et al.,1998).Identified by Robert Koch in 1882,Mycobacterium tuberculosis(***),the causative agent for tuberculosis,remains one of the most enigmatic *** interactions between *** and its environment have been extensively ***,our knowledge about potential ***-host interaction at the RNA level is still very *** we present our preliminary finding that suggests possible interactions of human miRNAs with *** transcripts and speculate possible roles of human miRNAs in regulating *** interactions.

关键词： tuberculosis al. targeted

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