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Use of neuron-specific enolase to predict mild brain injury in motorcycle crash patients with maxillofacial fractures: A pilot study

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Chinese Journal of Traumatology 2019年第1期22卷 47-50页

作者： Muhammad Ruslin jan wolff Harmas Yazid Yusuf Muhammad Zaifullah Arifin Paolo Boffano Tymour Forouzanfar Department of Oral and Maxillofacial Surgery Faculty of Dentistry Hasanuddin University Makassar Indonesia Department of Oral and Maxillofacial Surgery/Oral Pathology VU University Medical Center/Academic Center for Dentistry Amsterdam (ACTA) Amsterdam the Netherlands Department of Oral and Maxillofacial Surgery Faculty of Dentistry University of Padjadjaran Bandung Indonesia Department of Neurosurgery Faculty of Medicine University of Padjadjaran Bandung Indonesia

Purpose: Mild traumatic brain injury (TBI) is common but accurate diagnosis and its clinical consequences have been a problem. Maxillofacial trauma does have an association with TBI. Neuron-specific enolase (NSE) has been developed to evaluate neuronl damage. The objective of this study was to investigate the accuracy of NSE serum levels to detect mild brain injury of patients with sustained maxillofacial fractures during motor vehicle accidents. Methods: Blood samples were drawn from 40 healthy people (control group) and 48 trauma patients who has sustained isolated maxillofacial fractures and mild brain injury in motor vehicle accidents. Brain injuries were graded by Glasgow Coma Scale. In the trauma group, correlations between the NSE serum value and different facial fracture sites were also assessed. Results: The NSE serum level (mean ± SD, ng/ml) in the 48 patients with maxillofacial fractures and mild TBI was 13.12 ± 9.68, significantly higher than that measured in the healthy control group (7.72 ± 1.82, p < 0.001). The mean NSE serum level (ng/ml) in the lower part of the facial skeleton (15.44 with SD 15.34) was higher than that in the upper facial part (12.42 with SD 7.68);and the mean NSE level (ng/ml) in the middle-and lower part (11.97 with SD 5.63) was higher than in the middle part (7.88 with SD 2.64). Conclusion: An increase in NSE serum levels can be observed in patients sustained maxillofacial fractures and mild brain injury.

关键词： Neuron-specific enolase Serum Maxillofacial fractures Mild brain injuries

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Development of CO2 Selective Poly（Ethylene Oxide）-Based Membranes： From Laboratory to Pilot Plant Scale

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Engineering 2017年第4期3卷 485-493页

作者： Torsten Brinkmann Jelena Lilleparg Heiko Notzke jan Pohlmann Sergey Shishatskiy jan Wind Thorsten wolff Institute of Polymer Research Helmholtz-Zentrum Geesthacht Geesthacht 21502 Germany

Membrane gas separation is one of the most promising technologies for the separation of carbon dioxide （CO2） from various gas streams. One application of this technology is the treatment of flue gases from combustion processes for the purpose of carbon capture and storage. For this application, poly（ethylene oxide）-containing block copolymers such as Pebax or PolyActiveTM polymer are well suited. The thin-film composite membrane that is considered in this overview employs PolyActiveTM polymer as a selective layer material. The membrane shows excellent CO2 permeances of up to 4 m^3（STP）.（m^2·h·bar）^-1 （1 bar = 105 Pa） at a carbon dioxide/nitrogen （CO2/N2） selectivity exceeding 55 at ambient temperature. The membrane can be manufactured reproducibly on a pilot scale and mounted into fiat-sheet membrane modules of different designs. The operating performance of these modules can be accurately predicted by specifically developed simulation tools, which employ single-gas permeation data as the only experimental input. The performance of membranes and modules was investigated in different pilot plant studies, in which flue gas and biogas were used as the feed gas streams. The investigated processes showed a stable separation performance, indicating the applicability of PolyActiveTM polymer as a membrane material for industrialscale gas processing.

关键词： Gas permeation Thin-film composite membrane CO2 separation Carbon capture and storage Biogas processing Membrane modules

The role of zonal flows in reactive fluid closures

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Plasma Science and Technology 2018年第7期20卷 41-49页

作者： jan weiland Chalmers University of Technology and EURATOM-VR Association SE-41296 GothenburgSweden

We will give an overview of results obtained by our reactive fluid model. It is characterised as a fluid model where all moments with sources in the experiment are kept. Furthermore, full account is taken for the highest moments appearing in unexpanded denominators also including full toroidicity. It has been demonstrated that the strength of zonal flows is dramatically larger in reactive fluid closures than in those which involve dissipation. This gives a direct connection between the fluid closure and the level of excitation of turbulence. This is because zonal flows are needed to absorb the inverse cascade in quasi 2D turbulence. This also explains the similarity in structure of the transport coefficients in our model with a reactive closure in the energy equation and models which have a reactive closure because of zero ion temperature such as the Hasegawa-Wakatani model. Our exact reactive closure unifies several well-known features of tokamak experiments such as the L-H transition, internal transport barriers and the nonlinear Dimits upshift of the critical gradient for onset of transport. It also gives transport of the same level as that in nonlinear gyrokinetic codes. Since these include the kinetic resonance this confirms the validity of the thermodynamic properties of our model. Furthermore, we can show that while a strongly nonlinear model is needed in kinetic theory a quasilinear model is sufficient in the fluid description. Thus our quasilinear fluid model will be adequate for treating all relevant problems in bulk transport. This is finally confirmed by the reproduction by the model of the experimental power scaling of the confinement time Te ~ P-2/3. This confirms the validity of our reactive fluid model. This also gives credibility to our ITER simulations including the H-mode barrier. A new result is here, that alpha heating strongly reduces the slope of the H-mode barrier. This should significantly reduce the effects of ELM＇s.

关键词： turbulent transport improved mixing length estimates zonal flows toroidicity

Comparative study of electrostatic sensors with circular and probe electrodes for velocity measurement of pulverised coal

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仪器仪表学报 2007年第11期28卷 1921-1926页

作者： Krabicka jan Department of Electronics University of Kent

This paper presents recent progress on the velocity measurement of pulverised coal in pneumatic pipelines using electrostatic sensors in combination with correlation signal processing techniques.A comparative study of electrostatic sensors with circular and probe electrodes was conducted on a 94 mm bore horizontal pipeline in a 4 MW *** advantages and limitations of both sensors are *** results demonstrate that both sensors are capable of providing pulverised coal velocity measurement with excellent repeatability and dynamic response.

关键词：电话无线电电子仪器技术性能

Grain Size Distribution of Soils within the Cordillera Blanca, Peru: An Indicator of Basic Mechanical Properties for Slope Stability Evaluation

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Journal of Mountain Science 2014年第3期11卷 563-577页

作者： jan NOVOTNY jan KLIME ARCADIS CZ a.s. Institute of Hydrogeology Engineering Geology and Applied Geophysics Charles University in Prague Albertov Department of Engineering Geology Institute of Rock Structure and Mechanics Academy of Sciences of the Czech Republic v.v.i

This paper presents results of a study on the mechanical properties of sandy and gravely soils within the Cordillera Blanca, Peru. The soils were divided into groups according to their origin(glacial, fluvial, or debris flow). The grain size distribution of forty three soil samples was used to classify the soils according to the scheme of the Unified Soil Classification System(USCS). These distributions have then been used to estimate shear strength and hydraulic properties of the soils. There are clear differences between the soils which reflect their divergent origins. The glacial soils normally fit within one of two distinctive groups according to the proportion of fines(Group A, 7%-21.5%; Group B, 21%-65%). The estimation of shear strength at constant volume friction angle and peak shear strength of the glacial sediments with low content of fines was made using published data relating to the measured shear strength characteristics of soils with similar origins and grain size distributions. The estimated values were supported by measurements of the angle of repose taken from fourteen samples from two moraines and by shear tests on samples from one locality. The results of the grain size distribution werealso used to estimate the average hydraulic conductivity using the empirical Hazen formula which results were verified by field infiltration tests at two localities.

关键词： Moraines Grain size distribution Shearstrength Hydraulic conductivity Cordillera Blanca Peru

A new GIS-compatible methodology for visibility analysis in digital surface models of earth sites

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Geoscience Frontiers 2021年第4期12卷 21-33页

作者： Katerina Ruzickova jan Ruzicka jan Bitta VSB–Technical University of Ostrava Czech Republic

As a GIS tool,visibility analysis is used in many areas to evaluate both visible and non-visible *** analysis builds on a digital surface model describing the terrain morphology,including the position and shapes of all objects that can sometimes act as visibility ***,some barriers,for example vegetation,may be permeable to a certain *** extensive research and use of visibility analysis in different areas,standard GIS tools do not take permeability into *** article presents a new method to calculate visibility through partly permeable *** method is based on a quasi-Monte Carlo simulation with 100 iterations of visibility *** iteration result represents 1%of vegetation permeability,which can thus range from 1%to 100%visibility behind vegetation *** main advantage of the method is greater accuracy of visibility results and easy implementation on any GIS *** incorporation of the proposed method in GIS software would facilitate work in many fields,such as architecture,archaeology,radio communication,and the military.

关键词： Digital surface model Visibility analysis Topographic data processing Obstacle object Permeability

The effect of Tyrophagus putrescentiae on Fusarium poae transmission and fungal community in stored barley in a laboratory experiment

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Insect Science 2014年第1期21卷 65-73页

作者： jan Hubert Marta Nesvorna jan Kopecky Crop Research Institute Praha 6 Czech Repubfic

The effect of Tyrophagus putrescentiae on Fusarium poae transmission and fungal community composition was studied in nonsterile barley grain. The experiments included following treatments： control barley without mites; barley containing l0 or 50 mites without preincubation on E poae （Tpl0 and TpS0）; barley containing 10 or 50 mites after preincubation on E poae （FTp 10 and FTp50）. The number of mites, suc cessful transfer of E poae, and changes in the fungal communities were examined after 21 d of experiment. Increase of deoxynivalenol （DON） content in the barley was chosen as a criterion of successful Epoae transfer. The preincubation of T. putrescentiae on Epoae increased DON level approximately to 800 and 300μg/kg of grain for FTpl0 and FTpS0, respectively. T. putrescentiae population growth in FTpl0 was lower than in Tpl0, while no difference was found between FTp50 and Tp50. Fungal communities were compared by amplification, cloning and sequencing of ITS fragments, and operational taxonomic units （OTU） analysis. The OTU analysis did not support the transfer ofF. poae via mites. From the analyzed clones, only 13 cloned sequences clustered with E poae in an OTU defined at distance level 0.07. The related clones originated from FTpl0, Tpl 0, Tp50 and control treatments, but not from FTp50. However, the presence of E poae in FTp50 was confirmed by PCR amplification with specific primers. The observation may be explained by different effect of mite population density, that is, in the high density, （FTp50 treatment） the fungus was overgrazed, while the lower population density （FTp 10） supported E poae transfer.

关键词： barley deoxinivalenol (DON) Fusariumpoae mites mycotoxin storage

Stability Problems in Road and Pipeline Constructions and Their Mitigation——Examples from Sakhalin and Azerbaijan

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Journal of Mountain Science 2011年第2期8卷 307-313页

作者： NOVOTNY jan ARCADIS Geotechnika a.s. Charles University in Prague Faculty of Natural Science

The paper gives two examples of larger construction projects with typical stability problems. The first example is from Sakhalin Island in the Russian Far East. It is connected with a construction of oil and gas pipelines through the mountainous terrain in Makarov region. The region has an active geotectonic history and is highly affected by uncontrolled erosion and extensive landslips. Basic principles of landslide hazard mitigation are presented. The second example is from a motorway construction in Azerbaijan. This motorway leads from Baku to Russia through a seismo-tectonically active area at the toe of Caucasian mountains and in some places is situated in deep cuts at the toe of high slopes. This unsuitable routing, together with seismic activity, led to a slope stability failure of a slope affected by recent tectonic movements near the village of Devechi. Stability conditions and designed remedy measures are presented.

关键词： Stability problems Roads Pipelines Mitigation Sakhalin Azerbaijan