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Transfer learning from synthetic data for open-circuit voltage curve reconstruction and state of health estimation of lithium-ion batteries from partial charging segments

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Energy and AI 2024年第3期17卷 80-97页

作者： Tobias Hofmann Jacob Hamar Bastian Mager Simon Erhard jan Philipp schmidt Chair of Systems Engineering for Electrical Energy Storage University of BayreuthWeiherstraße 26Bayreuth95448BavariaGermany BMW Group Petuelring 130Munich80809BavariaGermany

Data-driven models for battery state estimation require extensive experimental training data,which may not be available or suitable for specific tasks like open-circuit voltage(OCV)reconstruction and subsequent state of health(SOH)*** study addresses this issue by developing a transfer-learning-based OCV reconstruction model using a temporal convolutional long short-term memory(TCN-LSTM)network trained on synthetic data from an automotive nickel cobalt aluminium oxide(NCA)cell generated through a mechanistic model *** data consists of voltage curves at constant temperature,C-rates between C/30 to 1C,and a SOH-range from 70%to 100%.The model is refined via Bayesian optimization and then applied to four use cases with reduced experimental nickel manganese cobalt oxide(NMC)cell training data for higher use *** TL models’performances are compared with models trained solely on experimental data,focusing on different C-rates and voltage *** results demonstrate that the OCV reconstruction mean absolute error(MAE)within the average battery electric vehicle(BEV)home charging window(30%to 85%state of charge(SOC))is less than 22 mV for the first three use cases across all *** SOH estimated from the reconstructed OCV exhibits an mean absolute percentage error(MAPE)below 2.2%for these *** study further investigates the impact of the source domain on TL by incorporating two additional synthetic datasets,a lithium iron phosphate(LFP)cell and an entirely artificial,non-existing,cell,showing that solely the shifting and scaling of gradient changes in the charging curve suffice to transfer knowledge,even between different cell chemistries.A key limitation with respect to extrapolation capability is identified and evidenced in our fourth use case,where the absence of such comprehensive data hindered the TL process.

关键词： Lithium-ion battery State of health estimation Transfer learning OCV curve Partial charging Synthetic data

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Enhancement of leukocyte adhesion after percutaneous irradiation in rats with hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第13期11卷 1991-1994页

作者： Sasa-Marcel Maksan Eduard schmidt Eduard Ryschich Wolfgang Harms jan schmidt Department of Surgery Department of Radiation Therapy

AIM: To evaluate the effects of percutaneous radiation on leukocyte-endothelium interaction (LEI) in experimental hepatocellular carcinoma (HCC). METHODS: Twelve ACI rats underwent HCC-inoculation, six of which on day 12 received low-dose external radiation and six did not. After 12 h intravital microscopy was performed. RESULTS: LEI was significantly reduced in tumor tissue. However,irradiation of liver sinusoids and tumor tissue with 6 Gy led to a significant activation of leukocyte adhesion in the tumor with a marked increase of the proinflammatory cytokine TNF-α. CONCLUSION: The findings indicate that the immune-logical tumor-endothelial barrier can be overcome by external irradiation.

关键词： Radiation Hepatocellular carcinoma Immune response Animal model

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Impact of antithrombin Ⅲ on hepatic and intestinal microcirculation in experimental liver cirrhosis and bowel inflammation: An in vivo analysis

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World Journal of Gastroenterology 2005年第32期11卷 4997-5001页

作者： Sasa-Marcel Maksan Zilfi lger Martha Maria Gebhard jan schmidt Department of SurgeryUniversity of Mainz Germany Department of SurgeryUniversity of Heidelberg Germany

AIM： To analyze the hepatic and intestinal microcirculation in an animal model of liver cirrhosis and inflammatory bowel disease （IBD） and to characterize bhe anti-inflammatory action of antithrombin Ⅲ （ATⅢ） on leukocyte kinetics and liver damage. METHODS： Hepatic and intestinal microcirculation was investigated by intravital videomicroscopy. Standardized models of experimental chronic liver cirrhosis and bowel inflammation were employed. Animals were divided into four groups （n = 6/group）： controls, animals with cirrhosis, animals with cirrhosis and IBD, animals with cirrhosis and IBD treated with ATIII. RESULTS： Cirrhosis facilitated leukocyte rolling and sticking in hepatic sinusoids （1.91±0.28 sticker/μm vs 0.5±0.5 sticker/μm in controls, P〈0.05）. The effect enhanced in animals with cirrhosis and IBD （5.4±1.65 sticker/μm）, but reversed after ATIII application （3.97±1.04 sticker/μm, P〈0.05）. Mucosal blood flow showed no differences in cirrhotic animals and controls （5.3±0.31 nL/min vs5.4±0.25 nL/min） and was attenuated in animals wibh cirrhosis and IBD significantly （3.49±0.6 nL/min）. This effect was normalized in the treatment group （5.13±0.4 nL/min, P〈0.05）. Enzyme values rose during development of cirrhosis and bowel inflammation, and reduced after ATIII application （P〈0.05）. CONCLUSION： Liver cirrhosis in the presence of IBD leads to a significant reduction in mucosal blood flow and an increase in hepatic leukocyte adherence with consecutive liver injury, which can be prevented by administration of ATⅢ.

关键词： Liver cirrhosis Microcirculation Bowel inflammation Liver Antithrombin Ⅲ

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The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines

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World Journal of Gastroenterology 2004年第24期10卷 3583-3589页

作者： Sven Eisold Michael Linnebacher EduardRyschich DaliborAntolovic UlfHinz Ernst Klar jan schmidt Department of General Surgery Thoracic and Vascular SurgeryUniversity of RostockSchillingallee 35D-18057 RostockGermany Molecular Pathology University of HeidelbergINFD-68120 HeidelbergGermany Department of General Surgery University of HeidelbergINFD-69120 HeidelbergGermany

AIM:There are conflicting data about p53 function on cellular sensitivity to the cytotoxic action of 5-fluorouracil (5-FU). Therefore the objective of this study was to determine the combined effects of adenovirus-mediated wild-type (wt) p53 gene transfer and 5-FU chemotherapy on pancreatic cancer cells with different p53 gene status. METHODS:Human pancreatic cancer cell lines Capan-1^(p53mut), Capan-2^(p53wt),FAMPAC^(p53mut),PANC1^(p53mut),and rat pancreatic cancer cell lines AS^(p53wt) and DSL6A^(p53null) were used for in vitro *** infection with different ratios of Ad- p53-particles (MOI) in combination with 5-FU,proliferation of tumor cells and apoptosis were quantified by cell proliferation assay (WST-1) and FACS (PI-staining).In addition,DSL6A syngeneic pancreatic tumor cells were inoculated subcutaneously in to Lewis rats for in vivo studies. Tumor size,apoptosis (TUNEL) and survival were determined. RESULTS:Ad-p53 gene transfer combined with 5-FU significantly inhibited tumor cell proliferation and substantially enhanced apoptosis in all four cell lines with an alteration in the p53 gene compared to those two cell lines containing *** vivo experiments showed the most effective tumor regression in animals treated with Ad-p53 plus *** in vitro and in vivo analyses revealed that a sublethal dose of Ad-p53 augmented the apoptotic response induced by 5-FU. CONCLUSION:Our results suggest that Ad-p53 may synergistically enhance 5-FU-chemosensitivity most strikingly in pancreatic cancer cells lacking p53 *** findings illustrate that the anticancer efficacy of this combination treatment is dependent on the p53 gene status of the target tumor cells.

关键词： Adenoviridae Adult Animals Antimetabolites, Antineoplastic Apoptosis Cell Division Cell Line, Tumor Combined Modality Therapy Drug Resistance, Neoplasm Female Fluorouracil Gene Expression Regulation, Neoplastic Gene Therapy Humans In Vitro Male Pancreatic Neoplasms Rats Rats, Inbred Lew Transduction, Genetic Tumor Suppressor Protein p53

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Increased apoptosis and decreased density of medial smooth muscle cells in human abdominal aortic aneurysms

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Chinese Medical Journal 2003年第10期116卷 1549-1552页

作者：张健 jan schmidt Eduard Ryschich Hardy Schumacher Jens R Allenberg Department of Vascular Surgery the First Affiliated HospitalChina Medical University Department of Vascular Surgery University of Heidelberg School of Medicine

Objective To determine the increase of apoptosis and the decrease of smooth muscle cells (SMCs) density in human abdominal aortic aneurysms (AAA). Methods In situ terminal transferase-mediated dUTP nick end labeling (TUNEL) was employed to detect apoptosis of SMCs in patients with AAA (n=25) and normal abdominal aortae (n=10). Positive cells were identified by specific cell marker in combination with immunohistochemistry. Meanwhile SMC counting was performed by anti-α-actin immunohistostaining to compare the SMC density. Results TUNEL staining revealed that there was significantly increased apoptosis in AAAs (average 8.6%) compared with normal abdominal aortae (average 0.95%, P <0.01). Double staining showed that most of these cells were SMCs. Counting of α-actin positive SMCs revealed that medial SMC density of AAAs (37.5±7.6 SMCs /HPF) was reduced by 79.1% in comparison with that of normal abdominal aortae (179.2±16.1 SMCs /HPF,P <0.01). Conclusions Significantly increased SMCs of AAA bear apoptotic markers initiating cell death. Elevated apoptosis may result in a decreased density of SMCs in AAA,which may profoundly influence the development of AAA.

关键词： aneurysm muscle,snooth cells apoptosis

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Disturbance of hepatic and intestinal microcirculation in experimental liver cirrhosis

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World Journal of Gastroenterology 2005年第6期11卷 846-849页

作者： Sasa-Marcel Maksan Eduard Ryschich Zilfi (U|¨)lger Martha Maria Gebhard jan schmidt Department of Surgery

AIM: To analyze hepatic, mesenteric and mucosal microcirculation and leukocyte-endothelium interaction (LEI) in a rat model with liver ***: Hepatic cirrhosis was induced in Wistar rats by gavage with carbon tetrachloride, and intravital videomicroscopy was performed in liver, mesentery and small intestine mucosa. Special emphasis is given on microcirculatory and morphometric changes during cirrhotic portal ***: LEI was influenced significantly in the cirrhotic liver but not in the gut. Blood flow measurement showed significant differences among liver, main mesenteric vessels and the mucosa. The results of our study indicate that liver cirrhosis leads to alterations in hepatic and mesenteric blood flow but not in mucosal blood ***: The enhanced inflammatory response in hepatic microvessels may be caused by a decrease of antithrombin Ⅲ levels and could be responsible for disturbances of organ pathology.

关键词： Liver cirrhosis Microcirculation Small intestine Liver

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Huge primitive neuroectodermal tumor of the pancreas:Report of a case and review of the literature

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World Journal of Gastroenterology 2006年第37期12卷 6070-6073页

作者： Thilo Welsch Gunhild Mechtersheimer Sebastian Aulmann Sascha A Mueller Markus W Buechler jan schmidt Peter Kienle Deptartment of Surgery University of Heidelberg INF 110 D-69120 Heidelberg Germany Deptartment of Pathology University of Heidelberg INF 220 D-69120 Heidel- berg Germany

Primitive neuroectodermal tumor (PNET) of the pancreas is an extremely rare tumor that usually occurs in children or young adults. We report a case of a 33-year-old male patient with an 18 cm × 18 cm × 16 cm mass arising from the pancreatic body and tail with a one- day history of abdominal pain. Initial CT scan showed no signs of metastatic tumor spread. The tumor caused intrabdominal bleeding and the patient underwent primary tumor resection including partial gastrectomy, left pancreatic resection and splenectomy. Diagnosis of PNET was confi rmed by histology, immunohistochemistry and FISH analysis. All neoplastic cells were stained positive for MIC2-protein (CD99). Approximately one month after surgery, several liver metastases were observed and the patient underwent chemotherapy according to the Euro- Ewing protocol. Subsequent relaparotomy excluded any residual hepatic or extrahepatic abdominal metastases. Although PNET in the pancreas is an extremely rare entity, it should be considered in the diffential diagnosis of pancreatic masses, especially in young patients. This alarming case particularly illustrates that PNET in the pancreas although in an advanced stage can present with only a short history of mild symptoms.

关键词： Primitive neuroectodermal tumor Pancreas MIC2-protein Ewing sarcoma Abdominal mass

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Synergistic effects of interferon-alpha in combination with chemoradiation on human pancreatic adenocarcinoma

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World Journal of Gastroenterology 2005年第10期11卷 1521-1528页

作者： Jian-Hua Ma Emilia Patrut jan schmidt Hanns-Peter Knaebel Markus W. Büchler Angela M(a|¨)rten Department of Surgery

AIM: To determine whether IFN-α is the agent that turns a slightly effective treatment (radiochemotherapy) into a potent therapy, we tested IFN-α for its synergistic ***: Eight pancreatic carcinoma cell lines were treated with the single agents and combinations of *** role of IFN-α regarding a) direct inhibitory effects; b)radio and chemosensitizing effects; c) anti-angiogenic properties and d) enhancement of immunogenicity was ***: Our results show that IFN-α has direct inhibitory properties and some synergistic influence as determined by AnnexinV/PI stain and cell count. IFN-α is also able to prevent the increase in proliferation rate and VEGF secretion of CDDP resistant cells. Having taken the results from immunogenicity experiments together, we found cells that can be influenced by IFN-α but were less susceptible against T cells. Furthermore, high expression of MHC molecules, CD118, EGF-R and Fas was predictive for a good ***: In conclusion, IFN-α has direct cytotoxic effects, acts as a radiosensitizer and circumvents tumor cell-regrowth after CDDP treatment. These mechanisms may be responsible for the good clinical outcome of CapRI.

关键词： Interferon-alpha Pancreatic adenocarcinoma Synergistic effects Combination therapy

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Noninvasive indocyanine green plasma disappearance rate predicts early complications,graft failure or death after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2011年第4期10卷 362-368页

作者： Lutz Schneider Martin Spiegel Sebastian Latanowicz Markus A Weigand jan schmidt Jens Werner Wolfgang Stremmel Christoph Eisenbach Department of General Surgery University of HeidelbergIm Neuenheimer Feld 110Heidelberg 69110Germany Department of Gastroenterology University of HeidelbergIm Neuenheimer Feld 410Heidelberg 69120Germany Department of Anaesthesiology University of HeidelbergIm Neuenheimer Feld 110Heidelberg 69110Germany

BACKGROUND:Early detection of graft malfunction or postoperative complications is essential to save patients and organs after orthotopic liver transplantation (OLT).Predictive tests for graft dysfunction are needed to enable earlier implementation of organ-saving interventions following *** study was undertaken to assess the value of indocyanine green plasma disappearance rates (ICG-PDRs) for predicting postoperative complications,graft dysfunction and patient survival following ***:Eighty-six patients undergoing OLT were included in this single-centre ***-PDR was assessed daily for the first 7 days following *** were graft loss or death within 30 days and postoperative complications,graft loss,or death within 30 ***:Postoperative complications of 31 patients included deaths (12 patients) or graft ***-PDR was significantly different in patients whose endpoints were graft loss or death beginning from day 3 and in those whose endpoints were graft loss,death,or postoperative complications beginning from day 4 after *** day 7 measurements,receiver operating characteristic curve analysis revealed an ICG-PDR cut-off for predicting death or graft loss of 9.6% per min (a sensitivity of 75.0%,a specificity of 72.6%,positive predictive value 0.35 negative predictive value 0.94).For prediction of graft loss,death or postoperative complications,the ICG-PDR cut-off was 12.3%per min (a sensitivity of 68.9%,a specificity of 66.7%,positive predictive value 0.57,negative predictive value 0.77).CONCLUSIONS:ICG-PDR measurements on postoperative day 7 are predictive of early patient outcomes following *** added value over that of routinely determined laboratory parameters is low.

关键词： indocyanine green liver function liver transplantation

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TIPSS for variceal hemorrhage after living related liver transplantation:A dangerous indication

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World Journal of Gastroenterology 2006年第3期12卷 493-495页

作者： Peter Schemmer Boris Radeleff Christa Flechtenmacher Arianeb Mehrabi Gtz M Richter Markus W Büchler jan schmidt Department of General Surgery Ruprecht-KarlsUniversity69120 HeidelbergGermany Department of RadiologyRuprecht-Karls-University69120 HeidelbergGermany Department of PathologyRuprechtKarls-University69120 HeidelbergGermany

The introduction of transjugular intrahepatic portalsystemic stent-shunt （TIPSS） has been a major breakthrough in the treatment of portal hypertension, which has evolved to a large extent, into a routine procedure. A 21-year-old male patient with progressive graft fibrosis/cirrhosis requiring TIPSS for variceal hemorrhage in the esophagus due to portal hypertension was unresponsive to conventional measures two years after living related liver transplantation （LDLT）. Subsequently, variceal hemorrhage was controlled, however, liver function decreased dramatically with consecutive multi organ failure. CT scan revealed substantial necrosis in the liver. The patient underwent successful ＂high urgent＂ cadaveric liver transplantation and was discharged on postoperative d 20 in a stable condition.

关键词： Portal hypertension Liver necrosis Fibrosis Cirrhosis

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