Noninvasive indocyanine green plasma disappearance rate predicts early complications,graft failure or death after liver transplantation

作     者：Lutz Schneider Martin Spiegel Sebastian Latanowicz Markus A Weigand Jan Schmidt Jens Werner Wolfgang Stremmel Christoph Eisenbach 

作者机构：Department of General SurgeryUniversity of HeidelbergIm Neuenheimer Feld 110Heidelberg 69110Germany Department of GastroenterologyUniversity of HeidelbergIm Neuenheimer Feld 410Heidelberg 69120Germany Department of AnaesthesiologyUniversity of HeidelbergIm Neuenheimer Feld 110Heidelberg 69110Germany 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2011年第10卷第4期

页      面：362-368页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported in part by a grant from the Else Kr ner-Fresenius-Stiftung to Christoph Eisenbach(EKFS A72/06) 

主　　题：indocyanine green liver function liver transplantation 

摘      要：BACKGROUND:Early detection of graft malfunction or postoperative complications is essential to save patients and organs after orthotopic liver transplantation (OLT).Predictive tests for graft dysfunction are needed to enable earlier implementation of organ-saving interventions following *** study was undertaken to assess the value of indocyanine green plasma disappearance rates (ICG-PDRs) for predicting postoperative complications,graft dysfunction and patient survival following ***:Eighty-six patients undergoing OLT were included in this single-centre ***-PDR was assessed daily for the first 7 days following *** were graft loss or death within 30 days and postoperative complications,graft loss,or death within 30 ***:Postoperative complications of 31 patients included deaths (12 patients) or graft ***-PDR was significantly different in patients whose endpoints were graft loss or death beginning from day 3 and in those whose endpoints were graft loss,death,or postoperative complications beginning from day 4 after *** day 7 measurements,receiver operating characteristic curve analysis revealed an ICG-PDR cut-off for predicting death or graft loss of 9.6% per min (a sensitivity of 75.0%,a specificity of 72.6%,positive predictive value 0.35 negative predictive value 0.94).For prediction of graft loss,death or postoperative complications,the ICG-PDR cut-off was 12.3%per min (a sensitivity of 68.9%,a specificity of 66.7%,positive predictive value 0.57,negative predictive value 0.77).CONCLUSIONS:ICG-PDR measurements on postoperative day 7 are predictive of early patient outcomes following *** added value over that of routinely determined laboratory parameters is low.