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Aerosol jet printing of surface acoustic wave microfluidic devices

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Microsystems & Nanoengineering 2024年第1期10卷 231-242页

作者： joseph Rich Brian Cole Teng Li Brandon Lu Hanyu Fu Brittany N.Smith jianping Xia Shujie Yang Ruoyu Zhong james L.Doherty Kanji Kaneko Hiroaki Suzuki Zhenhua Tian Aaron D.Franklin Tony jun Huang Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA Department of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Deptartment of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan Department of Chemistry Duke UniversityDurhamNC 27708USA

The addition of surface acoustic wave(SAW)technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes,including high-precision manipulation,versatility,integrability,biocompatibility,contactless nature,and rapid ***,the development of SAW microfluidic devices is limited by complex and time-consuming micro/nanofabrication techniques and access to cleanroom facilities for multistep photolithography and vacuum-based *** simplify the fabrication of SAW microfluidic devices with customizable dimensions and functions,we utilized the additive manufacturing technique of aerosol jet *** successfully fabricated customized SAW microfluidic devices of varying materials,including silver nanowires,graphene,and poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS).To characterize and compare the acoustic actuation performance of these aerosol jet printed SAW microfluidic devices with their cleanroom-fabricated counterparts,the wave displacements and resonant frequencies of the different fabricated devices were directly measured through scanning laser Doppler ***,to exhibit the capability of the aerosol jet printed devices for lab-on-a-chip applications,we successfully conducted acoustic streaming and particle concentration ***,we demonstrated a novel solution-based,direct-write,single-step,cleanroom-free additive manufacturing technique to rapidly develop SAW microfluidic devices that shows viability for applications in the fields of biology,chemistry,engineering,and medicine.

关键词： printing wave fluid

三维炭纤维预型体上烷烃气的催化炭沉积(英文)

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新型炭材料 2009年第3期24卷 251-259页

作者： Matthew j thornton Gavin S Walker School of Mechanical Materials and Manufacturing EngineeringUniversity of NottinghamUniversity ParkNottingham

研究了承载镍催化剂的三维(3D)炭纤维预型体,在含氢或无氢条件下,乙烷和合成天然气在其上面化学气相沉积形成的炭沉积率和碳纳米构结物。观察了炭沉积所获石墨纳米纤维、碳纳米管和石墨碳壳,得知沉积碳的纳米结构取决于沉积温度和碳源... 详细信息

研究了承载镍催化剂的三维(3D)炭纤维预型体,在含氢或无氢条件下,乙烷和合成天然气在其上面化学气相沉积形成的炭沉积率和碳纳米构结物。观察了炭沉积所获石墨纳米纤维、碳纳米管和石墨碳壳,得知沉积碳的纳米结构取决于沉积温度和碳源气组成。在650℃～800℃温间,总沉积时程直至12h,研究了烃类碳源气在氢气平衡下,从体积分数100%到20%变化情况。经Ni(NO3)2-6H2O甲醇溶液浸渍的3D炭纤维预型体在炭沉积前因溶液分解可还原出Ni。采用质量变化测定法、热谱-质谱分析仪、SEM、TEM和XRD对样品进行表征。结果表明:纤维状炭与囊包炭的比率随氢气含量的增加而增加,随反应温度的增高而减少。出乎意料的是,氢气的添加并不延长催化剂的寿命。该工艺过程对炭/炭复合材料的制备展示出良好的潜力。

关键词：催化生长炭炭纤维烷烃气浸渍显微镜方法

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第09期 2596-2597页

作者： Christopher j.O'Connell Matthew j.Robson Department of Genetics College of Medicine Harvard University james L. Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of Cincinnati Neuroscience Graduate Program College of MedicineUniversity of Cincinnati

Traumatic brain injury(TBI) is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

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Electro-acupuncture to prevent prolonged postoperative ileus:A randomized clinical trial

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World journal of Gastroenterology 2010年第1期16卷 104-111页

作者： M Kay Garcia joseph S Chiang Bob thornton j Lynn Palmer jennifer McQuade Lorenzo Cohen Department of Anesthesiology and Pain Medicine/Integrative Medicine M.D.Anderson Cancer CenterThe University of Texas Department of Anesthesiology and Pain Medicine M.D.Anderson Cancer CenterThe University of Texas Department of Palliative Care and Rehabilitation Medicine M.D.Anderson Cancer CenterThe University of Texas Department of Behavioral Science M.D.Anderson Cancer CenterThe University of Texas Department of GI Medical Oncology M.D. Anderson Cancer CenterThe University of Texas

AIM:To examine whether acupuncture can prevent prolonged postoperative ileus(PPOI)after intraperitoneal surgery for colon cancer. METHODS:Ninety patients were recruited from the Fudan University Cancer Hospital,Shanghai,China. After surgery,patients were randomized to receive acupuncture(once daily,starting on postoperative day 1, for up to six consecutive days)or usual *** was defined as an inability to pass flatus or have a bowel movement by 96 h after *** main outcomes were time to first flatus,time to first bowel movement, and *** outcomes were quality of life(QOL)measures,including pain, nausea,insomnia,abdominal distension/fullness,and sense of well-being. RESULTS:No significant differences in PPOI on day 4 (P=0.71)or QOL measures were found between the *** were also no group differences when the data were analyzed by examining those whose PPOI had resolved by day 5(P=0.69)or day 6(P= 0.88).No adverse events related to acupuncture were reported. CONCLUSION:Acupuncture did not prevent PPOI andwas not useful for treating PPOI once it had developed in this population.

关键词： Acupuncture Gastrointestinal motility Gastrointestinal disorders Gastrointestinal neoplasms

Bayesian Deep Learning for Dynamic Power System State Prediction Considering Renewable Energy Uncertainty

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journal of Modern Power Systems and Clean Energy 2022年第4期10卷 913-922页

作者： Shiyao Zhang james.j.Q.Yu Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Department of Computer Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

Modern power systems are incorporated with distributed energy sources to be environmental-friendly and ***,due to the uncertainties of the system integrated with renewable energy sources,effective strategies need to be adopted to stabilize the entire power ***,the system operators need accurate prediction tools to forecast the dynamic system states *** this paper,we propose a Bayesian deep learning approach to predict the dynamic system state in a general power ***,the input system dataset with multiple system features requires the data pre-processing ***,we obtain the dynamic state matrix of a general power system through the Newton-Raphson power flow ***,by incorporating the state matrix with the system features,we propose a Bayesian long short-term memory(BLSTM)network to predict the dynamic system state variables *** results show that the accurate prediction can be achieved at different scales of power systems through the proposed Bayesian deep learning approach.

关键词： Bayesian deep learning data analytics NewtonRaphson power flow renewable energy source system state

The Triple Combination of Meropenem,Avibactam,and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers

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Engineering 2024年第7期38卷 124-132页

作者： Zhuoren Ling Alistair james Macdonald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premchand-Branker Kate Cook Andrei Baran Charlotte Gray-Hammerton Claudia Orbegozo Rubio Edgars Suna jordan Mathias jürgen Brem Kirsty Sands Maria Nieto-Rosado Maria Mykolaivna Trush Nadira Naznin Rakhi Willames Martins Yuqing Zhou Christopher joseph Schofield Timothy Walsh Department of Biology&Ineos Oxford Institute for Antimicrobial Research University of OxfordOxford OX13REUK Chemistry Research Laboratory Department of Chemistry and the Ineos Oxford Institute for Antimicrobial ResearchUniversity of OxfordOxford OX13TAUK Latvian Institute of Organic Synthesis Riga LV-1006Latvia Department of Medical Microbiology Division of Infection and ImmunitySchool of MedicineCardiff UniversityCardiff CF144XNUK Enzymology and Applied Biocatalysis Research Center Faculty of Chemistry and Chemical EngineeringBabes-Bolyai UniversityCluj-Napoca 400028Romania

This work explores the potential of a triple combination of meropenem(MEM),a novel metallo-blactamase(MBL)inhibitor(indole-2-carboxylate 58(InC58)),and a serine-b-lactamase(SBL)inhibitor(avibactam(AVI))for broad-spectrum activity against carbapenemase-producing bacteria.A diverse panel comprising MBL-and SBL-producing strains was used for susceptibility testing of the triple combination using the agar dilution *** frequency of resistance(FoR)to MEM combined with InC58 was *** were sequenced and tested for cross resistance,fitness,and the stability of the resistance *** with the double combinations of MEM plus an SBL or MBL inhibitor,the triple combination extended the spectrum of activity to most of the isolates bearing SBLs(oxacillinase-48(OXA-48)and Klebsiella pneumoniae carbapenemase-2(KPC-2))and MBLs(New Delhi metallo-blactamases(NDMs)),although it was not effective against Verona integron-encoded metallo-blactamase(VIM)-carrying Pseudomonas aeruginosa(***)and OXA-23-carrying Acinetobacter baumannii(***).The FoR to MEM plus InC58 ranged from 2.22×10^(-7)to 1.13×10^(-6).The resistance correlated with mutations to ompC and comR,affecting porin C and copper permeability,*** mutants manifested a fitness cost,a decreased level of resistance during passage without antibiotic pressure,and cross resistance to another carbapenem(imipenem)and a b-lactamase inhibitor(taniborbactam).In conclusion,compared with the dual combinations,the triple combination of MEM with InC58 and AVI showed a much wider spectrum of activity against different carbapenemaseproducing bacteria,revealing a new strategy to combat b-lactamase-mediated antimicrobial resistance.

关键词： Carbapenemase Metallo/serine-b-lactamase inhibitor Avibactam Meropenem Antimicrobial resistance

Sun's Log-concavity Conjecture on the Catalan–Larcombe–French Sequence

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Acta Mathematica Sinica,English Series 2016年第5期32卷 553-558页

作者： james.j.Y.ZHAO Center for Applied Mathematics Tianjin University

Let {Pn},n≥0 denote the Catalan-Larcombe-French sequence, which naturally came from the series expansion of the complete elliptic integral of the first kind. In this paper, we prove the strict log-concavity of the sequence { n√Pn}n≥1, which was originally conjectured by Z. W. Sun. We also obtain the strict log-concavity of the sequence {n√Vn}n≥1, where {Vn}n≥0 is the Fennessey-Larcombe- French sequence arising from the series expansion of the complete elliptic integral of the second kind.

关键词： The Catalan-Larcombe-French sequence the Fennessey-Larcombe-French sequence logconcavity three-term recurrence relation

Origin of high particle number concentrations reaching the St. Louis, Midwest Supersite

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journal of Environmental Sciences 2015年第8期27卷 219-231页

作者： Benjamin de Foy james.j.Schauer Department of Earth and Atmospheric Sciences Saint Louis University Civil and Environmental Engineering University of Wisconsin

Ultrafine particles are associated with adverse health effects. Total Particle Number Concentration（TNC） of fine particles were measured during 2002 at the St. Louis — Midwest supersite. The time series showed overall low level with frequent large peaks. The time series was analyzed alongside criteria pollutant measurements and meteorological observations. Multiple regression analysis was used to identify further contributing factors and to determine the association of different pollutants with TNC levels. This showed the strong contribution of sulfur dioxide（SO2） and nitrogen oxides（NO x） to high TNC levels. The analysis also suggested that increased dispersion resulting from faster winds and higher mixing heights led to higher TNC levels. Overall, the results show that there were intense particle nucleation events in a SO2 rich plume reaching the site which contributed around 29% of TNC. A further 40% was associated with primary emissions from mobile sources. By separating the remaining TNC by time of day and clear sky conditions,we suggest that most likely 8% of TNC are due to regional nucleation events and 23% are associated with the general urban background.

关键词： Atmospheric aerosols Particle number concentrations Fine particles Sulfur dioxide plumes Mobile source emissions

Absence of Na^+/sugar cotransport activity in Barrett's metaplasia

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World journal of Gastroenterology 2008年第9期14卷 1365-1369页

作者： Lisa j Murray Owen Tully David S Rudolph Marysue Whitby Mary C Valenzano Giancarlo Mercogliano james.j thornton james M Mullin Lankenau Institute for Medical Research WynnewoodPAUnited States Saint Joseph's UniversityDepartment of BiologyPhiladelphiaPA 19096United States Lankenau Hospital Department of Medicine WynnewoodPA 19096United States Lankenau Hospital Department of MedicineWynnewoodPA 19096 United States Lankenau Institute for Medical Research WynnewoodPAUnited States Lankeanu Hospital Division of GastroenterologyWynnewood PA 19096United States Lankeanu Hospital Division of GastroenterologyWynnewoodPA 19096United States

AIM:To evaluate the presence of Na+-dependent, active, sugar transport in Barrett's epithelia as an intestinal biomarker, based on the well-documented, morphological intestinal phenotype of Barrett's esophagus (BE). METHODS: We examined uptake of the nonmeta- bolizable glucose analogue, alpha-methyl-D-glucoside (AMG), a substrate for the entire sodium glucose cotransporter (SGLT) family of transport proteins. During upper endoscopy, patients with BE or with uncomplicated gastroesophageal reflux disease (GERD) allowed for duodenal, gastric fundic, and esophageal mucosal biopsies to be taken. Biopsies were incubated in bicarbonate-buffered saline (KRB) containing 0.1 mmol/L 14C-AMG for 60 min at 20℃. Characterized by abundant SGLT, duodenum served as a positive control while gastric fundus and normal esophagus, known to lack SGLT, served as negative controls. RESULTS: Duodenal biopsies accumulated 249.84 ± 35.49 (SEM) picomoles AMG/μg DNA (n = 12), gastric fundus biopsies 36.20 ± 6.62 (n = 12), normal esophagus 12.10 ± 0.59 (n = 3) and Barrett's metaplasia 29.79 ± 5.77 (n = 8). There was a statistical difference (P < 0.01) between biopsies from duodenum and each other biopsy site but there was no statistically significant difference between normal esophagus and BE biopsies. 0.5 mmol/L phlorizin (PZ) inhibited AMG uptake into duodenal mucosa by over 89%, but had nosignificant effect on AMG uptake into gastric fundus, normal esophagus, or Barrett's tissue. In the absence of Na+ (all Na+ salts replaced by Li+ salts), AMG uptake in duodenum was decreased by over 90%, while uptake into gastric, esophageal or Barrett's tissue was statistically unaffected. CONCLUSION: Despite the intestinal enterocyte phenotype of BE, Na+-dependent, sugar transport activity is not present in these cells.

关键词： Barrett's esophagus Cancer Biomarker Sodium glucose cotransporters Glucose transport Alphamethyl-D-glucoside Phlorizin Esophagus Metaplasia