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MELD or MELD-Na as a predictive Model for Mortality Following Transjugular Intrahepatic portosystemic Shunt placement

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 38-44页

作者： Arunkumar Krishnan Tinsay A.Woreta Dhananjay Vaidya Yisi Liu james p.hamilton Kelvin Hong Alia Dadabhai Michelle Ma Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of General Internal Medicine Johns Hopkins University School of MedicineBaltimoreMDUSA Department of pediatrics Johns Hopkins University School of MedicineBaltimoreMDUSA Division of Interventional Radiology Johns Hopkins University School of MedicineBaltimoreMDUSA

Background and Aim:The model for end-stage liver disease(MELD)was originally developed to predict survival after transjugular intrahepatic portosystemic shunt(TIpS).The MELD-sodium(MELD-Na)score has replaced MELD for organ allocation for liver ***,there are limited studies to compare the MELD with MELD-Na to predict mortality after ***:We performed a retrospective chart review of patients who underwent TIpS placement between 2006 and 2016 at our *** primary outcome was mortality,and the secondary outcomes sought to assess which variables could provide prognostic information for mortality after TIpS *** performed receiver operating characteristic(ROC)curve analysis to assess the performance of MELD and ***:There were 186 eligible patients in the *** mean pre-TIpS MELD and MELD-Na were 13 and 15,***,mortality after TIpS was 15%at 30 days and 16.7%at 90 *** a comparison of the areas under the ROCs for MELD and MELD-Na,MELD was superior to MELD-Na for 30-day(0.762 vs.0.709)and 90-day(0.780 vs.0.730)mortality after *** optimal cutoff score for 30-day mortality was 15(0.676–0.848)for MELD and 17(0.610–0.808)for MELD-Na,whereas the optimal cutoff score for 90-day mortality was 16(95%CI:0.705–0.855)for MELD and 17(95%CI:0.643–0.817)for *** were 24 patients with high MELD-Na≥17,but with low MELDp was 8.3%.Conclusions:Although MELD-Na is a superior prognostic tool to MELD for predicting overall mortality in cirrhotic patients,MELD tended to outperform MELD-Na to predict mortality after TIpS.

关键词： Cirrhosis portal hypertension Model for end-stage liver disease Sodium Transjugular intrahepatic portosystemic shunt Outcomes Mortality

Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients

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World Journal of Gastroenterology 2022年第5期28卷 570-587页

作者： Arunkumar Krishnan Laura prichett Xueting Tao Saleh A Alqahtani james p hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim james J potter po-Hung Chen Tinsay A Woreta Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMD 21287United States Department of pediatrics Johns Hopkins University School of MedicineBaltimoreMD 21287United States Liver Transplant Center King Faisal Specialist Hospital&Research CenterRiyadh 12713Saudi Arabia

BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital *** This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were *** regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of *** more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALp)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and *** ALT,AST,T-Bil,and ALp levels were more commonly associated with disease *** adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during *** AST,T-Bil,and ALp were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and *** liver chemistries,specifically ALT,AST,ALp,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in t

关键词： Severe acute respiratory syndrome coronavirus 2 Liver injury Liver tests Aspartate aminotransferase Alanine aminotransferase bilirubin

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili patricia Graham Adriana Brooks Risset Silvera Alexander J.p.Goldschmidt Damien D.pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami project to Cure paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

SERVICE VALUE NETWORKS:INTO pRACTICE

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Journal of Systems Science and Systems Engineering 2007年第4期16卷 414-423页

作者： John hamilton Director of E-Business James Cook UniversityCairns4870Australia

Modeling a business to match its customer perceived （and customer desired） outcomes, remains an on-going task. This paper considers shows how a service value networks （SVNs） approach may be engaged to model, and deliver, understanding of the front-end business and its direct engagement with its immediate （or front-end） customers. These front-end customers may be either：（1） its off-line, in-store customers - engaging directly with the business sales staff （or representative）, or-（2） its on-line, virtual customers - engaging with the business via internet or remote access. In this situation, both the business, and the customer draw upon their respective viewpoints, and both sides influence the interaction. External to these business and customer influences are additional factors that capture the immediate and broader global effects - termed environmental effects. These three business-customer engagement areas of influence are captured by a SVN SEM approach. Without a business-customer encounter of some kind the likelihood of a services business, and a prospecting customer, successfully engaging in an exchange process is reduced. This exchange may be a physical, and/or services exchange, and/or an information and/or ideas exchange. To the business, this encounter is, in effect, a trade, and as a result, the business targets acquiring an economic exchange that will ultimately deliver a net positive economic outcome. To the customer, external and internal information feeds, servicing, perceived value, and satisfaction, are key encounter drivers. SVNs offers a new way to understand the business-customer encounter, and to then utilize this acquired knowledge to either：（1） build a strategic management model, or （2） reengineer its business networks, and to then create a re-positioned, more customer-aligned business operation - one that is capable of delivering win - win, competitive business-customer solutions.

关键词： Service value networks alignment structural equation modeling

BENCHMARKING ON-LINE SERVICES INDUSTRIES

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Journal of Systems Science and Systems Engineering 2006年第1期15卷 48-69页

作者： John hamilton Director of E-Business James Cook University Cairns 4870 Australia

The Web Quality Analyser (WQA) is a new benchmarking tool for industry. It has been extensively tested across services industries. Forty five critical success features are presented as measures that capture the user’s perception of services industry websites. This tool differs to previous tools, in that it captures the information technology (IT) related driver sectors of website performance, along with the marketing-services related driver sectors. These driver sectors capture relevant structure, function and performance components. An ‘on-off’ switch measurement approach determines each component. Relevant component measures scale into a relative presence of the applicable feature, with a feature block delivering one of the sector drivers. Although it houses both measurable and a few subjective components, the WQA offers a proven and useful means to compare relevant websites. The WQA defines website strengths and weaknesses, thereby allowing for corrections to the website structure of the specific business. WQA benchmarking against services related business competitors delivers a position on the WQA index, facilitates specific website driver rating comparisons, and demonstrates where key competitive advantage may reside. This paper reports on the marketing-services driver sectors of this new benchmarking WQA tool.

关键词： Benchmarking performance website service analysis compare

Waterbird use of farm dams in south-eastern Australia:abundance and influence of biophysical and landscape characteristics

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Chinese Birds 2017年第1期8卷 12-24页

作者： Andrew J.hamilton ChloéConort Aurore Bueno Christopher G.Murray james R.Grove Faculty of Veterinary and Agricultural Sciences The University of MelbourneDookie CampusCurrawaVIC 3647Australia Office of the Deputy Vice-Chancellor(Research and Innovation) Federation University AustraliaBallaratVIC 3353Australia Department of Rural Health Melbourne Medical School49 Graham StreetPO Box 6500SheppartonVIC 3632Australia École Nationale Supérieure Agronomique de Toulouse 31326 Castanet TolosanFrance Faculty of Science The University of MelbourneParkvilleVIC 3010Australia Faculty of Science Department of GeographyThe University of MelbourneParkvilleVIC 3010Australia

Background: While agriculture has taken much environmental water in Australia's Murray-Darling Basin, agricultural expansion has resulted in a vast number of farm dams, almost three-quarters of a million in the Murray-Darling Basin ***: Over a summer we studied(1) waterbird abundance and species richness and(2) the influence of biophysical and landscape characteristics across 49 farm dams at a large mixed-enterprise farm in northern Victoria on the southern reach of the Murray-Darling ***: On average, dams were found to host 27.1 ± 71.1 individuals/ha and 1.8 ± 2.9 species per pond. Such densities are comparable to those on natural wetlands. Dam surface area and perimeter and amount of vegetation were positively and strongly correlated with the Rallidae density(birds/ha), but no other parameters were strongly correlated with any other functional group. The landscape in which the dams were embedded had a highly significant effect(p plemented with further studies in other parts of the Basin and on other taxa, but given at our site they supported similar densities of individuals and species to natural wetlands, and given the fact that there are 710,539 farm dams in the Murray-Darling Basin, which hosts much of Australia's waterbird fauna, it is reasonable to suggest that farm dams are overlooked, and possibly very important, avian biodiversity hotspots. It also highlights the importance of a landscape setting, in which dams are situated, on the number of birds using the dams.

关键词： Farm ponds Waterbirds Waterfowl Zooplankton

Compressing local atomic neighbourhood descriptors

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npj Computational Materials 2022年第1期8卷 1593-1605页

作者： james p.Darby james R.Kermode Gábor Csányi Engineering Dept University of CambridgeTrumpington StCambridgeCB21PZUK Warwick Centre for predictive Modelling School of EngineeringUniversity of WarwickCoventryCV47ALUK

Many atomic descriptors are currently limited by their unfavourable scaling with the number of chemical elements S *** length of body-ordered descriptors,such as the SOAp power spectrum(3-body)and the(ACE)(multiple body-orders),scales as(NS)^(ν)whereν+1 is the body-order and N is the number of radial basis functions used in the density *** introduce two distinct approaches which can be used to overcome this scaling for the SOAp power ***,we show that the power spectrum is amenable to lossless compression with respect to both S and N,so that the descriptor length can be reduced from O(N^(2)S^(2))to O(NS).Secondly,we introduce a generalised SOAp kernel,where compression is achieved through the use of the total,element agnostic density,in combination with radial *** ideas used in the generalised kernel are equally applicably to any other body-ordered descriptors and we demonstrate this for the(ACSF).

关键词： SOAp scaling kernel

Continuous live cell imaging of cellulose attachment by microbes under anaerobic and thermophilic conditions using confocal microscopy

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Journal of Environmental Sciences 2013年第5期25卷 849-856页

作者： Zhi-Wu Wang Seung-Hwan Lee james G.Elkins Yongchao Li Scott hamilton-Brehm Jennifer L.Morrell-Falvey BioEnergy Science Center Biosciences DivisionOak Ridge National LaboratoryOak RidgeTN 37831USA College of Food Agricultural and Environmental SciencesThe Ohio State University1328 Dover RdWoosterOH 44691USA National Institute of Advanced Industrial Science and Technology Biomass Refinery Research CenterHiroshimaJapan Department of Forest Biomaterials Engineering College of Forest and Environmental SciencesKangwon National UniversityChuncheon 200-701Korea

Live cell imaging methods provide important insights into the dynamics of cellular processes that cannot be derived easily from population-averaged *** the bioenergy field,much research is focused on fermentation of cellulosic biomass by thermophilic microbes to produce biofuels;however,little effort is dedicated to the development of imaging tools to monitor this dynamic biological *** is,in part,due to the experimental challenges of imaging cells under both anaerobic and thermophilic *** an imaging system is described that integrates confocal microscopy,a flow cell device,and a lipophilic dye to visualize *** to technical obstacles regarding suitable fluorescent markers,photodamage during imaging,and maintenance of environmental conditions during imaging are *** system was utilized to observe cellulose colonization by Clostridium thermocellum under anaerobic conditions at 60℃.This method enables live cell imaging of bacterial growth under anaerobic and thermophilic conditions and should be widely applicable to visualizing different cell types or processes in real time.

关键词： thermophile lipophilic dye cellulose biofuel confocal laser scanning microscopy biofilm

Radical Addition of perfluorinated Alkyl Iodides to Multi- Layered Graphene and Single-Walled Carbon Nanotubes

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Nano Research 2010年第2期3卷 138-145页

作者： Christopher E.hamilton Jay R.Lomeda Zhengzong Sun james M.Tour Andrew R.Barron Richard E.Smalley Institute for Nanoscale Science and Technology Department of Chemistry and Department of Mechanical Engineering and Materials ScienceRice UniversityHoustonTexas 77005USA

A simple one-pot reaction that serves to functionalize graphite nanosheets(graphene)and single-walled carbon nanotubes(SWNTs)with perfluorinated alkyl groups is *** radical addition of 1-iodo-1H,1H,2H,2H-perfluorododecane to ortho-dichlorobenzene suspensions of the carbon nanomaterial is initiated by thermal decomposition of benzoyl ***,UV photolysis of 1-iodo-perfluorodecane serves to functionalize the carbon ***-SWNTs,perfluorododecyl-graphene,and perfluorodecyl-graphene are characterized by infrared(IR)and Raman spectroscopy,X-ray photoelectron spectroscopy(XpS),thermogravimetric analysis(TGA),and atomic force microscopy(AFM).The products show enhanced dispersability in CHCl3 as compared to unfunctionalized starting *** advantage of this one-pot functionalization procedure lies in the use of pristine graphite as starting material thereby avoiding the use of harsh oxidizing conditions.

关键词： Nanotube single-walled carbon nanotube graphene radical addition