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视盘地形测量基线与原发性开角型青光眼进展相关高眼压治疗研究中关于共焦扫描激光眼底镜的辅助研究

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美国医学会眼科杂志（中文版） 2006年第3期18卷 189-189页

作者： linda M. ZangwiU Robert N. Weinreb Julia A. Beiser Charles C. Berry George A. Cioffi Anne l Coleman Gary Trick Jeffrey M. liebmann james D. Brandt Jody R. Piltz-Seyrnour Keri A. Dirkes Suzanne Vega Michael A. Kass Mae O. Gordon 路遥（译）雷嘉启（校） for the Confocal Scanning laser Ophthalmoscopy Ancillary Study to the Octdar Hypertension Treatment Study Group 不详

目的：在高眼压的患者中研究共焦扫描激光眼底镜（CSlO）关于视盘地形的基线测量是否与原发性开角型青光眼（POAG）的发展有关。

关键词：原发性开角型青光眼扫描激光眼底镜地形测量高眼压共焦基线视盘治疗

坎布里亚郡不同社会经济状况引起不同的婴儿死亡率

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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 14-14页

作者： Dummer T. J. B. Parker l. 郭战宏 Paediatr./lifecourse E. R. G. Sir james Spence Inst. Child Hlth. Newcastle University QueenVictoriaRoad NewcastleNE1 4LP United Kingdom Prof.

Aims: To investigate infant deaths in Cumbria, 1950-93, in relation to individual and community level socioeconomic status. Methods: Retrospective birth cohort study of all 283 668 live births and 4889 infant deaths in Cumbria, 1950-93. Community deprivation (Townsend score) and individual social class were used to estimate socioeconomic status. logistic regression was used to investigate risk of infant death (early neonatal, neonatal, and postneonatal) in relation to social class and Townsend deprivation score, adjusting for year of birth, birth order, multiple births, and stratified by time period, 1950-65, 1966-75, 1976-85, 1986-93. Results: The risk of infant death in all categories was higher in the lower social classes and more deprived communities, although inequality in risk of neonatal death declined after 1975 to such an extent that there was no significant difference in neonatal death rates by socioeconomic status in the most recent time period. By contrast, there was no narrowing in socioeconomic inequality in postneonatal death risk over the study period. Community deprivation was associated with a significant increased risk of postneonatal death after adjusting for individual level socioeconomic status. Conclusions: Postneonatal deaths remain higher in the most deprived communities and in the more disadvantaged social classes. The social, lifestyle, and environmental determinates of adverse health outcomes for children need to be fully understood, and interventions should be designed and targeted at the more socially deprived sectors of our community.

关键词：坎布里亚婴儿死亡率活产婴儿新生儿期婴幼儿死亡多胎分娩新生儿死亡率 Townsend 队列研究个体水平

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深圳能源大厦

建筑实践 2019年第6期 26-33页

作者： Bjarke Ingels Andreas Klok Pedersen Martin Voelkle He Song Andre Schmidt Alessio Zenaro Alina Tamosiunaite Alysen Hiller Ana Merino Andreas Geisler Johansen Annette Jensen Armor Rivas Balaj IIulian Brian Yang Baptiste Blot Buster Christiansen Cecilia Ho Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Dave Brown Dennis Rasmussen Doug Stechschulte Eskild Nordbud Felicia Guldberg Fred Zhou Gaetan Brunet Gül Ertekin Henrik Kania Iris Van der Heide james Schrader Jan Magasanik Jan Borgstr?m Jeppe Ecklon Jelena Vucic Jo?o Albuquerque Jonas M?nster Karsten Hansen Malte Kloe Mikkel Marcker Stubgaard Michael Andersen Michal Kristof Min Ter lim Oana Simionescu Nicklas A. Rasch Philip Sima Rasmus Pedersen Rune Hansen Rui Huang Sofia Gaspar Stanley lung Sun Ming lee Takuya Hosokai Todd Bennett Xi Chen Xing Xiong Xiao lu Xu li Yijie Dan Zoltan Kalaszi BIG

深圳能源公司办公楼项目总建筑面积为96000m2,旨在让人在深圳的文化、政治和商业中心感到亲切的同时,在城市主轴线上建造一座可持续的新公共地标。本项目的体量和高度由中心区城市总体规划决定。主体建筑由两座塔楼组成,北楼高220m,南楼... 详细信息

深圳能源公司办公楼项目总建筑面积为96000m2,旨在让人在深圳的文化、政治和商业中心感到亲切的同时,在城市主轴线上建造一座可持续的新公共地标。本项目的体量和高度由中心区城市总体规划决定。主体建筑由两座塔楼组成,北楼高220m,南楼高120m,两座塔楼与邻近建筑的塔楼一起在深圳的中心形成一个连续的弧形天际线。在建筑底部,两座塔楼通过一个34m长,包括大厅、会议中心、自助餐厅和展览空间功

关键词： Michael 建筑面积建筑实践

Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang leilei Xiang Kelvin Sze-Yin leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao li Tong Zhang Natàlia Corcoll Min liu Daniel SAlessi Hui li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming luo lizhong Zhu Xiangdong li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu james M.Tiedje State Key laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

家族性渗出性玻璃体视网膜病遗传异质性的进一步证据:在一个常染色体显性遗传大家系中排除EVR1,EVR3,EVR4

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 29-29页

作者： Toomes C. Downey l.M. Bottomley H.M. 王海燕 MolecularMedicineUnit Clinical Sciences Building St. James' s University Hospital Leeds LS9 7TF United Kingdom

Background/aims: Familial exudative vitreoretinopathy (FEVR) is an inherited blinding condition characterised by abnormal development of the retinal vasculature. The aim of this study was to perform linkage analysis in a large family affected with FEVR to determine whether the mutation involved was in one of the three known autosomal dominant FEVR loci or in another as yet unidentified gene. Methods: Genomic DNA samples from family members were polymerase chain reaction (PCR) amplified with fluorescently tagged microsatellite markers spanning the EVR1/EVR4 locus (11q13- 14) and the EVR3 locus (11p12- 13). The resulting PCR products were resolved using an automated DNA sequencer and the alleles sized. These data were used to construct haplotypes across each locus and linkage analysis was performed to prove or exclude linkage. Results: The clinical evaluation in this family suggested features typical of FEVR, with deficient peripheral retinal vascularisation being the common phenotype in all affected individuals. However, linkage analysis proved that this family has a form of FEVR genetically distinct from the EVR1, EVR3 and EVR4 loci. Conclusion: The exclusion of linkage in this family to any of the known FEVR loci proves the existence of a fourth locus for autosomal dominant FEVR and shows that this rare disorder is far more heterogeneous than previously thought.

关键词：玻璃体视网膜 EVR1,EVR3,EVR4 渗出性族性视网膜血管遗传异质性连锁分析聚合酶链反应基因位点测序仪

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急性缺血性卒中静脉阿替普酶溶栓治疗的纳入和排除标准的科学依据美国心脏协会/美国卒中协会对医疗卫生专业人员发布的声明（续前）

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国际脑血管病杂志 2016年第5期24卷 385-406页

作者： Dawn O. Kleindorfer Opeolu M. Adeoye Andrew M. Demchuk Jennifer E. Fugate james C. Grotta Alexander A. Khalessi Elad I. levy Yuko Y. Palesch Shyam Prabhakaran Gustavo Saposnik Jeffrey l. Saver Eric E. Smith 高圆圆顾雨铖徐欣徐曼曼张佳慧李韶雅冒萧萧陈歆徐运不详南京大学医学院附属鼓楼医院神经内科 210008

19 颅内出血史根据最初的 FDA 标签和2013年AHA/ASA指南,颅内出血史是静脉阿替普酶治疗缺血性卒中的一项额外禁忌证或排除标准。最近修订后的标签仅将近期 ICH 列为一项警告,并且在禁忌证中删除了ICH史。与前面讨论的静脉阿替普酶治疗... 详细信息

19 颅内出血史根据最初的 FDA 标签和2013年AHA/ASA指南,颅内出血史是静脉阿替普酶治疗缺血性卒中的一项额外禁忌证或排除标准。最近修订后的标签仅将近期 ICH 列为一项警告,并且在禁忌证中删除了ICH史。与前面讨论的静脉阿替普酶治疗排除标准相似,文献回顾仅在大样本回顾性研究中发现了少量这类病例。缺乏相关数据可能是修订后的FDA 标签不再将 ICH 史作为禁忌证而仅将近期ICH 列为一项警告的原因。在这种情况下,FDA 如何定义“近期”一词尚不清楚。有趣的是,对在静脉阿替普酶治疗前通过 MRI 检测脑微出血（ cerebral microbleed, CMBs）存在情况进行的研究可为这个卒中亚组患者提供更多的见解。从病理生理学角度,这种微出血的原因尚不清楚,可能反映再灌注损伤或脑血管自动调节功能破坏。因此,在静脉阿替普酶治疗后出现这些损害可能没有意义或是人为信号。

关键词：急性缺血性卒中阿替普酶溶栓治疗美国心脏协会排除标准卫生专业人员静脉卒中协会

靶向微泡成像显示肿瘤新生血管:微型PET动态扫描评估小鼠体内的生物学分布

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国际医学放射学杂志 2008年第A6期31卷 502-502页

作者： J.K.Willmann C.Davis A.M.lutz M.l.Schipper C.H.Nielsen 向贤宏 Molecular Imaging Program at Stanford Department of Radiology and Bio-X Program Stanford University School of Medicine James H. Clark Center 318 Campus Dr East Wing 1st Floor Stanford CA 94305-5427 USA.

目的通过微型PET对活体小鼠的动态扫描来评价肿瘤血管内皮生成因子受体2(VEGFR2)相关的微泡靶向肿瘤新生血管在小鼠体内的分布。材料与方法

关键词：动态扫描 PET 靶向微泡 VEGFR 生成因子成像显示标记抗体摄取比放射性标记

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro lylyk Omer F Eker laura Mechtouff Michel Piotin Fabricio Oliveira lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S lopez Rivera james E Siegler Achmad Fidaus Sani Ajit S Puri Anna luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez luisa Fonseca M luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,plisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,plative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid