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Science China Chemistry 2017年第12期60卷 1563-1564页

作者： Tony D. james Department of Chemistry University of BathBath BA2 7AYUK

Chemosensors and imaging probes have been the focus of significant research interest over the past few decades. In part due to ease of preparation and simplicity in manipulation, fluorescent probes have been extensive... 详细信息

关键词： Light controlled imaging probes for intracellular target recognition photochromism enhance sensing precision

Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study

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World Journal of gastroenterology 2019年第16期25卷 1997-2009页

作者： Osman Oguz Ahsen Kaicheng Liang Hsiang-Chieh Lee Zhao Wang james g Fujimoto Hiroshi Mashimo Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology gastroenterology Section VA Boston Healthcare System Harvard School of Medicine Boston

BACKgROUND Chronic radiation proctopathy(CRP) occurs as a result of pelvic radiation therapy and is associated with formation of abnormal vasculature that may lead to persistent rectal bleeding. While incidence is declining due to refinement of radiation delivery techniques, CRP remains one of the major complications of pelvic radiation therapy and significantly affects patient quality of *** ablation(RFA) is an emerging treatment modality for eradicating abnormal vasculature associated with CRP. However, questions remain regarding CRP pathophysiology and optimal disease *** To study feasibility of optical coherence tomography angiography(OCTA) for investigating subsurface vascular alterations in CRP and response to RFA *** Two patients with normal rectum and 8 patients referred for, or undergoing endoscopic RFA treatment for CRP were imaged with a prototype ultrahighspeed optical coherence tomography(OCT) system over 15 OCT/colonoscopy visits(2 normal patients, 5 RFA-na?ve patients, 8 RFA-follow-up visits). OCT and OCTA was performed by placing the OCT catheter onto the dentate line and rectum without endoscopic guidance. OCTA enabled depth-resolved microvasculature imaging using motion contrast from flowing blood, withoutrequiring injected dyes. OCTA features of normal and abnormal microvasculature were assessed in the mucosa and submucosa. Blinded reading of OCTA images was performed to assess the association of abnormal rectal microvasculature with CRP and RFA treatment, and rectal telangiectasia density endoscopic *** OCTA/OCT images are intrinsically co-registered and enabled depth-resolved visualization of microvasculature in the mucosa and submucosa. OCTA visualized normal vascular patterns with regular honeycomb patterns vs abnormal vasculature with distorted honeycomb patterns and ectatic/tortuous microvasculature in the rectal mucosa. Normal arterioles and venules < 200 μm in diameter versus abnormal he

关键词： Optical coherence tomography Optical coherence tomography angiography Radiofrequency ablation Chronic radiation proctopathy Rectal telangiectasia density scoring system Subsurface microvascular imaging

Probing turbulence in galaxies with fast radio burst scintillation

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 177-178页

作者： james M.Cordes Department of Astronomy the Cornell Center for Astrophysics and Planetary ScienceCornell UniversityIthaca NY 14853USA

Interstellar scintillation(ISS)is a well-known phenomenon observed from pulsars in the Milky *** comprises intensity variations *** and frequency caused by constructive and destructive interference from multipath propagation,which is due to diffraction from fluctuations in electron density in the interstellar medium(ISM)on scales as small as~100 *** density fluctuations appear to be part of a turbulence process combined with discrete structures in electron density from other astrophysical processes;together these fluctuations extend to scales of pc or larger.

关键词： scales galaxies turbulence

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Continuous live cell imaging of cellulose attachment by microbes under anaerobic and thermophilic conditions using confocal microscopy

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Journal of Environmental Sciences 2013年第5期25卷 849-856页

作者： Zhi-Wu Wang Seung-Hwan Lee james g.Elkins Yongchao Li Scott Hamilton-Brehm Jennifer L.Morrell-Falvey BioEnergy Science Center Biosciences DivisionOak Ridge National LaboratoryOak RidgeTN 37831USA College of Food Agricultural and Environmental SciencesThe Ohio State University1328 Dover RdWoosterOH 44691USA National Institute of Advanced Industrial Science and Technology Biomass Refinery Research CenterHiroshimaJapan Department of Forest Biomaterials Engineering College of Forest and Environmental SciencesKangwon National UniversityChuncheon 200-701Korea

Live cell imaging methods provide important insights into the dynamics of cellular processes that cannot be derived easily from population-averaged *** the bioenergy field,much research is focused on fermentation of cellulosic biomass by thermophilic microbes to produce biofuels;however,little effort is dedicated to the development of imaging tools to monitor this dynamic biological *** is,in part,due to the experimental challenges of imaging cells under both anaerobic and thermophilic *** an imaging system is described that integrates confocal microscopy,a flow cell device,and a lipophilic dye to visualize *** to technical obstacles regarding suitable fluorescent markers,photodamage during imaging,and maintenance of environmental conditions during imaging are *** system was utilized to observe cellulose colonization by Clostridium thermocellum under anaerobic conditions at 60℃.This method enables live cell imaging of bacterial growth under anaerobic and thermophilic conditions and should be widely applicable to visualizing different cell types or processes in real time.

关键词： thermophile lipophilic dye cellulose biofuel confocal laser scanning microscopy biofilm

Exploring the mass gap:Black holes in green pea galaxies

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 170-171页

作者： james E.Rhoads School of Earth and Space Exploration Arizona State UniversityTempeAZ 85287USA

We know about black holes primarily on two mass scales(e.g.,see Figure 22 of ref.[1]).Supermassive black holes inhabit the centers of galaxies,where they sometimes power active galactic nuclei(AgN).Their populations can be probed through AgN surveys,tidal disruption event surveys,and(in the closest galaxies)stellar and gas dynamics in the innermost regions where the black hole dominates the gravitational potential.

关键词： galaxies tidal galactic

Treatment review of sight threatening circumscribed choroidal haemangioma

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 168-171页

作者： james FT Li Yim Teresa Sandinha Jan M Kerr Diana Ritchie Ewan g Kemp Tennent Institute of Ophthalmology GlasgowScotlandUK Beatson Oncology Centre GlasgowScotlandUK

AIMTo describe our clinical experience in treating circumscribed choroidal haemangioma (CCH) in a tertiary referral centre over a fifteen year period prior to photodynamic therapy.

关键词： circumscribed choroidal haemangioma plaque brachytherapy transpupillary thermotherapy

Social Computing Unhinged

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Journal of Social Computing 2020年第1期1卷 1-13页

作者： james Evans University of Chicago ChicagoIL 60637and Santa Fe InstituteSanta FeNM 87501USA.

Social computing is ubiquitous and intensifying in the 21st *** used to reference computational augmentation of social interaction through collaborative filtering,social media,wikis,and crowdsourcing,here I propose to expand the concept to cover the complete dynamic interface between social interaction and computation,including computationally enhanced sociality and social science,socially enhanced computing and computer science,and their increasingly complex combination for mutual *** recommends that we reimagine Computational Social Science as Social Computing,not merely using computational tools to make sense of the contemporary explosion of social data,but also recognizing societies as emergent computers of more or less collective intelligence,innovation and *** further proposes we imagine a socially inspired computer science that takes these insights into account as we build machines not merely to substitute for human cognition,but radically complement *** leads to a vision of social computing as an extreme form of human computer interaction,whereby machines and persons recursively combine to augment one another in generating collective intelligence,enhanced knowledge,and other social goods unattainable without each *** the example of science and technology,I illustrate how progress in each of these areas unleash advances in the others and the beneficial relationship between the technology and science of social computing,which reveals limits of sociality and computation,and stimulates our imagination about how they can reach past those limits together.

关键词： social computing complex systems computer supported cooperative work computational social science artificial intelligence human computer interaction human-centered computing

Inverse Eigenvalue Problems for Exploring the Dynamics of Systems Biology Models

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Advances in Applied Mathematics and Mechanics 2009年第6期1卷 711-728页

作者： james Lu Johann Radon Institute for Computational and Applied Mathematics Austrian Academy of SciencesAltenbergerstrasse 69 Linz 4010Austria

This paper describes inverse eigenvalue problems that arise in studying qualitative dynamics in systems biology *** algorithm based on lift-andproject iterations is proposed,where the lifting step entails solving a constrained matrix inverse eigenvalue *** particular,prior to carrying out the iterative steps,a-priori bounds on the entries of the Jacobian matrix are computed by relying on the reaction network structure as well as the form of the rate law expressions for the model under *** results on a number of models show that the proposed algorithm can be used to computationally explore the possible dynamical scenarios while identifying the important mechanisms via the use of sparsity-promoting regularization.

关键词： Inverse eigenvalue problems dynamical systems bifurcation biology sparsity

LSTM Network-Based Adaptation Approach for Dynamic Integration in Intelligent End-Edge-Cloud Systems

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Tsinghua Science and Technology 2024年第4期29卷 1219-1231页

作者： Xuan Yang james A.Esquivel graduate School Angeles University FoundationAngeles City 2009Philippinesand also with Shandong Provincial University Laboratory for Protected HorticultureWeifang University of Science and TechnologyWeifang 262700China graduate School Angeles University FoundationAngeles City 2009Philippines

Edge computing, which migrates compute-intensive tasks to run on the storage resources of edge devices, efficiently reduces data transmission loss and protects data privacy. However, due to limited computing resources and storage capacity, edge devices fail to support real-time streaming data query and processing. To address this challenge, first, we propose a Long Short-Term Memory (LSTM) network-based adaptive approach in the intelligent end-edge-cloud system. Specifically, we maximize the Quality of Experience (QoE) of users by automatically adapting their resource requirements to the storage capacity of edge devices through an event mechanism. Second, to reduce the uncertainty and non-complete adaption of the edge device towards the user’s requirements, we use the LSTM network to analyze the storage capacity of the edge device in real time. Finally, the storage features of the edge devices are aggregated to the cloud to re-evaluate the comprehensive capability of the edge devices and ensure the fast response of the user devices during the dynamic adaptation matching process. A series of experimental results show that the proposed approach has superior performance compared with traditional centralized and matrix decomposition based approaches.

关键词： quality of experience data query end-edge-cloud Long Short-Term Memory(LSTM)networks

Effect of Hind Leg Morphology on Performance of a Canine-inspired Quadrupedal Robot

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Journal of Bionic Engineering 2015年第3期12卷 339-351页

作者： james Andrew Smith Jamil Jivraj Ryerson University 350 Victoria St. Toronto ON Canada

Biomimetic leg designs often appear to be arbitrarily chosen. To make a more objective choice regarding biomimetic leg configuration for small canine-inspired robots, we compare one hind leg to the same leg arranged in a different orientation, and show that the less biomimetic leg provides better performance. This differently-oriented leg design, which we call ＂transverse-mirrored＂ was more efficient and faster, both in simulation and experiment even though both leg configurations used the same passive and active components, rest angles, and monoartieular knee spring. In experiments the normal configuration had a maximum speed of 0.33 m·s^-1 and a specific resistance of 5.1. Conversely, the less biomimetic transverse-mirrored configuration had a maximum speed of 0.4 m·s^-1 and specific resistance of 3.9. Therefore the transverse-mirrored leg＇s best performance yields a 21% increase in speed and 24% decrease in specific resistance when compared to the best performance achieved in the normal biomimetic leg. The major underlying reason is that the knee spring engages more readily in the transverse-mirrored configuration, resulting in this faster and more efficient locomotion. The conclusion is that simply copying from nature does not lead to optimal performance and that insight into the role played by passive design components on natural locomotory dynamics is important.

关键词： biomimetic legged robot quadruped leg design walking legged locomotion