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Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： K.d.james J.E.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].

关键词： medullary eliminate restricted

Competitive interactions and coexistence of sympatric flagship carnivores in Asia

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Integrative Zoology 2024年第2期19卷 183-199页

作者： Zhilin LI Jiayu LU Xiaoyi SHI Li’an dUO james L.d.SMITH Tianming WANG Tianjin Key Laboratory of Conservation and Utilization of Animal diversity College of Life SciencesTianjin Normal UniversityTianjinChina department of Fisheries Wildlife and Conservation BiologyUniversity of MinnesotaSt.PaulMinnesotaUSA Ministry of Education Key Laboratory for Biodiversity Science and Engineering College of Life SciencesBeijing Normal UniversityBeijingChina National Forestry and Grassland Administration Key Laboratory for Conservation Ecology of Northeast Tiger and Leopard BeijingChina

Understanding the competition and coexistence of flagship carnivores is key to creating strategies for their conservation in the face of global carnivore *** studies exploring the dynamics and competition between tigers(Panthera tigris)and leopards(***)span decades,there is a lack of understanding regarding the factors that influence their coexistence mechanisms on a broad scale,as well as the drivers determining their exploitative and interference *** gathered a comprehensive list of research papers among which 36 papers explored the interspecific interactions between tigers and leopards and tested the influence of biotic and abiotic factors on the coexistence mechanisms along three dimensions using multiple response variables regression models;we also tested the influence of ecological drivers determining the exploitative or interference competition between tigers and *** and ungulate density were the most important predictors in regulating the coexistence *** and leopards exhibited more positive relations/higher overlaps as elevation increased in the spatial *** addition,they showed a higher dietary overlap in the prey-rich *** determined that interference competition between tigers and leopards was less frequently observed in habitats with dense tree cover and homogeneous vegetation ***,studies with multiple metrics would promote the detection of interference *** study provides new insight into the competitive interactions and coexistence mechanisms of tigers and leopards on a broad ***-makers and managers should pay more attention to the factors of elevation,prey abundance,and habitat structures for the conservation of tigers and leopards.

关键词： carnivores coexistence mechanisms competitive interactions exploitative competition interference competition

Functionalization of cellulose carbon dots with different elements(N,B and S)for mercury ion detection and anti-counterfeit applications

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Chinese Chemical Letters 2024年第7期35卷 355-359页

作者： Xiaoning Li Quanyu Shi Meng Li Ningxin Song Yumeng Xiao Huining Xiao Tony d.james Lei Feng Second Affiliated Hospital of dalian Medical University Dalian 116023China Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control Department of Environmental Science and EngineeringNorth China Electric Power UniversityBaoding 071003China department of Chemical Engineering and Limerick Pulp&Paper Centre University of New Brunswick15 Dineen DriveFredericton NB E3B 5A3Canada department of Chemistry University of BathBath BA27AYUnited Kingdom School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Mercury ion(Hg^(2+)),as one of the most toxic heavy metal ions,accumulates easily in the environment,which can generate potential hazards to the ecosystem and human *** effectively detect and remove Hg^(2+),we fabricated four types of carbon dots(Cds)using carboxymethyl nanocellulose as a carbon source doped with different elements using a hydrothermal *** the Cds exhibited a strong fluorescence emission,excitation-dependent emission and possessed good water ***,the four fluorescent Cds were used for Hg^(2+)recognition in aqueous solution,where the Cds-N exhibited better sensitivity and selectivity for Hg^(2+)detection,with a low limit of detection of 8.29×10^(-6)mol/*** was determined that the fluorescence quenching could be ascribed to a photoinduced charge-transfer processes between Hg^(2+)and the *** addition,the Cds-N were used as a smart invisible ink for anticounterfeiting,information encryption and ***,the Cds-N were immersed into a cellulose(CMC)-based hydrogel network to prepare fluorescent hydrogels capable of simultaneously detecting and adsorbing Hg^(2+).We anticipate that this research will open possibilities for a green method to synthesize fluorescent Cds for metal ion detection and fluorescent ink production.

关键词： Carbon dots Functional groups Hg^(2+)detection Mechanism Anti-counterfeiting

Nickel sulfate solution fluoride separation with hydrous zirconium oxide

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Tungsten 2024年第2期6卷 367-381页

作者： Elbert M.Nigri Ummul K.Sultana André L.A.Santos james W.Vaughan Sonia d.F.Rocha department of Mining Engineering Federal University of Minas GeraisBelo Horizonte 31270-901Brazil School of Chemical Engineering University of QueenslandSt Lucia 4072Australia

Fluoride is an impurity in nickel sulfate production,which is required for electric vehicle *** zirconium oxide(HZO)was evaluated for removing fl uoride from nickel sulfate *** fluoride removal occurred at pH value 4 and optimal pH value is 4–5,considering Zr *** availability decreases with pH due to hydrogen fluoride and zirconium fluoride aqueous *** removal is initially rapid,with 50 wt.%removal in 7 min,followed by slow removal up to 68 wt.%after 72 h and follows second order rate *** removal was dominated by an ion exchange mechanism and resulting Zr–F bonds were observed using Fourier-transform infrared *** presence of nickel sulfate decreased loading capacity compared to a salt-free *** maintained adsorption capacity through five cycles of loading and regeneration.

关键词： Hydrous zirconium oxide Nickel sulfate Fluoride Adsorption Anion exchange

A Cover-Independent deep Image Hiding Method Based on domain Attention Mechanism

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Computers, Materials & Continua 2024年第3期78卷 3001-3019页

作者： Nannan Wu Xianyi Chen james Msughter Adeke Junjie Zhao School of Computer and Software Nanjing University of Information Science and TechnologyNanjing210044China School of Electronics and Information Engineering Nanjing University of Information Science and TechnologyNanjing210044China

Recently,deep image-hiding techniques have attracted considerable attention in covert communication and high-capacity information ***,these approaches have some *** example,a cover image lacks self-adaptability,information leakage,or weak *** address these issues,this study proposes a universal and adaptable image-hiding ***,a domain attention mechanism is designed by combining the Atrous convolution,which makes better use of the relationship between the secret image domain and the cover image ***,to improve perceived human similarity,perceptual loss is incorporated into the training *** experimental results are promising,with the proposed method achieving an average pixel discrepancy(APd)of 1.83 and a peak signal-to-noise ratio(PSNR)value of 40.72 dB between the cover and stego images,indicative of its high-quality ***,the structural similarity index measure(SSIM)reaches 0.985 while the learned perceptual image patch similarity(LPIPS)remarkably registers at ***,self-testing and cross-experiments demonstrate the model’s adaptability and generalization in unknown hidden spaces,making it suitable for diverse computer vision tasks.

关键词： deep image hiding attention mechanism privacy protection data security visual quality

Synthesis of carbon nitride in potassium hydroxide molten salt for efficient uranium extraction from radioactive wastewater

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 89-99页

作者： Shuang Liu Junhan Luo daniel-james Maguire Liyuan Zheng Zhe Wang Yuexiang Lu Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Nuclear Research Institute for Future Technology and Policy Seoul National UniversitySeoul 08826Republic of Korea department of Earth Sciences University of CambridgeCambridge CB23EQUK The MOE Key Laboratory of Resources and Environmental System Optimization College of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China

Photocatalysis-assisted removal of uranium has been proven as an effective method for the elimination of radioactive pollution from *** this work,carbon nitride materials were synthesized in potassium hydroxide(KOH)molten salt and applied to photocatalytic uranyl *** materials were confirmed to possess the triazine-s-heptazine structure by NMR,XPS and UV-Vis characterization,and exhibited a wider visible light absorption than graphitic carbon nitride(g-C_(3)N_(4)).The photocatalytic activity of the carbon nitride materials was tailored by varying the precursor mass *** carbon nitride obtained at 80%melamine as precursor(K-CN-80)exhibited the highest photocatalytic extraction ability and its photocatalytic reaction rate is 6.6 times faster than that of g-C_(3)N_(4).The influence of sacrificial agents was studied and the results showed that triethanolamine inhibited U(Ⅵ)photoreduction,but methanol can accelerate U(Ⅵ)photoreduction by consuming photogenerated *** unary KOH molten salt synthesis method has exceptional potential applications in the preparation of carbon nitrides,and the obtained products showed potential in extracting U(Ⅵ)from aqueous solutions for use in nuclear fuel industry and for U(Ⅵ)environmental pollution cleanup.

关键词： Uranium Carbon nitride Molten salt Photocatalysis Radioactive wastewater

Boosting Adversarial Training with Learnable distribution

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Computers, Materials & Continua 2024年第3期78卷 3247-3265页

作者： Kai Chen Jinwei Wang james Msughter Adeke Guangjie Liu Yuewei dai School of Electronics and Information Engineering Nanjing University of Information Science and TechnologyNanjing210044China Key Laboratory of Intelligent Support Technology for Complex Environments Ministry of EducationNanjing210044China School of Computer and Software Nanjing University of Information Science and TechnologyNanjing210044China Nanjing Center for Applied Mathematics Nanjing211135China

In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural *** training is one of the most potent methods to defend against adversarial ***,the difference in the feature space between natural and adversarial examples hinders the accuracy and robustness of the model in adversarial *** paper proposes a learnable distribution adversarial training method,aiming to construct the same distribution for training data utilizing the Gaussian mixture *** distribution centroid is built to classify samples and constrain the distribution of the sample *** natural and adversarial examples are pushed to the same distribution centroid to improve the accuracy and robustness of the *** proposed method generates adversarial examples to close the distribution gap between the natural and adversarial examples through an attack algorithm explicitly designed for adversarial *** algorithm gradually increases the accuracy and robustness of the model by scaling ***,the proposed method outputs the predicted labels and the distance between the sample and the distribution *** distribution characteristics of the samples can be utilized to detect adversarial cases that can potentially evade the model *** effectiveness of the proposed method is demonstrated through comprehensive experiments.

关键词： Adversarial training feature space learnable distribution distribution centroid

Aerosol jet printing of surface acoustic wave microfluidic devices

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Microsystems & Nanoengineering 2024年第1期10卷 231-242页

作者： Joseph Rich Brian Cole Teng Li Brandon Lu Hanyu Fu Brittany N.Smith Jianping Xia Shujie Yang Ruoyu Zhong james L.doherty Kanji Kaneko Hiroaki Suzuki Zhenhua Tian Aaron d.Franklin Tony Jun Huang department of Biomedical Engineering Duke UniversityDurhamNC 27708USA department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA department of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas Lord department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA deptartment of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan department of Chemistry Duke UniversityDurhamNC 27708USA

The addition of surface acoustic wave(SAW)technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes,including high-precision manipulation,versatility,integrability,biocompatibility,contactless nature,and rapid ***,the development of SAW microfluidic devices is limited by complex and time-consuming micro/nanofabrication techniques and access to cleanroom facilities for multistep photolithography and vacuum-based *** simplify the fabrication of SAW microfluidic devices with customizable dimensions and functions,we utilized the additive manufacturing technique of aerosol jet *** successfully fabricated customized SAW microfluidic devices of varying materials,including silver nanowires,graphene,and poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEdOT:PSS).To characterize and compare the acoustic actuation performance of these aerosol jet printed SAW microfluidic devices with their cleanroom-fabricated counterparts,the wave displacements and resonant frequencies of the different fabricated devices were directly measured through scanning laser doppler ***,to exhibit the capability of the aerosol jet printed devices for lab-on-a-chip applications,we successfully conducted acoustic streaming and particle concentration ***,we demonstrated a novel solution-based,direct-write,single-step,cleanroom-free additive manufacturing technique to rapidly develop SAW microfluidic devices that shows viability for applications in the fields of biology,chemistry,engineering,and medicine.

关键词： printing wave fluid

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi james d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell