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The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[^(18)F]fluoro-D-glucose positron emission tomography/computed tomography for non-prostate cancer-related pathology:A single centre retrospective study

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Asian Journal of Urology 2024年第1期11卷 33-41页

作者： Anthony Franklin Troy Gianduzzo Boon Kua David Wong Louise McEwan james walters Rachel Esler Matthew J.Roberts Geoff Coughlina John W.Yaxley Department of Urology The Wesley HospitalBrisbaneQLDAustralia Wesley Medical Research BrisbaneQLDAustralia School of Medicine The University of QueenslandBrisbaneQLDAustralia Department of Radiology Wesley Medical ImagingBrisbaneQLDAustralia Department of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Objective:To review the risk of prostate cancer(PCa)in men with incidentally reported increased intraprostatic uptake at 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography(18F-FDG PET/CT)ordered at Department of Urology,The Wesley Hospital,Brisbane,QLD,Australia for non-PCa related ***:Retrospective analysis of consecutive men between August 2014 and August 2019 presenting to a single institution for 18F-FDG PET/CT for non-prostate related conditions was *** were classified as benign,indeterminate,or malignant depending of the results of prostate-specific antigen(PSA),PSA velocity,biopsy histopathology,and three-Tesla(3 T)multiparametric MRI(mpMRI)Prostate Imaging Reporting and Data System score,or gallium-68-prostate-specific membrane antigen(68Ga-PSMA)PET/CT ***:Three percent(273/9122)of men demonstrated 18F-FDG avidity within the ***-five percent(231/273)were further investigated,including with PSA tests(227/231,98.3%),3 T mpMRI(68/231,29.4%),68Ga-PSMA PET/CT(33/231,14.3%),and prostate biopsy(57/231,24.7%).Results were considered benign in 130/231(56.3%),indeterminate in 31/231(13.4%),and malignant in 70/231(30.3%).PCa was identified in 51/57(89.5%)of the men who proceeded to biopsy,including 26/27(96.3%)men with Prostate Imaging Reporting and Data System scores 4-5 mpMRI and six men with a positive 68Ga-PSMA PET/*** most common Gleason score on biopsy was greater than or equal to 4+5(14/51,27.5%).68Ga-PSMA PET/CT was concordant with the 18F-FDG findings in 26/33(78.8%).All 13 men with a positive concordant 18F-FDG,3 T mpMRI,and 68Ga-PSMA PET/CT had PCa on *** was no statistically significant difference in the 18F-FDG maximum standardized uptake value between the benign or malignant groups(5.7 vs.6.1;p=0.580).Conclusion:In this study,after an incidental finding of an avid intraprostatic lesion on 18F-FDG PET/CT,70 of the 231 cases(30.3%;0.8%of the entire cohort)had results c

关键词： Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy

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Barriers and facilitators to participating in cardiac rehabilitation and physical activity:A cross-sectional survey

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World Journal of Cardiology 2022年第2期14卷 83-95页

作者： Matthew james Fraser Stephen J Leslie Trish Gorely Emma Foster Ronie walters Division of Biomedical Science University of the Highlands and IslandsInverness IV23JHUnited Kingdom Department of Cardiology NHS HighlandInverness IV23UJUnited Kingdom Department of Nursing and Midwifery University of the Highlands and IslandsInverness IV23JHUnited Kingdom Cardiac Unit NHSH NHS HighlandInverness IV23JHUnited Kingdom

BACKGROUND Cardiovascular diseases(CVD)have been shown to be the greatest cause of death worldwide and rates continue to *** is recommended that CVD patients attend cardiac rehabilitation(CR)following a cardiac event to reduce mortality,improve recovery and positively influence behaviour around CVD risk *** the recognised benefits and international recommendations for exercisebased CR,uptake and attendance remain suboptimal.A greater understanding of CR barriers and facilitators is required,not least to inform service *** understanding current cardiac patients’attitudes and opinions around CR and physical activity(PA)could inform patient-led ***,through understanding aspects of CR and PA that participants like/dislike could provide healthcare providers and policy makers with information around what elements to target in the *** To investigate participants’attitudes and opinions around CR and *** This study employed a cross-sectional survey design on 567 cardiac *** patients who were referred for standard CR classes at a hospital in the Scottish Highlands,from May 2016 to May 2017 were *** part of a larger survey,the current study analysed the free-text responses to 5 open-ended questions included within the wider *** were related to the participants’experience of CR,reasons for non-attendance,ideas to increase attendance and their opinions on *** data were analysed using a 6-step,reflexive thematic *** Two main topic areas were explored:“Cardiac rehabilitation experience”and“physical activity”.Self-efficacy was increased as a result of attending CR due to exercising with similar individuals and the safe environment *** ranged from age and health to distance and starting times of the classes which increased travel time and ***,responses demonstrated a lack of information and communication around the *** h

关键词： Cardiovascular disease Cardiac rehabilitation Physical activity Barriers Facilitators Patient experience

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Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis

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Eye and Vision 2018年第1期5卷 260-268页

作者： Liang Wang Ohemaa Kwakyi james Nguyen Esther Ogbuokiri Olwen Murphy Natalia Gonzalez Caldito Laura Balcer Elliot Frohman Teresa Frohman Peter A.Calabresi Shiv Saidha Department of Neurology Johns Hopkins University School of MedicineBaltimoreMDUSA Departments of Neurology Population Health and OphthalmologyNew York University School of MedicineNew YorkNYUSA Departments of Neurology and Ophthalmology University of Texas Austin Dell Medical SchoolAustinTXUSA

Background:The retinal microcirculation has been studied in various diseases including multiple sclerosis(MS).However,inter-eye correlations and potential differences of the retinal blood flow velocity(BFV)remain largely unstudied but may be important in guiding eye selection as well as the design and interpretation of studies assessing or utilizing retinal *** primary aim of this study was to determine inter-eye correlations in BFVs in healthy controls(HCs).Since prior studies raise the possibility of reduced BFV in MS eyes,a secondary aim was to compare retinal BFVs between MS eyes,grouped based on optic neuritis(ON)history and HC ***:Macular arteriole and venule BFVs were determined using a retinal function imager(RFI)in both eyes of 20 *** eye from a total of 38 MS patients comprising 13 eyes with ON(MSON)and 25 eyes without ON(MSNON)history were similarly imaged with ***:OD(right)and OS(left)BFVs were not significantly different in arterioles(OD:3.95±0.59 mm/s;OS:4.08±0.60 mm/s,P=0.10)or venules(OD:3.11±0.46 mm/s;OS:3.23±0.52 mm/s,P=0.06)in *** strong inter-eye correlations were also found between arteriolar(r=0.84,P<0.001)and venular(r=0.87,P<0.001)BFVs in ***(3.48±0.88 mm/s)and venular(2.75±0.53 mm/s)BFVs in MSNON eyes were significantly lower than in HC eyes(P=0.009 and P=0.005,respectively).Similarly,arteriolar(3.59±0.69 mm/s)and venular(2.80±0.45 mm/s)BFVs in MSON eyes were also significantly lower than in HC eyes(P=0.046 and P=0.048,respectively).Arteriolar and venular BFVs in MSON and MSNON eyes did not differ from each other(P=0.42 and P=0.48,respectively).Conclusions:Inter-eye arteriolar and venular BFVs do not differ significantly in HCs and are strongly *** findings support prior observations that arteriolar and venular BFVs may be reduced in MS ***,this seems to be the case in both MS eyes with and without a history of ON,raising the possibility of global blood flow alterations in ***

关键词： Inter-eye correlation Blood flow velocity Retinal function imager Neurology Multiple sclerosis Optic neuropathy

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温哥华公寓

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城市环境设计 2019年第2期118卷 210-219页

作者： Carl McDonald Melissa Bauld Aaron Mark Alan Tansey Alex Wu Alexandra Gustafsson Alina Tamosiunaite Amina Blacksher Aran Coakley Arash Adel Ahmadian Armen Menendian Barbora Srpkova Ben Zunkeler Benjamin Caldwell Benjamin Novacinski Bennett Gale Birk Daugaard Blake Theodore Smith Brian Foster Brian Rome Carolien Schippers Christopher james Malcolm Jr. Christopher Junkin Christopher Tron David Brown David Dottelonde Deborah Campbell Doug Stechschulte Douglass Alligood Edward Yung Elena Bresciani Filip Milovanovic Francesca Portesine Gabriel Hernandez Solano Gabriel Jewell-Vitale Hector Garcia Ivy Hume Jan Leenknegt Janice Rim John Kim Josiah Poland Julian Liang Julianne Gola Julie Kaufman Karol Bogdan Borkowski Kurt Nieminen Lauren Turner Lorenz Krisai Lucio Santos Marcella Martinez Martin Voelkle Matthew Dlugosz Megan Ng Michael Robert Taylor Otilia Pupezeanu Paula Domka Phillip MacDougall Ryan Yang Sean Franklin Sebastian Grogaard Simon Scheller Spencer Hayden Taylor Fulton Terrence Chew Terry Lallak Thomas Smith Tianqi Zhang Tobias Hjortdal Tran Le Valentina Mele Xinyu Wang Yaziel Juarbe Yoanna Shivarova Zach walters Zhifei Xu Andrew Latreille Glotman Simpson Urban YVR 运小红

温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的"温哥华主义"建筑的全新解读,配合一座纤细的塔楼,试图保留城... 详细信息

温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的"温哥华主义"建筑的全新解读,配合一座纤细的塔楼,试图保留城市视觉通廊并激活步行通道。住宅塔楼借助高度和毗邻河流的地理位置,是唯一可以同时享受水景和山景的建筑,坐拥温哥华广袤的自然风光。

关键词：温哥华平面图 Dialog 立面图

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