检索结果-南通市图书馆

疯狂英语（初中天地） 2009年第5期 46-48页

作者： james owen 宁波

小时候，当你下意识地使用左手时，是否遭到母亲或其他家人的极力制止？在某些人眼中．左撇子意味着异于常人、低人一等。其实不然，是时候为左利人群＂一雪前耻＂了--科学证实，左利也有很多好处哦……

关键词：进化下意识左撇子人群

在线全文

学校读者我要写书评

暂无评论

惊现比人还要大的巨型海蝎

英语沙龙（高中） 2008年第2期 6-8页

作者： james owen 小柯

英、德两国科研人员近日在一份化石研究报告中指出,他们发现一个远古海蝎子的巨爪化石。据推断,其肢体长度达到2.5米,比人类还大,是有史以来所发现的体型最大的节肢动物标本。

关键词：节肢动物化石记录新发现鱼类捕食科学家远古动物标本最大肢体长

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

乘火车游走新西兰南岛

疯狂英语（阅读版） 2011年第8期 33-37页

作者： james owen Sunset（译）

在皮克顿火车站候车——整洁的白：色木结构和红砖建筑，让人想起这样的陈词老调：在新西兰旅行，就像置身于五十年代的英国。列车停在唯一的站台边，车门上是老式的把手。排队买票的当地人都一副出席隆重场合的样子。然而我很惊奇地得... 详细信息

在皮克顿火车站候车——整洁的白：色木结构和红砖建筑，让人想起这样的陈词老调：在新西兰旅行，就像置身于五十年代的英国。列车停在唯一的站台边，车门上是老式的把手。排队买票的当地人都一副出席隆重场合的样子。然而我很惊奇地得知，这种感觉不是来自怀旧，而是源于新奇。

关键词：新西兰火车站五十年代木结构红砖

computed tomography and patient risk:Facts,perceptions and uncertainties

在线全文

学校读者我要写书评

暂无评论

World Journal of Radiology 2016年第12期8卷 902-915页

作者： Stephen P Power Fiachra Moloney Maria Twomey Karl james owen J O'connor Michael M Maher Department of Radiology Cork University Hospital

Since its introduction in the 1970s, computed tomography(cT) has revolutionized diagnostic decision-making. One of the major concerns associated with the widespread use of cT is the associated increased radiation exposure incurred by patients. The link between ionizing radiation and the subsequent development of neoplasia has been largely based on extrapolating data from studies of survivors of the atomic bombs dropped in Japan in 1945 and on assessments of the increased relative risk of neoplasia in those occupationally exposed to radiation within the nuclear industry. However, the association between exposure to low-dose radiation from diagnostic imaging examinations and oncogenesis remains unclear. With improved technology, significant advances have already been achieved with regards to radiation dose reduction. There are several dose optimization strategies available that may be readily employed including omitting unnecessary images at the ends of acquired series, minimizing the number of phases acquired, and the use of automated exposure control as opposed to fixed tube current techniques. In addition, new image reconstruction techniques that reduce radiation dose have been developed in recent years with promising results. These techniques use iterative reconstruction algorithms to attain diagnostic quality images with reduced image noise at lower radiation doses.

关键词： computed tomography Radiation dose Iterative reconstruction Neoplasia carcinogenesis

Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第12期11卷 3836-3846页

作者： Melissa M.clemens Stefanie Kennon-McGill Joel H.Vazquez owen W.Stephens Erich A.Peterson Donald J.Johann Felicia D.Allard Eric U.Yee Sandra SMccullough Laura P.james Brian N.Finck Mitchell R.McGill Department of Pharmacology and Toxicology College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Interdisciplinary Graduate Program in Biomedical Sciences Graduate SchoolUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Environmental and Occupational Health Fay W.Boozman College of Public HealthUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Winthrop P.Rockefeller cancer Institute University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of Pediatrics College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR2205USA Division of Geriatrics and Nutritional Sciences Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63110USA center for Dietary Supplement Research University of Arkansas for Medical SciencesLittle RockAR 72205USA

We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regeneration after acetaminophen(APAP)***,we hypothesized that exogenous PA is also *** test that,we treated mice with a toxic APAP dose at 0 h,followed by PA or vehicle(Veh)*** then collected blood and liver at 6,24,and 52 ***-treatment with PA 2 h after APAP protected against liver injury at 6 h,and the combination of PA and N-acetyl-L-cysteine(NAc)reduced injury more than NAc ***,PA did not affect canonical mechanisms of APAP ***,transcriptomics revealed that PA activated interleukin-6(IL-6)signaling in the *** with that,serum IL-6 and hepatic signal transducer and activator of transcription 3(Stat3)phosphorylation increased in PA-treated ***,PA failed to protect against APAP in IL-6-deficient ***,IL-6 expression increased 18-fold in adipose tissue after PA,indicating that adipose is a source of PA-induced circulating ***,however,exogenous PA did not alter regeneration,despite the importance of endogenous PA in liver repair,possibly due to its short *** data demonstrate that exogenous PA is also beneficial in APAP toxicity and reinforce the protective effects of IL-6 in this model.

关键词： Acute liver injury Acute liver failure Adipokine cytokine Dietary supplement Drug-induced liver injury Hepatotoxicity Lipid

在线全文

学校读者我要写书评

暂无评论

2007年诺贝尔和平奖

大学英语 2007年第12期 10-11页

作者： james owen 顾晓栋

威诺贝尔奖委员会宣布：AL·戈尔与政府间气候变化专业委员会（IPcc）因其宣传、认知人类引发的全球气候变暖方面的成就，平分2007年诺贝尔和平奖。

关键词：诺贝尔和平奖专业委员会全球气候变暖气候变化诺贝尔奖政府间

Inactivation of Mitochondrial complex Ⅰ Induces the Expression of a Twin cysteine Protein that Targets and Affects cytosolic, chloroplastidic and Mitochondrial Function

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2016年第5期9卷 696-710页

作者： Yan Wang Wenhui Lyu Oliver Berkowitz Jordan D. Radomiljac Simon R. Law Monika W. Murcha chris carrie Pedro F. Teixeira Beata Kmiec owen Duncan Olivier Van Aken Reena Narsai Elzbieta Glaser Shaobai Huang Ute Roessner A. Harvey Millar james Whelan Department of Animal Plant and Soil Science Australian Research Council Centre of Excellence in Plant Energy Biology School of Life Science La Trobe University Bundoora VIC 3086 Australia Ume(a)Plant Science centre(UPSc) Faculty of Science and Technology Ume(a)University Ume(a) Sweden Australian Research council centre of Excellence in Plant Energy Biology University of Western Australia 35 Stirling Highway Crawley WA 6009 Australia Department of Biology I Botany Ludwig-Maximilians-Universitat Munchen Groβhaderner Strasse 2-4 82152 Planegg-Martinsried Germany Department of Biochemistry and Biophysics Stockholm University Atrhenius Laboratories for Natural Sciences 10691 Stockholm Sweden School of BioSciences The University of Melbourne Melbourne VIC 3010 Australia

At12cys-1 （At5g64400） and At12cys-2 （At5g09570） are two closely related isogenes that encode small, twin cysteine proteins, typically located in mitochondria. At12cys-2 transcript is induced in a variety of mutants with disrupted mitochondrial proteins, but an increase in At12cys protein is only detected in mutants with reduced mitochondrial complex I abundance. Induction of At12cys protein in mutants that lack mitochondrial complex I is accompanied by At12cys protein located in mitochondria, chloroplasts, and the cytosoh Biochemical analyses revealed that even single gene deletions, i.e., At12cys-1 orAtl2cys-2, have an effect on mitochondrial and chloroplast functions. However, only double mutants, i.e., At12cys-1：At12cys.2, affect the abundance of protein and mRNA transcripts encoding translation elongation factors as well as rRNA abundance. Blue native PAGE showed that At12cys co-migrated with mitochondrial supercomplex I ＋ lU. Likewise, deletion of both At12cys-1 and At12cys-2 genes, but not single gene deletions, results in enhanced tolerance to drought and light stress and increased anti-oxidant capacity. The induction and multiple localization of At12cys upon a reduction in complex I abundance provides a mechanism to specifically signal mitochondrial dysfunction to the cytosol and then beyond to other organelles in the cell.

关键词： mitochondria complex I retrograde signaling chloroplast cytosol

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

奇妙邂逅最佳野生动物照片

英语教师 2007年第1期7卷 24-25页

作者： james owen 贾庆文

动物世界总是带给我们许多未知与神秘,而几位摄影家带给我们的图片则新颖而有趣。青年摄影家奖:"进退维谷"17岁的小虫狂热者里克·斯坦利正与一群博物学者在多米尼加共和国的热带雨林中探险,这时他和朋友听到头顶上传来一声尖叫。抬头... 详细信息

动物世界总是带给我们许多未知与神秘,而几位摄影家带给我们的图片则新颖而有趣。青年摄影家奖:"进退维谷"17岁的小虫狂热者里克·斯坦利正与一群博物学者在多米尼加共和国的热带雨林中探险,这时他和朋友听到头顶上传来一声尖叫。抬头一看。

关键词：野生动物热带雨林摄影家动物世界博物学照片英语教师双语阅读海象图片

Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”

在线全文

学校读者我要写书评

暂无评论

Bone Research 2019年第3期7卷 225-242页

作者： Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya james D. Brodell Jr. charles c. Lee Stephanie P. Hao Irvin Oh chao Xie Hani A. Awad John L. Daiss John R. owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA Department of Biomedical Engineering University of Rochester Medical Center Rochester NY USA Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA Department of Orthopaedics University of Rochester Medical Center Rochester NY USA Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY USA Department of Orthopaedic Surgery Kyoto University Kyoto Japan Department of Orthopaedic Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLcN) of cortical bone. In contrast, *** intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure.

关键词： disease caused by soft tissue necrotic tissuel

在线全文

学校读者我要写书评

暂无评论

对冲之王