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Papillary thyroid cancer and inflammatory bowel disease:Is there a relationship?

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World Journal of Gastroenterology 2013年第7期19卷 1079-1084页

作者： Irene S Sonu Wojciech Blonski ming Valerie Lin james Lewis Faten Aberra Gary R Lichtenstein Division of Internal Medicine Stanford University Hospital and ClinicsStanfordCA 94305United States Division of Internal Medicine UHS Wilson Medical CenterJohnson CityNY 13790United States Division of Digestive Diseases University of CincinnatiCincinnatiOH 45229United States Division of Gastroenterology Hospital of the University of PennsylvaniaUniversity of Pennsylvania School of MedicinePhiladelphiaPA 19103United States

AIM:To formally study age of diagnosis of papillary thyroid cancer(PTC) in inflammatory bowel disease(IBD) patients and evaluate the prevalence of PTC in IBD patients compared to a control *** that patients with IBD are more likely to be diagnosed with PTC than a control population.A retrospective cohort analysis was performed using the University of Pennsylvania Health System's electronic *** from 1998-2009 were included in the search,and patients in the cohort were selected based on ICD-9 *** criteria included the diagnosis of Crohn's disease(CD) or ulcerative colitis(UC) and the concurrent diagnosis of thyroid cancer in comparison to a control *** these methods 912 patients with CD and 1774 with UC were compared to 1638 diverticulitis and 19 447 asthma *** were performed using corrected chisquare *** primary outcome for this study was the diagnosis of *** to conduct this study was obtained by the Institutional Review Board at the University of ***:The mean age was 47.5 years(range:18-102 years) and 66% patients were *** analysis of variance model was used to compare the age of PTC diagnosis between the CD,UC,asthma and diverticulitis groups,and a statistically significant difference in age at PTC diagnosis was noted across all groups(F = 6.35,df = 3,P = 0.0006).The age of PTC diagnosis in CD patients was statistically significantly lower than UC,asthma,and diverticulitis patients(average PTC diagnosis age for CD 25,UC 49,asthma 45,diverticulitis 63).After covarying for sex and age in 2009,the difference in age at PTC diagnosis remained statistically significant(F = 4.13,df = 3,P = 0.0089).A total of 86 patients were diagnosed with *** patients(0.5%) with UC were diagnosed with *** with UC were not shown to be more likely to develop PTC [odds ratio(OR):1.544,95%CI 0.767-3.108] compared to asthma *** patients(0.4%) with CD were

关键词： Papillary thyroid cancer Inflammatory bowel disease Crohn disease Ulcerative colitis

Origin of the Oligocene Tuolangla porphyry-skarn Cu-W-Mo deposit in Lhasa terrane,southern Tibet

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China Geology 2020年第3期3卷 369-384页

作者： Yong Huang ming-hua Ren Wei Liang Guang-ming Li Kelly Heilbronn Zuo-wen Dai Yi-yun Wang Li Zhang Chengdu Center China Geological SurveyMinistry of Natural ResourcesChengdu 610081China Department of Geoscience University of NevadaLas VegasNV 89154-4010USA Economic Geology Research Center James Cook UniversityTownsville 4811Australia College of Earth Sciences Chengdu University of TechnologyChengdu 610059China

Although some porphyry-skarn deposits occur in post-collisional extensional settings,the post-collisional deposits remain poorly *** the authors describe the igneous geology,and mineralization history of Tuolangla,a newly-discovered porphyry-skarn Cu-W-Mo deposit in southern Tibet that belongs to the post-collisional *** deposit is associated with Lower Cretaceous Bima *** was intruded by granodiorite porphyry intrusions at about 23.1 *** investigation indicated that mineralization is spatially and temporally associated with granodiorite *** yielded a Re-Os weighted mean age of 23.5±0.3 Ma and is considered to represent the age of skarn mineralization at the ***δ^34S values of sulfides,concentrated in a range between 0.6‰to 3.4‰,show that the sulfur has a homogeneous source with characteristics of magmatic *** Pb isotopic compositions of sulfides indicate that ore-forming metal materials were derived from the mantle and ancient *** granodiorite porphyry displays high SiO2(68.78%–69.75%)and K2O(3.40%–3.56%)contents,and relatively lower Cr(2.4×10^-6–4.09×10^-6),Ni(2.79×10^-6–3.58×10^-6)contents,and positiveεHf(t)values(7.7–12.9)indicating that the mineralization porphyry was derived from the partial melting of juvenile lower *** Tuolangla deposit is located in the central part of Zedang *** terrane was once considered an ancient *** terrane is in tectonic contact with Cretaceous ophiolitic rocks to its south and Mesozoic continental margin arc volcanics and intrusions of the Gangdese batholith of the Lhasa terrane to its ***,the authors proposed that the Oligocene porphyry skarn Cu-W-Mo mineralization is probably associated with the Zedang *** finding may clarify why the Oligocene(about 23 Ma)deposits are found only in the Zedang area and why mineralization types of the Oligocene mineralization are considerably different from those of the Miocene(17–14 Ma)mine

关键词： Porphyry skarn type Cu-W-Mo deposit Geochronology Re-Os isotopic age Zircon U-Pb isotopic age Tuolangla Gangdese belt Tibet China

Speciation with gene flow via cycles of isolation and migration:insights from multiple mangrove taxa

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National Science Review 2019年第2期6卷 275-288页

作者： Ziwen He Xinnian Li ming Yang Xinfeng Wang Cairong Zhong Norman C.Duke Chung-I Wu Suhua Shi State Key Laboratory of Biocontrol Guangdong Key Lab of Plant Resources Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education InstitutesSchool of Life Sciences Sun Yat-Sen University Department of Ecology and Evolution University of Chicago CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences Hainan Dongzhai Harbor National Nature Reserve Administration Centre for Tropical Water and Aquatic Ecosystem Research James Cook University

Allopatric speciation requiring an unbroken period of geographical isolation has been the standard model of neo-Darwinism. While doubts have been repeatedly raised, strict allopatry without any gene flow remains a plausible mechanism in most cases. To rigorously reject strict allopatry, genomic sequences superimposed on the geological records of a well-delineated geographical barrier are necessary. The Strait of Malacca,narrowly connecting the Pacific and Indian Ocean coasts, serves at different times either as a geographical barrier or a conduit of gene flow for coastal/marine species. We surveyed 1700 plants from 29 populations of 5 common mangrove species by large-scale DNA sequencing and added several whole-genome assemblies. Speciation between the two oceans is driven by cycles of isolation and gene flow due to the fluctuations in sea level leading to the opening/closing of the Strait to ocean currents. Because the time required for speciation in mangroves is longer than the isolation phases, speciation in these mangroves has proceeded through many cycles of mixing-isolation-mixing, or MIM, cycles. The MIM mechanism, by relaxing the condition of no gene flow, can promote speciation in many more geographical features than strict allopatry can. Finally, the MIM mechanism of speciation is also efficient, potentially yielding mn(m > 1) species after n cycles.

关键词： speciation gene flow allopatry geographical isolation mangrove

Optical Design for Fingerprint Identification with Asymmetrical Aspheric Lens

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Optical Design for Fingerprint Identification with Asymmetri...

S4B-4 A Novel Allosteric Phosphodiesterase 4D Inhibitor BPN14770 Reverses Cognitive Impairment in Humanized PDE4D Mice

2007亚洲显示国际会议

作者： Han-Chung Hsu Hsiao-Fang Lin Lea-ming Lu james T.Wang Institute of Opto-Mechatronics Engineering National Central University.Jhongli TaiwanChina Department of Mechanical Engineering National Central University.Jhongli TaiwanChina Pou Yuen Technology 3C Product Pou Chen GroupChang HwaTaiwanChina

The optical design of optical prism with aspheric lens for fingerprint identification is *** propose a new structure for optical prism of fingerprint identification,which has an asymmetrical aspheric lens on the output *** is numerically shown under point approximate model that the optical properties of such prism are better than one of optical prism with aspheric *** the fingerprint range is 16(2)mm,the results show that the image contrast of our proposed prism is above 0.5 and the minimum image contrast for optical prism with aspheric lens is only 0.2.

关键词： Aspheric Lens Fingerprint Identification Asymmetrical Aspheric Lens Point Approximate Model Image Contrast

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神经药理学报 2018年第4期8卷 73-74页

作者： XU Ying ZHAng Chong YAng ming-xin ZHAng Han-Ting Mark Gurney james M.O’Donnell Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical SciencesUniversity at BuffaloState University of New YorkBuffaloNY14214USA Departments of Behavioral Medicine&Psychiatry and Physiology Pharmacology&NeuroscienceRockefeller Neurosciences InstituteWest Virginia University Health Sciences CenterMorgantownWV 26506USA Tetra Discovery Partners Inc. Grand RapidsMI 49503USA

Classical inhibitors of PDE4 lack subtype selectivity due to exact amino acid sequence conservation of the catalytic site,and consequently,development of these drugs has stalled due to dose-limiting side effects of nausea and *** use of subtype-selective inhibitors(i.e.,for PDE4A,B,or D)could overcome this issue,conservation of the catalytic region,to which classical inhibitors bind,limits this *** present study examined the effects of BPN14770,an allosteric inhibitor of PDE4D,which binds to a primate-specific,N-terminal region,conferring greater than 260-fold selectivity for ***14770 was 100-fold more potent for improving memory and cognition in humanized PDE4D(hPDE4D)mice,which expressed the primate-specific binding sequence,compared to wild-type mice;meanwhile,it exhibited low potency in a mouse surrogate model for *** behavioral and matching neurochemical data presented established a relationship between PDE4D target engagement and effects on cognition for ***,BPN14770 reversed memory and cognitive deficits induced byβ-amyloid peptide 1-42(Aβ42)in Morris water maze,Y maze and novel object recognition tests in the humanized PDE4D *** morphological analyses suggested that the number of dendrites and the dendritic length in the CA1 of hippocampus were significantly increased after the Aβ42-treated hPDE4D mice were administered of BPN14770 for two *** neurochemical and molecular biological assays suggested that neuroplasticity-related proteins and neurotrophic factor BDNF in the hippocampus of hPDE4D mice were significantly increased after the hPDE4D mice were treated with *** findings suggest clinical potential for PDE4D selective inhibitors in disorders with cognitive deficits such as Alzheimer’s disease,which affects approximately 20 million people worldwide and nearly 5 million people in the United States.

关键词： humanized PDE4D(hPDE4D)mice byβ-amyloid peptide 1-42

From molecules to networks 2nd ed.

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Malaria epidemiology and interventions in Ethiopia from 2001 to 2016

丛书名：科爱传播生命科学Ake ai chuan bo sheng ming ke xuee导读版

2010年

作者： Byrne John H. Roberts james Lewis

Includes bibliographical references and index.

ISBN: (纸本)9787030273932

Includes bibliographical references and index.

关键词： Molecular neurobiology. Cytology. Neurons.

来源：畅想之星图书光盘版（南... 评论

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Infectious Diseases of Poverty 2018年第1期7卷 1092-1100页

作者： Hiwot S Taffese Elizabeth Hemming-Schroeder Cristian Koepfli Gezahegn Tesfaye ming-chieh Lee james Kazura Gui-Yun Yan Guo-Fa Zhou National Malaria Program Federal Ministry of HealthAddis AbabaEthiopia Program in Public Health University of CaliforniaIrvineCA 92697USA Center for Global Health and Diseases Case Western Reserve UniversityClevelandOHUSA

Background:Ethiopia is one of the African countries where Plasmodium falciparum and *** *** and evaluation of current malaria transmission status is an important component of malaria control as it is a measure of the success of ongoing interventions and guides the planning of future control and elimination *** text:We evaluated changes in malaria control policy in Ethiopia,and reviewed dynamics of country-wide confirmed and clinical malaria cases by Plasmodium species and reported deaths for all ages and less than five years from 2001 to *** level annual parasite incidence was analysed to characterize the malaria transmission stratification as implemented by the Ministry of *** found that Ethiopia has experienced major changes from 2003 to 2005 and subsequent adjustment in malaria diagnosis,treatment and vector control *** interventions have been intensified represented by the increased insecticide treated net(ITN)and indoor residual spraying(IRS)coverage,improved health services and improved malaria ***,countrywide ITN and IRS coverages were low,with 64%ITN coverage in 2016 and IRS coverage of 92.5%in 2016 and only implemented in epidemic-prone areas of>2500 m *** malaria incidence rate dropped from an average of 43.1 cases per 1000 population annually between 2001 and 2010 to 29.0 cases per 1000 population annually between 2011 and *** deaths decreased from 2.1 deaths per 100000 people annually between 2001 and 2010 to 1.1 deaths per 100000 people annually between 2011 to *** was shrinkage in the malaria transmission map and high transmission is limited mainly to the western international border *** of *** malaria remained nearly unchanged from 2000 to 2016 indicating further efforts are needed to suppress ***:Malaria morbidity and mortality have been significantly reduced in Ethiopia since 2001,however,malaria case incide

关键词： Malaria control Policy Ethiopia Plasmodium falciparum Plasmodium vivax Epidemiology Incidence Spatial distribution

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禽流感基因疫苗的研制

中华生物医学工程杂志 2007年第3期13卷 190-192页

作者： Soumitra Roy ming Wang james M Wilson 19104 美国费城宾夕法尼亚大学基因治疗研究组广州疾病预防与控制中心中山大学疫苗研究所

流感病毒属于正粘病毒科，是一种带衣壳的负链单股RNA病毒。甲乙两型流感病毒为该病毒分科之下的两个属，是人类流感的相关致病原。当前应用的流感疫苗所含成分就是处于流行期间的甲乙型流感病毒的灭活株或减毒株。

关键词：禽流感基因疫苗流感病毒结构

青石棉诱导BEAS-2B细胞ERK1/2磷酸化表达的研究

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中华劳动卫生职业病杂志 2006年第10期24卷 597-600页

作者：王新朝吴逸明 james M.Samet Andrew J.Ghio 郑州大学公共卫生学院劳动卫生学与卫生毒理学教研室 450052 US Environmental Protection Agency Research Triangle Park

目的了解青石棉在致癌过程中引起信号转导蛋白变化的特点。方法使用人呼吸道上皮细胞株(human bronchial epithelial cell line,BEAS-2B)体外培养,以终浓度100μg/ml的青石棉和100 nmol/L表皮生长因子(epidermal growth factor,EGF)分... 详细信息

目的了解青石棉在致癌过程中引起信号转导蛋白变化的特点。方法使用人呼吸道上皮细胞株(human bronchial epithelial cell line,BEAS-2B)体外培养,以终浓度100μg/ml的青石棉和100 nmol/L表皮生长因子(epidermal growth factor,EGF)分别刺激BEAS-2B细胞30和120min,使用特异性抗磷酸化细胞外调节蛋白激酶(extracellular regulated protein kinase,ERK1/2)、ERK激酶(ERK kinase,MEK1/2)和抗总ERK1/2、MEK1/2抗体进行Western免疫印迹,检测相应的蛋白表达水平。结果青石棉刺激BEAS-2B细胞30min后,可诱导磷酸化ERK1/2的快速高表达,且此高表达可持续至120min,与对照组比较,差异有统计学意义(P＜0．05)；EGF作为诱导磷酸化ERK1/2的阳性刺激物,在30和120min两时段内均可诱导ERK1/2的激活,与对照组比较,差异有统计学意义(P＜0．05)；任何时间段刺激BEAS-2B,在对照、青石棉和EGF组间,总ERK1/2表达差异无统计学意义(P＞0．05)。青石棉刺激BEAS-2B细胞30、120min后,可诱导磷酸化MEK1/2的快速高表达,与对照组比较,差异有统计学意义(P＜0．05)。结论青石棉可快速诱导BEAS细胞产生磷酸化ERK1/2、MEK1/2蛋白的高表达,提示MAPKs参与了青石棉所致疾病的过程。

关键词：青石棉人呼吸道上皮细胞 ERK1/2 MEK1/2