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Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing Zhou Mei-Ying Zhang Ai-Ai Gao Cheng Zhu Tao He james G Herman ming-Zhou Guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND Targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detailed mechanism is *** To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** To reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ED)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both Png,alcohol consumption,TNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways,while inhibiting the ATM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

Surgical intervention combined with weight-bearing walking training promotes recovery in patients with chronic spinal cord injury:a randomized controlled study

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Neural Regeneration Research 2024年第12期19卷 2773-2784页

作者： Hui Zhu james D.Guest Sarah Dunlop Jia-Xin Xie Sujuan Gao Zhuojing Luo Joe E.Springer Wutian Wu Wise Young Wai Sang Poon Song Liu Hongkun Gao Tao Yu Dianchun Wang Libing Zhou Shengping Wu Lei Zhong Fang Niu Xiaomei Wang Yansheng Liu Kwok-Fai So Xiao-ming Xu Kunming Tongren Hospital KunmingYunnan ProvinceChina Neurological Surgery and the Miami Project to Cure ParalysisMiller School of MedicineUniversity of MiamiMiamiFLUSA School of Biological Sciences The University of Western AustraliaPerthWAAustralia Minderoo Foundation PerthWAAustralia Clinical Center for Spinal Cord Injury Kunming General Hospital of Chengdu Military CommandKunmingYunnan ProvinceChina Department of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisINUSA Department of Orthopedic Spinal Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Spinal Cord and Brain Injury Research Center Department of Physical Medicine and RehabilitationUniversity of Kentucky College of MedicineLexingtonKYUSA Guangdong-HongKong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina W.M.Keck Center for Collaborative Neuroscience Rutgers UniversityPiscatawayNJUSA Neurosurgery Department Chinese University of Hong KongPrince of Wales HospitalHong Kong Special Administration RegionChina Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA

For patients with chronic spinal cord injury,the co nventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection,pressure sores,osteoporosis,and deep vein *** is rarely perfo rmed on spinal co rd injury in the chronic phase,and few treatments have been proven effective in chronic spinal cord injury *** of effective therapies fo r chronic spinal co rd injury patients is *** conducted a randomized controlled clinical trial in patients with chronic complete thoracic spinal co rd injury to compare intensive rehabilitation(weight-bearing walking training)alone with surgical intervention plus intensive *** clinical trial was registered at ***(NCT02663310).The goal of surgical intervention was spinal cord detethering,restoration of cerebrospinal fluid flow,and elimination of residual spinal cord *** found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of American Spinal Injury Association Impairment Scale improvement,reduced spasticity,and more rapid bowel and bladder functional recovery than weight-bearing walking training ***,the surgical procedures and intensive rehabilitation were *** Spinal Injury Association Impairment Scale improvement was more common in T7-T11 injuries than in T2-T6 *** combined with rehabilitation appears to have a role in treatment of chronic spinal cord injury patients.

关键词： chronic spinal cord injury intensive rehabilitation locomotor training neurological recovery surgical intervention weightbearing walking training

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Effects of biochar on soil water retention curves of compacted clay during wetting and drying

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Biochar 2022年第1期4卷 1117-1130页

作者： james Tsz Fung Wong Ka Lai Chow Xun Wen Chen Charles Wang Wai ng ming Hung Wong Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongSARChina Department of Geography Hong Kong Baptist UniversityKowloon TongHong KongSARChina Consortium on Health EnvironmentEducation and Research(CHEER)Department of Science and Environmental StudiesThe Education University of Hong KongTai PoHong KongSARChina Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China State Environmental Protection Key Laboratory of Integrated Surface Water Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Compacted clay possesses a low water permeability and has been widely used in geo-environmental facilities such as landfill cover *** studies revealed the potential applications of compacted biochar-amended clay(BAC)as an alternative landfill cover ***,the effects of biochar on the soil water retention curves(SWRCs)of clay at low suction are not *** study can help fill this knowledge gap by measuring the wetting and drying SWRCs of clay and BAC(20%biochar).Soils were compacted in instrumented soil columns and subjected to a wetting and drying cycle,and soil water content and suction were measured along with the soil *** was saturated faster when compared with *** drying,the soil water content of clay at 65 mm depth dropped to almost zero,while about 5%of water was retained in *** showed that biochar increased the soil water retention capacity of compacted clay upon *** showed that biochar-clay composite possesses a higher soil water retention capacity at a low soil suction range(ng compacted biochar-clay composite as a hydraulic barrier to minimize desiccation-induced cracks and potentially promote its serviceability,especially in arid and semi-arid *** composite is also a carbon sink material that can reduce landfill gas emissions and pollutant leaching.

关键词： Soil amendment Biochar-clay composite Soil carbon Soil suction Soil depth

Bibliometrics analysis based on the Web of Science:Current trends and perspective of gastric organoid during 2010-2023

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World Journal of Gastroenterology 2024年第8期30卷 969-983页

作者： Kai-Lin Jiang Yue-Bo Jia Xue-Jiao Liu Qing-Ling Jia Li-Kun Guo Xiang-Xiang Wang Ke-ming Yang Chen-Heng Wu Bei-Bei Liang Jiang-Hong Ling Department of Gastroenterology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200021China Laboratory of Cancer Biology University of OxfordOxford OX37DQUnited Kingdom School of Traditional Chinese Medicine Shanghai University of Chinese MedicineShanghai 200021China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China

BACKGROUND Three-dimensional organoid culture systems have been established as a robust tool for elucidating mechanisms and performing drug efficacy *** use of gastric organoid models holds significant promise for advancing personalized medicine ***,a comprehensive bibliometric review of this burgeoning field has not yet been *** To analyze and understand the development,impact,and direction of gastric organoid research using bibliometric methods using data from the Web of Science Core Collection(WoSCC)*** This analysis encompassed literature pertaining to gastric organoids published between 2010 and 2023,as indexed in the *** and VOSviewer were used to depict network maps illustrating collaborations among authors,institutions and keywords related to gastric ***,co-citation,and burst analysis methodologies were applied to assess the impact and progress of *** A total of 656 relevant studies were *** majority of research was published in gastroenterology-focused ***,Yana Zavros,Hans Clevers,james M Wells,Sina Bartfeld,and Chen Zheng were the 5 most productive authors,while Hans Clevers,Huch Meritxell,Johan H van Es,Marc Van de Wetering,and Sato Toshiro were the foremost influential scientists in this *** from the University Medical Center Utrecht,Netherlands Institute for Developmental Biology(Utrecht),and University of Cincinnati(Cincinnati,OH,United States)made the most significant ***,gastric organoids are used mainly in studies investigating gastric cancer(GC),Helicobacter pylori-infective gastritis,with a focus on the mechanisms of GC,and drug screening *** Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening *** contributions from renowned academic institutions highlight this field’s dynamic growth.

关键词： Gastric organoid Gastric disease Bibliometrics analysis Gastric cancer Gastritis

Black holes as the source of dark energy:A stringent test with high-redshift JWST AGNs

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 181-188页

作者： Lei Lei Lei Zu Guan-Wen Yuan Zhao-Qiang Shen Yi-Ying Wang Yuan-Zhu Wang Zhen-Bo Su Wen-Ke Ren Shao-Peng Tang Hao Zhou Chi Zhang Zhi-Ping Jin Lei Feng Yi-Zhong Fan Da-ming Wei Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China

Studies have proposed that there is evidence for cosmological coupling of black holes(BHs)with an index of k≈3;hence,BHs serve as the astrophysical source of dark ***,the data sample is limited for the redshifts of≤*** recent years,the james Webb Space Telescope(JWST)has detected many high-redshift active galactic nuclei(AGNs)and *** the JWST NIRSpec-/NIRCam-resolved AGNs,three are determined to be in early-type host galaxies with a redshift of z~***,their M_(*)and MBH are in tension with the predicted cosmological coupling of black holes with k=3 at a confidence level of~2σ,which challenges the hypothesis that BHs serve as the origin of dark *** work on high-redshift AGNs using the JWST will further assess such a hypothesis by identifying more early-type host galaxies in the higher mass range.

关键词： dark energy supermassive black hole active galactic nuclei james Webb Space Telescope

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Acute penetrating injury of the spinal cord by a wooden spike with delayed surgery:a case report

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Neural Regeneration Research 2023年第12期18卷 2781-2784页

作者： james D.Guest Zhuojing Luo Yansheng Liu Hongkun Gao Dianchun Wang Xiao-ming Xu Hui Zhu Neurological Surgery and the Miami Project to Cure ParalysisMiller School of MedicineUniversity of MiamiMiamiFLUSA Kunming International Spine and Spinal Cord Injury Treatment CenterKunming Tongren HospitalKunmingYunnan ProvinceChina Department of Orthopedic Spinal Surgery Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Neurosurgery Kunming Tongren HospitalKunmingYunnan ProvinceChina Indiana University School of Medicine Stark Neurosciences Research InstituteIndianapolisINUSA

Rarely,penetrating injuries to the spinal cord result from wooden objects,creating unique challenges to mitigate neurological injury and high rates of infection and foreign body *** report a man who sustained a penetrating cervical spinal cord injury from a sharpened *** initially tetraparetic,he rapidly recovered *** risks of neurological deterioration during surgical removal made the patient reluctant to consent to surgery despite the impalement of the spinal cord.A repeat MRI on day 3 showed an extension of edema indicating progressive *** the 7~(th)day after injury,fever and paresthesias occurred with a large increase in serum inflammatory indicators,and the patient agreed to undergo surgical removal of the wooden *** discuss the management nuances related to wood,the longitudinal evolution of MRI findings,infection risk,surgical risk mitigation and technique,an inflammatory marker profile,long-term recovery,and the surprisingly minimal neurological deficits associated with low-velocity midline spinal cord *** patient had an excellent clinical *** main lessons are that a wooden penetrating central nervous system injury has a high risk for infection,and that surgical removal from the spinal cord should be performed soon after injury and under direct visualization.

关键词： case report interleukin-6 magnetic resonance imaging penetrating spinal cord injury wood

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天语计划——寻找第二个太阳系及探索动态宇宙

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天文学报 2024年第4期65卷 1-43页

作者：冯发波芮易成杜芝茂林清张聪聪周丹崔开明 OGIHARA Masahiro 杨明林杰蔡永志杨涛只庞晓莹简明杰李文雄郭恒潇史弦史建春李荐扬郭康柔姚嵩陈啊明贾鹏谭先瑜 JENKINS S.james 蒋宏轩张铭缘李可欣肖光耀郑书玥宣一帆郑捷何敏 JONES R.A.Hugh 宋翠英上海交通大学李政道研究所上海201210 上海交通大学物理与天文学院上海200240 上海天文馆(上海科技馆分馆) 上海200127 中国科学院上海天文台上海200030 同济大学测绘与地理信息学院上海200092 中国科学院星系宇宙学重点实验室(中国科学技术大学) 合肥230026 中国科学技术大学天文与空间科学学院合肥230026 中国科学院云南天文台昆明650216 中国科学院天体结构与演化重点实验室昆明650216 国际超新星中心-云南省国际超新星研究重点实验室昆明650216 西安交通大学物理学院西安710049 西交利物浦大学物理系苏州215123 上海师范大学上海市星系与宇宙学半解析研究重点实验室上海200234 Department of Astronomy Stockholm University Stockholm11421 中国科学院国家天文台北京100101 中山大学大气科学学院珠海519082 太原理工大学电子信息与光学工程学院太原030024 Instituto de Estudios Astrofısicos Facultad de Ingenierıa y CienciasUniversidad Diego Portales Santiago8170641 Centro de Astrof´ısica y Tecnologıas Afines(CATA)Santiago 8480000 山东大学空间与物理学院山东省光学天文与日地空间环境重点实验室威海264209 中国科学院国家天文台中国科学院天文光学技术重点实验室北京100101 Centre for Astrophysics Research University of Hertfordshire HertfordshireAL109AB 清华大学天体物理研究中心北京100084

像木星和土星这样的冷巨行星对类地行星的形成和宜居性起到了关键作用,因此,对像太阳系这样具有多个冷巨行星的系统的搜寻具有重要意义.Kepler以及TESS (Transiting Exoplanet Survey Satellite)太空望远镜成功地通过凌星的方法发现了... 详细信息

像木星和土星这样的冷巨行星对类地行星的形成和宜居性起到了关键作用,因此,对像太阳系这样具有多个冷巨行星的系统的搜寻具有重要意义.Kepler以及TESS (Transiting Exoplanet Survey Satellite)太空望远镜成功地通过凌星的方法发现了大量短周期行星,然而这些巡天项目的观测基线不足以发现更长周期的行星.为此,天语计划将部署两台1m望远镜(天语一号和天语二号),用于结合天语和其他计划的数据通过凌星法来发现冷巨行星及其他行星,并最终发现类太阳系.天语一号具有约10平方度的视场以及高速CMOS (complementary metal-oxide-semiconductor)科学相机,将对超过1000万颗恒星每小时进行一次高精度测光采样,并通过天语二号的多波段测光、光谱仪以及高分辨率成像对天语一号发现的候选行星进行确认.天语望远镜将放置于海拔约4000m的中国青海冷湖,是目前中国境内最好观测台址之一.天语对亮于14等星的测光精度为0.1%,对亮于18等星的测光精度优于1%,天语预计在5yr内将在类太阳周期发现超过300颗凌星行星,其中包括约17颗冷巨行星.基于系统轨道共面以及孪生地球发生率为10%的假设,天语预计将发现1-2个类太阳系,并可被未来的地球2.0计划所证实.此外,天语还将通过多种巡天观测模式测量从亚秒到周时标的光变,探测不同时标的时域现象,包括超新星早期光变、稀有变星和双星、潮汐瓦解事件、Be星、彗星活动以及系外小行星等.这些发现不仅将深化我们对宇宙的理解,还将为公众科学和科普提供重要平台.

关键词：技术:测光行星与卫星:探测行星与卫星:形成恒星:超新星:普通恒星:变星:普通小行星:普通恒星:伽马射线暴:普通

Attenuation of mitochondrial,but not cytosolic,Ca2+ overload reduces myocardial injury induced by ischemia and reperfusion

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Acta Pharmacologica Sinica 2006年第7期27卷 911-918页

作者： Kenneth WL KAM james SK SHAM Tlak-ming WOng Department of Physiology the University of Hong KongHong Kong SARChina Division of Pulmonary Critical Care Medicine Johns Hopkins School of MedicineBaltimoreMaryland 21224USA

Aim:Attenuation of mitochondrial Ca2+([Ca2+]m),but not cytosolic Ca2+([Ca2+]c),overload improves contractile *** hypothesized that attenuation of[Ca2+]m,but not[Ca2+]c,overload confers cardioprotection against ischemia/reperfusion-induced ***:Infarct size from isolated perfused rat heart,cell viability,and electrically-induced Ca2+transient in isolated rat ventricularmyocytes were *** determined the effects of BAPTA-AM,a Ca2+chelator,at concentrations that abolish the overload of both[Ca2+]cand[Ca2+]m,and ruthenium red,an inhibitor of mitochondrial uniporter of Ca2+transport,atconcentrations that abolish the overload of[Ca2+]m,but not[Ca2+]c,on cardiacinjury induced by ischemia/***:Attenuation of both[Ca2+]mand[Ca2+]cby BAPTA-AM,and attenuation of[Ca2+]m,but not[Ca2+]c,overloadby ruthenium red,reduced the cardiac injury observations,indicating the impor-tance of[Ca2+]min cardioprotection and contractile recovery in response to is-chemia/***:The study has provided unequivocal evidenceusing a cause-effect approach that attenuation of[Ca2+]m,but not[Ca2+]c,over-load is responsible for cardioprotection against ischemia/*** also confirmed the previous observation that attenuation of[Ca2+]m,but not[Ca2+]c,by ruthenium red improves contractile recovery following ischemia/reperfusion.

关键词： ruthenium red BAPTA-AM infarct size electrically-induced Ca2+transient isolated perfused rat heart cardiac myocytes

The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men

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Asian Journal of Andrology 2017年第1期19卷 113-116页

作者： Jeremv YC Teoh Steffi KK Yuen james HL Tsu Charles KW Wong Brian SH Ho Ada TL ng Wai-Kit Ma Kwan-Lun Ho ming-Kwong Yiu Division of Urology Department of Surgery Queen Mary Hospital University of Hong Kong Hong Kong China

We investigated the performance characteristics of prostate-specific antigen （PSA） and PSA density （PSAD） in Chinese men. All Chinese men who underwent transrectal ultrasound-guided prostate biopsy （TRUS-PB） from year 2000 to 2013 were included. The receiver operating characteristic （ROC） curves for both PSA and PSAD were analyzed. The sensitivity, specificity, positive predictive value （PPV） and negative predictive value （NPV） at different cut-off levels were calculated. A total of 2606 Chinese men were included. For the ROC, the area under curve was 0.770 for PSA （P〈 0.001） and 0.823 for PSAD （P〈 0.001）. PSA of 4.5 ng ml^-1 had sensitivity of 94.4%, specificity of 14.1%, PPV of 29.5%, and NPV of 86.9%; PSAD of 0.12 ng ml^-1cc^-1 had sensitivity of 94.5%, specificity of 26.6%, PPV of 32.8%, and NPV of 92.7%. On multivariate logistic regression analyses, PSA cut-off at 4.5 ng ml^-1 （OR 1.61, 95% CI 1.05-2.45, P = 0.029） and PSAD cut-off at 0.12 ng ml^-1 cc^-1 （OR 6.22, 95% CI 4.20-9.22, P 〈 0.001） were significant predictors for prostate cancer detection on TRUS-PB. In conclusion, the performances of PSA and PSAD at different cut-off levels in Chinese men were very different from those in Caucasians. PSA of 4.5 ng ml^-1 and PSAD of O. 12 ng ml^-1 cc^-1 had near 95% sensitivity and were significant predictors of prostate cancer detection in Chinese men.

关键词： Chinese prostate cancer transrectal ultrasound-guided prostate biopsy prostate-specific antigen prostate-specific antigen density