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Genetic variants in the ADD1 and GNB3 genes and bloodpressure response to potassium supplementation

Frontiers of Medicine 2010年第1期4卷 59-66页

作者： Dai-Hai YU De-Pei LIU Lai-Yuan WANG Jing CHeN Cashell e.JAQUISH Dabeeru C.RAO james e.hixson Jian-Feng HUANG Chung-Shiuan CHeN Charles GU Ji-Chun CHeN Jie CAO Shu-Feng CHeN Paul K.WHeLTON Jiang He Dong-Feng GU Department of evidence-based Medicine and Population Genetics Cardiovascular Institute and Fu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Chinese National Human Genome Center at Beijing Beijing 100176China Department of epidemiology Tulane University School of Public Health and Tropical MedicineNew OrleansLA 70112USA Department of Medicine Tulane University School of MedicineNew OrleansLA 70112USA National Heart Lungand Blood InstituteNational Institute of HealthBethesdaMD 20892USA Washington University in St.Louis School of Medicine St.LouisMO 63110USA University of Texas School of Public Health HoustonTX 77030USA Loyola University Medical Center MaywoodIL 60153USA

Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular ***,blood pressure(BP)responses to potassium supplementation vary among *** study was designed to examine the association between 12 single nucleotide polymorphisms(SNPs)in the adducin 1 alpha(ADD1)and guanine nucleotide binding protein(G protein)beta polypeptide 3(GNB3)genes and systolic BP(SBP),diastolic BP(DBP),and mean arterial pressure(MAP)responses to *** conducted a 7-day high-sodium intervention(307.8 mmol sodium/day)followed by a 7-day high-sodium with potassium-supplementation(60 mmol potassium/day)among 1906 Han Chinese participants from rural north *** measurements were obtained at the end of each intervention period using a random-zero *** identiﬁed signiﬁcant associations between ADD1 variant rs17833172 and SBP,DBP,and MAP responses to potassium-supplementation(all Pemained signiﬁcant after adjustment for multiple *** participants that were heterozygous or homozygous for the G allele of this marker,SBP,DBP,and MAP response to potassium-supplementation were–3.52(–3.82,–3.21),–1.41(–1.66,–1.15)and–2.12(–2.37,–1.87),respectively,as compared to the corresponding responses of 1.99(0.25,3.73),–0.65(–0.10,–0.21),and–0.23(–0.37,0.83),respectively,for those who were homozygous for A *** addition,participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation(P=0.0041 and 0.01,respectively),which was also significant after correction for multiple *** and MAP responses to potassiumsupplementation were–1.36(–1.63,–1.10)and–2.07(–2.32,–1.82)for those with at least G allele compared to corresponding responses of 0.86(–0.68,2.40)and–0.45(–1.74,0.84)for those who were homozygous for A *** summary,our study identified novel associations between

关键词： blood pressure genetics polymorphism dietary potassium potassium sensitivity adducin 1 alpha(ADD1) guanine nucleotide binding protein beta polypeptide 3(GNB3)

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Genome-Wide Linkage and Positional Association Analyses Identify Associations of Novel AFF3 and NTM Genes with Triglycerides:The GenSalt Study

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Journal of Genetics and Genomics 2015年第3期42卷 107-117页

作者： Changwei Li Lydia A.L.Bazzano Dabeeru C.Rao james e.hixson Jiang He Dongfeng Gu Charles C.Gu Lawrence C.Shimmin Cashell e.Jaquish Karen Schwander De-Pei Liu Jianfeng Huang Fanghong Lu Jie Cao Shen Chong Xiangfeng Lu Tanika N.Kelly Department of epidemiology Tulane University School of Public Health and Tropical Medicine Department of Medicine Tulane University School of Medicine Division of Biostatistics Washington University School of Medicine Department of epidemiology Human Genetics and Environmental SciencesUniversity of Texas School of Public Health State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center of Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Division of Prevention and Population Sciences National HeartLungBlood Institute National Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine Shandong Academy of Medical Sciences Department of epidemiology and Biostatistics Nanjing Medical University School of Public Health

We conducted a genome-wide linkage scan and positional association study to identify genes and variants influencing blood lipid levels among participants of the Genetic epidemiology Network of Salt-Sensitivity （GenSalt） study. The GenSalt study was conducted among 1906 participants from 633 Han Chinese families. Lipids were measured from overnight fasting blood samples using standard methods. Multipoint quantitative trait genome-wide linkage scans were performed on the high-density lipoprotein, low-density lipoprotein, and log- transformed triglyceride phenotypes. Using dense panels of single nucleotide polymorphisms （SNPs）, single-marker and gene-based association analyses were conducted to follow-up on promising linkage signals. Additive associations between each SNP and lipid phenotypes were tested using mixed linear regression models. Gene-based analyses were performed by combining P-values from single- marker analyses within each gene using the truncated product method （TPM）. Significant associations were assessed for replication among 777 Asian participants of the Multi-ethnic Study of Atherosclerosis （MeSA）. Bonferroni correction was used to adjust for multiple testing. In the GenSalt study, suggestive linkage signals were identified at 2p11.2-2q12.1 [maximum multipoint LOD score （MML） = 2.18 at 2q11.2] and t lq24.3-11q25 （MML = 2.29 at 11q25） for the log-transformed triglyceride phenotype. Follow-up analyses of these two regions revealed gene-based associations of charged multivesicular body protein 3 （CHMP3）, ring finger protein 103 （RNF103）, AF4/FMR2 family, member 3 （AFF3）, and neurotrirnin （NTM） with triglycerides （P = 4 ×10^-4, 1.00 × 10^-5, 2.00 × 10^-5, and 1.00 × 10^-7, respectively）. Both the AFF3 and NTM triglyceride associations were replicated among MeSA study participants（P = 1.00 × 10^-7 and 8.00× 10^-5, respectively）. Furthermore, NTM explained the linkage signal on chromosome 11, In conclusion, we identified novel genes associated with lipid

关键词： Lipids Linkage analysis Positional association analysis Gene-based analysis

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内皮系统基因与血压改变和高血压发病的关系:盐敏感遗传流行病学研究

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中华高血压杂志 2015年第10期23卷 998-998页

作者： Fangchao Liu Jiang He Dongfeng Gu Dabeeru C.Rao Jianfeng Huang james e.hixson Cashell e.Jaquish Jichun Chen Changwei Li Xueli Yang Jianxin Li Treva K.Rice Lawrence C.Shimmin Tanika N.Kelly

研究者在一个纵向家庭研究中以单标记和新基因为基础的方法探讨内皮系统基因与血压改变和高血压发病率的关系。方法：盐敏感性的遗传流行病学随访研究共纳入633个汉族家庭的1768位成员。使用随机零点血压计,获取基线和随访调查的共9次... 详细信息

研究者在一个纵向家庭研究中以单标记和新基因为基础的方法探讨内皮系统基因与血压改变和高血压发病率的关系。方法：盐敏感性的遗传流行病学随访研究共纳入633个汉族家庭的1768位成员。使用随机零点血压计,获取基线和随访调查的共9次血压值。

关键词：遗传流行病学内皮系统盐敏感性高血压新基因发病率随访研究随访调查

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中国人基因变异和体力活动的相互作用与血压相关

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中华高血压杂志 2012年第2期20卷 198-198页

作者： May e.Montasser Lawrence C.Shimmin Charles Gu Tanika N.Kelly Cashell e.Jaquish Treva Rice Dabeeru C.Rao Paul K.Whelton james e.hixson 罗冬梅叶鹏

维持血压动态平衡涉及遗传和非遗传因素之间复杂的相互作用，这对明确影响血压和高血压的遗传因素有巨大的挑战。该研究选取中国农村遗传基因相对均一的一人群队列，研究基因变异与体力活动相互作用对血压的影响。方法：根据是否进行体... 详细信息

维持血压动态平衡涉及遗传和非遗传因素之间复杂的相互作用，这对明确影响血压和高血压的遗传因素有巨大的挑战。该研究选取中国农村遗传基因相对均一的一人群队列，研究基因变异与体力活动相互作用对血压的影响。方法：根据是否进行体力活动将3142名入选者进行分组（体力活动组与非体力活动组），应用广义估计方程分析收缩压和舒张压与血压调控通路中24个基因表型改变的关系[包括196单核苷酸多态性（single-nucleotide polymorphisms，SNP）]。

关键词：体力活动血压动态相互作用基因变异中国农村非遗传因素单核苷酸多态性广义估计方程

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exploring the mass gap:Black holes in green pea galaxies

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 170-171页

作者： james e.Rhoads School of earth and Space exploration Arizona State UniversityTempeAZ 85287USA

We know about black holes primarily on two mass scales(e.g.,see Figure 22 of ref.[1]).Supermassive black holes inhabit the centers of galaxies,where they sometimes power active galactic nuclei(AGN).Their populations can be probed through AGN surveys,tidal disruption event surveys,and(in the closest galaxies)stellar and gas dynamics in the innermost regions where the black hole dominates the gravitational potential.

关键词： galaxies tidal galactic

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Prediction of performance, combustion and emission characteristics of diesel-thermal cracked cashew nut shell liquid blends using artificial neural network

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Frontiers in energy 2016年第1期10卷 114-124页

作者： Arunachalam VeLMURUGAN Marimuthu LOGANATHAN e. james GUNASeKARAN Department of Mechanical engineering Annamalai University Annamalainagar 608002 India

This paper explores the use of artificial neural networks （ANN） to predict performance, combustion and emissions of a single cylinder, four stroke stationary, diesel engine operated by thermal cracked cashew nut shell liquid （TC-CNSL） as the biodiesel blended with diesel. The tests were performed at three different injection timings （21°, 23°, 25℃A bTDC） by changing the thickness of the advance shim. The ANN was used to predict eight different engine-output responses, namely brake thermal efficiency （BTe）, brake specific fuel consumption （BSFC）, exhaust gas temperature （eGT）, carbon monoxide （CO）, oxide of nitrogen （NOx）, hydrocarbon （HC）, maximum pressure （Pm~,,） and heat release rate （HRR）. Four pertinent engine operating parameters, i.e., injection timing （IT）, injection pressure （IP）, blend percentage and pecentage load were used as the input parameters for this modeling work. The ANN results show that there is a good correlation between the ANN predicted values and the experimental values for various engine performances, combustion parameters and exhaust emission characteristics. The mean square error value （MSe） is 0.005621 and the regression value ofR2 is 0.99316 for training, 0.98812 for validation, 0.9841 for testing while the overall value is 0.99173. Thus the developed ANN model is fairly powerful for predicting the performance, combustion and exhaust emissions of internal combustion engines.

关键词： cashew nut shell liquid (CNSL) artificialneural networks (ANN) thermal cracking mean squareerror (MSe)

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Recent advances in nanomaterials for high-performance Li–S batteries

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Journal of energy Chemistry 2020年第8期29卷 86-106,I0004页

作者： james e.Knoop Seongki Ahn Joint School of Nanoscience and Nanoengineering North Carolina Agricultural and Technical State UniversityGreensboroNC 27401USA Research Organization for Nano and Life Innovation Waseda University513WasedatsurumakichoShinjuku-kuTokyo 162-0041Japan

This article reviews nanotechnology as a practical solution for improving lithium-sulfur batteries. Lithiumsulfur batteries have been widely examined because sulfur has many advantageous properties such as a high crustal abundance, low environmental impact, low cost, high gravimetric(2600 W h kg-1) and volumetric(2800 W h L-1) energy densities, assuming complete conversion of sulfur to lithium sulfide(Li2S)upon lithiation. However, lithium-sulfur batteries have not yet reach commercialization due to demerits involving the formation of soluble lithium polysulfides(Li2Sn, n=3–8), low electrical conductivity, and low loading density of sulfur. These issues arise mainly due to the polysulfide shuttle phenomenon and the inherent insulating nature of sulfur. To overcome these issues, strategies have been pursued using nanotechnology applied to porous carbon nanocomposites, hollow one-dimensional carbon nanomaterials, graphene nanocomposites, and three-dimensional carbon nanostructured matrices. This paper aims to review various solutions pertaining to the role of nanotechnology in synthesizing nanoscale and nanostructured materials for advanced and high-performance lithium–sulfur batteries. Furthermore, we highlight perspective research directions for commercialization of lithium–sulfur batteries as a major power source for electric vehicles and large-scale electric energy storage.

关键词： Nanotechnology Lithium–sulfur batteries Carbon nanomaterials Nanocomposite sulfur 3D nanostructured materials

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Correspondence of bubble size and frother partitioning in flotation

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Journal of Central South University 2014年第6期21卷 2383-2390页

作者：张炜 Jan e.Nesset james A.Finch Mining & Mineral Resources Division Department of Business AdministrationChinalco China Copper Corporation Limited Department of Mining and Materials engineering McGill UniversityMontrealQCH3A 0C5Canada

The size of bubbles created in the flotation process is of great importance to the efficiency of the mineral separation ***,it is believed that frother transport between phases is perhaps the most important reason for the interactive nature of the phenomena occurring in the bulk and froth phases in flotation,as frother adsorbed in the surface of rising bubbles is removed from the bulk phase and then released into the froth as a fraction of the bubbles *** causes the increased concentration in the froth compared to the bulk concentration,named as frother *** reflects the adsorption of frother on bubbles and how to influence bubble size is not *** currently exists no such a topic aiming to link these two key *** fill this vacancy,the correspondence between bubble size and frother partitioning was *** size was measured by sampling-for-imaging(SFI)*** total organic carbon(TOC)analysis to measure the frother partitioning between froth and bulk phases was *** have shown,with no exceptions including four different frothers,higher frother concentration is in the bulk than in the *** results also show strong partitioning giving an increase in bubble size which implies there is a compelling relationship between these two,represented by CFroth/CBulk and *** CFroth/CBulkand D32 curves show similar exponential decay relationships as a function of added frother in the system,strongly suggesting that the frother concentration gradient between the bulk solution and the bubble interface is the driving force contributing to bubble size reduction.

关键词： flotation frother bubble size frother partitioning total organic carbon (TOC) analysis concentration gradient

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A novel approach to prevent bubble coalescence during measurement of bubble size in flotation

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Journal of Central South University 2014年第1期21卷 338-343页

作者：张炜 Jan e.Nesset james A.Finch Mining and Mineral Resources Division Department of Business AdministrationChinalco China Copper Corporation Limited Department of Mining and Materials engineering McGill University

effect of frothers in preventing bubble coalescence during flotation of minerals has long been *** evaluate the performance of a frother,an apparatus to measure the bubble size is a basic *** Bubble Size Analyzer(MBSA) or bubble viewer that has been developed and completed by McGill University's Mineral Processing Group during the last decade is a unique instrument to serve this *** parameters which are thought to influence the bubble size measurements by McGill bubble viewer include water quality and frother concentration in the *** show that there is no difference in Sauter mean(D32) when tap or de-ionized water was used instead of process ***,the frother concentration,in this research DowFroth 250(DF250),inside the chamber exhibited a pronounced effect on bubble *** concentration below a certain point can not prevent coalescence inside the chamber and therefore caution must be taken in plant *** was also noted that the frother concentration which has been so far practiced in plant measurements(CCC75-CCC95) is high enough to prevent coalescence with the bubble viewer.

关键词： flotation frother bubble size bubble coalescence

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Bubble size as a function of some situational variables in mechanical flotation machines

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Journal of Central South University 2014年第2期21卷 720-727页

The specific results of the work investigating the effect of gas density and water temperature on bubble size were *** were surrogate variables designed to investigate the effect of viscosity(varying water temperature) and altitude(varying gas density).The results show that there is a measurable but relatively small effect of gas density on bubble *** D32 is revealed to increase proportionally as(ρ0/ρg)*** projected impact on flotation kinetics at 4500 m versus sea level is small,of the order of 0.5% recovery loss for a bank of eight flotation *** effect of water temperature(4-40 °C) on bubble size is more significant than gas *** relationship correlates with water viscosity values quite closely.A finding that D32 increases proportionally as(μ/μ20)0.776 highlights the importance of accounting for viscosity effects if,for example,large process temperature fluctuations or deviation from design/test conditions are expected.

关键词： flotation frother bubble size viscosity altitude

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