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Peripartum cardiomyopathy: A puzzle closer to solution

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World Journal of Cardiology 2014年第3期6卷 87-99页

作者： james d Fett Investigations of Pregnancy Associated Cardiomyopathy (IPAC) Peripartum Cardiomyopathy Network of North America (PCN)Cardiovascular InstituteUniversity of Pittsburgh Medical Center department of Adult Medicine Hospital Albert Schweitzer

Peripartum cardiomyopathy(PPCM) represents new heart failure in a previously heart-healthy peripartum patient. It is necessary to rule out all other known causes of heart failure before accepting a diagnosis of PPCM. The modern era for PPCM in the United States and beyond began with the report of the National In-stitutes of Health PPCM Workshop in 2000, clarifying all then-currently known aspects of the disease. Since then, hundreds of publications have appeared, an indi-cation of how devastating this disease can be to young mothers and their families and the urgent desire to find solutions for its cause and better treatment. The purpose of this review is to highlight the important ad-vances that have brought us nearer to the solution of this puzzle, focusing on what we have learned about PPCM since 2000; and what still remains unanswered. despite many improvements in outcome, we still do not know the actual triggers that initiate the pathological process; but realize that cardiac angiogenic imbalances resulting from complex pregnancy-related immune sys-tem and hormonal changes play a key role.

关键词： Peripartum cardiomyopathy Pregnancy Heart failure

delayed reception of live blowfly (Calliphora vicina and Chrysomya rufifacies)larval samples: implications for minimum postmortem interval estimates

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Forensic Sciences Research 2018年第1期3卷 27-39页

作者： Melanie S.Archer Stephanie d.Jones james F.Wallman department of Forensic Medicine Monash University/Victorian Institute of Forensic MedicineSouthbankAustralia Centre for Sustainable Ecosystem Solutions School of Biological SciencesUniversity of WollongongWollongongAustralia

Forensic entomology evidence collected by police and mortuary staff may be delayed in getting to the *** samples may continue developing and alter minimum postmortem interval (PMImin) *** study investigated development of simulated evidential samples of Calliphora vicina Robineau-desvoidy and Chrysomya rufifacies (Macquart) (diptera: Calliphoridae) *** of each species were studied in three developmental classes: "small" (late second/early third instar),"mid" (mid third instar) and "large" (late third instar).Seven replicates of 11 maggots in each class were assigned without food to four treatments: (1) 24 h at 20 ℃;(2) 24 h at 4 ℃;(3) 48 h at 20 ℃ and (4) 48 h at 4 ℃.There was a significant difference in absolute length change across treatments,reflecting size for C vicina,and interaction between size,time and temperature for *** vicina maggots showed minimal mortality,and most second instar larvae moulted by the experiment's *** rufifacies showed heavy mortality and minimal moulting from the second to third *** "large" *** maggots kept at room temperature for 48 h *** these results confirm that development can continue in live unfed maggot samples after their collection,it is not advisable to delay their preservation.

关键词： Forensic science forensic entomology forensic evidence larval development best practice sampling

Briancoppinsia,a new coelomycetous genus of Arthoniaceae(Arthoniales)for the lichenicolous Phoma cytospora,with a key to this and similar taxa

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Fungal diversity 2012年第1期52卷 1-12页

作者： Paul diederich james d.Lawrey Masoumeh Sikaroodi Pieter P.Gvan den Boom damien Ertz Musée national d’histoire naturelle 25 rue Munster2160 LuxembourgLuxembourg department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA Arafura 16 5691 JA Sonthe Netherlands Jardin Botanique National de Belgique Domaine de Bouchout1860 MeiseBelgium

Morphological,anatomical,chemical and molecular data suggest that a relatively common lichenicolous coelomycete on Lecanora conizaeoides is conspecific with Phoma cytospora,previously known only from parmelioid lichens,and that further populations on Cladonia and Pertusaria belong to the same *** species is distinguished from Phoma by several taxonomically important characters and obviously represents a previously unrecognized genus,for which the name Briancoppinsia is *** analyses using nuLSU and mtSSU sequences of isolates obtained in pure culture suggest that the new genus belongs to the Arthoniaceae(Arthoniales).This is the first obligate lichenicolous,non-lichenized anamorph confirmed to belong to the Arthoniales based on molecular data.

关键词： Anamorphic fungi Arthonia Conidial fungi Mitosporic fungi

Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease

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World Journal of Gastroenterology 2014年第36期20卷 13139-13145页

作者： Samuel d james Paul E Wise Tania Zuluaga-Toro david A Schwartz M Kay Washington Chanjuan Shi departments of Pathology Microbiology and Immunology Vanderbilt University Medical Center Nashville TN 37232 United States Section of Colon and Rectal Surgery Washington University in St. Louis Gainesville MO 63130 United States department of Pathology University of Florida Gainesville FL 32611 United States departments of Gastroenterology Hepatology and Nutrition Vanderbilt University Medical Center Nashville TN 37232 United States

AIM: To identify pathologic features associated with this “ulcerative colitis (UC)-like” subgroup of Crohn’s disease (Cd).

关键词： Ulcerative colitis-like Crohn’ s disease Ulcerative colitis Crohn’ s colitis Inflammatory bowel disease

Restoring nervous system structure and function using tissue engineered living scaffolds

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Neural Regeneration Research 2015年第5期10卷 679-685页

作者： Laura A.Struzyna james P.Harris Kritika S.Katiyar H.Isaac Chen d.Kacy Cullen Center for Brain Injury and Repair Department of NeurosurgeryPerelman School of MedicineUniversity of Pennsylvania Center for Neurotrauma Neurodegenerationand RestorationPhiladelphia Veterans Affairs Medical Center School of Biomedical Engineering Drexel University

Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following ner- vous system injury or neurodegenerative disease. disconnection of axon pathways - the long-distance fibers connecting specialized regions of the central nervous system or relaying peripheral signals - is a common feature of many neurological disorders and injury. However, functional axonal regenera- tion rarely occurs due to extreme distances to targets, absence of directed guidance, and the presence of inhibitory factors in the central nervous system, resulting in devastating effects on cognitive and sensorimotor function. To address this need, we are pursuing multiple strategies using tissue engi- neered ＂living scaffolds＂, which are preformed three-dimensional constructs consisting of living neural cells in a defined, often anisotropic architecture. Living scaffolds are designed to restore function by serving as a living labeled pathway for targeted axonal regeneration - mimicking key developmental mechanisms- or by restoring lost neural circuitry via direct replacement of neurons and axonal tracts. We are currently utilizing preformed living scaffolds consisting of neuronal dusters spanned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain. Although there are formidable challenges in predinical and clinical advancement, these living tissue engineered constructs represent a promising strategy to facilitate nervous system repair and functional recovery.

关键词： living scaffolds neural tissue engineering cell transplant biomaterials regeneration neurotrauma neurodegeneration axon pathfinding cell migration

Relating environmental variables with aquatic community structure in an agricultural/urban coldwater stream

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Ecological Processes 2021年第1期10卷 481-499页

作者： daniel T.L.Myers Richard R.Rediske james N.McNair Aaron d.Parker E.Wendy Ogilvie Annis Water Resources Institute Grand Valley State University740 W Shoreline DriveMuskegonMI 49401USA. Michigan department of Environment Great Lakesand Energy525 W Allegan StreetLansingMI 48909USA. Grand Valley Metropolitan Council 678 Front Avenue NWSuite 200Grand RapidsMI 49504USA.

Background:Urban areas are often built along large rivers and surrounded by agricultural *** may lead to small tributary streams that have agricultural headwaters and urbanized lower *** study objectives assessed are as follows:(1)landscape,geomorphic,and water quality variables that best explained variation in aquatic communities and their integrity in a stream system following this agricultural-to-urban land use gradient;(2)ways this land use gradient caused aquatic communities to differ from what would be expected for an idealized natural stream or other longitudinal gradients;and(3)whether the impacts of this land use gradient on aquatic communities would grow larger in a downstream direction through the agricultural and urban *** study area was an impaired coldwater stream in Michigan,***:Many factors structured the biological communities along the agricultural-to-urban land use *** woody debris had the strongest relationship with EPT(Ephemeroptera,Plecoptera,and Trichoptera)abundance and richness and were most common in the lower,urbanized *** streambed substrate had the strongest relationship with diptera taxa and surface air breather macroinvertebrates and was dominant in agricultural *** community assemblage was influenced largely by stream flow and temperature regimes,while poor fish community integrity in lower urban reaches could be impacted by geomorphology and episodic urban pollution *** macroinvertebrates were most abundant in deforested,first-order agricultural headwaters,while EPT macroinvertebrate richness was the highest downstream of agricultural areas within the urban zone that had extensive forest ***:Environmental variables and aquatic communities would often not conform with what we would expect from an idealized natural *** richness improved downstream of agricultural *** shows promise for the recovery of aquatic systems using we

关键词： Land use Habitat Stream Fish Macroinvertebrate Gradient

Tissue-specific Tregs in cancer metastasis:opportunities for precision immunotherapy

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Cellular & Molecular Immunology 2022年第1期19卷 33-45页

作者： Laura A.Huppert Michael d.Green Luke Kim Christine Chow Yan Leyfman Adil I.daud james C.Lee division of Hematology/Oncology Department of MedicineUniversity of CaliforniaSan FranciscoSan FranciscoCAUSA department of Radiation Oncology University of Michigan School of MedicineAnn ArborMIUSA Veterans Affairs Ann Arbor Healthcare System Ann ArborMIUSA University of California San Francisco School of MedicineSan FranciscoCAUSA Penn State College of Medicine HersheyPAUSA Parker Institute for Cancer Immunotherapy San FranciscoCAUSA

decades of advancements in immuno-oncology have enabled the development of current immunotherapies,which provide longterm treatment responses in certain metastatic cancer ***,cures remain infrequent,and most patients ultimately succumb to treatment-refractory metastatic *** insights suggest that tumors at certain organ sites exhibit distinctive response patterns to immunotherapy and can even reduce antitumor immunity within anatomically distant tumors,suggesting the activation of tissue-specific immune tolerogenic mechanisms in some cases of therapy *** immune cells known as regulatory T cells(Tregs)are present within all tissues in the body and coordinate the suppression of excessive immune activation to curb autoimmunity and maintain immune *** the high volume of research on Tregs,the findings have failed to reconcile tissue-specific Treg functions in organs,such as tolerance,tissue repair,and regeneration,with their suppression of local and systemic tumor immunity in the context of immunotherapy *** improve the understanding of how the tissue-specific functions of Tregs impact cancer immunotherapy,we review the specialized role of Tregs in clinically common and challenging organ sites of cancer metastasis,highlight research that describes Treg impacts on tissue-specific and systemic immune regulation in the context of immunotherapy,and summarize ongoing work reporting clinically feasible strategies that combine the specific targeting of Tregs with systemic cancer *** knowledge of Tregs in the framework of their tissue-specific biology and clinical sites of organ metastasis will enable more precise targeting of immunotherapy and have profound implications for treating patients with metastatic cancer.

关键词： Tissue Tregs Immunotherapy Organ-specific tolerance Metastasis Cancer

A simple,azulene-based colorimetric probe for the detection of nitrite in water

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 90-96,F0004页

作者： Lloyd C.Murfin Carlos M.Lopez-Alled Adam C.Sedgwick Jannis Wenk Tony d.james Simon E.Lewis department of Chemistry University of BathBath BA27AYUK Centre for Sustainable Chemical Technologies University of BathBath BA27AYUK department of Chemical Engineering and Water Innovation and Research Centre(WIRC@Bath) University of BathBath BA27AYUK

We describe the synthesis and evaluation of an azulene-based chemodosimeter for *** probe was found to undergo two distinct color changes upon introduction of aqueous nitrite ion.A near-instant formation of a grey color provides a qualitative indication of the presence of nitrite,followed by the formation of a deep-yellow/orange color,the endpoint from which quantitative data can be *** azulene probe exhibits 1:1 stoichiometry of reaction with nitrite in water,and is selective for nitrite over other *** azulene probe was applied to determine nitrite content in cured meat,and compared with the British Standard testing procedure(Griess test).The value obtained from the azulene-based probe agreed closely with the standard *** procedure only requires the preparation of one standard solution,instead of the three required for the standard Griess test.

关键词： azulene nitrite diazoquinone

Parameter space for magnetization effects in high-energy-density plasmas

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Matter and Radiation at Extremes 2021年第6期6卷 36-44页

作者： james d.Sadler Hui Li Kirk A.Flippo Los Alamos National Laboratory Los AlamosNew Mexico 87545USA

Magnetic fields are well known to affect the evolution of fluids via the J3B force,where J is the current density and B is the magnetic *** force leads to the influence of magnetic fields on hydrodynamics(magnetohydrodynamics).Magnetic fields are often neglected in modeling of high-energy-density plasmas,since J 3 B is very small compared with the plasma pressure ***,many experiments lie in a separate part of parameter space where the plasma is indirectly affected via magnetization of the heat flux and charged particle *** is true even for initially unmagnetized plasmas,since misaligned density and temperature gradients can self-generate magnetic *** comparing terms in the induction equation,we go on to estimate the regions of parameter space where these self-generated fields are strong enough to affect the hydrodynamics.

关键词： field magnetization energy