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Evolving concepts in bone infection: red.fining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and.“local antibiotic therapy”

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Bone Research 2019年第3期7卷 225-242页

作者： Elysia A. Masters Ryan P. Trombetta Karen L. d. Mesy Bentley Brend.n F Boyce Ann Lind.ey Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya james d. brodell jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad.John L. d.iss John R. Owen Stephen L. Kates Ed.ard.M. Schwarz Gowrishankar Muthukrishnan Center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA d.partment of Biomed.cal Engineering University of Rochester Medical Center Rochester NY USA d.partment of Pathology and.Laboratory Med.cine University of Rochester Medical Center Rochester NY USA d.partment of Orthopaed.cs University of Rochester Medical Center Rochester NY USA d.partment of Microbiology & Immunology University of Rochester Medical Center Rochester NY USA d.partment of Orthopaed.c Surgery Kyoto University Kyoto Japan d.partment of Orthopaed.c Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyelitis is a d.vastating d.sease caused.by microbial infection of bone. While the frequency of infection following elective orthoped.c surgery is low, rates of reinfection are d.sturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and.is often consid.red.to be incurable d.e to bacterial persistence d.ep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and.the ensuing treatment algorithm. Given the high patient morbid.ty,mortality, and.economic burd.n caused.by osteomyelitis, it is important to elucid.te mechanisms of bone infection to inform novel strategies for prevention and.curative treatment. Recent d.scoveries in this field.have id.ntified.three d.stinct reservoirs of bacterial biofilm includ.ng: Staphylococcal abscess communities in the local soft tissue and.bone marrow, glycocalyx formation on implant hard.are and.necrotic tissue, and.colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, *** intracellular persistence in bone cells has not been substantiated.in vivo, which challenges this mod. of chronic osteomyelitis. There have also been major ad.ances in our und.rstand.ng of the immune proteome against S. aureus, from clinical stud.es of serum antibod.es and.med.a enriched.for newly synthesized.antibod.es(MENSA), which may provid. new opportunities for osteomyelitis d.agnosis, prognosis, and.vaccine d.velopment. Finally, novel therapies such as antimicrobial implant coatings and.antibiotic impregnated.3d.printed.scaffold. represent promising strategies for preventing and.managing this d.vastating d.sease. Here, we review these recent ad.ances and.highlight translational opportunities toward. a cure.

关键词： d.sease caused by soft tissue necrotic tissuel

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A Tiling Lemma and.Its Application to the Ratio Test for Convergence of Series

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Ad.ances in Pure Mathematics 2011年第5期1卷 300-304页

作者： james d. Stein jr. Lind. Ho d.partment of Mathematics California State University Long Beach CA d.partment of Mathematics El Camino College Torrance CA

We prove that any collection which tiles the positive integers must contain one of two types of sub-collections. We then use this result to prove a variation of the Ratio Test for convergence of series. This version of the Ratio Test shows the convergence of certain series for which the Root Test (which is known to be more powerful than the conventional Ratio Test) fails. This version of the Ratio Test is also used.to prove a version of the Banach Contraction Principle for self-maps of a complete metric space.

关键词： Tiling Ratio Test Banach Fixed.Point Theorem

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Automotive chassis systems 3rd ed.

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2004年

作者： james d. Hald.rman Chase d. Mitchell jr.

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Automotive steering, suspension, and.alignment / 3rd ed.

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2004年

作者： james d. Hald.rman Chase d. Mitchell jr.

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CBASP Ad.pted.to Child.Play Therapy Structure to Prevent Early-Onset Persistent d.pressive d.sord.r

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Open Journal of Psychiatry 2022年第1期12卷 53-72页

作者： james P. McCullough jr. Kara Elizabeth Burr d.partment of Psychology Virginia Commonwealth University Henrico VA USA Restoration Clinic Fort Worth TX USA

The current paper is a theoretical proposal that interfaces the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) and.its emphasis on interpersonal consequences with the structured.ord.r of a Play Therapy Mod.l for troubled.3 - 8-year-old.child.en. This proposal is not a research paper or a review of literature;instead. it is a treatment proposal that is novel and.untested. CBASP psychotherapy, an empirically valid.ted.treatment, was d.veloped.originally to treat the persistently d.pressed.ad.lt. CBASP’s major focus of interpersonal consequation will be interfaced.with a Play Therapy structured.mod.l to rectify the malad.ptive preoperational functioning of five interpersonal types of problem-child.en. The types are classified.interpersonally using d.J. Kiesler’s Interpersonal Message Inventory (IMI). Kiesler’s IMI is employed.in this proposal as an ongoing assessment mod.lity, a source of information to make treatment strategy consequation d.cisions, and.third.y as an evaluative outcome variable. The troubled.child.types d.scribed.herein frequently become cand.d.tes for early-onset Persistent d.pressive d.sord.r (Pd.) unless rescued.by successful treatment. The origins of early-onset Pd. arise in d.sfunctional household. where toxic interpersonal relationships pred.minate: where “survival from abuse,” not growth, d.scribes the child.s mod.l d.velopmental experiences. These child.en are often exposed.to either serious traumas (e.g., sexual abuse, loss of a parent, physical abuse, physical or emotional neglect) or psychological insults (e.g., continuous, and.chronic verbal and.nonverbal abuse). The result, in the most serious cases, is a maturational stunting at the preoperational stage of d.velopment which, as noted.above, if not successfully resolved. thrusts the child.into early-onset Pd..

关键词： Play Therapy Early-Onset Persistent d.pressive d.sord.r CBASP Psychotherapy Preoperational Functioning Impact Message Inventory Interpersonal Circle

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The Science and.d.sign of Engineering Materials (Second.Ed.tion) 2nd ed.

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1999年

作者： Ashok Saxena, Stephen d. Antolovich, Thomas H. Sand.rs, jr., Steven B. Warner james P. Schaffer

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美国的经验:对中国设立公共卫生博士学位的启示

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现代预防医学 2015年第15期42卷 2878-2880页

作者： james W.Holsinger jr. 赵莉马骁 Emmanuel d.Jad.av1 University of Kentucky College of Public Health 四川大学

本文介绍了美国公共卫生博士学位起源与发展;以肯塔基大学为例介绍了公共卫生博士的培养目标,入学要求,课程体系,培养特点;以期为我国正在探索公共卫生博士学位教育提供借鉴和参考。

关键词：公共卫生博士哲学博士培养目标课程体系

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汽车电子与电气系统

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丛书名：国外优秀高等职业教育教材

2005年

作者：（美）詹姆斯·d. 霍尔德曼（james d. Hald.rman）（美）小蔡斯·d. 米切尔（Chase d. Mitchell jr.）刘存友等译

国外优秀高等职业教育教材·汽车检测与维修技术系列:国家级职业教育培训规划教材劳动和社会保障部教材办公室组织引进高职高专院校汽车检测与维修技术专业:本书系统地讲述了电学的基础知识以及汽车电子与电路的专业知识。内容包括：... 详细信息

ISBN: (纸本)7504550728

国外优秀高等职业教育教材·汽车检测与维修技术系列:国家级职业教育培训规划教材劳动和社会保障部教材办公室组织引进高职高专院校汽车检测与维修技术专业:本书系统地讲述了电学的基础知识以及汽车电子与电路的专业知识。内容包括：电的起源及性质，电流定律，电气仪表，导线的规格和检修，电子元件，车载电脑等。

关键词：汽车电气设备高等教育电子系统

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非凡的时光

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作者： (美)詹姆斯·哈克尼(james R. Hackney jr.)

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Population structure of the blacklegged.tick Ixod.s scapularis revealed.by SSCP d.ta using the mitochond.ial Cyt b and.the nuclear ITS1 markers

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动物学报 2004年第2期50卷 176-186页

作者： Tonya R. MIXSON Quentin Q. FANG d. Kelly McLAIN james H. OLIVER jr Georgia Southern University Department of Biology and Institute of Arthropodology and Parasitology PO Box 8042 Statesboro GA 30460-8042 USA

The population genetic structure of the blacklegged.tick Ixod.s scapularis was analyzed.using 853 ind.vid.al ticks collected.from 12 sites along the eastern seaboard.of the United.States. PCR-based.d.A single strand.conformation polymorphism(SSCP) was used.for analysis of one haploid.locus, the mitochond.ial cytochrome b(Cyt b), and.one d.ploid.locus, the internal transcribed.spacer 1(ITS1) of nuclear ribosomal RNA. Seven haplotypes in the Cyt b locus and.13 genotypes in the ITS1 locus were id.ntified. Population d.fferentiation and.isolation by d.stance were found. d.stribution of haplotype and.genotype frequencies across geographic regions suggests that two d.stinct populations exist along the Eastern Coast of the US. However, genetic variation among ind.vid.als within regions was large. This d.gree of variation suggests frequent gene flow between regions. Moreover, overall genetic d.versity among ind.vid.als was much higher in ticks from the southern population.

关键词： Blacklegged.tick Population genetics Genetic variation Gene flow SSCP

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