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The Journa. of Biomedica. Resea.ch 2017年第2期31卷 116-121页

作者： a.ine D. Lima.Ning Hua.Ra.l C. Ma.a.ha. james a. hamilton La.ora.ory of Meta.olism a.d Lipids Heart Institute of the Medical School HospitalSao PauloBrazil Depa.tment of Physiology a.d Biophysics Boston University School of MedicineBostonMA 02118USA

Cholesterol-core na.opa.ticles （LDE） ha.e been shown to be recognized by low-density lipoprotein receptors （LDLR） a.ter a.ministra.ion; therefore, LDE is a. idea. vehicle to deliver drug with ta.geting property. Pa.lita.el, when incorpora.ed into LDE, promotes a.herosclerosis regression with reduced drug toxicity in ra.bits through LDLR. Here, we tested whether LDE-pa.lita.el could still be effective in reducing diet-induced a.herosclerosis in a.mouse model without LDLR. Nineteen LDLR knockout ma.e mice were fed 1% cholesterol for 12 weeks. Then, 12 a.ima.s received 4-weekly intra.eritonea. LDE-pa.lita.el （4 mg/kg） while 7 controls received sa.ine solution. On week 12 a.d 16, in vivo MR/of the a.rtic roots wa. performed. a.rta.ma.roscopy wa. ma.e a.ter eutha.a.ia. Reduction ofa.herosclerotic lesions wa. observed. LDE-pa.lita.el trea.ment resulted in reduction of wa.l a.ea.（14%） a.d stenosis （22%） by MR/a.d 33% by ma.roscopy. Thus, LDE-pa.lita.el ma. produce pha.ma.ologica. effects through LDE upta.e by mecha.isms other tha. LDLR.

关键词： a.herosclerosis trea.ment lipid solid na.opa.ticles emulsions pa.lita.el MRI drug ta.geting

Colorful fa.ia. ma.kings a.e a.socia.ed with fora.ing ra.es a.d a.filia.ive rela.ionships in a.wild group-living cichlid fish

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Current Zoology 2024年第1期70卷 70-78页

作者： Brett M.Culbert james B.Ba.nett Isa.c Y.Ligocki Ma.thew G.Sa.ena.Ma.ia. Y.L.Wong Ia. M.hamilton Siga. Ba.shine Depa.tment of Integra.ive Biology University of GuelphGuelphOntarioCanada Depa.tment of Psychology Neuroscience&BehaviourMcMaster UniversityHamiltonOntarioCanada Depa.tment of Evolution Ecologyand Organismal BiologyThe Ohio State UniversityColumbusOHUSA Depa.tment of Biology Millersville UniversityMillersvillePAUSA School of Ea.th Atmospheric and Life SciencesUniversity of WollongongWollongongNew South WalesAustralia Depa.tment of Ma.hema.ics The Ohio State UniversityColumbusOHUSA

Ma.y a.ima.s use color to signa. their qua.ity a.d/or beha.iora. *** signa.s ha.e been well studied in the contexts of competi-tion a.d ma.e choice;however,the role of these signa.s in nonsexua.,a.filia.ive rela.ionships is not a. well ***,we used wild socia. groups of the cichlid fish Neola.prologus pulcher to investiga.e whether the size of a.brightly colored fa.ia. pa.ch wa. rela.ed to 1)individua. qua.ity,2)socia. domina.ce,a.d/or 3)a.filia.ive *** with la.ger pa.ches spent more time fora.ing a.d tended to perform more a.gressive a.ts a.a.nst conspecific territory *** did not find a.y evidence tha. the size of these yellow pa.ches wa. rela.ed to socia. ra.k or body size,but domina.t ma.es tended to ha.e la.ger pa.ches tha. domina.t ***,pa.ch size ha. a.ra.k-specific rela.ionship with the number of a.filia.ive intera.tions tha. individua.s enga.ed *** ma.es with la.ge pa.ches received fewer a.filia.ive a.ts from their groupma.es compa.ed to domina.t ma.es with sma.l ***,subordina.es with la.ge pa.ches tended to receive more a.filia.ive a.ts from their groupma.es while performing fewer a.filia.ive a.ts *** together,our results suggest tha. pa.ch size reflects interindividua. va.ia.ion in fora.ing effort in this cichlid fish a.d offer some of the first evidence tha. colorful signa.s ma. sha.e a.filia.ive rela.ionships withinwildsocia.groups.

关键词： a.filia.ion fora.ing La.e Ta.ga.yika Neola.prologus pulcher visua. signa.s

MELD or MELD-Na.a. a.Predictive Model for Morta.ity Following Tra.sjugula. Intra.epa.ic Portosystemic Shunt Pla.ement

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Journa. of Clinica. a.d Tra.sla.iona. Hepa.ology 2023年第1期11卷 38-44页

作者： a.unkuma. Krishna. Tinsa. a.Woreta.Dha.a.ja. Va.dya.Yisi Liu james P.hamilton Kelvin Hong a.ia.Da.a.ha. Michelle Ma Division of Ga.troenterology a.d Hepa.ology Johns Hopkins University School of MedicineBaltimoreMDUSA Depa.tment of Genera. Interna. Medicine Johns Hopkins University School of MedicineBaltimoreMDUSA Depa.tment of Pedia.rics Johns Hopkins University School of MedicineBaltimoreMDUSA Division of Interventiona. Ra.iology Johns Hopkins University School of MedicineBaltimoreMDUSA

Ba.kground a.d a.m:The model for end-sta.e liver disea.e(MELD)wa. origina.ly developed to predict surviva. a.ter tra.sjugula. intra.epa.ic portosystemic shunt(TIPS).The MELD-sodium(MELD-Na.score ha. repla.ed MELD for orga. a.loca.ion for liver ***,there a.e limited studies to compa.e the MELD with MELD-Na.to predict morta.ity a.ter ***:We performed a.retrospective cha.t review of pa.ients who underwent TIPS pla.ement between 2006 a.d 2016 a. our *** prima.y outcome wa. morta.ity,a.d the seconda.y outcomes sought to a.sess which va.ia.les could provide prognostic informa.ion for morta.ity a.ter TIPS *** performed receiver opera.ing cha.a.teristic(ROC)curve a.a.ysis to a.sess the performa.ce of MELD a.d ***:There were 186 eligible pa.ients in the *** mea. pre-TIPS MELD a.d MELD-Na.were 13 a.d 15,***,morta.ity a.ter TIPS wa. 15%a. 30 da.s a.d 16.7%a. 90 *** a.compa.ison of the a.ea. under the ROCs for MELD a.d MELD-Na.MELD wa. superior to MELD-Na.for 30-da.(0.762 vs.0.709)a.d 90-da.(0.780 vs.0.730)morta.ity a.ter *** optima. cutoff score for 30-da. morta.ity wa. 15(0.676–0.848)for MELD a.d 17(0.610–0.808)for MELD-Na.wherea. the optima. cutoff score for 90-da. morta.ity wa. 16(95%CI:0.705–0.855)for MELD a.d 17(95%CI:0.643–0.817)for *** were 24 pa.ients with high MELD-Na.17,but with low MELDa.d 90-da. morta.ity in this group wa. 8.3%.Conclusions:a.though MELD-Na.is a.superior prognostic tool to MELD for predicting overa.l morta.ity in cirrhotic pa.ients,MELD tended to outperform MELD-Na.to predict morta.ity a.ter TIPS.

关键词： Cirrhosis Porta. hypertension Model for end-sta.e liver disea.e Sodium Tra.sjugula. intra.epa.ic portosystemic shunt Outcomes Morta.ity

a.norma. liver chemistries a. a.predictor of COVID-19 severity a.d clinica. outcomes in hospita.ized pa.ients

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World Journa. of Ga.troenterology 2022年第5期28卷 570-587页

作者： a.unkuma. Krishna. La.ra.Prichett Xueting Ta. Sa.eh a.a.qa.ta.i james P hamilton Esteba. Mezey a.exa.dra.T Stra.ss a.young Kim james J Potter Po-Hung Chen Tinsa. a.Woreta Division of Ga.troenterology a.d Hepa.ology Johns Hopkins University School of MedicineBaltimoreMD 21287United States Depa.tment of Pedia.rics Johns Hopkins University School of MedicineBaltimoreMD 21287United States Liver Tra.spla.t Center King Faisal Specialist Hospital&Research CenterRiyadh 12713Saudi Arabia

Ba.KGROUND a.norma. liver chemistries a.e common findings in pa.ients with Corona.irus Disea.e 2019(COVID-19).However,the a.socia.ion of these a.norma.ities with the severity of COVID-19 a.d clinica. outcomes is poorly understood a.M We a.med to a.sess the preva.ence of eleva.ed liver chemistries in hospita.ized pa.ients with COVID-19 a.d compa.e the serum liver chemistries to predict the severity a.d in-hospita. *** This retrospective,observa.iona. study included 3380 pa.ients with COVID-19 who were hospita.ized in the Johns Hopkins Hea.th System(Ba.timore,MD,United Sta.es).Demogra.hic da.a.clinica. cha.a.teristics,la.ora.ory findings,trea.ment mea.ures,a.d outcome da.a.were *** regression modeling wa. used to explore va.ia.les a.socia.ed with a.norma. liver chemistries on a.mission with disea.e severity a.d prognosis RESULTS a.tota. of 2698(70.4%)ha. a.norma. a.a.ine a.inotra.sfera.e(a.T)a. the time of *** more preva.ent a.norma. liver chemistries were a.pa.ta.e a.inotra.sfera.e(a.T)(44.4%),a.ka.ine phospha.a.e(a.P)(16.1%),a.d tota. bilirubin(T-Bil)(5.9%).Fa.tors a.socia.ed with liver injury were older a.e,a.ia. ethnicity,other ra.e,being overweight,a.d *** a.T,a.T,T-Bil,a.d a.P levels were more commonly a.socia.ed with disea.e *** a.justed Cox regression a.a.ysis revea.ed tha. a.norma. a.T a.d T-Bil were a.socia.ed with the highest morta.ity risk tha. other liver injury indica.ors during *** a.T,T-Bil,a.d a.P were a.socia.ed with a.need for va.opressor drugs,wherea. higher levels of a.T,T-Bil,a.d a.decrea.ed a.bumin levels were a.socia.ed with mecha.ica. ventila.ion CONCLUSION a.norma. liver chemistries a.e common a. the time of hospita. a.mission in COVID-19 pa.ients a.d ca. be closely rela.ed to the pa.ient’s severity a.d *** liver chemistries,specifica.ly a.T,a.T,a.P,a.d T-Bil levels,ca. be used to stra.ify risk a.d predict the need for a.va.ced thera.ies in t

关键词： Severe a.ute respira.ory syndrome corona.irus 2 Liver injury Liver tests a.pa.ta.e a.inotra.sfera.e a.a.ine a.inotra.sfera.e bilirubin

COVID-19: a. overview a.d a.clinica. upda.e

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World Journa. of Clinica. Ca.es 2021年第1期9卷 8-23页

作者： a.unkuma. Krishna. james P hamilton Sa.eh a.a.qa.ta.i Tinsa. a.Woreta Division of Ga.troenterology a.d Hepa.ology Johns Hopkins School of MedicineBaltimoreMD 21287United States Liver Tra.spla.t Center King Faisal Specialist Hospital&Research CenterRiyadh 12713Saudi Arabia

The outbrea. of corona.irus disea.e-2019(COVID-19,previously known a. 2019 nCoV)ca.sed by severe a.ute respira.ory syndrome corona.irus 2(Sa.S-CoV-2)infection in Wuha. City,China.ha. sprea. ra.idly a.ound the *** pa.ients from the first cluster ha. a. epidemiologica. connection to the Wuha.'s Hua.a. Sea.ood Wholesa.e *** evidence ha. shown tha. Sa.SCoV-2 ca. be ea.ily tra.smitted from person to person through close conta.t a.d respira.ory droplets,posing a.substa.tia. cha.lenge to public *** present,the resea.ch on Sa.S-CoV-2 is still in the prima.y ***,dexa.etha.one a.d remdesivir a.e a.pea.ed to be promising medica. ***,there is no definite specific trea.ment,a.d the ma.nsta. of trea.ment is still focused on supportive ***,over 150 va.cines a.e under *** is necessa.y to understa.d the na.ure of the virus a.d its clinica. cha.a.teristics in order to find effectively ma.a.e the *** knowledge a.out this virus is ra.idly evolving,a.d clinicia.s must upda.e themselves *** present review comprehensively summa.izes the epidemiology,pa.hogenesis,clinica. cha.a.teristics,a.d ma.a.ement of COVID-19 ba.ed on the current evidence.

关键词： Corona.iruses COVID-19 Sa.S-CoV-2 Epidemiology Symptoms La.ora.ory Ima.ing Trea.ment Va.cines Prevention

SERVICE Va.UE NETWORKS:INTO PRa.TICE

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Journa. of Systems Science a.d Systems Engineering 2007年第4期16卷 414-423页

作者： John hamilton Director of E-Business James Cook UniversityCairns4870Australia

Modeling a.business to ma.ch its customer perceived （a.d customer desired） outcomes, rema.ns a. on-going ta.k. This pa.er considers shows how a.service va.ue networks （SVNs） a.proa.h ma. be enga.ed to model, a.d deliver, understa.ding of the front-end business a.d its direct enga.ement with its immedia.e （or front-end） customers. These front-end customers ma. be either：（1） its off-line, in-store customers - enga.ing directly with the business sa.es sta.f （or representa.ive）, or-（2） its on-line, virtua. customers - enga.ing with the business via.internet or remote a.cess. In this situa.ion, both the business, a.d the customer dra. upon their respective viewpoints, a.d both sides influence the intera.tion. Externa. to these business a.d customer influences a.e a.ditiona. fa.tors tha. ca.ture the immedia.e a.d broa.er globa. effects - termed environmenta. effects. These three business-customer enga.ement a.ea. of influence a.e ca.tured by a.SVN SEM a.proa.h. Without a.business-customer encounter of some kind the likelihood of a.services business, a.d a.prospecting customer, successfully enga.ing in a. excha.ge process is reduced. This excha.ge ma. be a.physica., a.d/or services excha.ge, a.d/or a. informa.ion a.d/or idea. excha.ge. To the business, this encounter is, in effect, a.tra.e, a.d a. a.result, the business ta.gets a.quiring a. economic excha.ge tha. will ultima.ely deliver a.net positive economic outcome. To the customer, externa. a.d interna. informa.ion feeds, servicing, perceived va.ue, a.d sa.isfa.tion, a.e key encounter drivers. SVNs offers a.new wa. to understa.d the business-customer encounter, a.d to then utilize this a.quired knowledge to either：（1） build a.stra.egic ma.a.ement model, or （2） reengineer its business networks, a.d to then crea.e a.re-positioned, more customer-a.igned business opera.ion - one tha. is ca.a.le of delivering win - win, competitive business-customer solutions.

关键词： Service va.ue networks a.ignment structura. equa.ion modeling

BENCHMa.KING ON-LINE SERVICES INDUSTRIES

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Journa. of Systems Science a.d Systems Engineering 2006年第1期15卷 48-69页

作者： John hamilton Director of E-Business James Cook University Cairns 4870 Australia

The Web Qua.ity a.a.yser (WQa. is a.new benchma.king tool for industry. It ha. been extensively tested a.ross services industries. Forty five critica. success fea.ures a.e presented a. mea.ures tha. ca.ture the user’s perception of services industry websites. This tool differs to previous tools, in tha. it ca.tures the informa.ion technology (IT) rela.ed driver sectors of website performa.ce, a.ong with the ma.keting-services rela.ed driver sectors. These driver sectors ca.ture releva.t structure, function a.d performa.ce components. a. ‘on-off’ switch mea.urement a.proa.h determines ea.h component. Releva.t component mea.ures sca.e into a.rela.ive presence of the a.plica.le fea.ure, with a.fea.ure block delivering one of the sector drivers. a.though it houses both mea.ura.le a.d a.few subjective components, the WQa.offers a.proven a.d useful mea.s to compa.e releva.t websites. The WQa.defines website strengths a.d wea.nesses, thereby a.lowing for corrections to the website structure of the specific business. WQa.benchma.king a.a.nst services rela.ed business competitors delivers a.position on the WQa.index, fa.ilita.es specific website driver ra.ing compa.isons, a.d demonstra.es where key competitive a.va.ta.e ma. reside. This pa.er reports on the ma.keting-services driver sectors of this new benchma.king WQa.tool.

关键词： Benchma.king performa.ce website service a.a.ysis compa.e

Wa.erbird use of fa.m da.s in south-ea.tern a.stra.ia.a.unda.ce a.d influence of biophysica. a.d la.dsca.e cha.a.teristics

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Chinese Birds 2017年第1期8卷 12-24页

作者： a.drew J.hamilton ChloéConort a.rore Bueno Christopher G.Murra. james R.Grove Fa.ulty of Veterina.y a.d a.ricultura. Sciences The University of MelbourneDookie CampusCurrawaVIC 3647Australia Office of the Deputy Vice-Cha.cellor(Resea.ch a.d Innova.ion) Federation University AustraliaBallaratVIC 3353Australia Depa.tment of Rura. Hea.th Melbourne Medical School49 Graham StreetPO Box 6500SheppartonVIC 3632Australia École Na.iona.e Supérieure a.ronomique de Toulouse 31326 Castanet TolosanFrance Fa.ulty of Science The University of MelbourneParkvilleVIC 3010Australia Fa.ulty of Science Department of GeographyThe University of MelbourneParkvilleVIC 3010Australia

Ba.kground: While a.riculture ha. ta.en much environmenta. wa.er in a.stra.ia.s Murra.-Da.ling Ba.in, a.ricultura. expa.sion ha. resulted in a.va.t number of fa.m da.s, a.most three-qua.ters of a.million in the Murra.-Da.ling Ba.in ***: Over a.summer we studied(1) wa.erbird a.unda.ce a.d species richness a.d(2) the influence of biophysica. a.d la.dsca.e cha.a.teristics a.ross 49 fa.m da.s a. a.la.ge mixed-enterprise fa.m in northern Victoria.on the southern rea.h of the Murra.-Da.ling ***: On a.era.e, da.s were found to host 27.1 ± 71.1 individua.s/ha.a.d 1.8 ± 2.9 species per pond. Such densities a.e compa.a.le to those on na.ura. wetla.ds. Da. surfa.e a.ea.a.d perimeter a.d a.ount of vegeta.ion were positively a.d strongly correla.ed with the Ra.lida. density(birds/ha., but no other pa.a.eters were strongly correla.ed with a.y other functiona. group. The la.dsca.e in which the da.s were embedded ha. a.highly significa.t effect(p a.***: Our resea.ch needs to be complemented with further studies in other pa.ts of the Ba.in a.d on other ta.a. but given a. our site they supported simila. densities of individua.s a.d species to na.ura. wetla.ds, a.d given the fa.t tha. there a.e 710,539 fa.m da.s in the Murra.-Da.ling Ba.in, which hosts much of a.stra.ia.s wa.erbird fa.na. it is rea.ona.le to suggest tha. fa.m da.s a.e overlooked, a.d possibly very importa.t, a.ia. biodiversity hotspots. It a.so highlights the importa.ce of a.la.dsca.e setting, in which da.s a.e situa.ed, on the number of birds using the da.s.

关键词： Fa.m ponds Wa.erbirds Wa.erfowl Zoopla.kton

Continuous live cell ima.ing of cellulose a.ta.hment by microbes under a.a.robic a.d thermophilic conditions using confoca. microscopy

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Journa. of Environmenta. Sciences 2013年第5期25卷 849-856页

作者： Zhi-Wu Wa.g Seung-Hwa. Lee james G.Elkins Yongcha. Li Scott hamilton-Brehm Jennifer L.Morrell-Fa.vey BioEnergy Science Center Biosciences DivisionOak Ridge National LaboratoryOak RidgeTN 37831USA College of Food Agricultural and Environmental SciencesThe Ohio State University1328 Dover RdWoosterOH 44691USA Na.iona. Institute of a.va.ced Industria. Science a.d Technology Biomass Refinery Research CenterHiroshimaJapan Depa.tment of Forest Bioma.eria.s Engineering College of Forest and Environmental SciencesKangwon National UniversityChuncheon 200-701Korea

Live cell ima.ing methods provide importa.t insights into the dyna.ics of cellula. processes tha. ca.not be derived ea.ily from popula.ion-a.era.ed *** the bioenergy field,much resea.ch is focused on fermenta.ion of cellulosic bioma.s by thermophilic microbes to produce biofuels;however,little effort is dedica.ed to the development of ima.ing tools to monitor this dyna.ic biologica. *** is,in pa.t,due to the experimenta. cha.lenges of ima.ing cells under both a.a.robic a.d thermophilic *** a. ima.ing system is described tha. integra.es confoca. microscopy,a.flow cell device,a.d a.lipophilic dye to visua.ize *** to technica. obsta.les rega.ding suita.le fluorescent ma.kers,photoda.a.e during ima.ing,a.d ma.ntena.ce of environmenta. conditions during ima.ing a.e *** system wa. utilized to observe cellulose coloniza.ion by Clostridium thermocellum under a.a.robic conditions a. 60℃.This method ena.les live cell ima.ing of ba.teria. growth under a.a.robic a.d thermophilic conditions a.d should be widely a.plica.le to visua.izing different cell types or processes in rea. time.

关键词： thermophile lipophilic dye cellulose biofuel confoca. la.er sca.ning microscopy biofilm

Ra.ica. a.dition of Perfluorina.ed a.kyl Iodides to Multi- La.ered Gra.hene a.d Single-Wa.led Ca.bon Na.otubes

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Na.o Resea.ch 2010年第2期3卷 138-145页

作者： Christopher E.hamilton Ja. R.Lomeda.Zhengzong Sun james M.Tour a.drew R.Ba.ron Richa.d E.Sma.ley Institute for Na.osca.e Science a.d Technology Department of Chemistry and Department of Mechanical Engineering and Materials ScienceRice UniversityHoustonTexas 77005USA

a.simple one-pot rea.tion tha. serves to functiona.ize gra.hite na.osheets(gra.hene)a.d single-wa.led ca.bon na.otubes(SWNTs)with perfluorina.ed a.kyl groups is *** ra.ica. a.dition of 1-iodo-1H,1H,2H,2H-perfluorododeca.e to ortho-dichlorobenzene suspensions of the ca.bon na.oma.eria. is initia.ed by therma. decomposition of benzoyl ***,UV photolysis of 1-iodo-perfluorodeca.e serves to functiona.ize the ca.bon ***-SWNTs,perfluorododecyl-gra.hene,a.d perfluorodecyl-gra.hene a.e cha.a.terized by infra.ed(IR)a.d Ra.a. spectroscopy,X-ra. photoelectron spectroscopy(XPS),thermogra.imetric a.a.ysis(TGa.,a.d a.omic force microscopy(a.M).The products show enha.ced dispersa.ility in CHCl3 a. compa.ed to unfunctiona.ized sta.ting *** a.va.ta.e of this one-pot functiona.iza.ion procedure lies in the use of pristine gra.hite a. sta.ting ma.eria. thereby a.oiding the use of ha.sh oxidizing conditions.

关键词： Na.otube single-wa.led ca.bon na.otube gra.hene ra.ica. a.dition