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Reconstruction options for acetabular revision

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World Journal of Orthopedics 2012年第7期3卷 95-100页

作者： Erica D Taylor james a browne Department of Orthopaedic Surgery University of VirginiaCharlottesvilleVA 22908United States

This article summarizes reconstruction options available for acetabular revision following total hip arthroplasty. A thoughtful methodology to the evaluation and treatment of patients with implant failure after joint replacement is essential to guarantee accurate diagnoses, appropriate triage to reconstruction options, and optimal clinical outcomes. In the majority of patients who undergo acetabular revision, factors such as bone loss and pelvic discontinuity provide a challenge in the selection and implementation of the proper reconstruction option. With advanced evaluation algorithms, imaging techniques, and implant designs, techniques have evolved to rebuild the compromised acetabulum at the time of revision surgery. However, clinical outcomes data for these techniques continue to lag behind the exponential increase in revision hip arthroplasty cases predicted to occur over the next several years. We encourage those involved in the treatment of patients undergoing hip replacement surgery to participate in well-designed clinical studies to enhance evidence-based knowledge regarding revision acetabular reconstruction options.

关键词： Hip Arthoplasty Revision Acetabulum Tantalum

Management of failed metal-on-metal total hip arthroplasty

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World Journal of Orthopedics 2012年第6期3卷 70-74页

作者： Justin W Griffin Michele D'Apuzzo james a browne Department of Orthopaedic Surgery University of Virginia Health System400 Ray C Hunt Dr. CharlottesvilleVA 22903 United States

The theoretical advantages of metal-on-metal(MOM)bearing couples in total hip arthroplasty(THA) have been recently balanced by concerns regarding adverse local and systemic effects. Higher than anticipated early revision rates have been reported by several joint registries. Failed MOM hips present with a spectrum of symptoms and findings and traditional methods of failure must be considered in addition to the failure modes that appear to be unique to the MOM bearing couple. Metal hypersensitivity and soft tissue immune reactions remain incompletely understood and require careful ongoing study. The tools available to evaluate MOM THAs and the indications for revision surgery remain to be defined. Outcomes following revision of MOM hips appear to depend on appropriate evaluation, early identification, and appropriate surgical management.

关键词： Hip arthroplasty Metal-on-metal Revision joint arthroplasty Pseudotumor Aseptic lymphocyticvasculitis-associated lesions Metal hypersensitivity

Higher cost of arthroplasty for hip fractures in patients transferred from outside hospitals vs primary emergency department presentation

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World Journal of Orthopedics 2022年第8期13卷 725-732页

作者： Emanuel C Haug Hakan Pehlivan J Ryan Macdonell Wendy Novicoff james browne Thomas Brown Quanjun Cui Department of Orthopedic Surgery University of VirginiaCharlottesvilleVA 22908United States Department of Orthopedic Surgery Preferred Pediatric Orthopedic SurgeryRidgewoodNJ 07450United States Department of Orthopedic Surgery Asheville Orthopedic AssociatesAshevilleNC 28801United States

BACKGROUND In 2016 Centers for Medicare and Medicaid Services proposed bundled payments for hip fractures to improve the quality and decrease costs of *** transferred from other facilities may be imposing a financial risk on the hospitals that accept these *** To determine the costs associated with patients that either presented to the emergency department or were transferred from another hospital or skilled nursing facility(SNF)with the diagnosis of a hip fracture requiring operative *** A retrospective single institution review was conducted for all arthroplasty patients from 2010 to *** criteria included a total or partial hip replacement for a hip *** criteria included pathologic,periprosthetic,and fracture *** was collected to compare total observed costs for patients from the emergency department,patients from skilled nursing facilities,and patients from an outside *** A total of 223 patients met the inclusion criteria.135(60.54%)of these patients presented primarily to the emergency department,58 patients(26.01%)were transferred from an outside hospital,and 30 patients(13.43%)were transferred from a *** data analysis showed that outside hospital patients demonstrated significantly greater total cost for their hospitalization($43302)compared to emergency department patients($28875,P=0.000)and SNF patients($28282,P=0.000).CONCLUSION Patients transferred from an outside hospital incurred greater costs for their hospitalization than patients presenting from an emergency department or *** is a strong argument for riskadjustment models when bundling payments for the care of hip fracture patients.

关键词： Total hip arthroplasty Cost Transfer Outside hospital Hip fracture

Distinct MLT asymmetry of auroral kilometric radiation observed by the FAST satellite

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Earth and Planetary Physics 2025年第1期9卷 188-193页

作者： JiaWen Tang Sai Zhang FuLiang Xiao HongMing Yang Si Liu YiHua He Chang Yang YuYue Jin ZhouKun Deng Ping Li Archie james Johnston School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410114China Hunan Province Higher Education Key Laboratory of Modeling and Monitoring on the Near-Earth Electromagnetic Environments Changsha University of Science and TechnologyChangsha 410114China School of Electrical and Information Engineering Changsha University of Science and TechnologyChangsha 410114China

Auroral Kilometric Radiation (AKR) is a common radio emission,which can contribute to the magnetosphere-ionosphereatmosphere co u *** emissions have been observed in all magnetic planet magnetospheres of the solar *** this study,using observations from the FAST satellite from 30 August 1996 to 9 September 2001,the distribution of AKR in altitude=500-4500 km and invariant latitude (|ILAT|)=60°-80°has been analyzed.63045 AKR samples have been identified with~48%(52%) samples on the dayside (nightside).Of considerable interest,there is a distinct MLT asymmetry with the high occurrence rate in MLT=05-08 and 18-22(02-05 and 12-17) in the northern (southern) *** distinct MLT asymmetry is associated with the direction of Bxof the interplaneta ry magnetic *** addition,the occurrence rate on the nightside clearly increases as the AE^(*) index *** study further enriches the information and understanding of AKR in the magnetosphere as well as other similar radio emissions.

关键词： asymmetry auroral kilometric radiation interplanetary magnetic field

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl james Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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避世之所加拿大亚瑟住宅

室内设计与装修 2025年第1期 46-49页

作者：无 james Brittain(摄影) coco(编译) 5468796 Architecture 不详

亚瑟住宅是为一对来自南非的夫妇设计的,他们一位是热衷园艺的木匠,另一位是急诊室医生。夫妇俩一直在寻找一个适中的“避难所”,与外界隔绝,并且有足够的空间来保护隐私。住宅所在的小区是一个成熟社区,原有的小平房正迅速被传统住宅... 详细信息

亚瑟住宅是为一对来自南非的夫妇设计的,他们一位是热衷园艺的木匠,另一位是急诊室医生。夫妇俩一直在寻找一个适中的“避难所”,与外界隔绝,并且有足够的空间来保护隐私。住宅所在的小区是一个成熟社区,原有的小平房正迅速被传统住宅取代。与此相反,亚瑟夫妇希望用一种深思熟虑的替代方案来挑战这种发展模式。

关键词：传统住宅替代方案保护隐私避难所亚瑟园艺小区加拿大

基于SEMI~F57-0301标准下,新一代化学品输送过程中,阀门管接件及其材料的选择、设计、生产和测试

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半导体技术 2005年第8期30卷 45-49页

作者： james M.Hanson RonnieA.browne Swagelok Company Swagelok Company

本文高度阐述了含氟聚合物阀门应用在半导体行业超高纯水系统和液体化学分配系统,阀门的选择、设计、生产和测试的问题。针对半导体工业发展的需求,以SEMIF57-0301为标准,对更加苛刻的应用进行了预先考虑和阐述。所阐述方法和理论同样... 详细信息

本文高度阐述了含氟聚合物阀门应用在半导体行业超高纯水系统和液体化学分配系统,阀门的选择、设计、生产和测试的问题。针对半导体工业发展的需求,以SEMIF57-0301为标准,对更加苛刻的应用进行了预先考虑和阐述。所阐述方法和理论同样适用于流量计,过滤器,调节阀等组件。

关键词： SEMI 输送过程阀门标准设计测试化学品管接件一代材料高纯水系统半导体行业含氟聚合物分配系统工业发展流量计过滤器调节阀应用需求

STUDIES OF THE ANTENNA EFFECT IN POLYMER MOLECULES ENERGY MIGRATION AND TRAPPING IN NAPHTHALENE-CONTAINING POLYELECTROLYTES

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Chinese Journal of Polymer Science 1998年第3期16卷 261-267页

作者： GUILLET james Department of Chemistry University of Toronto Toronto M5S 3H6 Canada

Polymers of 1- and 2-vinylnaphthalene containing more than about 50 mol% sulfonic acid groups dissolve in water to form 'hypercoiled' conformations which have many of the properties of micelles. Hydrophobic molecules such as anthracene and perylene are selectively absorbed in these pseudo micellar structures, and their fluorescence emission is sensitized by energy transfer from the surrounding naphthalene chromophores. When irradiated with UV light in the presence of oxygen, the emission of perylene rapidly decreases. It is proposed that this is due to reaction of singlet oxygen with the perylene trapped in the hypercoiled polymer. (Author abstract) 3 Refs.

关键词： Sulfonated vinyl naphthalene polymers Transport of excitation energy Anthracene Perylene Tripping