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Molecular studies resolve Nyholmiella (Orthotrichaceae) as a separate genus

Journal of Systematics and Evolution 2010年第3期48卷 183-194页

作者： jakub SAWICKI Vítězslav PLek Monika SZCZECINSKA Department of Botany and Nature Protection University of Warmia and Mazury in OlsztynPlacLódzki 110-727 OlsztynPoland Department of Biology & Ecology University of OstravaChittussiho 10CZ-710 00Czech Republic

Two Orthotrichum species of the subgenus Orthophyllum were compared with other representatives of this genus using internally transcribed spacer regions 1 and 2,the chloroplast trnH-psbA region,and inter-simple sequence repeat(ISSR)and intron-exon splice conjunction(ISJ)markers.The ISSR and ISJ markers used revealed many bands and mutations specific only to O.gymnostomum and O.obtusifolium.Phylogenetic analysis clearly supported previous concepts postulating that species of the subgenus Orthophyllum should be recognized as the separate genus Nyholmiella.

关键词： molecular taxonomy Nyholmiella Orthotrichum phylogeny.

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Resolving the α-Glycosidic Linkage of Arginine-Rhamnosylated Translation Elongation Factor P(EF-P) Triggers Generation of the First Arg Rha Specific Antibody

Resolving the α-Glycosidic Linkage of Arginine-Rhamnosylate...

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第二届糖合成化学青年学术研讨会

作者： Xiang Li Ralph Krafczyk jakub maco?ek Yu-Lei Li Yan Zou Bernd Simon Xing Pan Qiu-Ye Wu Fang Yan Shan Li Janosch Hennig Kirsten Jung Jürgen Lassak 胡宏岗 Department of Organic Chemistry School of Pharmacy Second Military Medical University School of Pharmacy Wei Fang Medical University

A previously discovered posttranslational modification strategy–arginine rhamnosylation–is essential for EF-P dependent rescue of polyproline stalled ribosomes in clinical relevant species such as Pseudomonas aeruginosa and Neisseria meningitidis2].However,almost nothing is known about this new type of N-linked glycosylation.In the present study,we used NMR spectroscopy to show for the first time that theaanomer of rhamnose is attached to Arg32 of EF-P,demonstrating that

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Factors influencing the failure of interferon-free therapy for chronic hepatitis C:Data from the Polish EpiTer-2 cohort study

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World Journal of Gastroenterology 2021年第18期27卷 2177-2192页

作者： Ewa Janczewska Mateusz Franciszek Kołek Beata Lorenc jakub Klapaczyński Magdalena Tudrujek-Zdunek Marek Sitko Włodzimierz Mazur Dorota Zarębska-Michaluk Iwona Buczyńska Dorota Dybowska Agnieszka Czauż-Andrzejuk Hanna Berak RafałKrygier Jerzy Jaroszewicz Jolanta Citko Anna Piekarska Beata Dobracka Łukasz Socha Zbigniew Deroń Łukasz Laurans Jolanta Białkowska-Warzecha Olga Tronina Brygida Adamek Krzysztof Tomasiewicz Krzysztof Simon Malgorzata Pawłowska Waldemar Halota Robert Flisiak Department of Basic Medical Sciences The School of Health Sciences in BytomMedical University of SilesiaBytom 41-902Poland Department of Animal Physiology Faculty of BiologyUniversity of WarsawWarszawa 02-096Poland Pomeranian Center of Infectious Diseases Medical University GdańskGdańsk 80-214Poland Department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry of Internal Affairs and AdministrationWarszawa 02-507Poland Department of Infectious Diseases Medical University of LublinLublin 20-081Poland Department of Infectious and Tropical Diseases Jagiellonian UniversityKraków 30-688Poland Clinical Department of Infectious Diseases Medical University of Silesia in KatowiceChorzów 41-500Poland Department of Infectious Diseases Jan Kochanowski University KielceKielce 25-369Poland Department of Infectious Diseases and Hepatology Medical University WrocławWrocław 51-149Poland Department of Infectious Diseases and Hepatology Ludwik Rydygier Collegium Medicum in Bydgoszcz Faculty of Medicine Nicolaus Copernicus University in ToruńBydgoszcz 85-030Poland Department of Infectious Diseases and Hepatology Medical University of BiałystokBiałystok 15-540Poland One-Day Department Hospital for Infectious Diseases in WarsawWarszawa 01-201Poland Outpatient Clinic State University of Applied Sciences in KoninKonin 62-510Poland Department of Infectious Diseases and Hepatology Medical University of Silesia in KatowiceBytom 41-902Poland Department of Medical Practice of Infections Regional HospitalOlsztyn 10-561Poland Department of Infectious Diseases and Hepatology Medical University ofŁódźŁódź90-419Poland MedicalSpec Center Wrocław 53-428Poland Department of Infectious Diseases Hepatology and Liver TransplantationPomeranian Medical UniversitySzczecin 71-455Poland Ward of Infectious Diseases and Hepatology Biegański Regional Specialist HospitalŁódź91-347Poland Infectious and Liver Diseases Clinic Multidisciplinary Regional HospitalGorzów Wielkopolski 66-400Poland Dep

BACKGROUND The introduction of direct-acting antiviral drugs into clinical practice has revolutionized the treatment of chronic hepatitis C,making it highly effective and safe for patients.However,few researchers have analyzed the factors causing therapy failure in some patients.AIM To analyze factors influencing the failure of direct antiviral drugs in the large,multicenter EpiTer-2 cohort in a real-world setting.METHODS The study cohort consisted of patients with chronic hepatitis C treated at 22 Polish centers from 2016-2020.Data collected from the online EpiTer-2 database included the following:hepatitis C virus(HCV)genotype,stage of fibrosis,hematology and liver function parameters,Child-Turcotte-Pugh and Model for End-stage Liver Disease scores,prior antiviral therapy,concomitant diseases,and drugs used in relation to hepatitis B virus(HBV)and/or human immunodeficiency virus(HIV)coinfections.Adverse events observed during the treatment and follow-up period were reported.Both standard and machine learning methods were used for statistical analysis.RESULTS During analysis,12614 patients with chronic hepatitis C were registered,of which 11938(mean age:52 years)had available sustained virologic response(SVR)data[11629(97%)achieved SVR and 309(3%)did not].Most patients(78.1%)were infected with HCV genotype 1b.Liver cirrhosis was diagnosed in 2974 patients,while advanced fibrosis(F3)was diagnosed in 1717 patients.We included patients with features of hepatic failure at baseline[ascites in 142(1.2%)and encephalopathy in 68(0.6%)patients].The most important host factors negatively influencing treatment efficacy were liver cirrhosis,clinical and laboratory features of liver failure,history of hepatocellular carcinoma,and higher body mass index.Among viral factors,genotype 3 and viral load also exerted an influence on treatment efficacy.Classical statistical analysis revealed that treatment ineffectiveness seemed to be influenced by the male sex,which was not confirmed by the multivariate analysis using the machine l

关键词： Advanced liver disease Chronic hepatitis C Direct-acting antiviral drugs Sustained virologic response Interferon-free therapy Antiviral therapy

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