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神经损伤与功能重建 2022年第11期17卷 682-682页

作者： jakob berner Tamara Weiss Helena Sorger Fikret Rifatbegovic Max Kauer Reinhard Windhager Alexander Dohnal Peter F Ambros Inge MAmbros Kaan Boztug Peter Steinberger Sabine Taschner-Mandl 杜一星(编译) St.Anna Children's Cancer Research Institute(CCRI) ViennaAustria St.Anna Children's Hospital ViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryMedical University of Vienna Department of Orthopedics and Trauma Surgery Medical University of ViennaViennaAustria Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases(LBI-RUD) ViennaAustria Center for Molecular Medicine(CeMM) ViennaAustria. Institute of Immunology Medical University of ViennaViennaAustria 不详

雪旺细胞(SCs)的可塑性潜能因其在神经损伤后和周围神经系统疾病中发挥作用而备受关注。有关免疫细胞和雪旺细胞之间相互作用的研究表明雪旺细胞参与炎症过程。然而,人类雪旺细胞的免疫能力主要是从神经病变中推断出来的,但神经损伤后... 详细信息

雪旺细胞(SCs)的可塑性潜能因其在神经损伤后和周围神经系统疾病中发挥作用而备受关注。有关免疫细胞和雪旺细胞之间相互作用的研究表明雪旺细胞参与炎症过程。然而,人类雪旺细胞的免疫能力主要是从神经病变中推断出来的,但神经损伤后雪旺细胞是否直接调节适应性免疫反应尚不清楚。本研究对人类修复相关雪旺细胞(hrSCs)的免疫调节能力进行综合分析,hrSCs概括了雪旺细胞对体外神经损伤的反应。我们使用有效的人类周围神经原代hrSCs培养模型,分析了转录组、分泌组、以及细胞表面与先天免疫和适应性免疫相关的通路和标志物相关的蛋白;进行了吞噬作用测定,并监测了同种异体共培养细胞中的T细胞亚群激活。本研究结果表明hrSC具有吞噬作用,这与MHCⅡ的高表达一致。此外,hrSC表达协同调节蛋白,如CD40、CD80、B7H3、CD58、CD86和HVEM,释放过多的趋化因子、基质重塑蛋白、促炎及抗炎细胞因子,并在IFNγ进行促炎刺激后上调T细胞对PD-L1分子的抑制。与单核细胞相反,单独的hrSC不足以触发同种异体CD4+和CD8+T细胞,但会限制外源激活的T细胞的数量和激活状态。本研究表明,hrSCs具有体外专职抗原呈递细胞的典型特征和功能,并表明这些细胞在神经再生过程中作为T细胞免疫负调节剂的新作用。

关键词： PD-L1 雪旺细胞抗原呈递细胞免疫能力免疫调节炎症神经损伤神经病变

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FamilyCoviDD19: results of a cross-sectional study—long-term outcomes of infected and uninfected household members

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Family Medicine and Community Health 2023年第3期11卷 31-44页

作者： Theresa S Horst jakob P Armann Maren Doenhardt Svenja Dresen Paula Czyborra Josephine Schneider Christin Gano Alexander Dalpke Christian Luck Annet Bluschke Magdalena Wekenborg Reinhard berner Judith Blankenburg Department of Pediatrics University Hospital and Medical Faculty Carl Gustav CarusTechnische UniversitatDresdenDresdenGermany Department of Infectious Diseases Medical Microbiology and HygieneUniversity Hospital HeidelbergHeidelbergGermany Institute of Medical Microbiology and Virology University Hospital and Medical Faculty Carl Gustav CarusTechnische UniversitatDresdenDresdenGermany Department of Child and Adolescent Psychiatry University Hospital and Medical Faculty Carl Gustav CarusTechnische UniversitatDresdenDresdenGermany Biological Psychology Technische UniversitatDresdenDresdenGermany Else Kroner Fresenius Center for Digital Health University Hospital and Medical Faculty Carl Gustav CarusTechnische UniversitatDresdenDresdenGermany

Objective In this study,we aimed to compare long-term physical and mental health outcome between SARS-CoV-2 infected and uninfected household members to differentiate between infection-related and pandemic-related outcomes after about two and a half years of the ***,possible differences in the outcome of adults and children and young people(CYP)were of *** In a cross-sectional study design,we compared the long-term physical and mental health outcome of between infected and uninfected as well as between adult and CYP(household members).Setting The FamilyCoviDD19 study—a serology study in households—was initially conducted to evaluate virus transmission in a close contact setting focusing on households with children and adolescents in *** least 1year after initial infection in the respective households,a follow-up took place in which the prevalence and type of possible long-term consequences were surveyed on the basis of self-reported information on physical and mental *** In this study,a total of 533 household members of 146 families participated and responded to our survey,including 296(55.5%)adults and 237(44.5%)*** The difference in frequency of reported symptoms between infected and uninfected individuals was very moderate,suggesting that the vast majority of reported symptoms were not attributable to a previous SARS-CoV-2 ***,regardless of age and infection status,this study showed overall high rates of self-reported symptoms with CYP having fewer long-term sequelae than adults oneyear after ***,over 50%of those reporting symptoms were not affected in their daily life,with CYPs reporting an even lower percentage compared with *** CYP are at reduced risk not only to develop symptomatic infection or severe disease courses(previous analyses)but also to develop infection-associated long-term sequelae(this study).Independent of infection CYP reported high rates of

关键词： infected sectional consequences

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