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Nylon 6-cellulose composite hosted in a hypodermic needle: Biofluid extraction and analysis by ambient mass spectrometry in a single device

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Journal of Pharmaceutical Analysis 2023年第11期13卷 1346-1352页

作者： jaime Millan-Santiago Rafael Lucena Soledad Cardenas Affordable and Sustainable Sample Preparation(AS2P)Research Group Analytical Chemistry DepartmentChemical Institute for Energy and Environment(IQUEMA)University of CordobaE-14071CordobaSpain

This study proposes a hypodermic needle(HN)as a sorbent holder and an electrospray(ESI)emitter,thus combining extraction and analysis in a single device.A novel nylon 6-cellulose(N6-Cel)composite sorbent is proposed to extract methadone from oral fluid *** cellulosic substrate provides the composite with high porosity,permitting the flow-through of the sample,while the polyamide contributes to the extraction of the *** low price of the devices(considering the holder and the sorbent)contributes to the affordability of the method,and their small size allows easy transportation,opening the door to on-site *** the optimum conditions,the analyte can be determined by high-resolution ambient ionization mass spectrometry at a limit of detection(LOD)as low as 0.3 mg/L and precision(expressed as relative standard deviation,RSD)better than 9.3%.The trueness,expressed as relative recovery(RR),ranged from 90%to 109%.As high-resolution mass spectrometers are not available in many laboratories,the method was also adapted to low-resolution *** this sense,the direct infusion of the eluates in a triple quadrupole-mass spectrometry provided an LOD of 2.2 mg/*** RSD was better than 5.3%,and the RR ranged from 96%to 121%.

关键词： ESI emitter Mass spectrometry Hypodermic needle Composite Methadone

Feeding on clean food?Potential effects of electric organ discharges by Torpedo spp.(Torpediniformes:Torpedinidae)on their trophically transmitted parasites

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Integrative Zoology 2022年第2期17卷 234-245页

作者： jaime PENADÉS-SUAY Tania REGACHO Francisco Javier AZNAR Marine Zoology Unit Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of ValenciaValènciaSpain LAMNA Association for the study of elasmobranchs from the Valencian Community ValènciaSpain

Members of the Torpedinidae(torpedoes)and Hypnidae(coffin ray)use electric organ discharges(EOD)to stun or kill their prey before *** investigated whether EOD could also negatively affect the helminth larvae infecting these preys through a surrogate model:we applied electric discharges to individuals of blue whiting,Micromesistius poutassou,that harbored live larvae of *** mortality throughout a 6-h period was significantly higher in the treatment group,suggesting that EODs could significantly hamper helminth *** then tested whether torpedinids and hypnids(“strong-EOD”families)harbored species-poor helminth(cestode)assemblages compared with“weak-EOD”Torpediniformes(Narcidae and Narkidae)and other *** on comparisons on estimated species diversity and mean species richness of tapeworms at host individual level we found that(i)Torpediniformes had the lowest tapeworm diversity of all Batoidea orders;(ii)Torpedo *** had the lowest mean cestode richness at host individual level,and this could not be related to other host factors influencing cestode diversity in chondrichthyans,that is body size,trophic level or dietary ***,a preliminary comparison between“strong-EOD”and“weak-EOD”Torpediniformes did not detect clear differences of cestode ***,evidence supporting an unambiguous contribution of EODs to depauperate cestode assemblages requires further research.

关键词： Anisakis Batoidea cestode EOD behavior Torpediniform Torpedo

A species-transport model for circulation in a leading-edge vortex

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Advances in Aerodynamics 2022年第1期4卷 762-779页

作者： Clara Giner-Morency jaime G.Wong Department of Mechanical Engineering University of AlbertaEdmontonT6G 1H9Canada

In this study,we propose a model to predict circulation growth along the span of a rotating wing,in which circulation transport is represented as species *** particles entering the vortex shear layer at the leading edge are initialized as vorticity-containing mass and are advected by the flow along the span.A circulation budget is presented,consisting of a generation and transport term,the latter derived from the vorticity transport equation,which leaves only two unknowns for the modeller to determine:the shear-layer thickness and the spanwise flow *** find that the model is insensitive to the value chosen for the shear-layer thickness,as varying the thickness by an order of magnitude only changes the output by a few ***,we use Bernoulli equation in a rotating coordinates system as a basic model for spanwise *** verify the accuracy of the model,the predicted circulation values are compared against experimental circulation values and show good agreement to measurements close to the axis of rotation,which corresponds to the spanwise locations at which the spanwise flow model best matches experimental *** is suggested,therefore,that this model produces accurate results subject to an appropriate spanwise flow model.

关键词： Leading-edge vortices Circulation transport Vortex growth Rotating wings

A re-evaluation of the average chain length of lacustrine sedimentary n-alkanes as a paleoproxy on the Qinghai-Tibet Plateau

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Frontiers of Earth Science 2023年第4期17卷 905-919页

作者： Mingda WANG Qin LI jaime TONEY David HENDERSON Juzhi HOU School of Geography Liaoning Normal UniversityDalian 116029China Alpine Paleoecology and Human Adaptation(ALPHA)Group State Key Laboratory of Tibetan Plateau Earth SystemResources and EnvironmentInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China School of Geographical and Earth Sciences University of GlasgowGlasgow G128QQScotlandUK CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China

Long-chain n-alkanes are one of the most common organic compounds in terrestrial plants and they are well-preserved in various geological archives.n-alkanes are relatively resistant to degradation and thus they can provide high-fidelity records of past vegetation and climate ***,previous studies have shown that the interpretation of n-alkane proxies,such as the average chain length(ACL),is often ambiguous since this proxy depends on more than one *** vegetation and climate could exert controls on the n-alkane ACL,and hence its interpretation requires careful consideration,especially in regions like the Qinghai-Tibet Plateau(QTP)where topography,biome type and moisture source are highly *** further evaluate the influences of vegetation and climate on the ACL in high-elevation lakes,we examined the n-alkane distributions of the surface sediments of 55 lakes across the *** results show that the ACL across a climatic gradient is significantly affected by precipitation,rather than by *** positive correlation between ACL and precipitation may be because of the effect of microbial degradation during ***,we suggest that more caution is needed in the interpretation of ACL data in different regions.

关键词： ACL average chain length n-alkanes leaf wax lake sediments Qinghai-Tibet Plateau

Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

Assessment of retracted papers,and their retraction notices,from a cancer journal associated with“paper mills”

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数据与情报科学学报:英文版 2023年第2期8卷 118-125页

作者： jaime A.Teixeira da Silva Serhii Nazarovets Independent researcher Ikenobe 3011-2Kagawa-ken761-0799Japan Borys Grinchenko Kyiv University 18/2 Bulvarno-Kudriavska Str.04053 KyivUkraine

Cancer research is occasionally described as being in a reproducibility *** cancer literature has ample papers retracted due to misconduct,including the use of paper mills,invalid authorship,or fake *** objective of this paper was to gain an appreciation of the balance of retractions and associated retraction notices of 23 retracted Cancer Biotherapy and Radiopharmaceuticals papers associated with paper *** 23 March 2023,these retracted papers had already accumulated 287 citations according to Web of Science Core Collection,253 according to Scopus,and 365 according to Google Scholar,i.e.,metrically speaking,they were highly *** authors had an affiliation(71%being a hospital)in ***(12/21;57%)of corresponding authors had emails with a@*** *** of the retraction notices(i.e.,17%)explicitly indicated paper mills as a reason for retraction although,in general,the retraction notices lacked details and background that could assist readers’understanding of the retractions.

关键词： Indexing Oncology Publishing history PubMed Retraction Notices Transparency

The ecological scale mediates whether trees experience drought legacies in radial growth

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Forest Ecosystems 2023年第3期10卷 298-306页

作者： Héctor Hernández-Alonso jaime Madrigal-González Fernando Silla Area of Ecology Faculty of BiologyUniversidad de SalamancaE-37007SalamancaSpain iuFOR-EiFAB Campus de SoriaUniversidad de ValladolidE-42004SoriaSpain

The impact of lag effects produced by disturbances on primary production has been a major concern among ecologists during the last *** and extreme climatic events are imposing drastic reductions in radial growth of trees as evidenced in tree-rings series Dendrochronological samples are obtained at tree level but analyzed at an aggregated scale(i.e.,mean chronologies),although aggregating tree-ring chronology on a regional scale may reduce the possibility of studying the variability of individual tree response to drought,by amplifying the average population ***,we conducted experimental research in which 370 trees of 5 species were analyzed to assess the potential statistical and scaling issues that may occur when using regressionbased methods to analyze ecosystem responses to *** legacy effects were quantified using individual and aggregated ***,lag effects were validated using confidence and prediction intervals to identify values falling outside the certainty of the climate-growth model Individual scale legacy effects contrasted with confidence intervals were commonly distributed across species but were scarce when compared with prediction *** analysis of aggregated scale legacies detected significant growth reductions when validated using prediction intervals;however,individual scale legacy lag effects were not *** finding directly contrasts the results obtained when using an aggregated *** results provide empirical evidence on how aggregating ecological data to infer processes that emerge from an individual scale can lead to distorted *** therefore encourage the use of individual based statistical and ecological procedures to analyze tree rings as a means of further understanding the ecosystem responses to disturbances.

关键词： Legacy effects Drought disturbances Tree growth Tree-ring width Dendrochronology Individual scale Mountainous forests

2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

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中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen Wade A.Weigel Michael M.Todd Richard P.Dutton Cynthia A.Lien Stuart A.Grant Joseph W.Szokol Lars I.Eriksson Myron Yaster Mark D.Grant Madhulika Agarkar Anne M.Marbella jaime F.Blanck Karen B.Domino 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

Avian malaria,haematocrit,and body condition in invasive wetland passerines settled in southwestern Spain

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Avian Research 2023年第1期14卷 99-107页

作者： jaime Muriel Luz Garcia-Longoria Sergio Magallanes Juan Antonio Ortiz Alfonso Marzal Instituto de Investigación en Recursos Cinegéticos(IREC) CSIC-UCLM-JCCMRonda de Toledo 1213005Ciudad RealSpain Universidad de Extremadura Facultad de BiologíaDepartamento de AnatomíaBiología Celular y Zoología Avenida de Elvas s/n06006BadajozSpain Estación Biológica de Donana(EBD-CSIC) Departamento de Ecología de los HumedalesAvda.Américo Vespucio 2641092SevillaSpain Hirundo Bird Ringing Group BadajozSpain Grupo de Investigaciones en Fauna Silvestre Universidad Nacional de San MartínJr.Maynas177722021TarapotoPeru

Avian malaria and related haemosporidian parasites can negatively impact fitness in many *** on the malaria infection and its physiological costs on their avian hosts is heavily skewed toward native passerines,with exotic species ***,introduced species may carry on and spread new pathogens to native species,and play a role on parasite transmission cycle in invaded bird communities as pathogen ***,we molecularly assess the prevalence and diversity of haemosporidian parasites in three introduced wetland passerines(the Red Avadavat Amandava amandava,the Yellow-crowned Bishop Euplectes afer,and the Common Waxbill Estrilda astrild)captured during the same season in southwestern *** also explored the relation between parasite infection,body condition,haematocrit,and uropygial gland *** detected an overall parasite prevalence of 3.55%,where Common Waxbills showed higher prevalence(6.94%)than Red Avadavats(1.51%).None Yellow-crowned Bishops were infected with *** 60%of infections were caused by Leucocytozoon,and about 40%by *** identified four unique lineages of Plasmodium and three of ***,91%of the identified host-parasite interactions represented new host records for these haemosporidian *** infection was not related to body condition,haematocrit,and uropygial gland volume of the wetland *** values varied seasonally among bird ***,haematocrit was positively related to body condition in the Yellow-crowned Bishops,but not in the other *** Avadavats had higher haematocrit levels than Yellow-crowned Bishops,whereas Common Waxbills showed the lower haematocrit *** uropygial gland volume was positively correlated with body condition in all bird *** Waxbills showed higher uropygial gland volumes related to their body size than birds from other two *** outcomes highlight the importance of e

关键词： Avian malaria Exotic species Introduced birds Leucocytozoon Plasmodium Uropygial gland