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Global Dynamics of a Multi-group SEIR Epidemic Model with Infection Age

Chinese Annals of Mathematics,Series B 2021年第6期42卷 833-860页

作者： Vijay Pal BAJIYA jai prakash tripathi Vipul KAKKAR Jinshan WANG Guiquan SUN Department of Mathematics Central University of RajasthanBandar Sindri-305817KishangarhAjmerRajasthanIndia Complex Systems Research Center Shanxi UniversityTaiyuan 030006China Department of Mathematics North University of ChinaTaiyuan 030051China Complex Systems Research Center Shanxi UniversityTaiyuan 030006China.

Consider the heterogeneity(e.g.,heterogeneous social behaviour,heterogeneity due to different geography,contrasting contact patterns and different numbers of sexual partners etc.)of host population,in this paper,the authors propose an infection age multigroup SEIR epidemic model.The model system also incorporates the feedback variables,where the infectivity of infected individuals may depend on the infection age.In the direction of mathematical analysis of model,the basic reproduction number R_0 has been computed.The global stability of disease-free equilibrium and endemic equilibrium have been established in the term of R_(0).More precisely,for R_(0)≤1,the disease-free equilibrium is globally asymptotically stable and for R_(0)>1,they establish global stability of endemic equilibrium using some graph theoretic techniques to Lyapunov function method.By considering a numerical example,they investigate the effects of infection age and feedback on the prevalence of the disease.Their result shows that feedback parameters have different and even opposite effects on different groups.However,by choosing an appropriate value of feedback parameters,the disease could be eradicated or maintained at endemic level.Besides,the infection age of infected individuals may also change the behaviour of the disease,global stable to damped oscillations or damped oscillations to global stable.

关键词： Multi-group model Infection age Feedback Graph-theoretic approach Lyapunov function

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Advancements on metal oxide semiconductor photocatalysts in photo-electrochemical conversion of carbon dioxide into fuels and other useful products

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Frontiers in Energy 2024年第2期18卷 187-205页

作者： jai prakash Zhangsen CHEN Shakshi SAINI Gaixia ZHANG Shuhui SUN Department of Chemistry National Institute of Technology HamirpurHamirpur 177005India Institut National de la Recherche Scientifique(INRS) Centre Énergie Matériaux TélécommunicationsVarennes J3X 1P7Canada Department of Chemistry Indian Institute of Technology MandiHimachal PradeshIndia Department of Electrical Engineering École de Technologie SupérieureMontréal H3C 1K3Canada

Due to its fascinating and tunable optoelectronic properties,semiconductor nanomaterials are the best choices for multidisciplinary applications.Particularly,the use of semiconductor photocatalysts is one of the promising ways to harness solar energy for useful applications in the field of energy and environment.In recent years,metal oxide-based tailored semiconductor photocatalysts have extensively been used for photocatalytic conversion of carbon dioxide(CO_(2))into fuels and other useful products utilizing solar energy.This is very significant not only from renewable energy consumption but also from reducing global warming point of view.Such current research activities are promising for a better future of society.The present mini-review is focused on recent developments(2–3 years)in metal oxide semiconductor hybrid photocatalysts-based photo-electrochemical conversion of CO_(2)into fuels and other useful products.First,general mechanism of photo-electrochemical conversion of CO_(2)into fuels or other useful products has been discussed.Then,various metal oxide-based emerging hybrid photocatalysts including tailoring of their morphological,compositional,and optoelectronic properties have been discussed with emphasis on their role in enhancing photoelectrochemical efficienty.Afterwards,mechanism of their photo-electrochemical reactions and applications in CO_(2)conversion into fuels/other useful products have been discussed.Finally,challenges and future prospects have been discussed followed by a summary.

关键词： metal-oxide semiconductors nanohybrid photocatalysts photo-electrochemical CO_(2)conversion tailoring morphology fuels challenges and future prospects

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A novel slot scheduling technique for duty-cycle based data transmission for wireless sensor network

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Digital Communications and Networks 2022年第3期8卷 351-358页

作者： Yogesh tripathi Arun prakash Rajeev tripathi Department of Electronics and Communication Engineering Motilal Nehru National Institute of Technology AllahabadPrayagraj211004India

The duty cycling process involves turning a radio into an active and dormant state for conserving energy. It is a promising approach for designing routing protocols for a resource-constrained Wireless Sensor Networks (WSNs). In the duty cycle-based WSNs, the network lifetime is improved and the network transmission is increased as compared to conventional routing protocols. In this study, the active period of the duty cycle is divided into slots that can minimize the idle listening problem. The slot scheduling technique helps determine the most efficient node that uses the active period. The proposed routing protocol uses the opportunistic concept to minimize the sender waiting problem. Therefore, the forwarder set will be selected according to the node's residual active time and energy. Further, the optimum routing path is selected to achieve the minimum forwarding delay from the source to the destination. Simulation analysis reveals that the proposed routing scheme outperforms existing schemes in terms of the average transmission delay, energy consumption, and network throughput.

关键词： Duty cycle Energy model Wireless sensor network Slot scheduling technique

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Exposure to Electromagnetic Fields from Mobile Phones and Fructose consumption Coalesce to Perturb Metabolic Regulators AMPK/SIRT1-UCP2/FOXO1 in Growing Rats

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Biomedical and Environmental Sciences 2023年第11期36卷 1045-1058页

作者： Ruchi tripathi Sanjay Kumar Banerjee Jay prakash Nirala Rajani Mathur Department of Pharmacology Delhi Institute of Pharmaceutical Sciences & ResearchDelhi Pharmaceutical Sciences and Research University(DPSR-U))New DelhiINDIA Drug Discovery Research Centre Translational Health Science and Technology InstituteFaridabadINDIA Department of Biotechnology National Institute of Pharmaceutical Education and ResearchGuwahatiINDIA School of Environmental Sciences Jawaharlal Nehru UniversityNew DelhiINDIA

Objective In this study,the combined effect of two stressors,namely,electromagnetic fields(EMFs)from mobile phones and fructose consumption,on hypothalamic and hepatic master metabolic regulators of the AMPK/SIRT1-UCP2/FOXO1 pathway were elucidated to delineate the underlying molecular mechanisms of insulin resistance.Methods Weaned Wistar rats(28 days old)were divided into 4 groups:Normal,Exposure Only(ExpO),Fructose Only(FruO),and Exposure and Fructose(EF).Each group was provided standard laboratory chow ad libitum for 8 weeks.Additionally,the control groups,namely,the Normal and FruO groups,had unrestricted access to drinking water and fructose solution(15%),respectively.Furthermore,the respective treatment groups,namely,the ExpO and EF groups,received EMF exposure(1,760 MHz,2 h/day x 8 weeks).In early adulthood,mitochondrial function,insulin receptor signaling,and oxidative stress signals in hypothalamic and hepatic tissues were assessed using western blotting and biochemical analysis.Result In the hypothalamic tissue of EF,SIRT1,FOXO 1,p-PI3K,p-AKT,ComplexⅢ,UCP2,MnSOD,and catalase expressions and OXPHOS and GSH activities were significantly decreased(P<0.05)compared to the Normal,ExpO,and FruO groups.In hepatic tissue of EF,the p-AMPKα,SIRT1,FOXO1,IRS1,p-PI3K,ComplexⅠ,Ⅱ,Ⅲ,Ⅳ,Ⅴ,UCP2,and MnSOD expressions and the activity of OXPHOS,SOD,catalase,and GSH were significantly reduced compared to the Normal group(P<0.05).Conclusion The findings suggest that the combination of EMF exposure and fructose consumption during childhood and adolescence in Wistar rats disrupts the closely interlinked and multi-regulated crosstalk of insulin receptor signals,mitochondrial OXPHOS,and the antioxidant defense system in the hypothalamus and liver.

关键词： EMF-mobile phone Fructose Childhood-adolescence Insulin receptor signal Mitochondrial OxPHOS Antioxidant system Hypothalamic insulin resistance Hepatic insulin resistance

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Hunting of hunted:an ensemble modeling approach to evaluate suitable habitats for caracals in India

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Ecological Processes 2022年第1期11卷 744-757页

作者： Ashish Kumar Jangid Chandra prakash Singh jai Singh Parihar Jasbir Singh Chauhan Rajnish Kumar Singh prakash Kumar Verma Amritanshu Singh Shantanu Sharma Shekhar Kolipaka Wildlife Institute of India DehradunUttarakhand 248001India Space Applications Centre Indian Space Research OrganisationAhmedabadGujarat 380015India Madhya Pradesh State Forest Department Madhya Pradesh Tiger Foundation SocietyKuno National ParkBhopalMadhya Pradesh 462001India Leo Foundation WageningenThe Netherlands

Background:Large-scale hunting and various anthropogenic pressures in the recent past have pushed the Asiatic caracal(Caracal caracal schmitzi),an elusive medium-sized and locally threatened felid species towards local extinction in India.Though widely distributed historically,it has been sparsely reported from several regions of central and northern states in India till twentieth century.Later,the species distribution became confined only to the states of Rajasthan,Gujarat and Madhya Pradesh,which have had reported sightings in the twenty-first century.In order to highlight the potentially suitable habitats for Asiatic caracals in India,we targeted forth-filtering of the spatial model ensemble by creating and utilizing the validated and spatially thinned species presence information(n=69)and related ecological variables(aridity,NDVI,precipitation seasonality,temperature seasonality,terrain ruggedness),filtered with anthropological variable(nightlight).Results:Out of eight spatial prediction models,the two most parsimonious models,Random Forest(AUC 0.91)and MaxEnt(AUC 0.89)were weighted and ensembled.The ensemble model indicated several clustered habitats,covering 1207.83 km^(2)areas in Kachchh(Gujarat),Aravalli mountains(Rajasthan),Malwa plateau(Rajasthan and Madhya Pradesh),and Bundelkhand region(Madhya Pradesh)as potentially suitable habitats for caracals.Output probabilities of pixels were further regressed with converted vegetation height data within selected highly potential habitats,i.e.,Ranthambore Kuno Landscape(RKL)(suitability~0.44+0.03(vegetation height)^(**),R^(2)=0.27).The regression model inferred a significant positive relation between vegetation height and habitat suitability,hence the lowest ordinal class out of three classes of converted vegetation height was masked out from the RKL,which yielded in an area of 567 km^(2) as potentially highly suitable habitats for caracals,which can be further proposed as survey areas and conservation priority areas for caracals.Conclusion:The study charts out

关键词： Medium-sized cat Caracal caracal schmitzi Potentially suitable habitat Drylands Potential survey area

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Microarchitectural mimicking of stroma-induced vasculature compression in pancreatic tumors using a 3D engineered model

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Bioactive Materials 2023年第4期22卷 18-33页

作者： Marcel Alexander Heinrich Irene Uboldi Praneeth Reddy Kuninty Marc J.K.Ankone Joop van Baarlen Yu Shrike Zhang Kartik jain jai prakash Department of Advanced Organ Bioengineering and Therapeutics Engineered Therapeutics SectionTechnical Medical CentreUniversity of Twente7500AEEnschedethe Netherlands Laboratorium Pathologie Oost-Nederland(LabPON) 7550 AMHengelothe Netherlands Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical School65 Landsdowne StCambridgeMA02139USA Department of Thermal and Fluid Engineering Biofluid Dynamics SectionUniversity of Twente7500 AE Enschedethe Netherlands

Fibrotic tumors,such as pancreatic ductal adenocarcinoma(PDAC),are characterized for high desmoplastic reaction,which results in high intra-tumoral solid stress leading to the compression of blood vessels.These microarchitectural alterations cause loss of blood flow and poor intra-tumoral delivery of therapeutics.Currently,there is a lack of relevant in vitro models capable of replicating these mechanical characteristics and to test anti-desmoplastic compounds.Here,a multi-layered vascularized 3D PDAC model consisting of primary human pancreatic stellate cells(PSCs)embedded in collagen/fibrinogen(Col/Fib),mimicking tumor tissue within adjunct healthy tissue,is presented to study the fibrosis-induced compression of vasculature in PDAC.It is demonstrated how the mechanical and biological stimulation induce PSC activation,extracellular matrix production and eventually vessel compression.The clinical relevance is confirmed by correlating with patient transcriptomic data.Furthermore,the effects of gradual vessel compression on the fluid dynamics occurring within the channel is evaluated in silico.Finally,it is demonstrated how cancer-associated fibroblast(CAF)-modulatory therapeutics can inhibit the cell-mediated compression of blood vessels in PDAC in vitro,in silico and in vivo.It is envisioned that this 3D model is used to improve the understanding of mechanical characteristics in tumors and for evaluating novel anti-desmoplastic therapeutics.

关键词： Pancreatic ductal adenocarcinoma Cancer-associated fibroblasts Collagen Fibrinogen Computational flow dynamics 3D in vitro model

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Profiling of Antifungal Activities from the Leaf Extract of Selected Apiaceae Family Plants against Aspergillus fumigates

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American Journal of Plant Sciences 2023年第1期14卷 1-14页

作者： Sakshi tripathi Vivek Morya Veeru prakash Department of Biochemistry and Biochemical Engineering Sam Higginbottom University of Agriculture Technology and Sciences Prayagraj India Centre of Energy and Environment Sustainability Lucknow India

Many ethnic plants are used as a source of traditional medicine to cure a variety of illnesses in both humans and animals. Developing secondary metabolites in plants with antifungal characteristics, offer alternative medications for reasonably priced and safe treatments. In the present study, methanolic, ethanolic, hexane and ethyl acetate leaves extracts of fifteen Apiaceae family plants were taken on the premise of their ethno botanical uses. The antifungal activity was assessed against significant fungal strain;Aspergillus fumigates by measuring minimum inhibitory concentration (MIC) and Zone of inhibition compared with standard drug fluconazole. Ethanol and methanol extracts of the plants were more effective than the hexane and ethyl acetate extracts against A. fumigates. Extracts of Cuminum cyminum, Pastinca sativa, Carum carvi, Dacus carota, Centella asiatica, Anthriscus cerefolium, Trachyspermum ammi, Pimpenella anisum and Apium graveolens showed relatively low inhibition effects between 3.5 to 8.5 mm. The MIC value of extracts was determined ranging between 0.8 to 0.43 μg/ml. The extract of Petroselinum crispum, Foeniculum vulgare, Ferula assaefoetida, Bunium persicum, Anethum graveolens and Coriander sativum could be considered as potential source of antifungal compounds for treating diseases in humans. Conclude remarks that these six extracts show astonishing fungicidal properties that can be used to discover drugs of very high potential.

关键词： Antifungal Aspergillus fumigatus Ethnobotanical Fungicidal Medicine

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Spectrum handoff scheme with multiple attributes decision making for optimal network selection in cognitive radio networks

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Digital Communications and Networks 2017年第3期3卷 164-175页

作者： Krishan Kumar Arun prakash Rajeev tripathi Department oJ:Electronics and Communication Engineering Motilal Nehru National Institute of Technology Allahabad 211004 India Electronics and Communication Engineering Department National Institute of Technology Hamirpur 177005 India Director Motilal Nehru National Institute of Technology Allahabad 211004 India

It is envisaged that in future Cognitive Radio (CR) networks deployment, multiple radio access networks may coexist. The networks may have different characteristics in terms of multiple attributes. CRs will have choices of selecting the optimal network out of the available networks. Optimal network selection is a challenging task that can be performed by spectrum handoff with Multiple Attribute Decision Making (MADM). The spectrum handoff decision with MADM provides wider and optimal choice with quality of service. This motivates the devolopment of a spectrum handoff scheme with MADM methods such as simple additive weighting, a technique for order preference by similarity to the ideal solution, a grey relational analysis and a cost function based method, which is the objective of this study. The CR preferences are based on voice, video and data services, called triple play services. The numerical results show that all MADM methods are effective for selecting the optimal network for spectrum handoff with a reduced complexity for the spectrum handoff decision. The paper shows that the proposed spectrum handoff scheme can be effectively implemented to select the optimal network according to triple play services in CR networks.

关键词： Spectrum handoff Cognitive radio SAW TOPSIS GRA Cost function

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Role of spleen tyrosine kinase in liver diseases

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World Journal of Gastroenterology 2020年第10期26卷 1005-1019页

作者： Dhadhang Wahyu Kurniawan Gert Storm jai prakash Ruchi Bansal Department of Biomaterials Science and Technology Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteEnschede 7500the Netherlands Department of Pharmacy Universitas Jenderal SoedirmanPurwokerto 53132Indonesia Department of Pharmaceutics University of UtrechtUtrecht 3454the Netherlands Department of Pharmacokinetics Toxicology and TargetingGroningen Research Institute of PharmacyUniversity of GroningenEnschede 7500the Netherlands

Spleen tyrosine kinase (SYK),a non-receptor tyrosine kinase,is expressed in most hematopoietic cells and non-hematopoietic cells and play a crucial role in both immune and non-immune biological responses.SYK mediate diverse cellular responses via an immune-receptor tyrosine-based activation motifs (ITAMs)-dependent signalling pathways,ITAMs-independent and ITAMs-semidependent signalling pathways.In liver,SYK expression has been observed in parenchymal (hepatocytes) and non-parenchymal cells (hepatic stellate cells and Kupffer cells) and found to be positively correlated with the disease severity.The implication of SYK pathway has been reported in different liver diseases including liver fibrosis,viral hepatitis,alcoholic liver disease,non-alcoholic steatohepatitis and hepatocellular carcinoma.Antagonism of SYK pathway using kinase inhibitors have shown to attenuate the progression of liver diseases thereby suggesting SYK as a highly promising therapeutic target.This review summarizes the current understanding of SYK and its therapeutic implication in liver diseases.

关键词： Spleen tyrosine kinase Liver diseases Inflammation Targeted therapeutics Spleen tyrosine kinase inhibitors

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Si–Ge based vertical tunnel field-effect transistor of junction-less structure with improved sensitivity using dielectric modulation for biosensing applications

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Chinese Physics B 2023年第12期32卷 644-651页

作者： Lucky Agarwal Varun Mishra Ravi prakash Dwivedi Vishal Goyal Shweta tripathi School of Electronics Engineering Vellore Institute of TechnologyChennai 600127India Department of Electronics and Communication Engineering Graphic Era(deemed to be University) DehradunUttarakhand 248002India Department of Electronics and Communication Engineering GLA UniversityMathura 281406India Department of Electronics and Communication Engineering Motilal Nehru National Institute of TechnologyAllahabad 211004India

A dielectric modulation strategy for gate oxide material that enhances the sensing performance of biosensors in junction-less vertical tunnel field effect transistors(TFETs)is reported.The junction-less technique,in which metals with specific work functions are deposited on the source region to modulate the channel conductivity,is used to provide the necessary doping for the proper functioning of the device.TCAD simulation studies of the proposed structure and junction structure have been compared,and showed an enhanced rectification of 10^(4) times.The proposed structure is designed to have a nanocavity of length 10 nm on the left-and right-hand sides of the fixed gate dielectric,which improves the biosensor capture area,and hence the sensitivity.By considering neutral and charged biomolecules with different dielectric constants,TCAD simulation studies were compared for their sensitivities.The off-state current IOFFcan be used as a suitable sensing parameter because it has been observed that the proposed sensor exhibits a significant variation in drain current.Additionally,it has been investigated how positively and negatively charged biomolecules affect the drain current and threshold voltage.To explore the device performance when the nanogaps are fully filled,half filled and unevenly filled,extensive TCAD simulations have been run.The proposed TFET structure is further benchmarked to other structures to show its better sensing capabilities.

关键词： biomolecules high-k dielectric junction-less vertical tunnel field effect transistor(TFET)

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