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Intraocular pressure measurement over soft contact lens by rebound tonometer: a comparative study

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 540-543页

作者： Senay asik Nacaroglu Emine Seker Un Mehmet Giray Ersoz Yelda Tasci Department of Ophthalmology Tepecik Traning and Research Hospital Department of Ophthalmology Akdagmadeni State Hospital

AIM: To evaluate the intraocular pressure(IOP)measurements by Icare rebound tonometer over a contact lens in comparison with Goldmann applanation tonometry(GAT). METHODS: Fifty patients using contact lens were included in this study. One of the eyes of the patients was selected randomly and their IOP were measured by rebound tonometer with and without contact lens(RTCL,RT respectively) and by GAT, as well as their central corneal thickness(CCT) by optical pachymeter. The results of both methods were compared by correlation analysis, general linear method repeated measure and Bland-Altman ***: Mean IOP values measured by RTCL, RT and GAT were 15.68 ±3.7, 14.50 ±3.4 and 14.16 ±2.8(P <0.001), respectively. Mean IOP by RTCL was significantly higher than the measurements implemented by RT and GAT(P <0.001), while there was no difference between the measurements by GAT and RT(P =0.629). There was a good level of positive correlation between GAT and RTCL as well as RT(r =0.786 P <0.001, r =0.833 P <0.001, respectively). We have observed that CCT increase did not show any correlation with the differences of the measurements between RTCL and RT(P =0.329), RTCL and GAT(P =0.07) as well as RT and GAT(P =0.189) in linear regression ***: The average of the measurements over contact lens by rebound tonometer was found to be higher than what was measured by GAT. Although this difference is statistically significant, it may be clinically negligible in the normal population.

关键词： contact lens intraocular pressure rebound tonometer

Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1662-1668页

作者： Betul Tugcu Senay asik Nacaroglu Asuman Gedikbasi Mehmet Uhri Nur Acar Hakan Ozdemir Department of Ophthalmology Faculty of Medicine Bezmialem University Istanbu134093 Turkey Department of Ophthalmology Bagcilar Training and Research Hospital Istanbu134200 Turkey Department of Biochemistry Bakirkoy Dr. Sadi Konuk Training and Research Hospital Istanbu134147 Turkey Department of Pathology Kanuni Sultan Suleyman Training and Research Hospital Istanbu134303 Turkey Department of Ophthalmology Acibadem University School of Medicine Istanbu134457 Turkey

AIM： To investigate the effect of pomegranate juice（PJ） intake on overall oxidation status in retinas of diabetic ***： Twenty-seven rats were divided into four groups as control（CO）, diabetic（DM）, control treated with PJ（CO-PJ）, and diabetic treated with PJ（DM-PJ）.The retina tissues were used to determine 8-hydroxy-2＇-deoxyguanosine（8 OHd G）, malondialdehyde（MDA）, reduced glutathione（GSH） levels, and the enzyme activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px）. RESULTS： The levels of 8 OHdG and MDA were significantly increased in the retina of DM group compared to CO group（P=0.001, P〈0.001 respectively）. Both 8 OHd G and MDA levels were decreased in PJ-DM group compared to DM group（P=0.004, P〈0.001 respectively）. The activities of antioxidant enzymes GSH, SOD, and GDH-Px were significantly decreased in the retina of DM group compared to CO group（P≤0.01）. GSH and GSH-Px activities were higher in PJ-DM group compared with DM group（P=0.010, P=0.042, respectively） but SOD activity was not statistically different（P=0.938）. CONCLUSION： PJ intake is found to be effective in decreasing oxidative end products, and in increasing the activities of antioxidant enzymes in diabetic retinas of rats, which suggests it may be effective against oxidative stress in diabetic retinas.

关键词： antioxidant enzymes diabetic retinopathy immunohistochemical staining oxidative stress pomegranate juice

C-type lectins and human epithelial membrane protein1:Are they new proteins in keratin disorders?

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Open Journal of Genetics 2013年第4期3卷 262-269页

作者： Nilufer Karadeniz Thomas Liehr Kristin Mrasek Ibrahim asik Zuleyha asik Nadezda Kosyakova Hasmik Mkrtchyan Medical Genetics of Zubeyde Hanim Maternity Hospital AnkaraTurkey Jena University Hospital Institute of Human GeneticsKollegiengasseJenaGermany Department of Anaesthesiology and Intensive Care Faculty of MedicineUniversity of AnkaraAnkaraTurkey Dermatology of Dr Sami Ulus Children’s Hospital AnkaraTurkey

Here we report a family with a clinical spectrum of Pachyonychia Congenita Tarda (PCT) encompassing two generations via a balanced chromosomal translocation between 4q26 and 12p12.3. We discuss the effects of chromosomal translocations on gene expression through involved breakpoints and structural gene abnormalities detected by array CGH. We believe that the family we present gives further insight to the better understanding of molecular and structural basis of keratin disorders, and to the late onset and genetic basis of PCT through the possible role of C-type lectins and human epithelial membrane protein1 (EMP1). Better understanding of the molecular basis of keratin disorders is the foundation for improved diagnosis, genetic counseling and novel therapeutic approaches to overcome the current treatment limitations related to this disease.

关键词： Keratins Palmoplantar Keratoderma Pachyonychia Congenital Tarda Lectins Epithelial Membrane Protein1 Gene Expression and Chromosome Translocation

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弱视儿童的临床概况和遮盖治疗结果

国际眼科杂志 2020年第11期20卷 1858-1865页

作者： Raju Kaiti Pabita Dhungel asik Pradhan Monica Chaudhry 尼泊尔眼科医院尼泊尔加德满都44600 太平洋大学验光学院美国俄勒冈州97116 昆士兰科技大学澳大利亚昆士兰4059 Ansal大学验光与视光科学系印度古鲁格拉姆22011

目的:研究弱视的临床表现,以及对弱视患者进行遮盖治疗的效果。方法:纵向研究。收集2015-04/2016-04 Dhulikhel医院眼科1092例患者数据。对检出的弱视60例患儿的视力、主诉、年龄、屈光状态、双眼屈光度和注视方式进行评估。并对检出的... 详细信息

目的:研究弱视的临床表现,以及对弱视患者进行遮盖治疗的效果。方法:纵向研究。收集2015-04/2016-04 Dhulikhel医院眼科1092例患者数据。对检出的弱视60例患儿的视力、主诉、年龄、屈光状态、双眼屈光度和注视方式进行评估。并对检出的弱视患儿进行遮盖治疗。结果:在研究期间接受检查的1092例儿童中,60例(5.49%)为弱视患者,其中,女性35例(58.30%),男性25例(41.70%),平均年龄为8.87±3.29岁。在43.3%(n=26)的弱视儿童中,经线性弱视是最常见的亚型,其次是远视性屈光参差性弱视(20%,n=12)。最常见的屈光不正是散光,占58.30%,其次是远视(22.50%)和近视(7.50%)。配戴眼镜联合遮盖治疗和主动视觉训练的依从性为73.30%(n=44)。3mo后不同治疗策略对弱视眼视力有显著改善(P=0.002)。结论:在尼泊尔等发展中国家,弱视发病率和相关的视力损害仍然是一个公共卫生问题。意识的缺乏,社区或学龄前儿童视力筛查的缺乏,会导致儿童较晚出现症状,并最终导致明显的视力损害。通过筛选就诊地点、及时转诊和适当的干预措施,这种状况可得到改善。

关键词：弱视遮盖治疗视力损害屈光不正斜视

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隐形眼镜使用者的依从性调查（英文）

国际眼科杂志 2017年第5期17卷 834-840页

作者： asik Pradhan Raju Kaiti Purushottam Dhungana 蒂尔冈加眼科研究所角膜和隐形眼镜组尼泊尔加德满都44600 加德满都大学Dhulikhel医院眼科尼泊尔Dhulikhel45200 蒂尔冈加眼科研究所屈光手术科尼泊尔加德满都44600

目的:从卫生和镜片、镜片盒及镜片护理液的更换来调查隐形眼镜配戴者的依从性。方法:以每天配戴镜片至少8h、持续配戴≥6mo的隐形眼镜配戴者为研究对象。采用半结构化、经过预先测试和验证的问卷调查表,在接受口头知情同意后评估软性隐... 详细信息

目的:从卫生和镜片、镜片盒及镜片护理液的更换来调查隐形眼镜配戴者的依从性。方法:以每天配戴镜片至少8h、持续配戴≥6mo的隐形眼镜配戴者为研究对象。采用半结构化、经过预先测试和验证的问卷调查表,在接受口头知情同意后评估软性隐形眼镜配戴者的依从性。每位受试者都接受访问,收集有关戴隐形眼镜使用历史的信息。年龄、性别、使用的镜片类型、配戴经验(a)、配戴时间和习惯、一天中持续使用镜片的时间和护理方法的细节都进行了记录。结果:共73名参与者的平均年龄为23.63±5.23y。观察到:依从性最高的项目为镜片清洁和消毒程序(98%);依从性最低的是隐形眼镜配件护理(81%)。依从性较差的是:更换镜片盒(41%),检查并丢弃过期的护理液(22%)和未能进行后续随访(22%)。镜片配戴的性别、配戴方式、配戴类型以及隐形眼镜使用年限依从性间无统计学差异。结论:这项研究结果证明总体上配戴者依从性良好。然而,在隐形眼镜盒和护理液等镜片配件的护理中,存在一定程度的不遵嘱执行。我们认为有必要考虑改善镜片护理操作依从性的方法。

关键词：隐形眼镜依从性镜片护理

The efficacy of vitamin E in preventing arthrofibrosis after joint replacement

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Animal Models and Experimental Medicine 2024年第2期7卷 145-155页

作者： Yingfang Fan Jean Yuh Sashank Lekkala Mehmet D.asik Andrew Thomson Madeline McCanne Mark A.Randolph Antonia F.Chen Ebru Oral Harris Orthopaedic Laboratory Department of Orthopaedic SurgeryMassachusetts General HospitalBostonMassachusettsUSA Department of Orthopaedic Surgery Harvard Medical SchoolBostonMassachusettsUSA Department of Surgery Harvard Medical SchoolBostonMassachusettsUSA Department of Orthopaedic Surgery Brigham and Women's HospitalBostonMassachusettsUSA

Background:Arthrofibrosis is a joint disorder characterized by excessive scar formation in the joint *** E is an antioxidant with potential anti-fibroblastic *** aim of this study was to establish an arthrofibrosis rat model after joint replacement and assess the effects of vitamin E supplementation on joint ***:We simulated knee replacement in 16 male Sprague–Dawley *** immobilized the surgical leg with a suture in full *** control groups were killed at 2 and 12 weeks(n=5 per group),and the test group was supplemented daily with vitamin E(0.2 mg/mL)in their drinking water for 12 weeks(n=6).We performed histological staining to investigate the presence and severity of *** staining andα2-macroglobulin(α2M)enzyme-linked immunosorbent assay(ELISA)were used to assess local and systemic *** weight bearing(total internal reflection)and range of motion(ROM)were collected for functional ***:The ROM and weight-bearing symmetry decreased after the procedure and recovered slowly with still significant deficit at the end of the study for both *** analysis confirmed fibrosis in both lateral and posterior periarticular *** E supplementation showed a moderate anti-inflammatory effect on the local and systemic *** vitamin E group exhibited significant improvement in ROM and weight-bearing symmetry at day 84 compared to the control ***:This model is viable for simulating arthrofibrosis after joint *** E may benefit postsurgical arthrofibrosis,and further studies are needed for dosing requirements.

关键词： arthrofibrosis range of motion total knee arthroplasty vitamin E

Short-term effects of intravitreal triamcinolone acetonide injection on ocular blood flow evaluated with color Doppler ultrasonography

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 811-815页

作者： Mustafa Alpaslan Anayol Yasin Toklu Elif asik Kamberoglu Sabri Raza Hasan Basri Arifoglu Huseyin Simavli Ayse Gul Kocak Altintas Saban Simsek Ulucanlar Eye Training and Research Hospital Department of Ophthalmology Ataturk Training and Research Hospital Department of Radiology Kecioren Training and Research Hospital Department of Ophthalmology Kayseri Training and Research Hospital Department of Ophthalmology Bolu Izzet Baysal State Hospital Department of Ophthalmology Yildirim Beyazit University School of Medicine

AIM:To evaluate the changes in ocular blood flow with color Doppler ultrasonography(CDU) after intravitreal triamcinolone acetonide(IVTA) ***:A total of 46 patients who underwent IVTA(4 mg/0.1 mL) injection for diabetic macular edema(DME)(n =22), central retinal vein occlusion(CRVO)(n =12) and choroidal neovascular membrane(CNVM)(n =12) were included in the study. Peak systolic velocity(PSV), end diastolic velocity(EDV) and resistivity index(RI) were measured from the ophthalmic artery(OA), the central retinal artery(CRA) and the posterior ciliary artery(PCA)of each patient with CDU before, at the end of the first week and at the end of the first month following IVTA ***:In the DME group, PSV of OA at the first of the first month(mean ±SD)(37.48 ±10.87 cm/s) increased compared to pre-injection value(31.39 ±10.84 cm/s)(P =0.048). There was a statistically significant decrease(P =0.049) in PSV of CRA at the end of the first month(7.97±2.67 cm/s) compared to the pre-injection(9.47±3.37 cm/s).There was not any statistically significant difference onthe other parameters in the DME group. Also, there was not any statistically significant difference on the ocular blood flow values in the CRVO and CNVM ***:We observed that 4 mg/0.1 mL IVTA increased PSV of OA and decreased PSV of CRA in DME patients and did not have any effect on ocular blood flow values of CRVO and CNVM patients.

关键词： intravitreal triamcinolone acetonide ocular blood flow diabetic macular edema central retinal vein occlusion choroidal neovascular membrane

无分电器点火系统—低射频干扰的固体高压分电器

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小型内燃机与车辆技术 1982年第1期 61-70页

作者： J.R.asik D.F.Moyer W.G.Rado 李及贤

普通的无触点点火系统分电器,具有两个主要功用:一是根据发动机转速和进气歧管的真空度为电子点火装置产生火花提前信号。对于这个功用,分电器可以被认为是一个简单的模拟计算机。二是机械式分度圆盘,它保证点火能量输送到相应的火花塞... 详细信息

普通的无触点点火系统分电器,具有两个主要功用:一是根据发动机转速和进气歧管的真空度为电子点火装置产生火花提前信号。对于这个功用,分电器可以被认为是一个简单的模拟计算机。二是机械式分度圆盘,它保证点火能量输送到相应的火花塞和气缸。对于这个

关键词：无分电器点火系统试验车工程车点火电嘴点火装置火花塞分电器感应线圈点火线圈干扰(电信) 射频干扰

盐胁迫环境下腐植酸类物质对小麦生长及矿物营养吸收的影响

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腐植酸 2009年第6期 30-35页

作者： Bar Bülent A k Murat Ali Turan Hakan elik Ali Vahap Katkat 刘海弟植物营养与土壤科学系乌卢达大学农学院布尔萨16059 中国科学院过程工程研究所北京100080

对在不同浓度的盐胁迫条件下,叶面喷施液态腐植酸和土壤施用腐植酸类物质对小麦作物生长和矿物营养吸收的影响进行了研究。通过添加不同量的NaCl得到不同的盐浓度环境。腐植酸类物质在作物种植前一个月施用,液态腐植酸在种苗发芽后20d和... 详细信息

对在不同浓度的盐胁迫条件下,叶面喷施液态腐植酸和土壤施用腐植酸类物质对小麦作物生长和矿物营养吸收的影响进行了研究。通过添加不同量的NaCl得到不同的盐浓度环境。腐植酸类物质在作物种植前一个月施用,液态腐植酸在种苗发芽后20d和35d喷施于小麦叶面。腐植酸类物质的施用量为0、1g/kg、2g/kg,液态腐植酸的浓度为0、0.1%、0.2%。盐度对小麦生长具有负面影响,它会降低小麦对除Na、Mn以外的矿物营养的吸收,影响小麦干重。通过在土壤施用腐植酸类物质可以增加小麦对N的吸收,叶面施用腐植酸可增加其对P、K、Mg、Na、Cu和Zn的吸收。研究结果显示:在土壤中施用腐植酸类物质,不同盐浓度与施用量之间存在较好的相关性,但叶面喷施时盐度和喷施量之间相关性并不明显。在盐胁迫环境的影响下,叶面喷施腐植酸的初始浓度和土壤中施用的腐植酸类物质的初施量都增加了作物对营养元素的吸收。

关键词：叶面喷施腐植酸腐植酸类物质盐度土壤施肥