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Amperometric Determination of Serum Cholesterol with Pencil Graphite Rod

American Journal of Analytical Chemistry 2010年第2期1卷 41-46页

作者： Nidhi Chauhan jagriti narang Chandra S. Pundir 不详

A cholesterol oxidase from Streptomycin sp. was immobilized onto pencil graphite rod and employed for amperometric determination of serum cholesterol. The method has the advantage over earlier amperometric methods that it requires low potential to generate electrons from H2O2, which does not allow ionization of serum substances. The optimum working conditions of amperometric determination were pH 6.8, 25?C and 30 s. The current measured was in proportion to cholesterol concentration ranging from 1.29×10-3 to 10.33×10-3 M. Minimum detection limit of the method was 0.09 ×10-3 M. Mean analytical recovery of added cholesterol (100 mg/dl and 200 mg/dl) in serum was 85.0% & 90.0% respectively. Within batch and between batch coefficients of variations were 1.59% & 4.15% respectively. A good correlation (r = 0.99) was obtained between serum cholesterol values by standard enzymic colorimetric method and the present method. No interference by metabolites was observed in the method. The enzyme electrode was reused 200 times over a period of 25 days, when stored at 4?

关键词： Cholesterol Cholesterol Oxidase Pencil Graphite Enzyme Electrode Serum Amperometric Biosensor

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Effect of blast inside tunnel on surrounding soil mass,tunnel lining,and superstructure for varying shapes of tunnels

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Underground Space 2021年第6期6卷 619-635页

作者： M.D.Goel Shivani Verma jagriti Mandal Sandeep Panchal Department of Applied Mechanics Visvesvaraya National Institute of Technology(VNIT)Nagpur 440010MaharashtraIndia Department of Mining Engineering Visvesvaraya National Institute of Technology(VNIT)Nagpur 440010MaharashtraIndia

In this study,a finite element(FE)analysis of shallow tunnels exposed to a blast inside the tunnel,with soil as surrounding medium and a structure at ground level,was *** ConWep program,developed by the US Army,was used to simulate blast loading using ABAQUS/Explicit■.Drucker-Prager(D-P)plasticity model,concrete damage plasticity(CDP),and Johnson-Cook(J-C)plasticity models were used to define the behavior of the soil,concrete,and reinforcement,*** analysis was carried out to compare the damages to the superstructure with variation in the cross-sectional shapes of the tunnel under internal blast *** tunnel shapes(circular,rectangular,and horseshoe cross-sections)were considered in the FE *** explosive of 100 kg TNT was located at the center of the cross-section of the *** response of the tunnel in terms of displacement and stress at critical locations was *** results showed that changes in the cross-section of the tunnel affect the stability of the tunnel,even when keeping all other factors *** was observed that the intensity of the stresses was the highest for a rectangular tunnel and lowest for a circular ***,it was also determined that the tunnel with a rectangular cross-section experienced the maximum displacement in the reinforced concrete(RC)lining compared with the horseshoe and circular *** displacement measured at critical structural members of the superstructure was found to be the highest for the tunnel with a rectangular cross-section and lowest for the tunnel with a circular cross-section.

关键词： Blast loading Numerical simulation ConWep Framed superstructure FE analysis ABAQUS/Explicit■

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Canagliflozin-current status in the treatment of type 2 diabetes mellitus with focus on clinical trial data

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World Journal of Diabetes 2014年第3期5卷 399-406页

作者： jagriti Bhatia Nanda Gamad Saurabh Bharti Dharamvir Singh Arya Department of Pharmacology All India Institute of Medical Sciences

Canagliflozin(CFZ) is a member of new class of glucose lowering agents, sodium-glucose co-transporter(SGLT) inhibitors, which got approval by food and drug administration. It has insulin independent action by blocking the transporter protein SGLT2 in the kidneys, resulting in urinary glucose excretion and reduction in blood glucose levels. In clinical trials, CFZ significantly decreased HbA1c level when administered either as monotherapy or as combined therapy with other anti-diabetic drugs. Intriguingly, it showed additional benefits like weight reduction and lowering of blood pressure. The commonly observed side effects were urinary and genital infections. It has exhibited favorable pharmacokinetic and pharmacodynamic profiles even in patients with renal and hepatic damage. Hence, this review purports to outline CFZ as a newer beneficial drug for type 2 diabetes mellitus.

关键词： Type 2 diabetes mellitus Sodium-glucose co-transporter 2 Canagliflozin Clinical trial Safety profile

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