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Molecula. a.pects of MERS-CoV

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Frontiers of Medicine 2017年第3期11卷 365-377页

作者： a.i a. Ra.a.n a.i M. Ba.zi Sha.sa. H. a.-a.med jaffar a. al-tawfiq Molecula. Dia.nostic La.ora.ory Johns Hopkins Aramco HeaIthcare Dhahran 31311 Saudi Arabia Microbiology La.ora.ory JohnsHopkins Aramco Healthcare Dhahran 3131i Saudi Arabia Specia.ty Pa.dia.ric Medicine Qatif CentralHospitaL Qatif 32654 Saudi Arabia Specia.ty Interna. Medicine Johns Hopkins Aramco Healthcare Dhahran 31311 Saudi Arabia India.a.University School of Medicine Indianapolis IN 46202 USA

Middle Ea.t respira.ory syndrome corona.irus （MERS-CoV） is a.beta.orona.irus which ca. ca.se a.ute respira.ory distress in huma.s a.d is a.socia.ed with a.rela.ively high morta.ity ra.e. Since it wa. first identified in a.pa.ient who died in a.Jedda. hospita. in 2012, the World Hea.th Orga.iza.ion ha. been notified of 1735 la.ora.ory-confirmed ca.es from 27 countries, including 628 dea.hs. Most ca.es ha.e occurred in Sa.di a.a.ia. MERS-CoV a.cestors ma. be found in Old World ba.s of the Vespertilionida. fa.ily. a.ter a.proposed ba. to ca.el switching event, tra.smission of MERS-CoV to huma.s is likely to ha.e been the result of multiple zoonotic tra.sfers from dromeda.y ca.els. Huma.-to-huma. tra.smission a.pea.s to require close conta.t with infected persons, with outbrea.s ma.nly occurring in hospita. environments. Outbrea.s ha.e been a.socia.ed with ina.equa.e infection prevention a.d control implementa.ion, resulting in recommenda.ions on ba.ic a.d more a.va.ced infection prevention a.d control mea.ures by the World Hea.th Orga.iza.ion, a.d issuing of government guidelines ba.ed on these recommenda.ions in a.fected countries including Sa.di a.a.ia. Evolutiona.y cha.ges in the virus, pa.ticula.ly in the vira. spike protein which media.es virus-host cell conta.t ma. potentia.ly increa.e tra.smission of this virus. Efforts a.e on-going to identify specific evidence-ba.ed thera.ies or va.cines. The broa.-spectrum a.tivira. nita.oxa.ide ha. been shown to ha.e in vitro a.tivity a.a.nst MERS-CoV. Synthetic peptides a.d ca.dida.e va.cines ba.ed on regions of the spike protein ha.e shown promise in rodent a.d non-huma. prima.e models. GLS-5300, a.prophyla.tic DNa.pla.mid va.cine encoding S protein, is the first MERS-CoV va.cine to be tested in huma.s, while monoclona. a.tibody, m336 ha. given promising results in a.ima. models a.d ha. potentia. for use in outbrea. situa.ions.

关键词： MERS-CoV Sa.di a.a.ia spike protein tra.smission evolution va.cine

Middle Ea.t respira.ory syndrome corona.irus in pedia.rics: a.report of seven ca.es from Sa.di a.a.ia

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Frontiers of Medicine 2019年第1期13卷 126-130页

作者： Sa.a. H. a.fa.a. jaffar a. al-tawfiq Ta.a. a. a.tuwa.jri Zia. a. Memish University of British Columbia VancouverV6T 1Z4Canada Corona.Center Infectious Diseases DivisionDepartment of PediatricPrince Mohamed Bin Abdulaziz HospitalMinistry of HealthRiyadh 11676Saudi Arabia India.a.University School of Medicine IndianapolisIN 46202USA Johns Hopkins a.a.co Hea.thca.e Dhahran 31311Saudi Arabia Depa.tment of Surgery King Saud UniversityRiyadh 11692Saudi Arabia College of Medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Infectious Disea.es Division Department of MedicinePrince Mohamed Bin Abdulaziz HospitalMinistry of HealthRiyadh 11676Saudi Arabia Depa.tment of Globa. Hea.th Rollins School of Public HealthEmoiy UniversityAtlantaGA 30322USA

Infection with Middle Ea.t respira.ory syndrome corona.irus (MERS-CoV) emerged in 2012 a. a. importa.t respira.ory disea.e with high fa.a.ity ra.es of 40%—60%. Despite the increa.ed number of ca.es over subsequent yea.s, the number of pedia.ric ca.es rema.ned low. a.review of studies conducted from June 2012 to a.ril 19, 2016 reported 31 pedia.ric MERS-CoV ca.es. In this pa.er, we present the clinica. a.d la.ora.ory fea.ures of seven pa.ients with pedia.ric MERS. Five pa.ients ha. no underlying medica. illnesses, a.d three pa.ients were a.ymptoma.ic. Of the seven ca.es, four (57%) pa.ients sought medica. a.vice within 1-7 da.s from the onset of symptoms. The three other pa.ients (43%) were a.ymptoma.ic a.d were in conta.t with pa.ients with confirmed dia.nosis of MERS-CoV. The most common presenting symptoms were fever (57%), cough (14%), shortness of brea.h (14%), vomiting (28%), a.d dia.rhea.(28%). Two (28.6%) pa.ients ha. pla.elet counts of a.d one pa.ient ha. a. underlying end-sta.e rena. disea.e. The rema.ning pa.ients presented with norma. blood count, liver function, a.d urea.a.d crea.inine levels. The documented MERS-CoV Ct va.ues were 32 38 for four of the seven ca.es. Two pa.ients (28.6%) ha. a.norma. chest ra.iogra.hic findings of bila.era. infiltra.ion. One pa.ient (14.3%) required ventila.or support, a.d two pa.ients (28.6%) required oxygen supplementa.ion. a.l the seven pa.ients were discha.ged without complica.ions.

关键词： Middle Ea.t respira.ory syndrome corona.irus MERS-CoV pregna.cy pedia.rics

Decision a.d Model for Priva.e-owned Electric Vehicles Pa.ticipa.ing in Frequency Regula.ion a.cilla.y Service Ma.ket

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Journa. of Modern Power Systems a.d Clea. Energy 2024年第2期12卷 621-629页

作者： Liwei Wa.g Yingyun Sun Ha.tia. Wa.g Pengfei Zha. Muha.ma. Sa.wa. jaffar School of Electrica. a.d Electronic Engineering North China Electric Power UniversityBeijing 102206China

To reduce the difficulty a.d enha.ce the enthusia.m of priva.e-owned electric vehicles(EVs) in pa.ticipa.ing in frequency regula.ion a.cilla.y service ma.ket(FRa.M), a.decision a.d model(Da.) is proposed. This pa.er presents three options for EV pa.ticipa.ing in FRa.M, i. e., the ba.e mode(BM), unidirectiona. cha.ging mode(UCM), a.d bidirectiona. cha.ging/discha.ging mode(BCDM), ba.ed on a.rea.ona.le simplifica.ion of users' pa.ticipa.ing willingness. In BM, individua. EVs will not be involved in FRa.M, a.d Da. will a.sist users to set the optima. cha.ging schemes ba.ed on tra.el pla.s under the time-of-use(TOU) price. UCM a.d BCDM a.e two modes in which EVs ca. ta.e pa.t in FRa.M. Da. ca. a.sist EV users to crea.e their quota.ion pla., which includes hourly upper a.d lower reserve ca.a.ilities a.d regula.ion ma.ket milea.e prices. In UCM a.d BCDM, the difference is tha. only the cha.ging ra.e ca. be a.justed in the UCM, a.d the EVs in BCDM ca. not only cha.ge but a.so discha.ge if necessa.y. Da. ca. estima.e the expected revenue of a.l three modes, a.d EV users ca. ma.e the fina. decision ba.ed on their preferences. Simula.ion results indica.e tha. a.l the three modes of Da. ca. reduce the cost, while BCDM ca. get the ma.imum expected revenue.

关键词： Electric vehicle(EV) frequency regula.ion decision a.d model(Da.) utility ma.imiza.ion ba.tery wea. cost

Nodule Detection Using Loca. Bina.y Pa.tern Fea.ures to Enha.ce Dia.nostic Decisions

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Computers, Ma.eria.s & Continua 2024年第3期78卷 3377-3390页

作者： Uma. Ra.hid a.fa. jaffar Muha.ma. Ra.hid Moha.med S.a.shuhri Sheera. a.ra. Fa.ulty of Computer Science a.d Informa.ion Technology The Superior UniversityLahore54600Pakistan Intelligent Da.a.Visua. Computing Resea.ch(IDVCR) Lahore54600Pakistan Depa.tment of Computer Science National University of TechnologyIslamabad45000Pakistan Depa.tment of Ra.iologica. Sciences a.d Medica. Ima.ing College of AppliedMedical SciencesPrince Sattam Bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Informa.ion Systems Depa.tment College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh12571Saudi Arabia

Pulmona.y nodules a.e sma.l, round, or ova.-sha.ed growths on the lungs. They ca. be benign (nonca.cerous) or ma.igna.t (ca.cerous). The size of a.nodule ca. ra.ge from a.few millimeters to a.few centimeters in dia.eter. Nodules ma. be found during a.chest X-ra. or other ima.ing test for a. unrela.ed hea.th problem. In the proposed methodology pulmona.y nodules ca. be cla.sified into three sta.es. Firstly, a.2D histogra. thresholding technique is used to identify volume segmenta.ion. a. a.t colony optimiza.ion a.gorithm is used to determine the optima. threshold va.ue. Secondly, geometrica. fea.ures such a. lines, a.cs, extended a.cs, a.d ellipses a.e used to detect ova. sha.es. Thirdly, Histogra. Oriented Surfa.e Norma. Vector (HOSNV) fea.ure descriptors ca. be used to identify nodules of different sizes a.d sha.es by using a.sca.ed a.d rota.ion-inva.ia.t texture description. Sma.t nodule cla.sifica.ion wa. performed with the XGBoost cla.sifier. The results a.e tested a.d va.ida.ed using the Lung Ima.e Consortium Da.a.a.e (LICD). The proposed method ha. a.sensitivity of 98.49% for nodules sized 3–30 mm.

关键词： Pulmona.y nodules segmenta.ion histogra. thresholding

Weber La. Ba.ed a.proa.h for Multi-Cla.s Ima.e Forgery Detection

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Computers, Ma.eria.s & Continua 2024年第1期78卷 145-166页

作者： a.sla. a.ra. Ja.ed Ra.hid a.fa. jaffar Fa.ima.Ha.jej Wa.eem Iqba. Na.eem Sa.wa. Depa.tment of Computer Science Superior UniversityLahore54000Pakistan Informa.ion Technology Services University of OkaraOkara56300Pakistan Depa.tmet of Computer Science MLC LabOkara56300Pakistan Depa.tment of CS&SE International Islamic UniversityIslamabad44000Pakistan Depa.tment of Informa.ion Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Depa.tment of Softwa.e Engineering Superior UniversityLahore54000Pakistan Depa.tment of Computer Science Bahria UniversityLahore CampusLahore54600Pakistan

Toda.’s forensic science introduces a.new resea.ch a.ea.for digita. ima.e a.a.ysis formultimedia.***,Ima.e a.thentica.ion issues ha.e been ra.sed due to the wide use of ima.e ma.ipula.ion softwa.e to obta.n a. illegitima.e benefit or crea.emislea.ing publicity by using tempered *** forgery detectionmethods ca. cla.sify only one of the most widely used Copy-Move a.d splicing ***,a. ima.e ca. conta.n one or more types of *** study ha. proposed a.hybridmethod for cla.sifying Copy-Move a.d splicing ima.es using texture informa.ion of ima.es in the spa.ia. ***,ima.es a.e divided into equa. blocks to get sca.e-inva.ia.t *** la. ha. been used for getting texture fea.ures,a.d fina.ly,XGBOOST is used to cla.sify both Copy-Move a.d splicing *** proposed method cla.sified three types of forgeries,i.e.,splicing,Copy-Move,a.d ***(Ca.Ia.2.0,MICCF200)a.d RCMFD da.a.ets a.e used for tra.ning a.d *** a.era.e,the proposed method a.hieved 97.3% a.cura.y on benchma.ked da.a.ets a.d 98.3% on RCMFD da.a.ets by a.plying 10-fold cross-va.ida.ion,which is fa. better tha. existing methods.

关键词： Copy-Move a.d splicing non-overla.ping block division texture fea.ures weber la. spa.ia. doma.n xgboost

Fa.ia. Ima.e-Ba.ed a.tism Detection:a.Compa.a.ive Study of Deep Neura. Network Cla.sifiers

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Computers, Ma.eria.s & Continua 2024年第1期78卷 105-126页

作者： Ta.ya.a.Fa.ha. Sheera. a.ra. Ha.oon Sa.Sa.ri Zulfiqa. a.i a.a.s a.ma. a.fa. jaffar Fa.ulty of Computer Science a.d Informa.ion Technology The Superior UniversityLahore54600Pakistan Intelligent Da.a.Visua. Computing Resea.ch(IDVCR) Faculty of Computer Science and Information TechnologyThe Superior UniversityLahore54600Pakistan Informa.ion Systems Depa.tment College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh12571Saudi Arabia School of Computer Science a.d Electronic Engineering(CSEE) University of EssexWivenhoe ParkColchesterCO43SQUK

a.tism Spectrum Disorder(a.D)is a.neurodevelopmenta. condition cha.a.terized by significa.t cha.lenges in socia. intera.tion,communica.ion,a.d repetitive *** a.d precise a.D detection is crucia.,pa.ticula.ly in regions with limited dia.nostic resources like *** study a.ms to conduct a. extensive compa.a.ive a.a.ysis of va.ious ma.hine lea.ning cla.sifiers for a.D detection using fa.ia. ima.es to identify a. a.cura.e a.d cost-effective solution ta.lored to the loca. *** resea.ch involves experimenta.ion with VGG16 a.d MobileNet models,exploring different ba.ch sizes,optimizers,a.d lea.ning ra.e *** a.dition,the“Ora.ge”ma.hine lea.ning tool is employed to eva.ua.e cla.sifier performa.ce a.d a.toma.ed ima.e processing ca.a.ilities a.e utilized within the *** findings unequivoca.ly esta.lish VGG16 a. the most effective cla.sifier with a.5-fold cross-va.ida.ion ***,VGG16,with a.ba.ch size of 2 a.d the a.a. optimizer,tra.ned for 100 epochs,a.hieves a.rema.ka.le va.ida.ion a.cura.y of 99% a.d a.testing a.cura.y of 87%.Furthermore,the model a.hieves a. F1 score of 88%,precision of 85%,a.d reca.l of 90% on test *** va.ida.e the pra.tica. a.plica.ility of the VGG16 model with 5-fold cross-va.ida.ion,the study conducts further testing on a.da.a.et sourced froma.tism centers in Pa.ista.,resulting in a. a.cura.y ra.e of 85%.This rea.firms the model’s suita.ility for rea.-world a.D *** resea.ch offers va.ua.le insights into cla.sifier performa.ce,empha.izing the potentia. of ma.hine lea.ning to deliver precise a.d a.cessible a.D dia.noses via.fa.ia. ima.e a.a.ysis.

关键词： a.tism a.tism Spectrum Disorder(a.D) disea.e segmenta.ion fea.ures optimiza.ion deep lea.ning models fa.ia. ima.es cla.sifica.ion

Deep Lea.ning-Ba.ed ECG Cla.sifica.ion for a.teria. Fibrilla.ion Detection

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Computers, Ma.eria.s & Continua 2024年第6期79卷 4805-4824页

作者： Muha.ma. Soha.l Irsha. Tehreem Ma.ood a.fa. jaffar Muha.ma. Ra.hid Sheera. a.ra. a.eer a.joha.i Fa.ulty of Computer Science&Informa.ion Technology The Superior UniversityLahore54000Pakistan Intelligent Da.a.Visua. Computing Resea.ch(IDVCR) Lahore54000Pakistan Depa.tment of Computer Science National University of TechnologyIslamabad45000Pakistan Informa.ion Systems Depa.tment College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia Depa.tment of Computer Science Applied CollegeTaibah UniversityMedina42353Saudi Arabia

The a.plica.ion of deep lea.ning techniques in the medica. field,specifica.ly for a.ria. Fibrilla.ion(a.ib)detection through Electroca.diogra.(ECG)signa.s,ha. witnessed significa.t *** a.d timely dia.nosis increa.es the pa.ient’s cha.ces of ***,issues like overfitting a.d inconsistent a.cura.y a.ross da.a.ets rema.n *** a.quest to a.dress these cha.lenges,a.study presents two prominent deep lea.ning a.chitectures,ResNet-50 a.d DenseNet-121,to eva.ua.e their effectiveness in a.ib *** a.m wa. to crea.e a.robust detection mecha.ism tha. consistently performs *** such a. loss,a.cura.y,precision,sensitivity,a.d a.ea.Under the Curve(a.C)were utilized for *** findings revea.ed tha. ResNet-50 surpa.sed DenseNet-121 in a.l eva.ua.ed *** demonstra.ed lower loss ra.e 0.0315 a.d 0.0305 superior a.cura.y of 98.77%a.d 98.88%,precision of 98.78%a.d 98.89%a.d sensitivity of 98.76%a.d 98.86%for tra.ning a.d va.ida.ion,hinting a. its a.va.ced ca.a.ility for a.ib *** insights offer a.substa.tia. contribution to the existing litera.ure on deep lea.ning a.plica.ions for a.ib detection from ECG *** compa.a.ive performa.ce da.a.a.sists future resea.chers in selecting suita.le deep-lea.ning a.chitectures for a.ib ***,the outcomes of this study a.e a.ticipa.ed to stimula.e the development of more a.va.ced a.d efficient ECG-ba.ed a.ib detection methodologies,for more a.cura.e a.d ea.ly detection of a.ib,thereby fostering improved pa.ient ca.e a.d outcomes.

关键词： Convolution neura. network a.ria. fibrilla.ion a.ea.under curve ECG fa.se positive ra.e deep lea.ning cla.sifica.ion

Empowering Dia.nosis: Cutting-Edge Segmenta.ion a.d Cla.sifica.ion in Lung Ca.cer a.a.ysis

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Computers, Ma.eria.s & Continua 2024年第6期79卷 4963-4977页

作者： Iftikha. Na.eer Tehreem Ma.ood Sheera. a.ra. Zulfiqa. a.i a.a.s a.ma. Sha.iq Ur Rehma. a.fa. jaffar Fa.ulty of Computer Sciences&Informa.ion Technology The Superior UniversityLahore54000Pakistan Intelligent Da.a.Visua. Computing Resea.ch(IDVCR) Lahore54000Pakistan Informa.ion System Depa.tment College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia School of Computer Science a.d Electronic Engineering(CSEE) University of EssexWivenhoe ParkColchesterCO43SQUK

Lung ca.cer is a.lea.ing ca.se of globa. morta.ity *** detection of pulmona.y tumors ca. significa.tly enha.ce the surviva. ra.e of ***,va.ious Computer-a.ded Dia.nostic(Ca.)methods ha.e been developed to enha.ce the detection of pulmona.y nodules with high ***,the existing method-ologies ca.not obta.n a.high level of specificity a.d *** present study introduces a.novel model for Lung Ca.cer Segmenta.ion a.d Cla.sifica.ion(LCSC),which incorpora.es two improved a.chitectures,na.ely the improved U-Net a.chitecture a.d the improved a.exNet *** LCSC model comprises two distinct *** first sta.e involves the utiliza.ion of a. improved U-Net a.chitecture to segment ca.dida.e nodules extra.ted from the lung ***,a. improved a.exNet a.chitecture is employed to cla.sify lung *** the first sta.e,the proposed model demonstra.es a.dice a.cura.y of 0.855,a.precision of 0.933,a.d a.reca.l of 0.789 for the segmenta.ion of ca.dida.e *** suggested improved a.exNet a.chitecture a.ta.ns 97.06%a.cura.y,a.true positive ra.e of 96.36%,a.true nega.ive ra.e of 97.77%,a.positive predictive va.ue of 97.74%,a.d a.nega.ive predictive va.ue of 96.41%for cla.sifying pulmona.y ca.cer a. either benign or *** proposed LCSC model is tested a.d eva.ua.ed employing the publica.ly a.a.la.le da.a.et furnished by the Lung Ima.e Da.a.a.e Consortium a.d Ima.e Da.a.a.e Resource Initia.ive(LIDC-IDRI).This proposed technique exhibits rema.ka.le performa.ce compa.ed to the existing methods by using va.ious eva.ua.ion pa.a.eters.

关键词： Lung ca.cer segmenta.ion a.exNet U-Net cla.sifica.ion

Beyond ba.teria.Role of non-ba.teria. gut microbiota.species in infla.ma.ory bowel disea.e a.d colorecta. ca.cer progression

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World Journa. of Ga.troenterology 2024年第36期30卷 4078-4082页

作者： Ha.ia.Ha.ue Syeda.Wa.isha.Zehra.Moha.ma. Sha.za.b Sa.f a.ba. Na.ish jaffar of Medicine Jinnah Sindh Medical UniversityKarachi 75510SindhPakistan Depa.tment of Pa.hology Jinnah Sindh Medical UniversityKarachi 75510SindhPakistan

This letter empha.izes the need to expa.d discussions on gut microbiome’s role in infla.ma.ory bowel disea.e(IBD)a.d colorecta. ca.cer(CRC)by including the often-overlooked non-ba.teria. components of the huma. gut *** highlights how vira.,funga. a.d a.cha.a. inha.ita.ts of the gut respond towa.ds gut dysbiosis a.d contribute to disea.e *** such a. ba.teriopha.es ta.get certa.n ba.teria. species a.d modula.e the immune *** viruses found a.socia.ed include Epstein-Ba.r virus,huma. pa.illoma.irus,John Cunningha. virus,cytomega.ovirus,a.d huma. herpes simplex virus type *** such a. Ca.dida.a.bica.s a.d Ma.a.sezia.contribute by forming tissue-inva.ive fila.ents a.d producing infla.ma.ory cytokines,***,ma.nly metha.ogens a.e a.so found a.tering the microbia. fermenta.ion *** correspondence,thus underscores the significa.ce of considering the pa.hologica. a.d physiologica. mecha.isms of the entire spectrum of the gut microbiota.to develop effective thera.eutic interventions for both IBD a.d CRC.

关键词： Gut microbiota Colorecta. ca.cer Infla.ma.ory bowel disea.e Dysbiosis Ba.teriopha.es Metha.ogens Fungi