Beyond bacteria:Role of non-bacterial gut microbiota species in inflammatory bowel disease and colorectal cancer progression

作     者：Hania Haque Syeda Warisha Zehra Mohammad Shahzaib Saif Abbas Nazish Jaffar 

作者机构：of MedicineJinnah Sindh Medical UniversityKarachi 75510SindhPakistan Department of PathologyJinnah Sindh Medical UniversityKarachi 75510SindhPakistan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2024年第30卷第36期

页      面：4078-4082页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gut microbiota Colorectal cancer Inflammatory bowel disease Dysbiosis Bacteriophages Methanogens Fungi 

摘      要：This letter emphasizes the need to expand discussions on gut microbiome’s role in inflammatory bowel disease(IBD)and colorectal cancer(CRC)by including the often-overlooked non-bacterial components of the human gut *** highlights how viral,fungal and archaeal inhabitants of the gut respond towards gut dysbiosis and contribute to disease *** such as bacteriophages target certain bacterial species and modulate the immune *** viruses found associated include Epstein-Barr virus,human papillomavirus,John Cunningham virus,cytomegalovirus,and human herpes simplex virus type *** such as Candida albicans and Malassezia contribute by forming tissue-invasive filaments and producing inflammatory cytokines,***,mainly methanogens are also found altering the microbial fermentation *** correspondence,thus underscores the significance of considering the pathological and physiological mechanisms of the entire spectrum of the gut microbiota to develop effective therapeutic interventions for both IBD and CRC.