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Bioactive Materials 2023年第3期21卷 358-380页

作者： Nem Singh Jungryun kim jaewon kim Kyungwoo Lee Zehra Zunbul Injun Lee Eunji kim Sung-Gil Chi Jong Seung kim Department of Chemistry Korea UniversitySeoul02841South Korea Department of Life Science Korea UniversitySeoul02841South Korea

Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research *** unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs,such as poor localization at the tumor site,high drug doses and toxicity,recurrence,and poor immune ***,inadequate biocompatibility restricts their potential in clinical ***,advanced nanomaterials with high biocompat-ibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of *** properties of nanoscale covalent organic frameworks(nCOFs),such as suitable size,modular pore geometry and porosity,and straightforward post-synthetic modification via simple organic transformations,make them incredibly attractive for future *** ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted *** review summarizes recently published applications of COFs in drug delivery,photo-immuno therapy,sonodynamic therapy,photothermal therapy,chemotherapy,pyroptosis,and combination *** we mainly focused on modifications of COFs to enhance their biocompatibility,efficacy and potential clinical *** review will provide the fundamental knowledge in designing biocompatible nCOFs-based nano-medicines and will help in the rapid development of cancer drug carriers and theranostics.

关键词： doses medicines compatibility

Regulating the microenvironment with nanomaterials:Potential strategies to ameliorate COVID-19

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药学学报:英文版 2023年第9期13卷 3638-3658页

作者： Zhicheng Liu Zhuolei Han Xin Jin Jusung An jaewon kim Wenting Chen Jong Seung kim Ji Zheng Jun Deng Department of Urology Xinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China Department of Urology Urological Surgery Research InstituteSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Burn Research Southwest HospitalState Key Lab of TraumaBurn and Combined InjuryChongqing Key Laboratory for Disease ProteomicsThird Military Medical University(Army Medical University)Chongqing 400038China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Department of Chemistry Korea UniversitySeoul 02841South Korea Department of Rheumatology and Clinical Immunology Army Medical CenterThird Military Medical University(Army Medical University)Chongqing 400042China

COVID-19,caused by SARS-CoV-2,has resulted in serious economic and health *** treatments remain inadequate to extinguish the epidemic,and efficient therapeutic approaches for COVID-19 are urgently being ***,accumulating evidence suggests that microenvironmental disorder plays an important role in the progression of COVID-19 in *** addition,recent advances in nanomaterial technologies provide promising opportunities for alleviating the altered homeostasis induced by a viral infection,providing new insight into COVID-19 *** literature reviews focus only on certain aspects of microenvironment alterations and fail to provide a comprehensive overview of the changes in homeostasis in COVID-19 *** fill this gap,this review systematically discusses alterations of homeostasis in COVID-19 patients and potential ***,advances in nanotechnology-based strategies for promoting homeostasis restoration are ***,we discuss the challenges and prospects of using nanomaterials for COVID-19 *** review provides a new strategy and insights into treating COVID-19 and other diseases associated with microenvironment disorders.

关键词： Coronavirus disease 19 Severe acute respiratory syndrome coronavirus 2 Therapeutic approaches Nanotechnology Nanomaterial technologies Microenvironment Microenvironmental disorder Altered homeostasis

Postmortem ^(7)Li NMR analysis for assessing the reversibility of lithium metal electrodes in lithium metal batteries

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Journal of Energy Chemistry 2024年第7期94卷 430-440页

作者： jaewon Baek Sunha kim Hee-Tak kim Oc Hee Han Department of Chemical&Biomolecular Engineering KAISTDaejeon 34141Republic of Korea Metropolitan Seoul Center Korea Basic Science InstituteSeoul 03759Republic of Korea Graduate School of Analytical Science&Technology Chungnam National UniversityDaejeon 34134Republic of Korea

Despite the proficiency of lithium(Li)-7 NMR spectroscopy in delineating the physical and chemical states of Li metal electrodes,challenges in specimen preparation and interpretation impede its *** this study,we conducted a comprehensive postmortem analysis utilizing ^(7)Li NMR,employing a stan-dard magic angle spinning probe to examine protective-layer coated Li metal electrodes and LiAg alloy electrodes against bare Li metal electrodes within Li metal batteries(LMBs).Our investigation explores the effects of sample burrs,alignment with the magnetic field,the existence of liquid electrolytes,and precycling on the ^(7)Li NMR *** contrasting NMR spectra before and after cycling,we identi-fied alterations in Li^(0) and Li^(+) signals attributable to the degradation of the Li metal *** NMR analyses decisively demonstrate the efficacy of the protective layer in mitigating dendrite and solid elec-trolyte interphase ***,we noted that Li*ions near the Li metal surface exhibit magnetic susceptibility anisotropy,revealing a novel approach to studying diamagnetic species on Li metal elec-trodes in *** study provides valuable insights and practical guidelines for characterizing distinct lithium states within LMBs.

关键词： NMR spectroscopy Lithium-7 Lithium metal battery Electrolyte Electrode-protective layer Solid electrolyte interface Magnetic susceptibility anisotropy Lithium-metal NMR signal Diamagnetic^(7)Li NMR signal

Nanowire-assisted freestanding liquid metal thin-film patterns for highly stretchable electrodes on 3D surfaces

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npj Flexible Electronics 2022年第1期6卷 956-963页

作者： Minwoo kim Chulmin Cho Wooseop Shin Jung Jae Park jaewon kim Phillip Won Carmel Majidi Seung Hwan Ko Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoulGwanak-guKorea Mechatronics Research Samsung ElectronicsHwaseong-siGyeonggi-doKorea Soft Machines Lab Department of Mechanical EngineeringCarnegie Mellon UniversityPittsburghPAUSA Institute of Advanced Machines and Design/Institute of Engineering Research Seoul National UniversitySeoulKorea

Stretchable electronics is playing an integral role in fields such as wearable electronics and soft *** soft conductive materials,liquid metal is drawing intense attention as an electrode material due to its liquid nature at room ***,the merits of liquid metal conductor are limited by the presence of substrates or enclosed microchannels from physical disturbances by the underlying substrate when applying it to 3D surface and modifying complex *** overcome this limitation,we develop freestanding patterned liquid metal thin-film conductor(FS-GaIn).FS-GaIn was achieved by introducing metal nanowires to liquid metal and subsequent sequential selective laser processing and etching of directly patterned *** can be applied directly to nonflat surface without *** incorporated into electrical circuits,FS-GaIn shows high electrical conductivity,stretchability,and *** concept of freestanding liquid metal can open a functionality to the conventional liquid metal electronics.

关键词： liquid film free

Azimuthal rotation-controlled nanoinscribing for continuous patterning of period-and shapetunable asymmetric nanogratings

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Microsystems & Nanoengineering 2024年第3期10卷 207-218页

作者： Useung Lee Hyein kim Dong Kyo Oh Nayeong Lee Jonggab Park jaewon Park Hyunji Son Hyunchan Noh Junsuk Rho Jong G.Ok Department of Mechanical and Automotive Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea National Institute of Nanomaterials Technology(NINT) Pohang 37673Republic of Korea Present address:Department of Mechanical Engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Research Team Hyundai Motor Group150 Hyundaiyeonguso-roHwaseong-siGyeonggi 18280Republic of Korea

We present an azimuthal-rotation-controlled dynamic nanoinscribing(ARC-DNI)process for continuous and scalable fabrication of asymmetric nanograting structures with tunable periods and shape profiles.A sliced edge of a nanograting mold,which typically has a rectangular grating profile,slides over a polymeric substrate to induce its burrfree plastic deformation into a linear *** this continuous nanoinscribing process,the“azimuthal angle,”that is,the angle between the moving direction of the polymeric substrate and the mold’s grating line orientation,can be controlled to tailor the period,geometrical shape,and profile of the inscribed *** modulating the azimuthal angle,along with other important ARC-DNI parameters such as temperature,force,and inscribing speed,we demonstrate that the mold-opening profile and temperature-and time-dependent viscoelastic polymer reflow can be controlled to fabricate asymmetric,blazed,and slanted nanogratings that have diverse geometrical profiles such as trapezoidal,triangular,and ***,period-and profile-tunable ARC-DNI can be utilized for the practical fabrication of diverse optical devices,as is exemplified by asymmetric diffractive optical elements in this study.

关键词： tunable asymmetric rotation

Hybridization of different types of exceptional points

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Photonics Research 2019年第12期7卷 1473-1478页

作者： JINHYEOK RYU SUNJAE GWAK jaewon kim HYEON-HYE YU JI-HWAN kim JI-WON LEE CHANG-HWAN YI CHIL-MIN kim Department of Emerging Materials Science DGISTDaegu 42988South Korea Institut fur Physik Technische Universitat IlmenauD-98693 IlmenauGermany Samsung Electro-Mechanics Suwon 16674South Korea

A large number of different types of second-order non-Hermitian degeneracies called exceptional points(EPs)were found in various physical systems depending on the mechanism of coupling between *** show that these EPs can be hybridized to form higher-order EPs,which preserve the original properties of the initial EPs before *** a demonstration,we hybridize chiral and supermode second-order EPs,where the former and the latter are the results of intra-disk and inter-disk mode coupling in an optical system comprised of two Mie-scale microdisks and one Rayleigh-scale *** high sensitivity of the resulting third-order EP against external perturbations in our feasible system is emphasized.

关键词： exceptional coupling system

Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography

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Microsystems & Nanoengineering 2023年第2期9卷 367-379页

作者： Geon Kook Yehhyun Jo Chaerin Oh Xiaojia Liang jaewon kim Sang-Mok Lee Subeen kim Jung-Woo Choi Hyunjoo Jenny Lee School of Electrical Engineering Korea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon 34141South Korea KAIST Institute for NanoCentury(KINC) 291 Daehak-roYuseong-guDaejeon 34141Republic of Korea

Transcranial focused ultrasound stimulation is a promising therapeutic modality for human brain disorders because of its noninvasiveness,long penetration depth,and versatile spatial control capability through beamforming and beam ***,the skull presents a major hurdle for successful applications of ultrasound ***,skull-induced focal aberration limits the capability for accurate and versatile targeting of brain *** addition,there lacks a fully functional preclinical neuromodulation system suitable to conduct behavioral ***,we report a miniature ultrasound system for neuromodulation applications that is capable of highly accurate multiregion targeting based on acoustic *** work includes the design and implementation of an acoustic lens for targeting brain regions with compensation for skull aberration through time-reversal recording and a phase conjugation ***,we utilize MEMS and 3D-printing technology to implement a 0.75-g lightweight neuromodulation system and present in vivo characterization of the packaged system in freely moving *** preclinical system is capable of accurately targeting the desired individual or multitude of brain regions,which will enable versatile and explorative behavior studies using ultrasound neuromodulation to facilitate widespread clinical adoption.

关键词： versatile utilize recording

Rapid determination of lithium-ion battery degradation: High C-rate LAM and calculated limiting LLI

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Journal of Energy Chemistry 2022年第4期31卷 663-671页

作者： Gyuwon Seo Jaeyun Ha Moonsu kim Jihyeon Park jaewon Lee Eunoak Park Sungyool Bong Kiyoung Lee Soon Jong Kwon Seung-pil Moon Jinsub Choi Jaeyoung Lee Electrochemical Reaction and Technology Laboratory School of Earth Sciences and Environmental EngineeringGwangju Institute of Science and Technology(GIST)Gwangju 61005South Korea Department of Chemistry and Chemical Engineering Inha UniversityIncheon 22212South Korea Ertl Center for Electrochemistry and Catalysis GISTGwangju 61005South Korea Korea Electric Power Corporation Research Institute Daejeon 34056South Korea International Future Research Center of Chemical Energy Storage and Conversion Processes(ifRC-CHESS) GISTGwangju 61005South Korea

Herein,incremental capacity-differential voltage (IC-DV) at a high C-rate (HC) is used as a non-invasive diagnostic tool in lithium-ion batteries,which inevitably exhibit capacity fading caused by multiple mechanisms during charge/discharge *** battery degradation modes are complex,the simple output of capacity fading does not yield any useful data in that *** IC and DV curves obtained under restricted conditions (<0.1C,25℃) were applied in non-invasive analysis for accurate observation of degradation symptoms,a facile,rapid diagnostic approach without intricate,complex calculations is critical in on-board ***,Li Ni_(0.5)Mn_(0.3)Co_(0.2)O_(2)(NMC532)/graphite pouch cells were cycled at 4 and 6C and the degradation characteristics,i.e.,loss of active materials (LAM) and loss of lithium inventory (LLI),were parameterized using the IC-DV *** the incremental current cycling,the initial steep LAM and LLI slopes underwent gradual transitions to gentle states and revealed the gap between low-and high-current measurements.A quantitative comparison of LAM at high and low C-rate showed that a IC;revealed the relative amount of available reaction region limited by cell ***,this did not provide a direct relationship for estimating the LAM at a low ***,the limiting LLI,which is calculated at a C-rate approaching 0,was obtained by extrapolating the LLI through more than two points measured at high C-rate,and therefore,the LLI at 0.1C was accurately determined using rapid cycling.

关键词： Battery degradation Rapid degradation diagnosis Loss of active materials(LAM) Loss of lithium inventory(LLI) Incremental capacity(IC) Differential voltage(DV)

Microfluidic systems for axonal growth and regeneration research

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Neural Regeneration Research 2014年第19期9卷 1703-1705页

作者： Sunja kim jaewon Park Arum Han Jianrong Li Department of Veterinary Integrative Biosciences Texas A&M UniversityCollege Station Institution for Neuroscience Texas A&M UniversityCollege Station Department of Electrical and Computer Engineering Texas A&M UniversityCollege Station

Damage to the adult mammalian central nervous system （CNS） often results in persistent neurological deficits with limited recovery of functions. The past decade has seen in- creasing research efforts in neural regeneration research with the ultimate goal of achieving functional recovery. Many studies have focused on prevention of further neural damage and restoration of functional connections that are com- promised after iniurY or pathological damage.

关键词： Microfluidic systems for axonal growth and regeneration research CNS Figure

Frequency comb-to-comb stabilization over a 1.3-km free-space atmospheric optical link

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Light(Science & Applications) 2022年第9期11卷 2207-2216页

作者： jaewon YANG DONG IL LEE DONG-CHEL SHIN JAEHYUN LEE BYUNG SOO kim HYUN JAY KANG YOUNG-JIN kim SEUNG-WOO kim Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Presently with Korea Research Institute of Standards and Science(KRISS) 267 Gajeong-roYuseong-guDaejeon 34113Republic of Korea

Stabilizing a frequency comb to an ultra-stable optical frequency reference requires a multitude of optoelectronic peripherals that have to operate under strict ambient ***,the frequency comb-to-comb stabilization aims to synchronize a slave comb to a well-established master comb with a substantial saving in required equipment and ***,we report an utmost case of frequency comb-to-comb stabilization made through a 1.3 km free-space optical(FSO)link by coherent transfer of two separate comb lines along with a feedback suppression control of atmospheric phase *** FSO link offers a transfer stability of 1.7×10-15 at 0.1 s averaging,while transporting the master comb,s stability of 1.2×10-15 at 1.0 s over the entire spectrum of the slave *** remote comb-to-comb stabilization is intended to expedite diverse long-distance ground-to-ground or ground-to-satellite applications;as demonstrated here for broadband molecular spectroscopy over a 6THz bandwidth as well as ultra-stable microwaves generation with phase noise of-80dBc Hz-1 at 1 Hz.

关键词： optical stabilization microwave