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Enhancement of porcine in vitro embryonic development through luteolin‑mediated activation of the Nrf2/Keap1 signaling pathway

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Journal of Animal Science and Biotechnology 2024年第2期15卷 600-613页

作者： Se-Been Jeon Pil-Soo Jeong Min Ju Kim Hyo-Gu Kang Bong-Seok Song Sun-Uk Kim Seong-Keun Cho Bo-Woong sim Futuristic Animal Resource&Research Center(FARRC) Korea Research Institute of Bioscience and Biotechnology(KRIBB)Cheongju 28116Republic of Korea Department of Animal Science College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea Department of Animal Science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeon 34134Republic of Korea Department of Functional Genomics University of Science and TechnologyDaejeon 34113Republic of Korea Department of Animal Science Life and Industry Convergence Research Institute(RICRI)College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea

Background Oxidative stress,caused by an imbalance in the production and elimination of intracellular reactive oxygen species(ROS),has been recognized for its detrimental effects on mammalian embryonic ***(Lut)has been documented for its protective effects against oxidative stress in various ***,its specific role in embryonic development remains *** study aims to investigate the influence of Lut on porcine embryonic development and to elucidate the underlying *** After undergoing parthenogenetic activation(PA)or in vitro fertilization,embryos supplemented with 0.5μmol/L Lut displayed a significant enhancement in cleavage and blastocyst formation rates,with an increase in total cell numbers and a decrease in the apoptosis rate compared to the *** on D2 and D6 revealed that embryos with Lut supplementation had lower ROS levels and higher glutathione levels compared to the ***,Lut supplementation significantly augmented mitochondrial content and membrane ***,activation of the Nrf2/Keap1 signaling pathway was observed in embryos supplemented with Lut,leading to the upregulation of antioxidant-related gene transcription *** further validate the relationship between the Nrf2/Keap1 signaling pathway and effects of Lut in porcine embryonic development,we cultured PA embryos in a medium supplemented with brusatol,with or without the inclusion of *** positive effects of Lut on developmental competence were negated by brusatol *** Our findings indicate that Lut-mediated activation of the Nrf2/Keap1 signaling pathway contributes to the enhanced production of porcine embryos with high developmental competence,and offers insight into the mechanisms regulating early embryonic development.

关键词： Luteolin Mitochondrial function Nrf2/Keap1 signaling pathway Oxidative stress Porcine embryo development

Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer

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Acta Pharmaceutica Sinica B 2020年第3期10卷 399-413页

作者： Puvanesswaray Ramakrishnan Wei Mee Loh Subash CBGopinath Srinivasa Reddy Bonam Ismail M.Fareez Rhanye Mac Guad Maw Shin sim Yuan Seng Wu Ageing and Age-Associated Disorders Research Group Faculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia Depanment of Pharmacology Faculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia School of Bioprocess Engineering Universiti Malaysia PerlisArau 02600Malaysia Institute of Nano Electronic Engineering Universiti Malaysia PerlisKangar 01000Malaysia UMR 7242 CNRS-University of StrasbourgBiotechnology and Cell Signaling/Laboratory of Excellence MedalisIllkirch 67400France Department of Oral Biology and Biomedical Sciences Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia Department of Biomedical Science and Therapeutics Faculty of Medicine and Health ScienceUniversiti Malaysia SabahKota Kinabalu 88400Malaysia Department of Pharmaceutical Life Sciences Faculty of PharmacyUniversity of MalayaKuala Lumpur 50603Malaysia Department of Biochemistry Faculty of Medicine Bioscience and NursingMAHSA UniversitySelangor 42610Malaysia

Activated pancreatic stellate cells(PSCs)have been widely accepted as a key precursor of excessive pancreatic fibrosis,which is a crucial hallmark of chronic pancreatitis(CP)and its formidable associated disease,pancreatic cancer(PC).Hence,anti-fibrotic therapy has been identified as a novel therapeutic strategy for treating CP and PC by targeting *** of the anti-fibrotic agents have been limited to phaseⅠ/Ⅱclinical trials involving vitamin analogs,which are abundant in medicinal plants and have proved to be promising for clinical *** use of phytomedicines,as new anti-fibrotic agents,has been applied to a variety of complementary and alternative *** aim of this review was to present a focused update on the selective new potential anti-fibrotic agents,including curcumin,resveratrol,rhein,emodin,green tea catechin derivatives,metformin,eruberin A,and ellagic acid,in combating PSC in CP and PC *** aimed to describe the mechanism(s)of the phytochemicals used,either alone or in combination,and the associated molecular *** of them were tested in PC models with similar mechanism of actions,and curcumin was tested *** research may explore the issues of bioavailability,drug design,and nano-formulation,in order to achieve successful clinical outcomes with promising activity and tolerability.

关键词： Pancreatic stellate cells Anti-fibrotic Chronic pancreatitis Pancreatic cancer Phytochemicals Curcumin Resverastrol Rhein Emodin Green tea catechin

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基于分布式传感网络的结构模态识别方法

土木工程学报 2010年第3期43卷 106-110页

作者：张敏谢慧才 Sung han sim B F Spencer Jr 汕头大学汕头515063 深圳大学深圳518063 美国伊利诺伊大学香槟分校

结构的模态参数识别是结构健康监测系统的基本任务。随着工程结构的日益大型化和复杂化,振动测试时需要布置大量的传感器。传统的集中采集和处理技术将难以胜任海量数据的处理要求,采用无线智能传感器的结构健康监测系统正是应运而生的... 详细信息

结构的模态参数识别是结构健康监测系统的基本任务。随着工程结构的日益大型化和复杂化,振动测试时需要布置大量的传感器。传统的集中采集和处理技术将难以胜任海量数据的处理要求,采用无线智能传感器的结构健康监测系统正是应运而生的新方向,而分布式采集和处理是其特点。在无线智能传感网络拓扑结构中采用分布式算法求解结构整体振型,利用随机子空间法识别各子结构模态,结合粒子群优化算法调整子振型获取结构整体振型。通过混凝土钢管拱桥模型试验验证了分布式算法的可行性,并利用模态置信度(MAC)对比分析了由分布式模态识别方法和集中式模态识别方法得到的结果,结果表明两种算法吻合较好。

关键词：结构健康监测智能传感器网络模态识别集中式分布式

Etoposide-induced apoptosis results in chromosome breaks within the <i>AF</i>9 gene: Its implication in chromosome rearrangement in leukaemia

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Advances in Bioscience and Biotechnology 2012年第6期3卷 686-694页

作者： Cynthia Patricia Nicholas Sai-Peng sim Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia

Treatment with etoposide (VP-16) has been associated with translocation of the mixed lineage leukaemia (MLL) gene seen in treatment-related acute myeloid leukaemia (t-AML). Among the different partner genes, AF9 is the most common partner gene of MLL. AF9 shares similar structural element with the MLL gene. Various mechanisms of translocation have been proposed for the MLL gene, including apoptosis, particularly the apoptotic nuclease. In the current study, we show that VP-16 induced cleavage of the AF9 gene in both leukaemic cells and cultured normal blood cell. All the breakpoints were mapped within the BCR1 of the AF9 gene. AF9 cleavages in leukaemic cells were abolished by pre-treatment with caspase inhibitor (Z-DEVD-FMK), suggesting the involvement of caspase-activated DNase (CAD). The absence of AF9 cleavage in K562 cells further supported the involvement of apoptosis. However, AF9 cleavages in cultured normal blood cell were not eliminated by caspase inhibitor. The possible role of CAD and other apoptotic nucleases/effectors that could be involved in AF9 translocation are discussed.

关键词： Etoposide (VP-16) Apoptosis AF9 Chromosome Breaks Leukaemia

Genome-wide SNP discovery and core marker sets for assessment of genetic variations in cultivated pumpkin(Cucurbita spp.)

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Horticulture Research 2020年第1期7卷 1139-1148页

作者： Nam Ngoc Nguyen Minkyung Kim Jin-Kee Jung Eun-Jo Shim Sang-Min Chung Younghoon Park Gung Pyo Lee Sung-Chur sim Department of Bioresources Engineering Sejong UniversitySeoul 05006South Korea Seed Testing and Research Center Korea Seed&Variety ServiceGimcheon 39660South Korea Department of Life Sciences Dongguk UniversitySeoul 04620South Korea Department of Horticultural Bioscience Pusan National UniversityMiryang 50463South Korea Department of Plant Science and Technology Chung-Ang UniversityAnsung 17546South Korea Plant Engineering Research Institute Sejong UniversitySeoul 05006South Korea

Three pumpkin species Cucurbita maxima,***,and *** are commonly cultivated *** identify genome-wide SNPs in these cultivated pumpkin species,we collected 48 F1 cultivars consisting of 40 intraspecific hybrids(15 ***,18 ***,and 7 ***)and 8 interspecific hybrids(*** x ***).Genotyping by sequencing identified a total of 37,869 confident SNPs in this *** SNPs were filtered to generate a subset of 400 SNPs based on polymorphism and genome *** the 400 SNPs,288 were used to genotype an additional 188 accessions(94 F1 cultivars,50 breeding lines,and 44 landraces)with a SNP array-based *** polymorphisms were observed in 224 SNPs(78.0%)and were used to assess genetic variations between and within the four predefined populations in 223 cultivated pumpkin *** principal component analysis and UPGMA clustering found four major clusters representing three pumpkin species and interspecific *** genetic differentiation was supported by pairwise Fst and Nei’s genetic *** interspecific hybrids showed a higher level of genetic diversity relative to the other three *** the 224 SNPs,five subsets of 192,96,48,24,and 12 markers were evaluated for variety *** 192,96,and 48 marker sets identified 204(91.5%),190(85.2%),and 141(63.2%)of the 223 accessions,respectively,while other subsets showed<25%of variety identification *** SNP markers provide a molecular tool with many applications for genetics and breeding in cultivated pumpkin.

关键词： breeding cultivar Cucurbita

ON INVENTORY STRATEGIES OF ONLINE RETAILERS

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Journal of Systems Science and Systems Engineering 2005年第1期14卷 52-72页

作者： Frank Y. CHEN S. H. HUM Cheryl H. sim Department of System Engineering and Engineering Management The Chinese University of Hong Kong Hong Kong NUSBusiness School The National University of Singapore 1 Business Link Singapore 117592 National Library Board of Singapore Singapore

This study focuses on inventory strategies of Internet retailers (etailers). The etailer faces options of holding her own inventory or outsourcing through the third party(ies). We assess etailer inventory strategies through mathematical modeling and numerical experiments. When ordering and holding her own stock, the etailer has full control of the order fulfillment process but bears the inventory-related risk. When outsourcing stock, etailer’s orders may not get an equal priority as for those of the third party’s own. Built upon simple operations research models, the numerical experiments suggest that the etailer is better off relying on others to fulfill orders if her demand (profit margin) is low, but should revert to the strategy of maintaining her own inventory if her sales volume (profit margin) is relatively high. Other factors are also investigated. These findings seem to confirm what are being practiced in the industry.

关键词： Electronic commerce e-retailer fulfillment inventory

A Certain Subclass of Analytic Functions with Bounded Positive Real Part

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Advances in Pure Mathematics 2013年第4期3卷 409-414页

作者： Young Jae sim Oh Sang Kwon Department of Mathematics Kyungsung UniversityBusanSouth Korea

For real numbers α and β such that 0≤α<1<β, we denote by T(α,β) the class of normalized analytic functions which satisfy , where U denotes the open unit disk. We find some relationships involving functions in the class T(α,β). And we estimate the bounds of coefficients and solve Fekete-Szego problem for functions in this class. Furthermore, we investigate the bounds of initial coefficients of inverse functions or bi-univalent functions.

关键词： Functions of Bounded Positive Real Part Fekete-Szego Problem Inverse Functions Bi-Univalent Functions

Phenolics-saponins rich fraction of defatted kenaf seed meal exhibits cytotoxicity towards cancer cell lines

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 404-409页

作者： Latifah Saiful Yazan Napsiah Abd Rahman Kim Wei Chan Wan Nor Hafiza Wan Abd Ghani Yin sim Tor Jhi Biau Foo Laboratory of Molecular Biomedicine Institute of BioscienceUniversiti Putra Malaysia (UPM) Department of Biomedical Science Faculty of Medicine and Health SciencesUniversiti Putra Malaysia (UPM)

Objectives: To determine the cytotoxicity of crude ethanolic extract, n-butanol fraction and aqueous fraction on selected cancer cell lines, and to observe the morphological changes of the cancer cells treated with n-butanol ***: The cytotoxic effect of n-butanol fraction, crude ethanolic extract and aqueous fraction on breast cancer(MCF-7 and MDA-MB-231), colon cancer(HT29), lung cancer(A549), cervical cancer(He La) and normal mouse fibroblast(3T3) cell lines was determined using MTT assay. The morphological changes of the treated cells were observed under an inverted light ***: n-Butanol fraction was the most cytotoxic towards HT29 and MCF-7 cells in a dose-dependent manner compared to crude ethanolic extract and aqueous fraction(P < 0.05). The IC50 of n-butanol fraction for HT29 and MCF-7 was(780.00 ± 28.28)and(895.00 ± 7.07) mg/m L, respectively. Cell shrinkage, membrane blebbing and formation of apoptotic bodies were noted following treatment of HT29 cells with n-butanol ***: In conclusion, n-butanol fraction was more cytotoxic than crude ethanolic extract and aqueous fraction towards the selected cancerous cell lines and induced apoptosis in HT29 cells.

关键词： Defatted kenaf seed meal Phenolic-saponin rich fraction Cytotoxic Apoptosis

Frequentist Model Averaging and Applications to Bernoulli Trials

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Open Journal of Statistics 2016年第3期6卷 545-553页

作者： Georges Nguefack-Tsague Walter Zucchini siméon Fotso Biostatistics Unit Department of Public Health Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde Cameroon Institute for Statistics and Econometrics University of Goettingen Goettingen Germany Department of Mathematics Higher Teachers’ Training College University of Yaoundé I Yaoundé Cameroon

In several instances of statistical practice, it is not uncommon to use the same data for both model selection and inference, without taking account of the variability induced by model selection step. This is usually referred to as post-model selection inference. The shortcomings of such practice are widely recognized, finding a general solution is extremely challenging. We propose a model averaging alternative consisting on taking into account model selection probability and the like-lihood in assigning the weights. The approach is applied to Bernoulli trials and outperforms Akaike weights model averaging and post-model selection estimators.

关键词： Model Selection Post-Model Selection Estimator Frequentist Model Averaging Bernoulli Trials