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Mechanical strength and corrosion resistance of Al-additive friction stir welded AZ31B joints

Journal of Magnesium and Alloys 2023年第5期11卷 1519-1535页

作者： jae-yeon kim Eun-Woo kim Dong-O kim Eun-Kyo Ju Ji-Eun Lee jaeheon Lee Jai-Won Byeon Mining Engineering Department Colorado School of MinesGoldenCO 80401USA Department of Materials Science and Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea

Compared to other structural alloys,magnesium alloys have a relatively poor corrosion resistance and low mechanical strength,which can be further deteriorated when these alloys are subjected to joining processes using the existing joining methods.Herein,we propose for the first time an additive friction stir-welding(AFSW)using fine Al powder as an additive to improve the mechanical strength as well as corrosion resistance of AZ31B weld joints.AFSW is a solid-state welding method of forming a high-Al AZ31B joint via an in-situ reaction between pure Al powders filled in a machined groove and the AZ31B matrix.To optimize the process parameters,AFSW was performed under different rotational and transverse speeds,and number of passes,using tools with a square or screw pin.In particular,to fabricate a weld zone,where the Al was homogenously dispersed,the effects of the groove shape were investigated using three types of grooves:surface one-line groove,surface-symmetric grooves,and inserted symmetric grooves.The homogenous and defect-less AFS-welded AZ31B joint was successfully fabricated with the following optimal parameters:1400 rpm,25 mm/min,four passes,inserted symmetric grooves,and the tool with a square pin.The AFSW fully dissolved the additive Al intoα-Mg and in-situ precipitated Mg_(17)Al_(12)particles,which was confirmed via scanning electron microscopy,transmission electron microscope,and X-ray diffraction analyses.The microhardness,joint efficiency,and elongation at the fracture point of the AFS-welded AZ31B joint were 80 HV,101%,and 8.9%,respectively.These values are higher than those obtained for the FS-welded AZ31 joint in previous studies.The corrosion resistance of the AFS-welded AZ31B joint,evaluated via hydrogen evolution measurements and potentiodynamic polarization tests,was enhanced to 55%relative to the FS-welded AZ31B joint.

关键词： AZ31B magnesium alloy Additive friction stir-welding In-situ reaction Mg_(17)Al_(12)particles Joint efficiency Corrosion resistance

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植物乳杆菌KCCM 11613P发酵的旋覆花花瓣提取物的抗黑素生成的作用(英文)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第9期18卷 816-824页

作者： Eun-hye PARK Won-young BAE jae-yeon kim Kee-tae kim Hyun-dong PAIK Department of Food Science and Biotechnology of Animal Resources Konkuk University Bio/Molecular Informatics Center Konkuk University

目的:研究植物乳杆菌发酵对旋覆花花瓣提取物对酪氨酸酶的抑制效果,为开发旋覆花提取物作为潜在的皮肤增白成分提供依据。创新点:发现旋覆花植物乳杆菌发酵的提取物可以作为有效的美白材料。方法:比较研究了植物乳杆菌发酵的旋覆花花瓣... 详细信息

目的:研究植物乳杆菌发酵对旋覆花花瓣提取物对酪氨酸酶的抑制效果,为开发旋覆花提取物作为潜在的皮肤增白成分提供依据。创新点:发现旋覆花植物乳杆菌发酵的提取物可以作为有效的美白材料。方法:比较研究了植物乳杆菌发酵的旋覆花花瓣提取物对酪氨酸酶活性的抑制作用,并测定了提取物中总黄酮和多酚类化合物的含量。通过体外酪氨酸酶和左旋多巴(L-DOPA)染色来测定其对皮肤的美白活性。结论:旋覆花花瓣经过72小时的发酵后,其提取物中总黄酮含量提高13.4%。采用500μg/ml发酵和未发酵的提取物处理B16F10细胞,细胞活性分别为100.26%和92.15%。此外,发酵72小时后,该提取物对酪氨酸酶活性的抑制率由29.33%上升到41.74%。未处理的对照组B16F10细胞酪氨酸酶活性增加到145.69%。结果表明,旋覆花发酵提取物对酪氨酸酶活性呈剂量依赖性抑制是促黑激素(α-MSH)的刺激引起。旋覆花植物乳杆菌发酵的提取物可以作为有效的美白材料。

关键词：旋覆花类黄酮植物乳杆菌抗氧化剂酪氨酸酶抑制剂

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Intelligent structured nanocomposite adhesive for bioelectronics and soft robots

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Nano Research 2024年第2期17卷 534-549页

作者： yeon Soo Lee Min-Seok kim Da Wan kim Changhyun Pang School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Mechanical Metrology Group Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Electronic Engineering Korea National University of TransportationChungbuk 27469Republic of Korea Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The remarkable functionality of biological systems in detecting and adapting to various environmental conditions has inspired the design of the latest electronics and robots with advanced features.This review focuses on intelligent bio-inspired strategies for developing soft bioelectronics and robotics that can accommodate nanocomposite adhesives and integrate them into biological surfaces.The underlying principles of the material and structural design of nanocomposite adhesives were investigated for practical applications with excellent functionalities,such as soft skin-attachable health care sensors,highly stretchable adhesive electrodes,switchable adhesion,and untethered soft robotics.In addition,we have discussed recent progress in the development of effective fabrication methods for micro/nanostructures for integration into devices,presenting the current challenges and prospects.

关键词： biomimetics bio-adhesive switchable adhesion bioelectronics nanocomposite soft robotics

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Comparative efficacy and optimal duration of first-line antibiotic regimens for acute otitis media in children and adolescents:a systematic review and network meta-analysis of 89 randomized clinicaltrials

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World Journal of Pediatrics 2024年第3期20卷 219-229页

作者： Min Seo kim jae Han kim Seohyun Ryu Seung Won Lee Dong Keon Yon Eunyoung kim Ai Koyanagi Elena Dragioti jae Il Shin Lee Smith Samsung Advanced Institute forHealth Sciences&Technology(SAIHST) Samsung Medical CenterSungkyunkwan UniversitySeoulRepublic of Korea Yonsei University Collegeof Medicine SeoulRepublicof Korea Department of Precision Medicine Sungkyunkwan University School of MedicineSuwonRepublic of Korea Center for Digital Health Medical Science Research InstituteKyung Hee University College of MedicineSeoulRepublic of Korea Evidence-Based Research Laboratory Department of Clinical Pharmacy and Pharmaceutical CareCollege of PharmacyChung-Ang UniversitySeoulRepublic of Korea Parc Sanitari Sant Joan de Deu/CIBERSAM/ISCIII Universitat de BarcelonaFundacio Sant Joan de Déu.Sant Boi de LlobregatBarcelonaSpain ICREA Pg.Lluis Companys 23BarcelonaSpain Pain and Rehabilitation Centre and Department of Medical and Health SciencesLinkoping University58185 LinkopingSweden Department of Pediatrics Yonsei University College of MedicineYonsei-ro 50Seodaemun-gu8044Seoul 03722Republic of Korea Centre for Health Performanceand WellbeingAnglia Ruskin UniversityCambridge CB11PTUK Research Laboratory Psychology of Patients Families&Health ProfessionalsDepartment of NursingSchool of Health SciencesUniversity of IoanninaIoannina 45500Greece

Introduction Antibiotic use for acute otitis media(AOM)is one of the major sources of antimicrobial resistance.However,the effective minimal antibiotic duration for AOM remains unclear.Moreover,guidelines often recommend broad ranges(5-10 days)of antibiotic use,yet the clinical impact of such a wide window has not been assessed.Methods We systematically searched PubMed/MEDLINE,Embase,Scopus,Web of Science,and Cochrane Library from database inception to 6 October 2021.Network meta-analysis was conducted on randomized controlled trials that assessed antibiotic treatment for AOM in children(PROSPERO CRD42020196107).Results For amoxicillin and amoxicillin-clavulanate,7-day regimens were noninferior to 10-day regimens in clinical responses[amoxicillin:risk ratio(RR)0.919(95%CI 0.820-1.031),amoxicillin-clavulanate:RR 1.108(0.957-1.282)],except for≤2 years.For the third-generation cephalosporins,7-day and 10-day regimens had similar clinical responses compared to placebo[7-day:RR 1.420(1.190-1.694),10-day:RR 1.238(1.125-1.362)compared to placebo].However,5-day regimens of amoxicillin-clavulanate and third-generation cephalosporins were inferior to 10-day regimens.Compared to amoxicillin,a shorter treatment duration was tolerable with amoxicillin-clavulanate.Conclusions Our findings indicated that 1O days of antibiotic use may be unnecessarily long,while the treatment duration should be longer than 5 days.Otherwise,5-day regimens would be sufficient for a modest treatment goal.Our findings revealed that the current wide range of recommended antibiotic durations may have influenced the clinical outcome of AOM,and a narrower antibiotic duration window should be re-established.

关键词： Amoxicillin-potassium Amoxicillin Antibacterial agents Cephalosporins Duration of therapy

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Immediate secondary rhinoplasty using a folded dermofat graft for resolving complications related to silicone implants: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2426-2430页

作者： Hoon kim Jong Hyup kim In Chang Koh Soo yeon Lim Department of Plastic and Reconstructive Surgery Konyang University HospitalUniversity of Konyang College of MedicineMyunggok Medical Research InstituteDaejeon 35365South Korea

BACKGROUND Various surgical techniques have been developed to enhance the nose shapes of Asian patients.Silicone implant augmentation rhinoplasty is widely used because it is relatively easy to perform and often yields satisfactory outcomes.However,this technique may lead to complications,including ischemia,necrosis,and over-augmentation.The most appropriate management of these complications,including infection,is immediate implant removal and revision surgery once the accompanying inflammation has healed.Occasionally,the patient may experience distress from nasal deformities during the intervention period.CASE SUMMARY Herein,we describe the case of a patient who underwent a secondary dorsal augmentation,with a folded dermofat graft harvested from the inguinal area and simultaneous implant removal,successfully preventing dimpling of the nasal deformity.CONCLUSION This surgical method can effectively manage implant-related complications following augmentation rhinoplasty using a silicone implant and provide satis-factory patient outcomes.

关键词： Complications Nose deformities Acquired Rhinoplasty Dermofat Surgery Plastic Case report

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A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

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Genes & Diseases 2024年第2期11卷 512-515页

作者： June-Ha Shin Hwa-Ryeon kim jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been identified.Nevertheless,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still incomplete.To complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

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Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

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Nano-Micro Letters 2024年第3期16卷 254-302页

作者： Hyeonseok kim Bruno Rigo Gabriella Wong Yoon jae Lee Woon‑Hong Yeo IEN Center for Wearable Intelligent Systems and Healthcare Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health care.Design considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human tissues.In addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and hemocompatibility.The wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease diagnosis.Lastly,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

关键词： Implantable electronics Biomedical systems Batteryless devices Wireless electronics Physiological signal monitoring

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Comparison of macular changes according to the etiology of optic neuritis:a cross-sectional study

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 686-692页

作者： Yeji Moon Sung-Min kim jae Ho Jung Department of Ophthalmology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Neurology Seoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University College of MedicineSeoul 03080Republic of Korea

AIM:To compare the macular structure including foveal thickness among patients with optic neuritis(ON)according to the etiology and to investigate the possible correlation between structural and visual outcomes METHODS:In this retrospective cross-sectional study,the clinical data of patients with aquaporin-4 immunoglobulin G-related ON(AQP4 group,40 eyes),myelin oligodendrocyte glycoprotein IgG-related ON(MOG group,31 eyes),and multiple sclerosis-related ON(MS group,24 eyes)were obtained.The retinal thickness of the foveal,parafoveal and perifoveal regions were measured.Visual acuity(VA),visual field index and mean deviation were measured as visual outcomes.RESULTS:The AQP4 group showed a significantly thinner fovea(226.4±13.4μm)relative to the MOG(236.8±14.0μm,P=0.015)and MS(238.9±14.3μm,P=0.007)groups.The thickness in the parafoveal area also was thinner in the AQP4 group,though the difference in perifoveal retinal thickness was not significant.Foveal thickness was correlated with VA in the AQP4 group(coefficientρ=-0.418,P=0.014),but not in the MOG and MS groups(P=0.218 and P=0.138,respectively).There was no significant correlation between foveal thickness and visual field test in all three groups.CONCLUSION:The significant thinning in the fovea and parafoveal areas in the AQP4 group compared to the MOG and MS groups are found.Additionally,macular changes in AQP4-ON show a significant correlation with VA.The results provide the possibility that retinal structural damage could reflect functional damage in AQP4-ON,distinct from MOGON and MS-ON.

关键词： foveal thickness optic neuritis aquaporin-4 immunoglobulin myelin oligodendrocyte glycoprotein multiple sclerosis

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Sleep Posture Classification Using RGB and Thermal Cameras Based on Deep Learning Model

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1729-1755页

作者： Awais Khan Chomyong kim Jung-yeon kim Ahsan Aziz Yunyoung Nam Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea ICT Convergence Research Center Soonchunhyang UniversityAsan31538Korea Emotional and Intelligent Child Care Convergence Research Center Soonchunhyang UniversityAsan31538Korea

Sleep posture surveillance is crucial for patient comfort,yet current systems face difficulties in providing compre-hensive studies due to the obstruction caused by blankets.Precise posture assessment remains challenging because of the complex nature of the human body and variations in sleep patterns.Consequently,this study introduces an innovative method utilizing RGB and thermal cameras for comprehensive posture classification,thereby enhancing the analysis of body position and comfort.This method begins by capturing a dataset of sleep postures in the form of videos using RGB and thermal cameras,which depict six commonly adopted postures:supine,left log,right log,prone head,prone left,and prone right.The study involves 10 participants under two conditions:with and without blankets.Initially,the database is normalized into a video frame.The subsequent step entails training a fine-tuned,pretrained Visual Geometry Group(VGG16)and ResNet50 model.In the third phase,the extracted features are utilized for classification.The fourth step of the proposed approach employs a serial fusion technique based on the normal distribution to merge the vectors derived from both the RGB and thermal datasets.Finally,the fused vectors are passed to machine learning classifiers for final classification.The dataset,which includes human sleep postures used in this study’s experiments,achieved a 96.7%accuracy rate using the Quadratic Support Vector Machine(QSVM)without the blanket.Moreover,the Linear SVM,when utilized with a blanket,attained an accuracy of 96%.When normal distribution serial fusion was applied to the blanket features,it resulted in a remarkable average accuracy of 99%.

关键词： Human sleep posture VGG16 deep learning ResNet50 fusion machine learning

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Varifocal occlusion in an optical see-through near-eye display with a single phase-only liquid crystal on silicon

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Photonics Research 2024年第4期12卷 833-853页

作者： WOONGSEOB HAN jae-WON LEE JUNG-YEOP SHIN MyeonG-HO CHOI HAK-RIN kim jae-HYEUNG PARK Department of Electrical and Computer Engineering Inha University100 Inha-roMichuhol-guIncheon 22212Republic of Korea School of Electronic and Electrical Engineering Kyungpook National University80 Daehak-roBuk-guDaegu 41566Republic of Korea School of Electronics Engineering Kyungpook National University80 Daehak-roBuk-guDaegu 41566Republic of Korea Department of Information and Communication Engineering Inha University100 Inha-roMichuhol-guIncheon 22212Republic of Korea

We propose a near-eye display optics system that supports three-dimensional mutual occlusion.By exploiting the polarization-control properties of a phase-only liquid crystal on silicon (LCoS),we achieve real see-through scene masking as well as virtual digital scene imaging using a single LCoS.Dynamic depth control of the real scene mask and virtual digital image is also achieved by using a focus tunable lens (FTL) pair of opposite curvatures.The proposed configuration using a single LCoS and opposite curvature FTL pair enables the self-alignment of the mask and image at an arbitrary depth without distorting the see-through view of the real scene.We verified the feasibility of the proposed optics using two optical benchtop setups:one with two off-the-shelf FTLs for continuous depth control,and the other with a single Pancharatnam–Berry phase-type FTL for the improved form factor.

关键词： optics crystal phase

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