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Correlation of fatty liver and abdominal fat distribution using a simple fat computed tomography protocol

World Journal of Gastroenterology 2011年第28期17卷 3335-3341页

作者： Seonah Jang Chang Hee Lee kyung Mook choi Jongmee Lee jae Woong choi Kyeong Ah Kim Cheol Min Park Department of Radiology Korea University Guro HospitalKorea University College of Medicine Department of Internal Medicine (Division of Endocrinology and Metabolism) Korea University Guro HospitalKorea University College of Medicine

AIM: To evaluate the relationship between hepatic fat infiltration and abdominal fat volume by using computed tomography (CT).METHODS: Three hundred and six patients who visited our obesity clinic between November 2007 and April 2008 underwent fat protocol CT *** age range of the patients was 19 to 79 years and the mean age was 49 *** male to female ratio was 116:*** and spleen attenuation measurements were taken with three regions of interests (ROIs) from the liver and two ROIs from the *** attenuation indices (HAIs) were measured as follows: (1) hepatic parenchymal attenuation (CTLP);(2) liver to spleen attenuation ratio (LS ratio);and (3) difference between hepatic and splenic attenuation (LSdif).Abdominal fat volume was measured using a 3 mm slice CT scan starting at the level of the umbilicus and was automatically calculated by a *** fat was classified into total fat (TF),visceral fat (VF),and subcutaneous fat (SF).We used a bivariate correlation method to assess the relationship between the three HAIs and TF,VF,and ***: There were significant negative correlations between CTLP,LS ratio,and LSdif with TF,VF,and SF,*** CTLP showed a strong negative correlation with TF and VF (r = -0.415 and -0.434,respectively,P < 0.001).The correlation between CTLP and SF was less significant (r = -0.313,P < 0.001).CONCLUSION: Fatty infiltration of the liver was correlated with amount of abdominal fat and VF was more strongly associated with fatty liver than SF.

关键词： Steatosis Computed tomography Abdominal fat Visceral fat Subcutaneous fat

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Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1117-1122页

作者： Prashamsa Koirala Su Hui Seong Hyun Ah Jung jae Sue choi Department of Food and Life Science Pukyong National University Department of Food Science and Human Nutrition Chonbuk National University

Objective: To discover lead lupane triterpenoid's potential isolated from Pueraria lobata roots against b-site amyloid precursor protein cleaving enzyme 1(BACE1), which serve as a rate limiting step in amyloid beta(Aβ) production altering the course of Alzheimer's disease. In addition, enzyme kinetics study and molecular docking were conducted to establish the inhibition type and structure activity ***: A systematic study of 70% ethanolic P. lobata root extract was employed to identify its BACE1 inhibitory potential. Further, BACE1 inhibitory potential of two lupane terpenoids, yielded from ethanolic extract, was assessed. In order to determine their inhibition mode, Lineweaver–Burk plots and Michaelis–Menten model for BACE1 was performed. Auto Dock 4.2 program in addition determined the molecular interaction of BACE1 with isolated ***: Considering the inhibitory potential of 70% ethanolic extract of P. lobata against BACE1(IC_(50)= 80.35 mg/mL), lupeol and lupenone were subsequently isolated and exhibited notable or moderate BACE1 inhibitory activity with IC_(50) values of 5.12 and 62.98 mmol/L, respectively, as compared to the positive control quercetin(IC_(50)= 21.28 mmol/L). The enzyme kinetics study enabled us to identify both compounds as competitive inhibitors, where lupeol displayed a very potent inhibition against BACE1 with low inhibition constant(Ki) value of 1.43 mmol/L, signifying greater binding *** order to understand the binding mechanism and structure–activity relationship of two triterpene-based BACE1 inhibitors, we employed computer aided docking studies which evidently revealed that hydroxyl group of lupeol formed two hydrogen bonds with the ASP32(catalytic aspartic residue) and SER35 residues of BACE1 with the binding energy of(-8.2 kcal/mol), while the ketone group of lupenone did not form any hydrogen bonds with BACE1 giving evidence for less binding affinity. These results in turn have predicted the dep

关键词： Pueraria lobata BACE1 Lupeol Lupenone Molecular docking Kinetics

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Unlocking power of neighboring vacancies in boosting hydrogen evolution reactions on two-dimensional NiPS3 monolayer

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eScience 2024年第3期4卷 104-115页

作者： Hyun Gu Han jae Won choi Minsu Son Ki Chul Kim Computational Materials Design Laboratory Department of Chemical EngineeringKonkuk UniversitySeoul 05029The Republic of Korea Division of Chemical Engineering Konkuk UniversitySeoul 05029The Republic of Korea

This study investigates the effect of defect engineering on the catalytic activity of a NiPS3 monolayer catalyst for the hydrogen evolution reaction(HER).Three different types of vacancies on the basal plane of the monolayer are explored through a multi-step mechanism involving the dissociative adsorption of a water molecule and subsequent electrochemical adsorption of the dissociated ***-formation of vacancies in both Ni and S sites is found to be the most effective in enhancing the catalytic performance of the monolayer.A key resource for the reaction thermodynamics is the S-substitution-like physisorption of a water molecule on a vacant S site,followed by the dissociative occupation of OH and H into vacant sites of S and Ni elements,boosted by the NiS di-vacancy configuration with low activation energy *** reveals the highest contribution of bonding orbitals to the monolayer-H bond makes it the most desirable defect engineering approach for transition metal phosphorus chalcogenides with high HER ***,this study highlights the significance of controlled defect engineering in augmenting the catalytic performance of NiPS3 monolayer catalysts for HER.

关键词： Hydrogen evolution reaction Defect engineering Transition metal phosphorus trichalcogenide Density functional theory Reaction thermodynamics

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Bioinspired Multi-material Polyjet-printed Frog Robot for Synchronous and Asynchronous Swimming

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Journal of Bionic Engineering 2023年第3期20卷 923-933页

作者： Afaque Manzoor Soomro jae-Wook Lee Fida Hussain Memon Faheem Ahmed Kashif Hussain kyung Hyun choi Department of Mechatronics Engineering Jeju National UniversityJeju63243South Korea Department of Electrical Engineering Sukkur IBA UniversitySukkur65200Pakistan

This paper proposes the bioinspired soft frog robot. All printing technology was used for the fabrication of the robot. Polyjet printing was used to print the front and back limbs, while ultrathin filament was used to print the body of the robot, which makes it a complete soft swimming robot. Dual thrust generation approach has been proposed by embedding the main muscle and antagonistic muscle in all the limbs, which enables it to attain high speed (18 mm/s), significant control to swim in dual mode (synchronous and asynchronous modes). To achieve the swimming motion of frog, four SMA (BMF 300) muscle wires were used. The frog robot is named as (FROBOT). The hind limbs are 60 mm long and 10 mm thick on average, while the front limbs are 35 mm long and 7 mm thick. Model-based design and rigorous analysis of the dynamics of real frogs have allowed FROBOT to be developed to swim at a level that is remarkably consistent with real frogs. Electrical and mechanical characteristics have been performed. In addition, the test data were further processed using TRACKER to analyze angle, displacement and velocity. FROBOT (weighs 65 g) can swim at different controllable frequencies (0.5–2 Hz), can rotate in any direction on command from custom built LabVIEW software allowing it to swim with speed up to 18 mm/s on deep water surface (100 cm) with excellent weight balance.

关键词： Bioinspired Soft robotics Frog FROBOT Asynchronous swimming

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Current diagnosis and treatment of benign biliary stricturesafter living donor liver transplantation

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World Journal of Gastroenterology 2016年第4期22卷 1593-1606页

作者： jae Hyuck Chang Inseok Lee Myung-Gyu choi Sok Won Han Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

Despite advances in surgical techniques, benign biliary strictures after living donor liver transplantation(LDLT) remain a significant biliary complication and play an important role in graft and patient survival. Benign biliary strictures after transplantation are classified into anastomotic or non-anastomotic strictures. These two types differ in presentation, outcome, and response to therapy. The leading causes of biliary strictures include impaired blood supply, technical errors during surgery, and biliary anomalies. Because patients usually have non-specific symptoms, a high index of suspicion should be maintained. Magnetic resonance cholangiography has gained widespread acceptance as a reliable noninvasive tool for detecting biliary complications. Endoscopy has played an increasingly prominent role in the diagnosis and treatment of biliary strictures after LDLT. Endoscopic management in LDLT recipients may be more challenging than in deceased donor liver transplantation patients because of the complex nature of the duct-to-duct reconstruction. Repeated aggressive endoscopic treatment with dilation and the placement of multiple plastic stents is considered the first-line treatment for biliary strictures. Percutaneous and surgical treatments are now reserved for patients for whom endoscopic management fails and for those with multiple, inaccessible intrahepatic strictures or Roux-en-Y anastomoses. Recent advances in enteroscopy enable treatment, even in these latter cases. Direct cholangioscopy, another advanced form of endoscopy, allows direct visualization of the inner wall of the biliary tree and is expected to facilitate stenting or stone extraction. Rendezvous techniques can be a good option when the endoscopic approach to the biliary stricture is unfeasible. These developments have resulted in almost all patients being managed by the endoscopic approach.

关键词： Biliary strictures Living donor liver transplantation Endoscopic retrograde cholangiography Percutaneous transhepatic cholangiography Biliarycomplication

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Absorption-Dominant mmWave EMI Shielding Films with Ultralow Reflection using Ferromagnetic Resonance Frequency Tunable M-Type Ferrites

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Nano-Micro Letters 2023年第6期15卷 1-23页

作者： Horim Lee Seung Han Ryu Suk Jin Kwon jae Ryung choi Sang‑bok Lee Byeongjin Park Composites Research Division Korea Institute of Materials Science797 ChangwondaeroSeongsan‑GuChangwonGyeongsangnam‑Do 51508Republic of Korea

Although there is a high demand for absorption-dominant electromagnetic interference(EMI) shielding materials for 5G millimeter-wave(mmWave) frequencies, most current shielding materials are based on reflection-dominant conductive materials. While there are few absorption-dominant shielding materials proposed with magnetic materials, their working frequencies are usually limited to under 30 GHz. In this study, a novel multi-band absorption-dominant EMI shielding film with M-type strontium ferrites and a conductive grid is proposed. This film shows ultralow EMI reflection of less than 5% in multiple mmWave frequency bands with sub-millimeter thicknesses, while shielding more than 99.9% of EMI. The ultralow reflection frequency bands are controllable by tuning the ferromagnetic resonance frequency of M-type strontium ferrites and composite layer geometries. Two examples of shielding films with ultralow reflection frequencies, one for 39 and 52 GHz 5G telecommunication bands and the other for 60 and 77 GHz autonomous radar bands, are presented. The remarkably low reflectance and thinness of the proposed films provide an important advancement toward the commercialization of EMI shielding materials for 5G mmWave applications.

关键词： 5G communication MmWave EMI shielding M-type ferrites

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Anti-acetylcholinesterase activity of the aglycones of phenolic glycosides isolated from Leonurus japonicus

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 849-854页

作者： Agung Nugroho jae Sue choi Joon-Pyo Hong Hee-Juhn Park Department of Agro-industrial Technology Faculty of AgricultureLambung Mangkurat UniversityBanjarbaru 70714 Indonesia Department of Food Science and Nutrition Pukyong National UniversityBusan 48513Republic of Korea Department of Pharmaceutical Engineering Sangji UniversityWonju 26339Republic of Korea

Objective: To find the genuine structure with anti-acetylcholinesterase(anti-ACh E) from the phenolic glycosides abundant in Leonurus japonicus(Lamiaceae). The assay for antiACh E activity is often used to lead anti-Alzheimer's ***: The five phenolic glycosides, tiliroside, leonurusoside C, 2’’’-syringoylrutin,rutin, and lavanduliofolioside were isolated from L. japonicus. The activities of the glycosides were relatively low. Seven compounds including p-coumaric acid, caffeic acid, hydroxytyrosol, salidroside, syringic acid, kaempferol, and quercetin, which are produced by the hydrolysis of the five glycosides, were also assayed for anti-ACh E ***: Of those seven compounds, the five compounds other than salidroside and syringic acid exhibited potent anti-ACh E activities. In particular, the IC_(50)s of caffeic acid and quercetin were(1.05 ± 0.19) and(3.58 ± 0.02) mg/m L, respectively. Rutin was the most abundant flavonoid in the extract(9.18 mg/g as measured by HPLC).Conclusion: The substances with potent anti-ACh E were caffeic acid, quercetin, pcoumaric acid, kaempferol, and hydroxytyrosol that can be produced from their glycosides.

关键词： Leonurus japonicus Lamiaceae Acetylcholinesterase Phenolic glycosides Quercetin Caffeic acid

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The secretory products of Trichomonas vaginalis decrease fertilizing capacity of mice sperm in vitro

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Asian Journal of Andrology 2015年第2期17卷 319-323,I0012页

作者： jaesook Roh Young-Su Lim Min-Young Seo Yuri choi jae-Sook Ryu Department of Anatomy and Cell Biology Laboratory of Reproductive Endocrinology College of Medicine Hanyang University Seoul Korea Department of Anesthesiology and Pain Medicine St. Mary's Hospital Catholic University Incheon Korea Department of Environmental Biology and Medical Parasitology College of Medicine Hanyang University Seoul Korea.

Trichomonas vaginalis infection is one of the most prevalent sexually transmitted infections in humans and is now recognized as an important cause of infertility in men. There is little information about the effect of extracellular polymeric substances （EPS） from T. vaginalis on sperm, but previous reports do not provide a conclusive description of the functional integrity of the sperm. To investigate the impact of EPS on the fertilizing capacity of sperm, we assessed sperm motility, acrosomal status, hypo-osmotic swelling, and in vitro fertilization rate after incubating the sperm with EPS in vitro using mice. The incubation of sperm with EPS significantly decreased sperm motility, viability, and functional integrity in a concentration and time-dependent manner. These effects on sperm quality also resulted in a decreased fertilization rate in vitro. This is the first report that demonstrates the direct negative impact of the EPS of T. vaginalis on the fertilization rate of sperm in vitro. However, further study should be performed using human sperm to determine if EPS has similar negative impact on human sperm fertilizing capacity in vitro.

关键词： extracellular polymeric substances fertilization sperm Trichomonas vaginalis

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Anti-Alzheimer's disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 101-108页

作者： Md.Yousof Ali Susoma Jannat Hyun Ah Jung Ran Joo choi Anupom Roy jae Sue choi Department of Food and Life Science Pukyong National University Department of Food Science and Human Nutrition Chonbuk National University Angiogenesis& Chinese Medicine Laboratory Department of Pharmacology University of Cambridge

Objective: To use structure-activity analysis to study the anti-Alzheimer's disease(anti-AD) activity of natural coumarins isolated from Angelica decursiva and Artemisia capillaries, along with one purchased coumarin(daphnetin). Methods: Umbelliferone, umbelliferone 6-carboxylic acid, scopoletin, isoscopoletin, 7-methoxy coumarin, scoparone, scopolin, and esculetin have been previously isolated; however 2'-isopropyl psoralene was isolated from Angelica decursiva for the first time to evaluate their inhibitory effects against acetylcholinesterase(ACh E), butyrylcholinesterase(BCh E), and β-site amyloid precursor protein cleaving enzyme 1(BACE1) enzyme activity. We scrutinized the potentials of coumarins as cholinesterase and BACE1 inhibitors via enzyme kinetics and molecular docking simulation. Results: Among the test compounds, umbelliferone 6-carboxylic acid, esculetin and daphnetin exhibited potent inhibitory activity against ACh E, BCh E and BACE1. Both esculetin and daphnetin have a catechol group and exhibit significant anti-AD activity against ACh E and BCh E. In contrast, presence of a sugar moiety and methoxylation markedly reduced the anti-AD activity of the coumarins investigated in this study. With respect to BACE1 inhibition, umbelliferone 6-carboxylic acid, esculetin and daphnetin contained carboxyl or catechol groups, which significantly contributed to their antiAD activities. To further investigate these results, we generated a 3D structure of BACE1 using Autodock 4.2 and simulated binding of umbelliferone 6-carboxylic acid, esculetin and daphnetin. Docking simulations showed that different residues of BACE1 interacted with hydroxyl and carboxylic groups, and the binding energies of umbelliferone 6-carboxylic acid, esculetin and daphnetin were negative(-4.58,-6.25 and-6.37 kcal/mol respectively). Conclusions: Taken together, our results suggest that umbelliferone 6-carboxylic acid, esculetin and daphnetin have anti-AD effects by inhibiting ACh E, BCh

关键词： Umbelliferone 6-carboxylic acid Esculetin Daphnetin Coumarins Cholinesterase BACE1

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Selective Growth of ZnO Nanorods on SiO2/Si Substrates Using a Graphene Buffer Layer

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Nano Research 2011年第5期4卷 440-447页

作者： Won Mook choi kyung-Sik Shin Hyo Sug Lee Dukhyun choi Kihong Kim Hyeon-Jin Shin Seon-Mi Yoon jae-Young choi Sang-Woo Kim Samsung Advanced Institute of Technology Giheung Yongin Gyeonggi 446-712 Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan （SKKU） Advanced Institute of Nanotechnology （SAINT） Center for Human Interface Nanotechnology （HINT） Sungkyunkwan University Suwon 440-746 Republic of Korea Department of Mechanical Engineering Kyung Hee University Yongin Gyeonggi 446-701 Republic of Korea

A promising strategy for the selective growth of ZnO nanorods on SiO2/Si substrates using a graphene buffer layer in a low temperature solution process is described. High densities of ZnO nanorods were grown over a large area and most ZnO nanorods were vertically well-aligned on graphene. Furthermore, selective growth of ZnO nanorods on graphene was realized by applying a simple mechanical treatment, since ZnO nanorods formed on graphene are mechanically stable on an atomic level. These results were confirmed by first principles calculations which showed that the ZnO-graphene binding has a low destabilization energy. In addition, it was found that ZnO nanorods grown on SiO2/Si with a graphene buffer layer have better optical properties than ZnO nanorods grown on bare SiO2/Si. The nanostructured ZnO-graphene materials have promising applications in future flexible electronic and optical devices.

关键词： Graphene ZnO nanorod heterojunction selective growth solution

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