Anti-acetylcholinesterase activity of the aglycones of phenolic glycosides isolated from Leonurus japonicus

作     者：Agung Nugroho Jae Sue Choi Joon-Pyo Hong Hee-Juhn Park 

作者机构：Department of Agro-industrial TechnologyFaculty of AgricultureLambung Mangkurat UniversityBanjarbaru 70714 Indonesia Department of Food Science and NutritionPukyong National UniversityBusan 48513Republic of Korea Department of Pharmaceutical EngineeringSangji UniversityWonju 26339Republic of Korea 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2017年第7卷第10期

页      面：849-854页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Sangji University Research Fund(Grant No.2016-0101) 

主　　题：Leonurus japonicus Lamiaceae Acetylcholinesterase Phenolic glycosides Quercetin Caffeic acid 

摘      要：Objective: To find the genuine structure with anti-acetylcholinesterase(anti-ACh E) from the phenolic glycosides abundant in Leonurus japonicus(Lamiaceae). The assay for antiACh E activity is often used to lead anti-Alzheimer s ***: The five phenolic glycosides, tiliroside, leonurusoside C, 2’’’-syringoylrutin,rutin, and lavanduliofolioside were isolated from L. japonicus. The activities of the glycosides were relatively low. Seven compounds including p-coumaric acid, caffeic acid, hydroxytyrosol, salidroside, syringic acid, kaempferol, and quercetin, which are produced by the hydrolysis of the five glycosides, were also assayed for anti-ACh E ***: Of those seven compounds, the five compounds other than salidroside and syringic acid exhibited potent anti-ACh E activities. In particular, the IC_(50)s of caffeic acid and quercetin were(1.05 ± 0.19) and(3.58 ± 0.02) mg/m L, respectively. Rutin was the most abundant flavonoid in the extract(9.18 mg/g as measured by HPLC).Conclusion: The substances with potent anti-ACh E were caffeic acid, quercetin, pcoumaric acid, kaempferol, and hydroxytyrosol that can be produced from their glycosides.