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World Journal of Clinical Cases 2020年第7期8卷 1251-1256页

作者： Hong Jun Kim Sun Kyung Baek Chi Hoon Maeng Si-Young Kim Tae Sung Park jae joon han Department of Hematology and Medical Oncology Kyung Hee UniversitySeoul 02447South Korea Department of Laboratory Medicine Kyung Hee UniversitySeoul 02447South Korea

BACKGROUND Acute myeloid leukemia(AML)harboring 11q23 translocations is classified as therapy-related AML in patients who have undergone prior treatment with cytotoxic *** have been only a few reports of AML that subsequently developed during imatinib mesylate(IM)treatment for gastrointestinal stromal tumors(GISTs).CASE SUMMARY A 63-year-old woman was diagnosed with a hepatic GIST recurrence in April 2012;she was administered IM 400 mg/*** November 2015,she developed dyspnea with pancytopenia while IM treatment was continued for 42 mo.A chromosome study using a bone marrow sample showed a 46,XX karyotype with t(11;19)(q23;p13.1)in 22 of 26 analyzed metaphase *** in situ hybridization using the locus-specific indicator(11q23)gene break-apart probe showed positive rearrangement in 82%of interphase ***-transcription polymerase chain reactions subsequently confirmed the KMT2A/ELL *** achieved complete response with incomplete neutrophil recovery with two decitabine treatment *** the third cycle of decitabine,the disease relapsed,and she refused further *** died of hemorrhagic stroke 5 mo after *** the best of our knowledge,this is the first report of AML with KMT2A gene rearrangements in a patient with a GIST receiving IM *** Physicians should consider the potential risks of developing hematologic malignancies,including therapy-related AML,in patients with GISTs receiving IM treatment.

关键词： Acute myeloid leukemia Gastrointestinal stromal tumor Imatinib KMT2A Myelodysplastic syndrome Case report

A new species of Zanclognatha Lederer and three new records of the families Erebidae and Noctuidae(Lepidoptera,Noctuoidea)from Korea,with notes on larval feeding habits

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Journal of Forestry Research 2021年第3期32卷 1235-1240页

作者： Kang-Won Lee joon-Mo Koo jae-Dong Kim Hui-Lin han Kyu-Tek Park Holoce Ecosystem Conservation Research Institution HoengseongGangweon Province 225-841Republic of Korea Department of Plant Medicine Chungbuk National UniversityCheongju28644Republic of Korea Department of Applied Biology College of Agriculture and Life ScienceChungnam National UniversityDaejeon 34134Republic of Korea School of Forestry Northeast Forestry UniversityHarbin 150040China Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education Northeast Forestry UniversityHarbin 150040People’s Republic of China Bioresource and Environmental Center Incheon National UniversityIncheon 22012Republic of Korea

A new species of Zanclognatha Lederer,1857 of the family Erebidae,*** sp.n.,one species of Family Erebidea,Asota egens(Walker,1854)and two species of Family Noctuidae:Meganephria retinea Gyulai and Ronkay,1999 and Amphipyra subrigua Bremer and Grey,1853,are reported for the first time from *** addition,larval feeding habits with their host plants for three species are newly recognized from *** of adults,larvae for Zanclognatha querciella and Meganephria retinea,and the genitalia of male or female for all species are provided.

关键词： Host plants New species New records Korean peninsula Taxonomy

Fault area estimation using traveling wave for wide area protection

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Journal of Modern Power Systems and Clean Energy 2016年第3期4卷 478-486页

作者： jae-Won LEE Won-Ki KIM joon han Won-Hyeok JANG Chul-Hwan KIM Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Daewoo Shipbuilding&Marine Engineering Co. Ltd.GeojeRepublic of Korea Electrical and Computer Engineering Department University of Illinois at Urbana-ChampaignChampaignILUSA

As the increasing number of Phasor Measurement Units(PMUs) are deployed, wide area protection in power systems has been gaining interest. In particular, fault detection, fault classification and fault area estimation are essential to reduce the damage of faults, and even prevent catastrophic cascades of failures. In this paper, we present a scheme for fault area estimation using PMUs and traveling wave theory. The purpose of this paper is to formulate a scheme for fault area estimation by calculating the approximate fault location based on traveling wave *** research has targeted at reliable operation of wide transmission system through the estimation of fault *** verify the suggested scheme, the various simulations are performed in practical Korean power transmission *** simulation results show that the proposed scheme has a good performance with high accuracy for estimating fault area.

关键词： Fault area estimation Phasor measurement unit(PMU) Transmission line system Traveling wave Wide area protection

Fe_(3)GeTe_(2):a site-differentiated Hund metal

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npj Computational Materials 2022年第1期8卷 2355-2360页

作者： Taek Jung Kim Siheon Ryee Myung joon han Department of Physics KAISTDaejeon34141Republic of Korea I.Institute of Theoretical Physics University of HamburgNotkestrasse 9-11Hamburg22607Germany

Magnetism in two-dimensional(2D)van der Waals(vdW)materials has lately attracted considerable attention from the point of view of both fundamental science and device ***,establishing a detailed and solid understanding of their magnetism is the key first step toward various *** Fe_(3)GeTe_(2)is a representative ferromagnetic(FM)metal in this family,many aspects of its magnetic and electronic behaviors still remain ***,we report our new finding that Fe_(3)GeTe_(2)is a special type of correlated metal known as“Hund metal”.Furthermore,we demonstrate that Hund metallicity in this material is quite unique by exhibiting remarkable site dependence of Hund correlation strength,hereby dubbed“site-differentiated Hund metal”.Within this new picture,many of the previous experiments can be clearly understood,including the ones that were seemingly contradictory to one another.

关键词： strength establishing metallic

Integrating Hormone- and Micromolecule- Mediated Signaling with Plasmodesmal Communication

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Molecular Plant 2016年第1期9卷 46-56页

作者： Xiao han jae-Yean Kim Biotechnology Research Institute Chinese Academy of Agricultural Science Beijing 100081 China Division of Applied Life Science (BK21 plus program) Plant Molecular Biology & Biotechnology Research Center Gyeongsang National University Jinju 660-701Korea

Intercellular and supracellular communications through plasmodesmata are involved in vital processes for plant development and physiological responses. Micro- and macromolecules, including hormones, RNA, and proteins, serve as biological information vectors that traffic through the plasmodesmata between cells. Previous studies demonstrated that the plasmodesmata are elaborately regulated, whereby a long queue of multiple signaling molecules forms. However, the mechanism by which these signals are coupled or coor- dinated in terms of simultaneous transport in a single channel remains a puzzle. In the last few years, several phytohormones that could function as both non-cell-autonomous signals and plasmodesmal regulators have been disclosed. Plasmodesmal regulators such as auxin, salicylic acid, reactive oxygen species, gibberellic acids, chitin, and jasmonic acid could regulate intercellular trafficking by adjusting plasmodesmal permeability. Here, callose, along with β-glucan synthase and β-glucanase, plays a critical role in regulating plasmodesmal permeability. Interestingly, most of the previously identified regulators are capable of diffusing through the plasmodesmata. Given the small sizes of these molecules, the plasmo- desmata are prominent intercellular channels that allow diffusion-based movement of those signaling molecules. Obviously, intercellular communication is under the control of a major mechanism, named a feedback loop, at the plasmodesmata, which mediates complicated biological behaviors. Prospective research on the mechanism of coupling micromolecules at the plasmodesmata for developmental signaling and nutrient provision will help us to understand how plants coordinate their development and photosynthetic assimilation, which is important for agriculture.

关键词： callose cell-to-cell movement hormone intercellular signaling plasmodesmata

A Kinetic Study on the Control of Nitrogen in Molten Slag and Metal

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Journal of Iron and Steel Research International 2011年第S2期18卷 301-309页

作者： Seung Min han Dong joon Min Technical Research Laboratories POSCO Pohang 790-785 KOREA Department of Materials Science and Engineering YONSEI University Seoul 120-749 KOREA

Nitrogen can easily contaminate molten steel during the steelmaking process and due to the low nitrogen capacity in slag, it is difficult to remove entrapped nitrogen from liquid steel. Degassing is often done to the steel at secondary steelmaking to lower the nitrogen content, but the control can often be kinetically limited by the steel grade and also the slag composition. Thus, a fundamental understanding of nitrogen dissolution into molten slag and metal including the rate of nitrogen dissolution can help in controlling nitrogen content in the final *** kinetics of nitrogen dissolution in the molten calcium aluminate based slags and in molten steel with various element additions was investigated by measuring the 14N-15N isotope exchange reaction using a mass spectrometer at 1873 *** show that effect of elements on the rate constant of nitrogen dissolution such as Ni in Fe is relatively minimal similar to molybdenum. The surface rate constant of nitrogen dissolution in liquid Fe-10%Ni alloy was found to be 3.77×10-5 (mol/cm2·s·atm).The rate constant of nitrogen dissolution in the CaO-Al2O3-CaF2 slag was found to be wedge shaped, which decreased with increasing CaF2 to about 20 mol% followed by an increase through the rest of the CaF2 composition range. This was related to the effect of CaF2 on the structure of Al-O bonds for this slag.

关键词： rate constant slag structure molten steel isotope exchange technique adsorption coefficient nitrogen surface dissolution

Neonatal erythema multiforme associated with a rotavirus infection:A case report

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World Journal of Clinical Cases 2023年第24期11卷 5749-5754页

作者： Jung jae Kim joon Kee Lee Department of Pediatrics Chungbuk National University HospitalCheongju 28644South Korea Department of Pediatrics Chungbuk National UniversityCheongju 28644South Korea

BACKGROUND Erythema multiforme(EM)is an extremely rare condition in neonates,and studies suggest its association with certain infections and neonatal vaccinations;however,few specific etiological agents have been ***,a common pathogenic gastrointestinal virus in the neonatal period that is preventable via vaccination,has not been identified as a possible *** report the case of a neonate who was referred for skin lesions presenting as EM,where a meticulous workup identified rotavirus as the sole causative *** SUMMARY A 14-day-old male infant was admitted to our hospital with a 1-day history of skin *** medical history or medication intake was *** for the complaint of skin lesions,the caregivers denied any abnormal *** tests,including routine laboratory evaluations,were performed to identify the cause of skin *** tests for Immunoglobulin M for Toxoplasma,Rubella,Cytomegalovirus,Herpes Simplex Virus,and Epstein-Barr virus viral-capsid antigen were all *** polymerase chain reaction(PCR)tests for respiratory viruses and bacterial pathogens were negative(including the severe acute respiratory syndrome coronavirus 2).Multiple PCR tests for gastrointestinal viruses and bacterial pathogens demonstrated evidence of rotavirus *** growth was reported in the blood and urine *** patient received intravenous fluids for hydration;meanwhile,no other medications were *** lesions improved rapidly without specific treatment,and full recovery was achieved within a *** The possibility of rotavirus,a major cause of pediatric gastrointestinal infections,being a trigger for neonatal EM should be considered.

关键词： Erythema multiforme Gastrointestinal diseases Neonate Rotavirus Skin abnormalities Case report

Primordial germ cell-mediated transgenesis and genome editing in birds

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Journal of Animal Science and Biotechnology 2018年第2期9卷 257-267页

作者： jae Yong han Young Hyun Park Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences College of Agriculture and Life Sciences Seoul National University Institute for Biomedical Sciences Shinshu University

Transgenesis and genome editing in birds are based on a unique germline transmission system using primordial germ cells(PGCs), which is quite different from the mammalian transgenic and genome editing system. PGCs are progenitor cells of gametes that can deliver genetic information to the next generation. Since avian PGCs were first discovered in nineteenth century, there have been numerous efforts to reveal their origin, specification, and unique migration pattern, and to improve germline transmission efficiency. Recent advances in the isolation and in vitro culture of avian PGCs with genetic manipulation and genome editing tools enable the development of valuable avian models that were unavailable before. However, many challenges remain in the production of transgenic and genome-edited birds,including the precise control of germline transmission, introduction of exogenous genes, and genome editing in ***, establishing reliable germline-competent PGCs and applying precise genome editing systems are critical current issues in the production of avian models. Here, we introduce a historical overview of avian PGCs and their application, including improved techniques and methodologies in the production of transgenic and genome-edited birds, and we discuss the future potential applications of transgenic and genome-edited birds to provide opportunities and benefits for humans.

关键词： Avian Genome editing Primordial germ cell Transgenesis

Clinical outcome of Fitz-Hugh-Curtis syndrome mimicking acute biliary disease

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World Journal of Gastroenterology 2008年第45期14卷 6975-6980页

作者： Seong Yong Woo Jin Il Kim Dae Young Cheung Se Hyun Cho Soo-Heon Park joon-Yeol han jae Kwang Kim Division of Gastroenterology and Hepatology Department of Internal Medicine the Catholic University of Korea

AIM: To analyze the clinical characteristics of patients diagnosed with Fitz-Hugh-Curtis ***: The clinical courses of patients that visited St. Mary's Hospital with abdominal pain from January 2005 to December 2006 and were diagnosed with Fitz-Hugh-Curtis syndrome were ***: Fitz-Hugh-Curtis syndrome was identified in 22 female patients of childbearing age; their mean age was 31.0 ± 8.1 years. Fourteen of these cases presented with pain in the upper right abdomen alone or together with pain in the lower abdomen, and six patients presented with pain only in the lower abdomen. The first impression at the time of visit was acute cholecystitis or cholangitis in 10 patients and acute appendicitis or pelvic inflammatory disease in eight patients. Twenty-one patients were diagnosed by abdominal computer tomograghy (CT), and the results of abdominal sonography were normal for 10 of these patients. Chlamydia trichomatis was isolated from 18 patients. Two patients underwent laparoscopic adhesiotomy and 20 patients were completely cured by antibiotic ***: For women of childbearing age with acute pain in the upper right abdomen alone or together with pain in the lower abdomen, Fitz-Hugh-Curtis syndrome should be considered during differential diagnosis. Moreover, in cases suspected to be Fitz-Hugh-Curtis syndrome, abdominal CT, rather than abdominal sonography, assists in the diagnosis.

关键词： Chlamydia trichomatis Abdominal pain Fitz-Hugh-Curtis syndrome

Low-Programmable-Voltage Nonvolatile Memory Devices Based on Omega-shaped Gate Organic Ferroelectric P(VDF-TrFE) Field Effect Transistors Using p-type Silicon Nanowire Channels

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Nano-Micro Letters 2015年第1期7卷 35-41页

作者： Ngoc Huynh Van jae-Hyun Lee Dongmok Whang Dae joon Kang Department of Physics Institute of Basic SciencesSungkyunkwan University School of Advanced Materials Science and Engineering SKKU Advanced Institute of Nanotechnology Sungkyunkwan University

A facile approach was demonstrated for fabricating high-performance nonvolatile memory devices based on ferroelectric-gate field effect transistors using a p-type Si nanowire coated with omega-shaped gate organic ferroelectric poly(vinylidene fluoride-trifluoroethylene)(P(VDF-Tr FE)). We overcame the interfacial layer problem by incorporating P(VDF-Tr FE) as a ferroelectric gate using a low-temperature fabrication process. Our memory devices exhibited excellent memory characteristics with a low programming voltage of ±5 V, a large modulation in channel conductance between ON and OFF states exceeding 105, a long retention time greater than 3 9 104 s, and a high endurance of over 105 programming cycles while maintaining an ION/IOFFratio higher than 102.

关键词： Si nanowires Field effect transistor Ferroelectric memory