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Incidence and Related Risk Factors of Junctional Ectopic Tachycardia in Infants after Cardiac Surgery for Congenital Heart Disease

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Congenital Heart Disease 2022年第5期17卷 569-578页

作者： jae hee seol Se Yong Jung jae Young Choi Han Ki Park Young Hwan Park Nam Kyun Kim Department of Pediatrics Congenital Heart Disease CenterDivision of Pediatric CardiologySeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics Yonsei University Wonju College of MedicineWonjuKorea Department of Thoracic and Cardiovascular Surgery Division of Cardiovascular SurgeryCongenital Heart Disease CenterSeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics and Biomedical Engineering School of MedicineEmory UniversityAtlantaUSA

Objective:Junctional ectopic tachycardia is common after cardiac surgery for congenital heart ***,its incidence and related risk factors in infants after cardiac surgery are not well *** objective of this study was to determine the overall incidence and related risk factors for junctional ectopic tachycardia in neonates and ***:We enrolled a total of 271 patients aged<1 year who underwent open cardiac surgery at Severance Cardiovascular Hospital from January 2018 to December *** criteria were immediate postoperative mortality,other arrhythmias detected in the perioperative period,and ***:The overall incidence of junctional ectopic tachycardia was 12.9%.The logistic regression analysis revealed that longer cardiopulmonary bypass time,surgery involving atrioventricular node stretching,and the presence of early repolarization on preoperative electrocardiography increased the risk of junctional ectopic *** with junctional ectopic tachycardia had longer intubation time and intensive care unit ***:Junctional ectopic tachycardia is a common arrhythmia after cardiac surgery for congenital heart disease in ***,infants developing junctional ectopic tachycardia after cardiac surgery have specific preoperative electrocardiography *** risk factors for junctional ectopic tachycardia were associated not only with surgical procedural factors but also with preoperative electrocardiographic parameters.

关键词： Junctional ectopic tachycardia congenital heart disease early re-polarization

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Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease:A Single-Center Retrospective Study

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Congenital Heart Disease 2021年第3期16卷 233-244页

作者： Se Yong Jung Doyoung Jung Ah Young Kim jae hee seol Jung Min Park Jo Won Jung jae Young Choi Division of Pediatric Cardiology Congenital Heart Disease CenterSeverance Cardiovascular HospitalDepartment of PediatricsYonsei University College of MedicineSeoulKorea

Purpose:This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension(PAH)associated with congenital heart disease(CHD).Materials and Methods:We conducted a retrospective study of patients with CHD-associated PAH,treated with selexipag since December *** adult patients(mean age,45.4 years;women,77%)were treated with selexipag as add-on *** characteristics,World Health Organization functional class,6-minute walking distance(6MWD)test results,N-terminal pro-B-type natriuretic peptide levels,echocardiographic data,and incidence of side effects were ***:The majority of patients(12/13,92.3%)experienced more than one treatment-associated complication;one patient dropped out of the study due to intolerable *** results of 6MWD test(from 299.2±56.2 m to 363.8±86.5 m,p=0.039)and tricuspid regurgitation(TR)pressure gradient(from 84.7±20.5 mmHg to 61.6±24.0 mmHg,p=0.018)improved and remained improved after selexipag treatment in 12 *** on the results of a non-invasive risk assessment,8(66.7%)patients showed improvement,3(25.0%)showed no interval change,and the status of one patient(8.3%)***,compared to patients treated with a low dosage,patients treated with a medium-to-high dosage showed a greater increase in 6MWD results(88.3±26.4 m vs.55.3±27.6 m,p=0.043)and a greater reduction in the TR pressure gradient(-33.7±10.9 mmHg vs.-12.5±12.0 mmHg,p=0.015).Conclusion:Selexipag is an efficient pulmonary vasodilator as add-on therapy in treating CHD-associated PAH.

关键词： Selexipag congenital heart disease pulmonary arterial hypertension

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Microstructure and Mechanical Properties of Mg-Al-Ca-Nd Alloys Fabricated by Gravity Casting

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Journal of Materials Science & Technology 2008年第1期24卷 85-88页

作者： Hyeon-Taek Son jae-seol Lee Ik-Hyun Oh Chang-Seog Kang Korea Institute of Industrial Technology 1110-90ryong-dong Buk-gu Gwangju 500-480 South Korea

The aims of this study are to investigate the effects of Nd addition in the Mg-Al-Ca alloys on microstructure and mechanical *** of as-cast Mg-5Al-3Ca alloy containing Nd consists ofα-Mg matrix, eutectic phase and Al-Nd rich intermetallic *** Nd addition was increased,α-Mg matrix morphology was changed from dendritic to equiaxed grains and average value of grain size was *** addition to Mg-5Al-3Ca based alloys resulted in the formation of Al-Nd rich intermetallic compounds at grain boundary andα-Mg matrix *** these Al-Nd rich intermetallic compounds were dispersed *** these alloys,two kinds of eutectic phases were observed,*** irregular-shape structure at grain boundary and fine needle-shape structure in theα-Mg matrix *** is found that the ultimate strength showed the maximum value of 271 MPa at Mg-5Al-3Ca-2Nd alloy and elongation was decreased as the addition of Nd was increased.

关键词： Mg-AI-Ca alloy Neodymium (Nd) Rare earth element

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Segregation of voiced and unvoiced components from residual of speech signal

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Journal of Central South University 2012年第2期19卷 496-503页

作者： JO Cheol-woo KIM jae-hee School of Mechatronics Changwon National University

In conventional source-filter models, voiced and unvoiced components were considered independently. However, in practice it was difficult to separate the source into two parts. An actual source consists of a mixture of two sources and the ratio varies according to the content or the intention of speaker. It had been investigated to separate the voiced and unvoiced components for different source models. Source signals were modeled based on the residual signal measured from inverse filtering. Three different source models were assumed. The parameters of each model were optimized for the original speech signal using a genetic algorithm. The resulting parameters were compared in terms of the mel-cepstral distance to the original signal, the spectrogram and the spectral envelope from the synthesized signal. The optimization method achieves an improvement of 15% for the Klatt model, but there is little improvement in the modified residual case.

关键词： voice source model synthesis optimization genetic algorithm

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Multi-faceted small molecule for Alzheimer’s disease

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Neural Regeneration Research 2023年第10期18卷 2198-2199页

作者： Min hee Park hee Kyung Jin jae-sung Bae KNU Alzheimer’s Disease Research Institute Department of PhysiologySchool of MedicineKyungpook National UniversityDaeguSouth Korea KNU Alzheimer’s Disease Research Institute Department of Laboratory Animal MedicineCollege of Veterinary MedicineKyungpook National UniversityDaeguSouth Korea

The main pathologies of Alzheimer’s disease(AD)are the accumulation of amyloid-B(AB)and tau ta ngles,and these two fundamental pathologies accompany the va rious neuropathological features,such as neuroinfla mmation,... 详细信息

关键词： Alzheimer tau amyloid

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Risk factors for complications associated with upper gastrointestinal foreign bodies

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World Journal of Gastroenterology 2015年第26期21卷 8125-8131页

作者： Kyong hee Hong Yoon jae Kim jae Hak Kim Song Wook Chun hee Man Kim jae hee Cho Division of Gastroenterology Department of Internal MedicineDongguk University Ilsan HospitalGraduate School Division of Gastroenterology Department of Internal MedicineGachon University Gil Medical Center Division of Gastroenterology Department of Internal MedicineMyongji Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineYonsei University Wonju College of Medicine

AIM: To investigate predictive risk factors associated with complications in the endoscopic removal of foreign bodies from the upper gastrointestinal ***: We retrospectively reviewed the medical records of 194 patients with a diagnosis of foreign body impaction in the upper gastrointestinal tract,confirmed by endoscopy,at two university hospital in South *** demographic data,including age,gender,intention to ingestion,symptoms at admission,and comorbidities,were *** features of the foreign bodies,such as type,size,sharpness of edges,number,and location,were *** data those were analyzed included duration of foreign body impaction,duration of endoscopic performance,endoscopic device,days of hospitalization,complication rate,30-d mortality rate,and the number of operationsrelated to foreign body ***: The types of upper gastrointestinal foreign bodies included fish bones,drugs,shells,meat,metal,and animal *** locations of impacted foreign bodies were the upper esophagus(57.2%),mid esophagus(28.4%),stomach(10.8%),and lower esophagus(3.6%).The median size of the foreign bodies was 26.2 ± 16.7 *** 194 patients,endoscopic removal was achieved in 189,and complications developed in 51 patients(26.9%).Significant complications associated with foreign body impaction and removal included deep lacerations with minor bleeding(n = 31,16%),ulcer(n = 11,5.7%),perforation(n = 3,1.5%),and abscess(n = 1,0.5%).Four patients underwent operations because of incomplete endoscopic foreign body *** multivariate analyses,risk factors for endoscopic complications and failure were sharpness(HR = 2.48,95%CI: 1.07-5.72; P = 0.034) and a greater than 12-h duration of impaction(HR = 2.42,95%CI: 1.12-5.25,P = 0.025).CONCLUSION: In cases of longer than 12 h since foreign body ingestion or sharp-pointed objects,rapid endoscopic intervention should be provided in patients with ingested foreign bodies.

关键词： Emergency department Foreign body Upper gastrointestinal tract Endoscopy Complication

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On the stacking fault forming probability and stacking fault energy in carbon-doped 17 at%Mn steels via transmission electron microscopy and atom probe tomography

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Journal of Materials Science & Technology 2022年第20期115卷 177-188页

作者： Hyo Ju Bae Kwang Kyu Ko Muhammad Ishtiaq Jung Gi Kim Hyokyung Sung jae Bok seol Department of Materials Engineering and Convergence Technology Center for K-metalGyeongsang National University(GNU)Jinju 52828South Korea

Assessing the stacking fault forming probability(P_(sf)) and stacking fault energy(SFE)in medium-or highMn base structural materials can anticipate and elucidate the microstructural evolution before and after ***,these two parameters have been determined from theoretical calculations and empirical ***,the estimation of SFE values in Fe–Mn–C ternary systems is a longstanding debate due to the complicated nature of carbon:that is,whether the carbon doping indeed plays an important role in the formation of stacking faults;and how the amount of carbon atoms exist at grain boundaries or at internal grains with respect to the nominal carbon doping ***,the use of atom probe tomography and transmission electron microscopy(TEM)unveils the influence of carbondoping contents on the structural properties of dual-phase Fe–17 Mn–x C(x=0–1.56 at%)steels,such as carbon segregation free energy at grain boundaries,carbon concentration in grain interior,interplanar D-spacings,and mean width of intrinsic stacking faults,which are essential for SFE *** next determined the Psfvalues by two different methods,viz.,reciprocal-space electron diffraction measurements and stacking fault width measurements in real-space TEM ***,SFEs in the Fe–17 Mn–x C systems were calculated on the basis of the generally-known SFE *** found that the high amount of carbon doping gives rise to the increased SFE from 8.6 to 13.5 m J/m^(2)with non-linear *** SFE trend varies inversely with the mean width of localized stacking faults,which pass through both other stacking faults and pre-existingε-martensite plates without much difficulty at their intersecting *** high amount of carbon doping acts twofold,through increasing the segregation free energy(due to more carbon at grain boundaries)and large lattice expansion(due to increased soluble carbon at internal grains).The experimental data obtained here strengthens the composition-

关键词： Stacking fault formation probability Stacking fault energy High-Mn steel Electron diffraction

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Reduced micro RNA 375 in colorectal cancer upregulates metadherin-mediated signaling

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World Journal of Gastroenterology 2019年第44期25卷 6495-6507页

作者： seol-hee Han Ji-Su Mo Won-Cheol Park Soo-Cheon Chae Department of Pathology School of MedicineWonkwang UniversityIksanChonbuk 54538South Korea Digestive Disease Research Institute Wonkwang UniversityIksanChonbuk 54538South Korea

BACKGROUND The human microRNA 375(MIR375)is significantly downregulated in human colorectal cancer(CRC)and we have previously shown that MIR375 is a CRCassociated *** metadherin(MTDH)is a candidate target gene of *** To investigate the interaction and function between MIR375 and MTDH in human *** A luciferase reporter system was used to confirm the effect of MIR375 on MTDH *** expression levels of MIR375 and the target genes were evaluated by quantitative RT-PCR(qRT-PCR),western blotting,or *** MTDH expression was found to be upregulated in human CRC tissues compared to that in healthy *** show that MIR375 regulates the expression of many genes involved in the MTDH-mediated signal transduction pathways[BRAF-MAPK and phosphatidylinositol-4,5-biphosphate-3-kinase catalytic subunit alpha(PIK3CA)-AKT]in CRC *** MTDH expression levels were found to inhibit NF-κB inhibitor alpha,which further upregulated NFKB1 and RELA expression in CRC *** Our findings suggest that suppressing MIR375 expression in CRC regulates cell proliferation and angiogenesis by increasing MTDH ***,MIR375 may be of therapeutic value in treating human CRC.

关键词： MicroRNA 375 Metadherin Mitogen-activated protein kinase Angiogenesis Cell proliferation Colorectal cancer

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Down-scaled regional ocean modeling system (ROMS) for high-resolution coastal hydrodynamics in Korea

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Acta Oceanologica Sinica 2013年第9期32卷 50-61页

作者： LIM Hak-Soo KIM Chang S PARK Kwang-Soon SHIM jae seol CHUN Insik Korea Institute of Ocean Science and Technology Konkuk University

A down-scaled operational oceanographic system is developed for the coastal waters of Korea using a re- gional ocean modeling system （ROMS）. The operational oceanographic modeling system consists of at- mospheric and hydrodynamic models. The hydrodynamic model, ROMS, is coupled with wave, sediment transport, and water quality modules. The system forecasts the predicted results twice a day on a 72 h basis, including sea surface elevation, currents, temperature, salinity, storm surge height, and wave information for the coastal waters of Korea. The predicted results are exported to the web-GIS-based coastal informa- tion system for real-time dissemination to the public and validation with real-time monitoring data using visualization technologies. The ROMS is two-way coupled with a simulating waves nearshore model, SWAN, for the hydrodynamics and waves, nested with the meteorological model, WRE for the atmospheric surface forcing, and externally nested with the eutrophication model, CE-QUAL-ICM, for the water quality. The op- erational model, ROMS, was calibrated with the tidal surface observed with a tide-gage and verified with current data observed by bottom-mounted ADCP or AWAC near the coastal waters of Korea. To validate the predicted results, we used real-time monitoring data derived from remote buoy system, HF-radar, and geostationary ocean color imager （GOCI）. This down-scaled operational coastal forecasting system will be used as a part of the Korea operational oceanographic system （KOOS） with other operational oceanographic systems.

关键词： down-scaled operational oceanographic system regional ocean modeling system wave coupledmodel real-time monitoring system

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Comparison of intra peritoneal anti-adhesive polysaccha rides derived from Phellinus mushrooms in a rat peritonitis model

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World Journal of Gastroenterology 2005年第6期11卷 810-816页

作者： jae-Sung Bae Kwang-Ho Jang hee-Kyung Jin Department of Surgery Department of Laboratory Animal Medicine

AIM: To assess the adhesion- and abscess-reducing capacities of various concentrations of polysaccharides derived from fungus, Phellinus gilvus (PG) or Phellinus linteus (PL) in a rat peritonitis ***: In 96 SD rats, experimental peritonitis was induced using the cecal ligation and puncture model (CLP).Rats were randomly assigned to 8 groups; Ringer's lactate solution (RL group), hyaluronic acid (HA group), 0.025%,0.25%, and 0.5% polysaccharides from PG (PG0.025, 0.25,and 0.5 groups), and PL (PL0.025, 0.25, and 0.5 groups).Adhesions and abscesses were noted at 7 d after ***-PCR assay was performed to assess the cecal ***: Adhesion formation was significantly reduced in PG0.25, 0.5, PL0.25, 0.5, and HA groups (2.5±0.7,2.4±0.7, 3.8±1.0, 3.6±0.8, and 2.7±1.1, P＜0.05). The incidence of abscesses was significantly reduced in all treated groups compared to RL group (58%, P＜0.05). The urokinase-type plasminogen activator (uPA) gene expression was greatly up-regulated by increasing the concentration of polysaccharides. The urokinase-type plasminogen activator receptor (uPAR) and tumor necrosis factor (TNF)-α mRNA were highly expressed in PG0.25, 0.5, PL0.25, and ***: We concluded that 0.5% polysaccharide derived from PG and PL was the optimal concentration in preventing adhesion and abscess formation and may act by modulating activity of uPA and TNF-α in a rat peritonitis model.

关键词： Adhesion Abscess Phellinus gilvus, Phellinus linteus Polysaccharides

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