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Effectiveness of gastric cancer screening programs in South Korea:Organized vs opportunistic models

World Journal of Gastroenterology 2013年第5期19卷 736-741页

作者： Beom Jin kim Chae Heo Byoung Kwon kim jae Yeol kim jae gyu kim Department of Internal Medicine Chung-Ang University College of MedicineHeukseok-dongDongjak-guSeoul 156-755South Korea Department of Pathology Green Cross Reference Laboratory314 Pojung-dongGiheung-guYongin-siKyunggi-do 446-913South Korea

AIM:To investigate the outcome and effectiveness of two screening programs,National Cancer Screening Program(NCSP)and opportunistic screening(OS),for the detection of gastric cancer. METHODS:A total of 45 654 subjects underwent upper endoscopy as part of the NCSP or OS at the Chung-Ang University Healthcare System in Korea between January 2007 and December *** study population was comprised of subjects over the age of 40 *** specifically,subjects who took part in the NCSP were Medicaid recipients and beneficiaries of the National Health Insurance *** photo-graphs from the endoscopies diagnosed as gastric cancer were reviewed by two experienced endoscopists. RESULTS:The mean age of the screened subjects was 55 years for men and 54 years for women.A total of 126 cases(0.28%)of gastric cancer were detected from both screening programs;100 cases(0.3%)from NCSP and in 26 cases(0.2%)from *** proportion of early gastric cancer(EGC)detected in NCSP was higher than that in OS(74.0%vs 53.8%,P=0.046). Among the 34 416 screenees in NCSP,6585(19.1%) underwent upper endoscopy every other year as *** the 11 238 screenees in OS,3050(27.1%) underwent upper endoscopy at least once every two years during the study *** detection rate of gastric cancer was found to be significantly higher during irregular follow-up than during regular follow-up in both screening programs(0.3%vs 0.2%,P=0.036).A higher incidence of EGC than advanced gastric cancer was observed during regular follow-up compared with irregular follow-up. CONCLUSION:Compliance to the screening program is more important than the type of screening system used.

关键词： Gastric cancer National Cancer Screening Program Opportunistic screening Early gastric cancer

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： jae-Hong kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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Impact of surgical volume on nationwide hospital mortality after pancreaticoduodenectomy

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World Journal of Gastroenterology 2012年第31期18卷 4175-4181页

作者： Chul-gyu kim Sungho Jo jae Sun kim Department of Nursing Cheongju UniversityCheongjuChungbuk 360-764South Korea Department of Surgery Dankook University College of MedicineCheoanChungnam 330-714South Korea Health Insurance Review and Assessment Service Seoul 137-706South Korea

AIM:To evaluate the impact of surgical volume on nationwide hospital mortality after pancreaticoduodenectomy(PD) for periampullary tumors in South ***:Periampullary cancer patients who underwent PD between 2005 and 2008 were analyzed from the database of the Health Insurance Review and Assessment Service of South Korea.A total of 126 hospitals were divided into 5 categories,each similar in terms of surgical volume for each *** used hospital mortality as a quality indicator,which was defined as death during the hospital stay for PD,and calculated adjusted mortality through multivariate logistic models using several confounder ***:A total of eligible 4975 patients were enrolled in this *** annual surgical volume of hospitals was markedly varied,ranging from 215 PDs in the very-high-volume hospital to < 10 PDs in the verylow-volume *** route,type of medical security,and type of operation were significantly different by surgical *** overall hospital mortality was 2.1% and the observed hospital mortality by surgical volume showed statistical *** volume,age,and type of operation were independent risk factors for hospital death,and adjusted hospital mortality showed a similar difference between hospitals with observed *** result of the HosmerLemeshow test was 5.76(P = 0.674),indicating an acceptable appropriateness of our regression ***:The higher-volume hospitals showed lower hospital mortality than the lower-volume hospitals after PD in South Korea,which were clarified through the nationwide database.

关键词： Hospital mortality Pancreaticoduodenecto-my South Korea Databases Factual Logistic models Risk factors

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User Recognition System Based on Spectrogram Image Conversion Using EMG Signals

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Computers, Materials & Continua 2022年第7期72卷 1213-1227页

作者： jae Myung kim gyu Ho Choi Min-Gu kim Sung Bum Pan Interdisciplinary Program in IT-Bio Convergence System Chosun UniversityGwangju61452Korea IT Research Institute Chosun UniversityGwangju61452Korea

Recently,user recognitionmethods to authenticate personal identity has attracted significant attention especially with increased availability of various internet of things(IoT)services through fifth-generation technology(5G)based mobile *** EMG signals generated inside the body with unique individual characteristics are being studied as a part of nextgeneration user recognition ***,there is a limitation when applying EMG signals to user recognition systems as the same operation needs to be repeated while maintaining a constant strength of muscle over ***,it is necessary to conduct research on multidimensional feature transformation that includes changes in frequency features over *** this paper,we propose a user recognition system that applies EMG signals to the short-time fourier transform(STFT),and converts the signals into EMG spectrogram images while adjusting the time-frequency resolution to extract multidimensional *** proposed system is composed of a data pre-processing and normalization process,spectrogram image conversion process,and final classification *** experimental results revealed that the proposed EMG spectrogram image-based user recognition system has a 95.4%accuracy performance,which is 13%higher than the EMGsignal-based *** a user recognition accuracy improvement was achieved by using multidimensional features,in the time-frequency domain.

关键词： EMG user recognition spectrogram CNN

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Utilizing 3,4-ethylenedioxythiophene(EDOT)-bridged non-fullerene acceptors for efficient organic solar cells

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Journal of Energy Chemistry 2022年第2期31卷 194-204页

作者： Sung jae Jeon Young Hoon kim Ie Na kim Nam gyu Yang Ji Hee Yun Doo Kyung Moon Nano and Information Materials(NIMs)Laboratory Department of Chemical EngineeringKonkuk University120 Neungdong-ro Gwangjin-guSeoul 05029South Korea Department of Academy of Applied Science and Technology Konkuk University120 Neungdong-ro Gwangjin-guSeoul 05029South Korea

A rational design of efficient low-band-gap non-fullerene acceptors(NFAs)for high-performance organic solar cells(OSCs)remains challenging;the main constraint being the decrease in the energy level of the lowest unoccupied molecular orbitals(LUMOs)as the bandgap of A-D-A-type NFAs ***,the short current density(J_(sc))and open-circuit voltage(V_(oc))result in a trade-off relationship,making it difficult to obtain efficient ***,three NFAs(IFL-ED-4 F,IDT-ED-4 F,and IDTT-ED-2 F)were synthesized to address the above-mentioned issue by introducing 3,4-ethylenedioxythiophene(EDOT)as aπ-*** NFAs exhibit relatively low bandgaps(1.67,1.42,and 1.49 eV,respectively)and upshifted LUMO levels(-3.88,-3.84,and-3.81 eV,respectively)compared with most reported low-band-gap ***,the photovoltaic devices based on IDT-ED-4 F blended with a PBDB-T donor polymer showed the best power conversion efficiency(PCE)of 10.4%with a high J_(sc) of 22.1 mA cm^(-2) and Voc of 0.884 V among the examined *** contrast,IDTT-ED-4 F,which was designed with an asymmetric structure of the D-p-A type,showed the lowest efficiency of 1.5%owing to the poor morphology and charge transport properties of the binary ***,when this was introduced as the third component of the PM6:BTP-BO-4 Cl,complementary absorption and cascade energy-level alignment between the two substances could be ***,the IDTT-ED-4 F-based ternary blend device not only improved the Jscand Voc,but also achieved a PCE of 15.2%,which is approximately 5.3%higher than that of the reference device with a minimized energy loss of 0.488 *** addition,the universality of IDTT-ED-2 F as a third component was effectively demonstrated in other photoactive systems,specifically,PM6:BTPe C9 and PTB7-Th:IEICO-4 *** work facilitates a better understanding of the structure–property relationship for utilizing efficient EDOT-bridged NFAs in high-performance OSC applications.

关键词： Non-fullerene acceptor 3,4-ethylenedioxythiophene Organic solar cell π-bridge π-spacer

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Retroperitoneal desmoplastic small round cell tumor:Pediatric patient treated with multimodal therapy

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World Journal of Gastroenterology 2009年第33期15卷 4212-4214页

作者： Yong Seok kim Seong jae Cha Yoo Shin Choi Beom gyu kim Sung Jun Park In Taik Chang Department of Surgery College of MedicineChung-Ang University

A desmoplastic small round cell tumor (DSRCT) is a rare, aggressive mesenchymal neoplasm. Although a DSRCT can develop at various sites, the intraabdominal site is the most common location. These tumors are found most commonly among young adolescents and the prognosis is extremely poor. Multimodal treatment with surgery, chemotherapy and radiotherapy is very important for these rare cases, and this treatment can improve patient survival. In this report, we describe the case of an 8-year-old boy diagnosed with DSRCT located in the retroperitoneal space. The patient has undergone surgical resection and adjuvant chemoradiation therapy, and is currently alive without disease recurrence.

关键词： Retroperitoneum Desmoplastic small round cell tumor Multimodal therapy

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STUDY ON DRILLING CHARACTERISTICS AND MECHANICAL PROPERTIES OF CFRP COMPOSITES

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Acta Mechanica Solida Sinica 2008年第4期21卷 364-368页

作者： Seung-Chul Lee Seong-Taek Jeong Jong-Nam Park Sun-Jin kim gyu-jae Cho Department of Mechanical Engineering Chosun UniversityGraduate SchoolGwangjuKorea Small Business Corporation GwangjuKorea Department of Computer Mechanic Chosun College of Science & TechnologyGwangjuKorea Department of Fire Safety Management Seokang CollegyGwangjuKorea Department of Mechanical Engineering Chosun UniversityGwangjuKorea

Stacking plates of CFRP composite materials are increasingly used because of their unique characteristics. However, unlike other materials used in metallurgy they have a disadvantage of uneven quality and anisotropy when combined with other composites. Hence, specimens of CFRP stacking plates are manufactured by changing orientation angles throughout three quasiisotropic plies （0°/45°/90°/-45°）68, （03°/453°/903°/-453°）2s, and （06°/456°/906°/-456°）s and throughout three cross plies （0°/90°/0°/90°）68, （03 °/903 °/03°/903°）2s, and （06 °/906 °/06°/906°）8 In this study 3-point bending tests and transverse bending tests have been carried out in order to find out mechanical characteristics according to orientation angles by stacking in 6 different types along with the change of stacking composition method of a CFRP composite.

关键词： composite materials stacking plates

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Nanograin network memory with reconfigurable percolation paths for synaptic interactions

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Light(Science & Applications) 2023年第6期12卷 1040-1050页

作者： Hoo-Cheol Lee Jungkil kim Ha-Reem kim Kyoung-Ho kim Kyung-Jun Park jae-Pil So Jung Min Lee Min-Soo Hwang Hong-gyu Park Department of Physics Korea UniversitySeoul 02841Republic of Korea Department of Physics Jeju National UniversityJeju 63243Republic of Korea Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea

The development of memory devices with functions that simultaneously process and store data is required for efficient *** achieve this,artificial synaptic devices have been proposed because they can construct hybrid networks with biological neurons and perform neuromorphic ***,irreversible aging of these electrical devices causes unavoidable performance *** several photonic approaches to controlling currents have been suggested,suppression of current levels and switching of analog conductance in a simple photonic manner remain ***,we demonstrated a nanograin network memory using reconfigurable percolation paths in a single Si nanowire with solid core/porous shell and pure solid core *** electrical and photonic control of current percolation paths enabled the analog and reversible adjustment of the persistent current level,exhibiting memory behavior and current suppression in this single nanowire *** addition,the synaptic behaviors of memory and erasure were demonstrated through potentiation and habituation *** habituation was achieved using laser illumination on the porous nanowire shell,with a linear decrease in the postsynaptic ***,synaptic elimination was emulated using two adjacent devices interconnected on a single ***,electrical and photonic reconfiguration of the conductive paths in Si nanograin networks will pave the way for next-generation nanodevice technologies.

关键词： electrical percolation network

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THE ENERGY CONSERVATIONS AND LOWER BOUNDS FOR POSSIBLE SINGULAR SOLUTIONS TO THE 3D INCOMPRESSIBLE MHD EQUATIONS

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Acta Mathematica Scientia 2020年第1期40卷 237-244页

作者： jae-Myoung kim Department of Mathematics Education Andong National University AndongRepublic of Korea

In this note,we give a new proof to the energy conservation for the weak solutions of the incompressible 3D MHD ***,we give the lower bounds for possible singular solutions to the incompressible 3D MHD equations.

关键词： MHD equation lower bounds incompressible

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Sprinkle formulations——A review of commercially available products

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Asian Journal of Pharmaceutical Sciences 2020年第3期15卷 292-310页

作者： Han Sol Lee Jeong-Jun Lee Myeong-gyu kim Ki-Taek kim Cheong-Weon Cho Dae-Duk kim jae-Young Lee College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Graduate School of Clinical Pharmacy CHA UniversityPocheon 11160Republic of Korea College of Pharmacy and Natural Medicine Research Institute Mokpo National UniversityJeonnam 58554Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea

Currently, sixty-five original sprinkle drug products are available in various dosage forms including tablets, powders, granules, immediate-release capsules, extended-release capsules, delayed-release capsules, and multiparticulate drug delivery systems. By sprinkling on soft food vehicles, these products provide dosing flexibility and convenience of administration, which potentially improve the compliance of patients with *** to these advantages, the growth of sprinkle products picked up since the 1990s, and several regulatory issues regarding this dosage form have been raised and *** this article, the types of sprinkle formulations were discussed by dividing them into seven categories, and the commercial products were summarized in terms of the drug substance, pharmaceutical excipients, storage conditions and administration methods. In addition, several US Food and Drug Administration guidelines related to the regulatory issues of sprinkle formulations were reviewed, which led to the conclusion that the future development of this promising dosage form demands integrated guidance for industry rather than scattered information in various documents.

关键词： Sprinkle formulation Soft food Geriatric Pediatric Dysphagia Guidance for industry

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