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Negative oncologic impact of poor postoperative pain control in left-sided pancreatic cancer

World Journal of Gastroenterology 2017年第4期23卷 676-686页

作者： Eun-Ki Min jae uk chong Ho Kyoung Hwang Sang Joon Pae Chang Moo Kang Woo Jung Lee Yonsei University College of Medicine Seoul 03722 Department of Hepatobiliary and Pancreatic Surgery Yonsei University College of Medicine Pancreaticobiliary Cancer Clinic Yonsei Cancer CenterSeverance Hospital National Health Insurance Corporation Ilsan Hospital

AIMTo investigate the association between postoperative pain control and oncologic outcomes in resected pancreatic ductal adenocarcinoma (PDAC).METHODSFrom January 2009 to December 2014, 221 patients were diagnosed with PDAC and underwent resection with curative intent. Retrospective review of the patients was performed based on electronic medical records system. One patient without records of numerical rating scale (NRS) pain intensity scores was excluded and eight patients who underwent total pancreatectomy were also excluded. NRS scores during 7 postoperative days following resection of PDAC were reviewed along with clinicopathologic characteristics. Patients were stratified into a good pain control group and a poor pain control group according to the difference in average pain intensity between the early (POD 1, 2, 3) and late (POD 5, 7) postoperative periods. Cox-proportional hazards multivariate analysis was performed to determine association between postoperative pain control and oncologic *** total of 212 patients were dichotomized into good pain control group (n = 162) and poor pain control group (n = 66). Median follow-up period was 17 mo. A negative impact of poor postoperative pain control on overall survival (OS) was observed in the group of patients receiving distal pancreatectomy (DP group; 42.0 mo vs 5.0 mo, P = 0.001). Poor postoperative pain control was also associated with poor disease-free survival (DFS) in the DP group (18.0 mo vs 8.0 mo, P = 0.001). Patients undergoing pancreaticoduodenectomy or pylorus-preserving pancreaticoduodenectomy (PD group) did not show associations between postoperative pain control and oncologic outcomes. Poor patients’ perceived pain control was revealed as an independent risk factor of both DFS (HR = 4.157; 95%CI: 1.938-8.915; P < 0.001) and OS (HR = 4.741; 95%CI: 2.214-10.153; P < 0.001) in resected left-sided pancreatic *** postoperative pain relief durin

关键词： Pancreatic cancer Pancreatectomy Survival Postoperative pain Recurrence

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu chong Gao Yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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Origin of superior low-cycle fatigue resistance of an interstitial metastable high-entropy alloy

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Journal of Materials Science & Technology 2022年第20期115卷 115-128页

作者： Seyed Amir Arsalan Shams jae Wung Bae jae Nam Kim Hyoung Seop Kim Taekyung Lee chong Soo Lee Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 37673Republic of Korea Department of Materials Science and Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea

In this study, the deformation behaviors and related microstructural evolutions were investigated in either monotonic or cyclic deformation modes in an interstitial metastable high-entropy alloy. These investigations aimed to reveal the mechanisms underlying the superior low-cycle fatigue(LCF) life of this alloy.A thermomechanical process was applied to induce fine-grained(FG) and coarse-grained(CG) microstructures in Fe–30Mn–10Co–10Cr–0.4C(atomic percentage) alloy. Their superior combination of strength and ductility was attributed to the appearance of deformation-induced ε-martensite and the presence of carbon. The CG alloy showed a greater volume fraction of ε-martensite than the FG alloy in the monotonic deformation mode, and vice versa in the cyclic mode. Such a disparity was interpreted in light of the back-stress effect of the relaxed γ-grain boundaries in the latter mode. Meanwhile, the γ-to-ε phase transformation under cyclic loading at low strain amplitudes(0.4%) barely led to an improved fatigue life as compared with that at higher strain amplitudes(≥ 0.55%). The high reversibility of partial dislocation motions under cyclic loading and delaying the formation of dislocation cells through the martensitic transformation could explain why the alloys investigated in this study exhibited a superior LCF life compared with high-entropy alloys reported in previous studies.

关键词： High-entropy alloy Transformation-induced plasticity Monotonic deformation Cyclic deformation Low-cycle fatigue Stacking faults

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Inhibitory actions of mibefradil on steroidogenesis in mouse Leydig cells： involvement of Ca^2＋ entry via the T-type Ca^2＋ channel

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Asian Journal of Andrology 2010年第6期12卷 807-813页

作者： jae-Ho Lee Jong-uk Kim Changhoon Kim Churl K. Min Institute of Tissue Regeneration Engineering Dankook University Cheonan 330714 South Korea Department of Molecular Sciences and Technology Ajou University Suwon 443749 South Korea Division of Cardiology Department of Medicine Emory University Atlanta GA 30322 USA Department of Biological Sciences Aj ou University Suwon 443749 South Korea

Intracellular cAMP and Ca^2＋ are involved in the regulation of steroidogenic activity in Leydig cells, which coordinate responses to luteinizing hormone （LH） and human ehorionic gonadotropin （hCG）. However, the identification of Ca^2＋ entry implicated in Leydig cell steroidogenesis is not well defined. The objective of this study was to identify the type of Ca^2＋ channel that affects Leydig cell steroidogenesis. In vitro steroidogenesis in the freshly dissociated Leydig cells of mice was induced by hCG incubation. The effects of mibefradil （a putative T-type Ca^2＋ channel blocker） on steroidogenesis were assessed using reverse transcription （RT）-polymerase chain reaction analysis for the steroidogenic acute regulatory protein （STAR） mRNA expression and testosterone production using radioimmunoassay. In the presence of 1.0 mmol L-1 extracellular Ca^2＋, hCG at 1 to 100 IU noticeably elevated both StAR mRNA level and testosterone secretion （P 〈 0.05）, and the stimulatory effects of hCG were markedly diminished by mibefradil in a dose-dependent manner （P 〈 0.05）. Moreover; the hCG-induced increase in testosterone production was completely removed when external Ca^2＋ was omitted, implying that Ca entry is needed for hCG-induced steroidogenesis. Furthermore, a patch-clamp study revealed the presence of mibefradil-sensitive Ca^24- currents seen at a concentration range that nearly paralleled those inhibiting steroidogenesis. Collectively, Our data provide evidence that hCG-stimulated steroidogenesis is mediated at least in part by Ca^2＋ entry carried out by the T-type Ca^2＋ channel in the Leydig cells of mice.

关键词： Leydig cells mibefradil STAR steroidogenesis T-type Ca^2+ channel

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Recent advances in hydrogen storage technologies based on nanoporous carbon materials

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Progress in Natural Science:Materials International 2012年第6期22卷 631-638页

作者： Seung jae Yang Haesol Jung Taehoon Kim chong Rae Park Carbon Nanomaterials Design Laboratory Global Research LaboratoryResearch Institute of Advanced Materialsand Department of Materials Science and EngineeringSeoul National UniversitySeoul 151-744Republic of Korea

Hydrogen is a promising energy carrier that can potentially facilitate a transition from fossil fuels to sustainable energy sources without producing harmful *** to realizing a hydrogen economy,however,viable hydrogen storage materials must be *** adsorption in porous solids provides an opportunity for hydrogen storage under low-stringency *** adsorbed hydrogen molecules are weakly bound to a surface and,hence,are easily *** the various surface candidates,porous carbons appear to provide efficient hydrogen storage,with the advantages that porous carbon is relatively low-cost to produce and is easily *** this review,we summarize the preparation methods,pore characteristics,and hydrogen storage capacities of representative nanoporous carbons,including activated carbons, zeolite-templated carbon,and carbide-derived *** focus particularly on a series of nanoporous carbons developed recently:metal-organic framework-derived carbons,which exhibit promising properties for use in hydrogen storage applications.

关键词： Hydrogen storage MOF-derived carbon Nanoporous carbons Structure-property relationship

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Effect of mixing structure on the hygroscopic behavior of ultrafine ammonium sulfate particles mixed with succinic acid and levoglucosan

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Particuology 2014年第2期12卷 27-34页

作者： Shila Maskey Ka Yan chong Gibaek Kim jae-Seok Kim Arshad Ali Kihong Park National Leading Research Laboratory School of Environmental Science and EngineeringGwangju Institute of Science and Technology(GIST)

Understanding the interactions between water and atmospheric aerosols is critical for estimating their impact on the radiation budget and cloud formation. The hygroscopic behavior of ultrafine （〈100nm） ammonium sulfate particles internally mixed with either succinic acid （slightly soluble） or levoglucosan （soluble） in different mixing structures （core-shell vs. well-mixed} were measured using a hygroscopicity tandem differential mobility analyzer （HTDMA）. During the hydration process （6-92% relative humidity （RH））, the size of core-shell particles （ammonium sulfate and succinic acid） remained unchanged until a slow increase in particle size occurred at 79Y~ RH; however, an abrupt increase in size （i.e., a clear deliquescence） was observed at ~72% RH for well-mixed particles with a similar volume fraction to the core-shell particles （80：20 by volume）. This increase might occur because the shell hindered the complete dissolution of the core-shell particles below 92% RH. The onset RH value was lower for the ammonium sulfate/levoglucosan core-shell particles than the ammonium sulfate/succinic acid core-shell particles due to levoglucosan＇s higher solubility relative to succinic acid. The growth factor （GF） of the core-shell particles was lower than that of the well-mixed particles, while the GF of the ammonium sulfate/levoglucosan particles was higher than that of ammonium sulfate/succinic acid particles with the same volume fractions. As the volume fraction of the organic species increased, the GF decreased. The data suggest that the mixing structure is also important when determining hygroscopic behavior of the mixed particles.

关键词： Ultrafine particles Hygroscopicity Mixing structure Core-shell

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Avoiding heating interference and guided thermal conduction in stretchable devices using thermal conductive composite islands

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Nano Research 2021年第9期14卷 3253-3259页

作者： Seung Ji Kang Haeleen Hong Chanho Jeong Ju Seung Lee Hyewon Ryu jae-hun Yang Jong uk Kim Yiel jae Shin Tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Biomedical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical Institute for Convergence(BICS) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The miniaturization and high integration of devices demand significant thermal management *** technologies for the thermal management of electronics show some limitations in the case of multiple chip arrays.A device in multiple chip array is affected by heat from adjacent devices,along with thermal conductive *** address this problem,we present a nano composite of aligned boron nitride(BN)nanosheet islands with porous polydimethylsiloxane(PDMS)foam to have mechanical stability and non-thermal *** islands of tetrahedrally-structured BN in the composite have a high thermal conductivity of 1.219 W·m^(-1)·K^(-1) in the through-plane direction(11.234W·m^(-1)·K^(-1)in the in-plane direction)with 16 wt.%loading of *** the other hand,porous PDMS foam has a low thermal conductivity of 0.0328W·m^(-1)·K^(-1) in the through-plane direction at 70%*** pathways are then formed only in the structured BN islands of the *** porous PDMS foam can be applied as a thermal barrier between structured BN islands to inhibit thermal interference in multiple device ***,this composite can maintain selective thermal dissipation performance with 70%tensile *** beauty of the work is that it could have guided heat dissipation by assembling of multiple layers which have high vertical thermal conductive islands,while inhibiting thermal *** selective heat dissipating composite can be applied as a heatsink for multiple chip arrays electronics.

关键词： selective thermal conduction non-thermal interference thermal conductive composite island stretchable electronics structured boron nitride nanosheet(s-BN) porous polydimethylsiloxane(p-PDMS)

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A feasible route to produce 1.1 GPa ferritic-based low-Mn lightweight steels with ductility of 47%

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Journal of Materials Science & Technology 2022年第22期117卷 225-237页

作者： Kwang Kyu Ko Hyo Ju Bae Eun Hye Park Hyeon-uk Jeong Hyoung Seok Park jae Seok Jeong Jung Gi Kim Hyokyung Sung Nokeun Park jae Bok Seol Department of Materials Engineering and Convergence Technology Center for K-metalGyeongsang National University(GNU)Jinju 52828South Korea School of Materials Science and Engineering Yeungnam UniversityGyeongbuk 38541South Korea Materials Research Team R&D Hyundai MobisYongin 16891South Korea Materials Technology Development Team Doosan Heavy Industries&ConstructionChangwon 51711South Korea

High- and medium-Mn (H/M-Mn) base lightweight steels are a class of ultrastrong structural materials with high ductility compared to their low-Mn counterparts with low strength and poor ***, producing these H/M-Mn materials requires the advanced or high-tech manufacturing techniques, which can unavoidably provoke labor and cost concerns. Herein, we have developed a facilestrategy that circumvents the strength–ductility trade-off in low-Mn ferritic lightweight steels, by employing low-temperature tempering-induced partitioning (LTP). This LTP treatment affords a typical Fe-2.8Mn-5.7Al-0.3C (wt.%) steel with a heterogeneous size-distribution of metastable austenite embeddedin a ferrite matrix for partitioning more carbon into smaller austenite grains than into the larger austenite ones. This size-dependent partitioning results in slip plane spacing modification and lattice strain,which act through dislocation engineering. We ascribe the simultaneous improvement in strength andtotal elongation to both the size-dependent dislocation movement in austenite grains and the controlleddeformation-induced martensitic transformation. The low-carbon-partitioned large austenite grains increase the strength and ductility as a consequence of the combined martensitic transformation andhigh dislocation density-induced hardening and by interface strengthening. Additionally, high-carbonpartitioned small austenite grains enhance the strength and ductility by planar dislocation glide (inthe low strain regime) and by cross-slipping and delayed martensitic transformation (in the high strainregime). The concept of size-dependent dislocation engineering may provide different pathways for developing a wide range of heterogeneous-structured low-Mn lightweight steels, suggesting that LTP maybe desirable for broad industrial applications at an economic cost.

关键词： Low-Mn lightweight steel Carbon partitioning Metastable austenite Dislocation movement

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Fully tunable Fabry-Pérot cavity based on MEMS Sagnac loop reflector with ultra-low static power consumption

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Microsystems & Nanoengineering 2024年第4期10卷 355-365页

作者： Young jae Park Man jae Her Youngjae Jeong Dong Ju Choi Dong uk Kim Min Gi Lim Myung Seok Hong Hyug Su Kwon Kyoungsik Yu Sangyoon Han Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Agency for Defense Development DaejeonRepublic of Korea

The Fabry-Pérot interferometer,a fundamental component in optoelectronic systems,offers interesting applications such as sensors,lasers,and *** this work,we show a tunable Fabry-Pérot cavity consisting of tunable Sagnac loop reflectors(SLRs)and phase shifters based on electrostatic microelectromechanical(MEMS)*** fabrication process of the device is compatible with the standard wafer-level silicon photonics fabrication *** electrostatic actuation mechanism provides well-balanced,scalable pathways for efficient tuning *** extinction ratio of the continuously tunable SLRs’reflectivity is larger than 20 *** 2πphase shifting is achieved,and response times of all the components are less than 25μ*** actuators have extremely low static power,measuring under 20 fW and the energy needed for tuning is both below 20 pJ.

关键词： tunable tuning interferometer

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Function-regeneration of non-porous hydrolyzed-MOF-derived materials

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Nano Research 2019年第8期12卷 1921-1930页

作者： Yo Chan Jeong Jin Weon Seo jae Ho Kim Seunghoon Nam Min Chang Shin Young Shik Cho Jin Syul Byeon chong Rae Park Seung jae Yang Carbon Nanomaterials Design Laboratory Research Institute of Advanced Materials and Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Advanced Nanohybrids Lab. Department of Chemical Engineering Inha UniversityIncheon 22212Republic of Korea School of Advanced Materials Engineering College of Engineering Andong National University Andong Gyeongsangbuk-do 36729Republic of Korea

A facile synthetic strategy based on a water-based process is developed for the preparation of metal-organic framework (MOF)-derived materials by revisiting the hydrolyzed non-porous metal-organic frameworks (h-MOF). The poor water stability of MOF has been recognized as key limitations for its commercialization and large-scale applications because the hydrolysis resulted in the complete loss of their functionalities. However, we found that the negative effect of hydrolysis on MOF can be nullified during the heat treatment. As similar to the intact MOF, h-MOF can be used as a precursor for the preparation of MOF-derived materials from porous MOF-derived carbons (MDCs) to MDC@ZnO composites. The property of h-MOF-derived materials is almost equivalent to that of MOF-derived materials. In addition, h-MOF turned the weakness of water instability to the strength of facile water-based process for hybridization. With the demonstration of the hybrid composite between h-MDC@ZnO and reduced graphene oxide (rGO) as a prototype example, it exhibited superior electrochemical performance when evaluated as an electrode material for lithium-ion batteries.

关键词： nanomaterials metal-organic framework (MOF) porous materials MOF-derived carbon hydrolyzed MOF

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