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Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑hee Lee Byoungjoon Hwang Sojung seo Ji‑Hun seo Dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

The Spatial Effects of Antenna Configuration in a Large Area Inductively Coupled Plasma System for Flat Panel Displays

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Plasma Science and Technology 2014年第8期16卷 758-766页

作者： seon-Geun OH Young-Jun LEE jae-Hong JEON Jong-Hyeon seo hee-Hwan CHOE School of Electronics Telecommunication and Computer EngineeringKorea Aerospace University Department of Material Science and Engineering Korea Aerospace University

Spatial distributions of plasma parameters such as electron density, electron temperature and electric potential were investigated using a commercial simulation software （COMSOLTM） to predict the effects of antenna configuration in a large area inductively cou- pled plasma （ICP） system for flat panel displays. Nine planar antenna sets were evenly placed above a ceramic window. While the electron density was influenced by both the input current and gas pressure, the electron temperature and electric potential were dominantly affected by the gas pressure.

关键词： plasma ICP antenna configuration simulation

Pyunkang-hwan (Pyunkang-Tang) ameliorates air pollutant-induced inflammatory hypersecretion of airway mucus and bleomycin-induced pulmonary fibrosis in rats

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Journal of Traditional Chinese Medicine 2016年第5期36卷 663-670页

作者： Hyo-seok seo Hyun jae Lee Choong jae Lee Department of Pharmacology School of Medicine Chungnam National University Department of Health Management Sahmyook University

OBJECTIVE: To investigate the effect of Pyunkanghwan(Pyunkang-tang) extract(PGT) on secretion of airway mucin in an experimental animal model involving hyperplasia of goblet cells and mucus hypersecretion, and to test its effects on bleomycin(BLM)-induced pulmonary fibrosis in ***: The protective activity of orally administered PGT was assessed in two rat pulmonary disease models. Effects on hypersecretion of pulmonary mucin in sulfur dioxide(SO_2)-induced bronchitis in rats were assessed by quantifying the amount of mucus secreted and examining histopathology in the tracheal epithelium. In a rat model for BLMinduced pulmonary fibrosis, toxicity to the pulmonary system was examined by measuring levels of malondialdehyde and hydroxyproline,indicators of lipid peroxides and collagen,respectively, in lung tissue 28 days post-BLM treatment. Serial sections of lung tissue were stained with Masson trichrome to visualize collagen deposition. Effects of PGT on collagen synthesis were also assessed in vitro, in a cell culture ***: PGT inhibited mucin secretion and normalized SO_2-induced increased muco- substances in goblet cells. In the BLM- induced model,PGT decreased the characteristic histopathological features of lung fibrosis and inhibited fibrotic lesions, as indicated by decreased hydroxyproline content. PGT also inhibited the BLM-induced increase in malondialdehyde levels, demonstrating its protective effect against lipid peroxidation in cell membranes of the lung. In MLg 2908 mouse lung fibroblast cells, PGT decreased transforming growth factor(TGF)-β-stimulated type I collagen ***: PGT can inhibit both hypersecretion of airway mucins and pulmonary fibrosis.

关键词： Pyunkang-hwan(Pyunkang-tang) Air pollutants Bleomycin Pulmonary fibrosis Airway mucin

Reconstruction of Rabbit Corneal Layer Composed of Corneal Fibroblasts and Corneal Epithelium on the Lyophilized Amniotic Membrane

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Chemical Research in Chinese Universities 2006年第2期22卷 150-156页

作者： AHN jae-il JANG In-keun YOON Mun-young seo Young-kwon YOON hee-hun KIN jae-chan SONG Kye-yong YANG Eun-kyung PARK Jung-keug Department of Chemical and Biochemical Engineering Dongguk University Seoul Korea Department of Ophthalmology Chung-Ang University Hospital Seoul Korea Department of Pathology College of Medicine Chung-Ang University Seoul Korea R & D Center Bioland Ltd. Chun-An Korea

Many researchers have employed the cryopreserved amniotic membrane（CAM） and corneal epithelial cells in the treatment of a severely damaged burned cornea, with corneal epithelial cells cultured on an amniotic membrane （AM）. The lyophilized amniotic membrane（LAM） has a higher graft take and a longer shelf life; it is easier to store and safer because of gamma irradiation. Two Teflon rings（ Ahn＇s supporter） were made for culturing the cells on the LAM, and were then used to support the LAM. To reconstruct a corneal layer composed of corneal fibroblasts and epithelium, the corneal fibroblasts were first cultivated on the stromal side of LAM for five days, foUowed by epithelial cells culture on the epithelial side, by using the air-liquid interface culture. The reconstructed corneal layer composed of corneal fibroblasts and corneal epithelial cells has a much healthier basal layer of corneal epithelium than the reconstructed corneal epithelium, which was got by using only corneal epithelial cells, and resembles the epithelium of normal corneas, without the horny layer. Thus, the reconstruction of the corneal layer by using a LAM is considered to be a good in vitro model, not only for its application in toxicological test kits, but also for transplantation in patients with a severely damaged cornea.

关键词： Lyophilized amniotic membrane Corneal layer Corneal fibroblast Corneal epithelium

Segregation of voiced and unvoiced components from residual of speech signal

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Journal of Central South University 2012年第2期19卷 496-503页

作者： JO Cheol-woo KIM jae-hee School of Mechatronics Changwon National University

In conventional source-filter models, voiced and unvoiced components were considered independently. However, in practice it was difficult to separate the source into two parts. An actual source consists of a mixture of two sources and the ratio varies according to the content or the intention of speaker. It had been investigated to separate the voiced and unvoiced components for different source models. Source signals were modeled based on the residual signal measured from inverse filtering. Three different source models were assumed. The parameters of each model were optimized for the original speech signal using a genetic algorithm. The resulting parameters were compared in terms of the mel-cepstral distance to the original signal, the spectrogram and the spectral envelope from the synthesized signal. The optimization method achieves an improvement of 15% for the Klatt model, but there is little improvement in the modified residual case.

关键词： voice source model synthesis optimization genetic algorithm

Multi-faceted small molecule for Alzheimer’s disease

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Neural Regeneration Research 2023年第10期18卷 2198-2199页

作者： Min hee Park hee Kyung Jin jae-sung Bae KNU Alzheimer’s Disease Research Institute Department of PhysiologySchool of MedicineKyungpook National UniversityDaeguSouth Korea KNU Alzheimer’s Disease Research Institute Department of Laboratory Animal MedicineCollege of Veterinary MedicineKyungpook National UniversityDaeguSouth Korea

The main pathologies of Alzheimer’s disease(AD)are the accumulation of amyloid-B(AB)and tau ta ngles,and these two fundamental pathologies accompany the va rious neuropathological features,such as neuroinfla mmation,... 详细信息

关键词： Alzheimer tau amyloid

Risk factors for complications associated with upper gastrointestinal foreign bodies

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World Journal of Gastroenterology 2015年第26期21卷 8125-8131页

作者： Kyong hee Hong Yoon jae Kim jae Hak Kim Song Wook Chun hee Man Kim jae hee Cho Division of Gastroenterology Department of Internal MedicineDongguk University Ilsan HospitalGraduate School Division of Gastroenterology Department of Internal MedicineGachon University Gil Medical Center Division of Gastroenterology Department of Internal MedicineMyongji Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineYonsei University Wonju College of Medicine

AIM: To investigate predictive risk factors associated with complications in the endoscopic removal of foreign bodies from the upper gastrointestinal ***: We retrospectively reviewed the medical records of 194 patients with a diagnosis of foreign body impaction in the upper gastrointestinal tract,confirmed by endoscopy,at two university hospital in South *** demographic data,including age,gender,intention to ingestion,symptoms at admission,and comorbidities,were *** features of the foreign bodies,such as type,size,sharpness of edges,number,and location,were *** data those were analyzed included duration of foreign body impaction,duration of endoscopic performance,endoscopic device,days of hospitalization,complication rate,30-d mortality rate,and the number of operationsrelated to foreign body ***: The types of upper gastrointestinal foreign bodies included fish bones,drugs,shells,meat,metal,and animal *** locations of impacted foreign bodies were the upper esophagus(57.2%),mid esophagus(28.4%),stomach(10.8%),and lower esophagus(3.6%).The median size of the foreign bodies was 26.2 ± 16.7 *** 194 patients,endoscopic removal was achieved in 189,and complications developed in 51 patients(26.9%).Significant complications associated with foreign body impaction and removal included deep lacerations with minor bleeding(n = 31,16%),ulcer(n = 11,5.7%),perforation(n = 3,1.5%),and abscess(n = 1,0.5%).Four patients underwent operations because of incomplete endoscopic foreign body *** multivariate analyses,risk factors for endoscopic complications and failure were sharpness(HR = 2.48,95%CI: 1.07-5.72; P = 0.034) and a greater than 12-h duration of impaction(HR = 2.42,95%CI: 1.12-5.25,P = 0.025).CONCLUSION: In cases of longer than 12 h since foreign body ingestion or sharp-pointed objects,rapid endoscopic intervention should be provided in patients with ingested foreign bodies.

关键词： Emergency department Foreign body Upper gastrointestinal tract Endoscopy Complication

TGF-β2 downregulates osteogenesis under inflammatory conditions in dental follicle stem cells

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International Journal of Oral Science 2018年第4期10卷 232-243页

作者： Soyoun Um Joo-hee Lee Byoung-Moo seo Biotooth Engineering Lab Dental Research InstituteDental Regenerative BiotechnologyDepartment of Dental ScienceSchool of DentistrySeoul National University Biotooth Engineering Lab Department of Oral and Maxillofacial Surgery and Craniomaxillofacial Life ScienceDental Research InstituteSchool of DentistrySeoul ational University

Bone formation is important for the reconstruction of bone-related structures in areas that have been damaged by *** conditions such as those that occur in patients with rheumatoid arthritis, cystic fibrosis, and periodontitis have been shown to inhibit osteoblastic differentiation. This study focussed on dental follicle stem cells(DFSCs), which are found in developing tooth germ and participate in the reconstruction of alveolar bone and periodontal tissue in periodontal disease. After bacterial infection of inflamed dental tissue, the destruction of bone was observed. Currently, little is known about the relationship between the inflammatory environment and bone formation. Osteogenic differentiation of inflamed DFSCs resulted in decreased alkaline phosphatase(ALP) activity and alizarin red S staining compared to normal DFSCs. Additionally, in vivo transplantation of inflamed and normal DFSCs demonstrated severe impairment of osteogenesis by inflamed DFSCs. Protein profile analysis via liquid chromatography coupled with tandem mass spectrometry was performed to analyse the differences in protein expression in inflamed and normal tissue. Comparison of inflamed and normal DFSCs showed significant changes in the level of expression of transforming growth factor(TGF)-β2. Porphyromonas gingivalis(P.g.)-derived lipopolysaccharide(LPS) was used to create in vitro inflammatory conditions similar to periodontitis. The osteogenic differentiation of LPS-treated DFSCs was suppressed, and the cells displayed low levels of TGF-β1 and high levels of TGF-β2. DFSCs treated with TGF-β2 inhibitors showed significant increases in alizarin red S staining and ALP activity. TGF-β1 expression was also increased after inhibition of TGF-β2. By examining inflamed DFSCs and LPS-triggered DFSCs, these studies showed both clinically and experimentally that the increase in TGF-β2 levels that occurs under inflammatory conditions inhibits bone formation.

关键词： TGF downregulates osteogenesis under inflammatory conditions in dental follicle stem cells

Wet tissue adhesive polymeric powder hydrogels for skeletal muscle regeneration

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Bioactive Materials 2024年第10期40卷 334-344页

作者： Mingyu Lee Daun seo Junggeon Park Sun Hong Lee Jin Jeon Woochan Kim Jangho Kim hee seok Yang jae Young Lee School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea Department of Nanobiomedical Science&BK21 FOUR NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Department of Convergence Biosystems Engineering Chonnam National UniversityGwangju61186Republic of Korea Department of Rural and Biosystems Engineering Chonnam National UniversityGwangjuRepublic of Korea Interdisciplinary Program in IT-Bio Convergence System Chonnam National UniversityGwangju61186Republic of Korea

Volumetric muscle loss(VML)frequently results from traumatic incidents and can lead to severe functional *** have been widely employed for VML tissue regeneration,which are unfortunately ineffective because of the lack of intimate contact with injured tissue for structural and mechanical *** hydrogels allow for strong tissue connections for wound ***,conventional adhesive hydrogels exhibit poor tissue adhesion in moist,bleeding wounds due to the hydration layer at the tissue–hydrogel interfaces,resulting in insufficient *** this study,we developed a novel,biocompatible,wet tissue adhesive powder hydrogel consisting of dextran-aldehyde(dex-ald)and gelatin for the regeneration of *** powder absorbs the interfacial tissue fluid and buffer solution on the tissue,spontaneously forms a hydrogel,and strongly adheres to the tissue via various molecular interactions,including the Schiff base *** particular,the powder composition with a 1:4 ratio of dex-ald to gelatin exhibited optimal characteristics with an appropriate gelation time(258 s),strong tissue adhesion(14.5 kPa),and ***-ald/gelatin powder hydrogels presented strong adhesion to various organs and excellent hemostasis compared to other wet hydrogels and fibrin glue.A mouse VML injury model revealed that the dex-ald/gelatin powder hydrogel significantly improved muscle regeneration,reduced fibrosis,enhanced vascularization,and decreased ***,our wet-adhesive powder hydrogel can serve as an effective platform for repairing various tissues,including the heart,muscle,and nerve tissues.

关键词： Powder Hydrogel Wet-adhesive Skeletal muscle regeneration